ATE467630T1 - Verfahren und zwischenprodukte zur herstellung eines makrozyklischen proteasehemmers von hcv - Google Patents

Verfahren und zwischenprodukte zur herstellung eines makrozyklischen proteasehemmers von hcv

Info

Publication number
ATE467630T1
ATE467630T1 AT08708576T AT08708576T ATE467630T1 AT E467630 T1 ATE467630 T1 AT E467630T1 AT 08708576 T AT08708576 T AT 08708576T AT 08708576 T AT08708576 T AT 08708576T AT E467630 T1 ATE467630 T1 AT E467630T1
Authority
AT
Austria
Prior art keywords
hcv
producing
protease inhibitor
intermediate products
macrocyclic protease
Prior art date
Application number
AT08708576T
Other languages
English (en)
Inventor
Andras Horvath
Dominique Paul Michel Depre
Dominic John Ormerod
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of ATE467630T1 publication Critical patent/ATE467630T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT08708576T 2007-02-01 2008-02-01 Verfahren und zwischenprodukte zur herstellung eines makrozyklischen proteasehemmers von hcv ATE467630T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07101571 2007-02-01
PCT/EP2008/051269 WO2008092955A1 (en) 2007-02-01 2008-02-01 Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv

Publications (1)

Publication Number Publication Date
ATE467630T1 true ATE467630T1 (de) 2010-05-15

Family

ID=38337997

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08708576T ATE467630T1 (de) 2007-02-01 2008-02-01 Verfahren und zwischenprodukte zur herstellung eines makrozyklischen proteasehemmers von hcv

Country Status (25)

Country Link
US (2) US8212043B2 (de)
EP (1) EP2121674B1 (de)
JP (1) JP5563830B2 (de)
KR (1) KR101598135B1 (de)
CN (3) CN103145699B (de)
AR (1) AR065137A1 (de)
AT (1) ATE467630T1 (de)
AU (1) AU2008209697B2 (de)
BR (1) BRPI0806853B1 (de)
CA (1) CA2677173C (de)
CL (1) CL2008000322A1 (de)
CY (1) CY1110893T1 (de)
DE (1) DE602008001251D1 (de)
DK (1) DK2121674T3 (de)
ES (1) ES2345857T3 (de)
HK (3) HK1137442A1 (de)
HR (1) HRP20100429T1 (de)
IL (1) IL199276A (de)
MX (1) MX2009008271A (de)
PL (1) PL2121674T3 (de)
PT (1) PT2121674E (de)
RU (1) RU2483067C2 (de)
SI (1) SI2121674T1 (de)
TW (1) TWI455936B (de)
WO (1) WO2008092955A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
EP2121674B1 (de) * 2007-02-01 2010-05-12 Tibotec Pharmaceuticals Verfahren und zwischenprodukte zur herstellung eines makrozyklischen proteasehemmers von hcv
US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
CN102264715B (zh) * 2008-12-23 2015-12-02 奥索-麦克尼尔-詹森药品公司 用于制备hcv的大环蛋白酶抑制剂的方法及中间体
RU2536868C2 (ru) * 2009-02-27 2014-12-27 Орто-Макнейл-Янссен Фармасьютикалз Инк Аморфная соль макроциклического ингибитора hcv
TW201040181A (en) 2009-04-08 2010-11-16 Idenix Pharmaceuticals Inc Macrocyclic serine protease inhibitors
US9284307B2 (en) 2009-08-05 2016-03-15 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors
AU2011209051B2 (en) 2010-01-27 2015-01-15 AB Pharma Ltd. Polyheterocyclic compounds highly potent as HCV inhibitors
US9586893B2 (en) * 2010-03-16 2017-03-07 Janssen Pharmaceuticals Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV
TW201309690A (zh) 2011-02-10 2013-03-01 Idenix Pharmaceuticals Inc 巨環絲胺酸蛋白酶抑制劑，其醫藥組合物及其於治療ｈｃｖ感染之用途
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2012171332A1 (zh) 2011-06-16 2012-12-20 爱博新药研发(上海)有限公司 抑制丙型肝炎病毒的大环状杂环化合物及其制备和应用
AR087993A1 (es) 2011-09-22 2014-04-30 Janssen Pharmaceuticals Inc Procesos e intermediarios para la preparacion de un inhibidor macrociclico de la proteasa del hcv
UA116774C2 (uk) 2012-03-01 2018-05-10 Еррей Біофарма Інк. Інгібітори серин/треонінкінази
JP6158168B2 (ja) * 2012-03-14 2017-07-05 積水メディカル株式会社 光学活性２−ビニルシクロプロパン−１，１−ジカルボン酸エステルの製造法
CN103387509B (zh) * 2012-05-11 2016-06-08 重庆博腾制药科技股份有限公司 一种hcv蛋白酶抑制剂中间体的制备方法
JP6154474B2 (ja) 2012-10-19 2017-06-28 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎ウイルス阻害剤
US9334279B2 (en) 2012-11-02 2016-05-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9598433B2 (en) 2012-11-02 2017-03-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2914614B1 (de) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Inhibitoren des hepatitis-c-virus
FR2998892B1 (fr) 2012-12-04 2015-01-02 Pf Medicament Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments
EP2964664B1 (de) 2013-03-07 2017-01-11 Bristol-Myers Squibb Company Hemmer des hepatitis-c-virus
CN105237528B (zh) * 2014-06-09 2019-06-04 深圳翰宇药业股份有限公司 Hcv抑制剂的中间体以及由其制备hcv抑制剂的方法
CN105175406B (zh) * 2014-06-09 2019-06-04 深圳翰宇药业股份有限公司 Hcv抑制剂的中间体以及由其制备hcv抑制剂的方法
MA41812A (fr) 2015-03-27 2018-01-30 Janssen Pharmaceuticals Inc Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc
CN107098805A (zh) * 2017-05-17 2017-08-29 盐城同泰化工科技有限公司 一种4‑环戊酮‑1，2‑二甲酸的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA74546C2 (en) 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US7125845B2 (en) 2003-07-03 2006-10-24 Enanta Pharmaceuticals, Inc. Aza-peptide macrocyclic hepatitis C serine protease inhibitors
DK1713823T3 (da) * 2004-01-30 2010-03-08 Medivir Ab HCV NS-3 serinproteaseinhibitorer
PE20070343A1 (es) * 2005-07-29 2007-05-12 Medivir Ab Inhibidores macrociclicos del virus de la hepatitis c
PE20070211A1 (es) * 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
EP2121674B1 (de) * 2007-02-01 2010-05-12 Tibotec Pharmaceuticals Verfahren und zwischenprodukte zur herstellung eines makrozyklischen proteasehemmers von hcv

Also Published As

Publication number Publication date
EP2121674A1 (de) 2009-11-25
SI2121674T1 (sl) 2010-09-30
AR065137A1 (es) 2009-05-20
CA2677173C (en) 2017-12-12
HRP20100429T1 (hr) 2010-09-30
US20120238746A1 (en) 2012-09-20
TW200846346A (en) 2008-12-01
KR101598135B1 (ko) 2016-02-26
CN103145699B (zh) 2015-09-09
HK1186458A1 (zh) 2014-03-14
HK1137442A1 (en) 2010-07-30
JP5563830B2 (ja) 2014-07-30
CL2008000322A1 (es) 2008-09-05
US8212043B2 (en) 2012-07-03
BRPI0806853A2 (pt) 2014-04-29
KR20090107038A (ko) 2009-10-12
JP2010517972A (ja) 2010-05-27
CN103145699A (zh) 2013-06-12
DK2121674T3 (da) 2010-09-13
CN105111200A (zh) 2015-12-02
CN101600713A (zh) 2009-12-09
RU2483067C2 (ru) 2013-05-27
AU2008209697B2 (en) 2014-02-20
EP2121674B1 (de) 2010-05-12
US8722892B2 (en) 2014-05-13
MX2009008271A (es) 2009-08-12
BRPI0806853B1 (pt) 2018-03-20
TWI455936B (zh) 2014-10-11
DE602008001251D1 (de) 2010-06-24
PL2121674T3 (pl) 2010-10-29
CN101600713B (zh) 2014-11-12
RU2009132673A (ru) 2011-03-10
CA2677173A1 (en) 2008-08-07
PT2121674E (pt) 2010-09-03
IL199276A (en) 2014-12-31
ES2345857T3 (es) 2010-10-04
WO2008092955A1 (en) 2008-08-07
HK1217952A1 (zh) 2017-01-27
CY1110893T1 (el) 2015-06-10
AU2008209697A1 (en) 2008-08-07
US20100041889A1 (en) 2010-02-18

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