ATE465266T1 - Zusammensetzungen und verfahren zur verpackung von alpavirus-vektoren - Google Patents
Zusammensetzungen und verfahren zur verpackung von alpavirus-vektorenInfo
- Publication number
- ATE465266T1 ATE465266T1 AT99966715T AT99966715T ATE465266T1 AT E465266 T1 ATE465266 T1 AT E465266T1 AT 99966715 T AT99966715 T AT 99966715T AT 99966715 T AT99966715 T AT 99966715T AT E465266 T1 ATE465266 T1 AT E465266T1
- Authority
- AT
- Austria
- Prior art keywords
- alphavirus
- vectors
- packaging
- nucleic acid
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36151—Methods of production or purification of viral material
- C12N2770/36152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Packages (AREA)
- Wrappers (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Laminated Bodies (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11473298P | 1998-12-31 | 1998-12-31 | |
PCT/US1999/031193 WO2000039318A1 (en) | 1998-12-31 | 1999-12-30 | Compositions and methods for packaging of alphavirus vectors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE465266T1 true ATE465266T1 (de) | 2010-05-15 |
Family
ID=22357098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99966715T ATE465266T1 (de) | 1998-12-31 | 1999-12-30 | Zusammensetzungen und verfahren zur verpackung von alpavirus-vektoren |
Country Status (7)
Country | Link |
---|---|
US (1) | US6242259B1 (de) |
EP (1) | EP1141361B1 (de) |
AT (1) | ATE465266T1 (de) |
AU (1) | AU2220800A (de) |
CA (1) | CA2359013C (de) |
DE (1) | DE69942280D1 (de) |
WO (1) | WO2000039318A1 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5792462A (en) | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
US6844188B1 (en) | 1998-04-08 | 2005-01-18 | University Of North Carolina At Chapel Hill | Methods and modified cells for the treatment of cancer |
US6423544B1 (en) * | 1998-12-31 | 2002-07-23 | Chiron Corporation | Compositions and methods for producing recombinant virions |
US6329201B1 (en) * | 1998-12-31 | 2001-12-11 | Chiron Corporation | Compositions and methods for packaging of alphavirus vectors |
EP1035205A1 (de) * | 1999-03-08 | 2000-09-13 | Stichting Dienst Landbouwkundig Onderzoek | Sich nicht verbreitendes Pestivirus |
US6783939B2 (en) | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
US6982087B2 (en) * | 2000-09-07 | 2006-01-03 | The University Of North Carolina At Chapel Hill | Vectors derived from South African Arbovirus No. 86 |
WO2002062949A2 (en) | 2000-10-20 | 2002-08-15 | Canji, Inc | Aptamer-mediated regulation of gene expression |
CN1520303B (zh) * | 2001-03-27 | 2013-04-24 | 纽约大学 | 利用基于α病毒且靶向高亲和性层粘连蛋白受体的载体进行肿瘤治疗 |
ES2345876T3 (es) | 2001-05-31 | 2010-10-05 | Novartis Vaccines And Diagnostics, Inc. | Particulas de replicones de alfavirus quimericos. |
US7045335B2 (en) * | 2001-09-06 | 2006-05-16 | Alphavax, Inc. | Alphavirus replicon vector systems |
WO2003029492A1 (en) * | 2001-09-28 | 2003-04-10 | Justin Gallivan | Metabolic genes and related methods and compositions |
US20050215472A1 (en) * | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
EP3184539A3 (de) * | 2001-10-23 | 2017-09-13 | PSMA Development Company L.L.C. | Psma antikörper |
AU2003282538A1 (en) * | 2002-10-10 | 2004-05-04 | Oxford Biomedica (Uk) Limited | Gene regulation with aptamer and modulator complexes for gene therapy |
CA2509973C (en) | 2002-12-13 | 2013-02-26 | Alphavax, Inc. | Multi-antigenic alphavirus replicon particles and methods |
DK3246399T3 (da) | 2002-12-13 | 2021-10-04 | Alphavax Inc | Alfavirus-partikler og fremgangsmåder til fremstilling |
KR101454842B1 (ko) * | 2003-03-20 | 2014-11-04 | 알파벡스, 인크. | 개선된 알파바이러스 레플리콘 및 헬퍼 구축물 |
PT1651666E (pt) * | 2003-07-11 | 2009-08-28 | Alphavax Inc | Vacinas de citomegalovírus à base de alfavírus |
US7910093B2 (en) | 2003-08-19 | 2011-03-22 | New York University | Method for detecting cancer cells and monitoring cancer therapy |
DE602005012382D1 (de) | 2004-05-18 | 2009-03-05 | Alphavax Inc | Von tc-83 abgeleitete alphavirus-vektoren, partikel und verfahren |
JP4896021B2 (ja) | 2004-05-21 | 2012-03-14 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | 呼吸器系病原体ワクチンのためのアルファウイルスベクター |
WO2006085983A2 (en) | 2004-07-09 | 2006-08-17 | University Of North Carolina At Chapel Hill | Viral adjuvants |
US20060198854A1 (en) * | 2004-12-28 | 2006-09-07 | Peter Pushko | Vector platforms derived from the alphavirus vaccines |
CA2597921A1 (en) * | 2005-02-15 | 2007-04-26 | University Of North Carolina At Chapel Hill | New live virus vaccines |
EP2535355B1 (de) | 2005-03-23 | 2019-01-02 | Genmab A/S | Antikörper gegen CD38 zur Behandlung von multiplem Myelom |
US7303898B2 (en) * | 2005-03-29 | 2007-12-04 | New York University | Defective sindbis viral vectors |
JP2009511636A (ja) | 2005-10-18 | 2009-03-19 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | アルファウイルスレプリコン粒子による粘膜免疫および全身免疫 |
WO2008085557A2 (en) | 2006-09-12 | 2008-07-17 | Alphavax, Inc. | Alphavirus replicon particles encoding il- 12 as immunological adjuvants |
ES2517869T3 (es) | 2006-09-12 | 2014-11-04 | Alphavax, Inc. | Partículas de replicones de alfavirus emparejadas con antígenos proteicos como adyuvantes inmunológicos |
ES2673823T3 (es) * | 2006-11-03 | 2018-06-25 | Alphavax, Inc. | Formulaciones de alfavirus y de partículas de replicones de alfavirus y métodos relacionados |
EP2183368B1 (de) | 2007-06-21 | 2016-08-10 | Alphavax, Inc. | Promotorenlose kassetten zur expression von alphavirus-strukturproteinen |
DK2222697T3 (da) | 2007-11-01 | 2013-03-11 | Perseid Therapeutics Llc | Immunsuppressive polypeptider og nukleinsyrer |
WO2010065414A1 (en) | 2008-12-01 | 2010-06-10 | Alphavax, Inc. | Use of micrornas to control virus helper nucleic acids |
WO2010118244A1 (en) | 2009-04-08 | 2010-10-14 | Alphavax, Inc. | Alphavirus Replicon Particles Expressing TRP2 |
US20140093556A1 (en) | 2011-01-28 | 2014-04-03 | Sanofi Pasteur Sa | Immunological Compositions Against HIV |
WO2014140938A2 (en) | 2013-03-14 | 2014-09-18 | Centre Hospitalier Universitaire Vaudois | Immunological methods |
JP2019511255A (ja) | 2016-01-11 | 2019-04-25 | バーンダリ,インク. | マイクロニードル組成物およびそれを使用する方法 |
NL2022538B1 (en) | 2019-02-08 | 2020-08-19 | Academisch Ziekenhuis Groningen | Methods for providing purified viral particles of Semliki Forest Virus (SFV), preparations obtainable thereby, and uses thereof. |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5792462A (en) * | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
JP4383530B2 (ja) | 1996-04-05 | 2009-12-16 | ノバルティス バクシンズ アンド ダイアグノスティックス, インコーポレーテッド | 細胞巨大分子合成の阻害が減少したアルファウイルスベクター |
-
1999
- 1999-12-30 AT AT99966715T patent/ATE465266T1/de active
- 1999-12-30 US US09/476,299 patent/US6242259B1/en not_active Expired - Lifetime
- 1999-12-30 DE DE69942280T patent/DE69942280D1/de not_active Expired - Lifetime
- 1999-12-30 CA CA2359013A patent/CA2359013C/en not_active Expired - Fee Related
- 1999-12-30 WO PCT/US1999/031193 patent/WO2000039318A1/en active Application Filing
- 1999-12-30 EP EP99966715A patent/EP1141361B1/de not_active Expired - Lifetime
- 1999-12-30 AU AU22208/00A patent/AU2220800A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69942280D1 (de) | 2010-06-02 |
CA2359013C (en) | 2011-02-01 |
CA2359013A1 (en) | 2000-07-06 |
EP1141361A1 (de) | 2001-10-10 |
AU2220800A (en) | 2000-07-31 |
EP1141361B1 (de) | 2010-04-21 |
US6242259B1 (en) | 2001-06-05 |
WO2000039318A1 (en) | 2000-07-06 |
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