ATE452193T1 - Xenobiotische induzierung der genexpression von zytochrom p450 cyp3a4 - Google Patents

Xenobiotische induzierung der genexpression von zytochrom p450 cyp3a4

Info

Publication number: ATE452193T1
Authority: AT; Austria
Prior art keywords: seq; cytochrome; gene expression; cyp3a4; cyp3a4 gene
Prior art date: 1998-05-21

Application number

AT99923306T

Other languages

English (en)

Inventor

Christopher Liddle

Bryan James Goodwin

Original Assignee

Univ Sydney

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-21

Filing date

1999-05-20

Publication date

2010-01-15

1999-05-20 Application filed by Univ Sydney filed Critical Univ Sydney

2010-01-15 Application granted granted Critical

2010-01-15 Publication of ATE452193T1 publication Critical patent/ATE452193T1/de

Links

102000004328 Cytochrome P-450 CYP3A Human genes 0.000 title abstract 3
108010081668 Cytochrome P-450 CYP3A Proteins 0.000 title abstract 3
230000014509 gene expression Effects 0.000 title abstract 2
230000006698 induction Effects 0.000 title 1
239000002676 xenobiotic agent Substances 0.000 title 1
230000002034 xenobiotic effect Effects 0.000 title 1
230000002068 genetic effect Effects 0.000 abstract 2
239000002773 nucleotide Substances 0.000 abstract 2
125000003729 nucleotide group Chemical group 0.000 abstract 2
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
108020005029 5' Flanking Region Proteins 0.000 abstract 1
108091027981 Response element Proteins 0.000 abstract 1
239000003623 enhancer Substances 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000002103 transcriptional effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT99923306T 1998-05-21 1999-05-20 Xenobiotische induzierung der genexpression von zytochrom p450 cyp3a4 ATE452193T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPP3628A AUPP362898A0 (en)	1998-05-21	1998-05-21	Xenobiotic induction of gene expression
PCT/AU1999/000381 WO1999061622A1 (en)	1998-05-21	1999-05-20	Xenobiotic related induction of gene expression

Publications (1)

Publication Number	Publication Date
ATE452193T1 true ATE452193T1 (de)	2010-01-15

Family

ID=3807879

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99923306T ATE452193T1 (de)	1998-05-21	1999-05-20	Xenobiotische induzierung der genexpression von zytochrom p450 cyp3a4

Country Status (10)

Country	Link
US (3)	US6984489B1 (de)
EP (2)	EP1082437B1 (de)
JP (1)	JP4446603B2 (de)
AT (1)	ATE452193T1 (de)
AU (2)	AUPP362898A0 (de)
CA (1)	CA2333016C (de)
DE (1)	DE69941813D1 (de)
DK (2)	DK1082437T3 (de)
ES (1)	ES2337967T3 (de)
WO (1)	WO1999061622A1 (de)

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US6984773B1 (en) *	1998-01-09	2006-01-10	The Salk Institute For Biological Studies	Transgenic mice expressing a human SXR receptor polypeptide
US6756491B2 (en)	1998-01-09	2004-06-29	The Salk Institute For Biological Studies	Steroid-activated nuclear receptors and uses therefor
AUPP362898A0 (en)	1998-05-21	1998-06-11	University Of Sydney, The	Xenobiotic induction of gene expression
AU2006200258B2 (en) *	1999-12-09	2009-04-09	The Salk Institute For Biological Studies	Novel steroid-activated nuclear receptors and uses therefor
WO2001079845A1 (en) *	2000-04-12	2001-10-25	Puracyp	Compositions and methods for induction of proteins involved in xenobiotic metabolism
AU2001285842A1 (en) *	2000-07-25	2002-02-05	Epidauros Biotechnologie Ag	Assay for screening compounds for inducing drug metabolizing enzymes
EP1356097A2 (de) *	2000-08-11	2003-10-29	City of Hope	Der antineoplastische wirkstoff et-743 inhibiert die transaktivierung durch sxr
SE0003393D0 (sv) *	2000-09-22	2000-09-22	Pharmacia & Upjohn Ab	Promoter sequences
AUPR116100A0 (en)	2000-11-01	2000-11-23	University Of Sydney, The	P450 gene regulation
JP2004512054A (ja) *	2000-11-01	2004-04-22	ザ・ユニバーシティ・オブ・シドニー	Ｃｙｐ３ａ４シトクロムｐ４５０遺伝子調節を分析するためのトランスジェニック動物
US7449567B2 (en)	2001-04-12	2008-11-11	Xenogen Corporation	Isolation and identification of mouse and human transcription control elements associated with cytochrome expression
WO2003085112A1 (en) *	2002-04-09	2003-10-16	Universität Basel	Enhancer sequence of the 5-aminolevulinic synthase gene
EP1827087B8 (de) *	2004-12-13	2012-09-12	ITI Scotland Limited	Verwendung transgener tiere um den metabolismus und die toxizität von medikamenten zu analysieren
CN108271422A (zh)	2015-06-25	2018-07-10	株式会社国际电气通信基础技术研究所	基于器官间串扰***的预测装置及预测程序
JP6332780B2 (ja)	2016-03-29	2018-05-30	株式会社国際電気通信基礎技術研究所	医薬組成物又は食品組成物、及び有効成分の体内での効果の評価方法

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US5851819A (en) *	1987-06-16	1998-12-22	National Institutes Of Health	Vectors carrying MDR1 cDNA which confer multidrug resistance on transduced cells
US4997757A (en) *	1987-12-23	1991-03-05	Genebiomed, Inc.	Process for detecting potential carcinogens
US5429948A (en)	1988-03-02	1995-07-04	Gentest Corporation	Human cell line stably expressing 5cDNAS encoding procarcinogen-activating enzymes and related mutagenicity assays
GB9308271D0 (en)	1993-04-21	1993-06-02	Univ Edinburgh	Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method
US6620593B1 (en)	1993-07-20	2003-09-16	Sumitomo Chemical Company, Limited	Method for safety evaluation of chemical compound using recombinant yeast expressing human cytochrome P450
US6432639B1 (en) *	1997-09-10	2002-08-13	Dna Sciences Laboratories, Inc.	Isolated CYP3A4 nucleic acid molecules and detection methods
US6756491B2 (en)	1998-01-09	2004-06-29	The Salk Institute For Biological Studies	Steroid-activated nuclear receptors and uses therefor
EP1066320A4 (de)	1998-03-27	2005-03-16	Glaxo Group Ltd	Zellkern waisenrezeptor
AUPP362898A0 (en)	1998-05-21	1998-06-11	University Of Sydney, The	Xenobiotic induction of gene expression
AU774183B2 (en) *	1998-12-17	2004-06-17	Xenogen Corporation	Non-invasive evaluation of physiological response in a mammal
EP1206906A4 (de)	1999-08-13	2004-12-29	Kirin Brewery	Maus, die träger des menschlichen cytochrom p450 ist
EP1088900A1 (de)	1999-09-10	2001-04-04	Epidauros Biotechnologie AG	Polymorphismen des menschlichen CYP3A4, CYP3A7 und hPXR Gene, und ihre Anwendung in Diagnose und Therapie
WO2001079845A1 (en)	2000-04-12	2001-10-25	Puracyp	Compositions and methods for induction of proteins involved in xenobiotic metabolism
AU2001285842A1 (en)	2000-07-25	2002-02-05	Epidauros Biotechnologie Ag	Assay for screening compounds for inducing drug metabolizing enzymes
WO2002025270A1 (en)	2000-09-21	2002-03-28	Baylor College Of Medicine	Screening systems and methods for identifying modulators of xenobiotic metabolism
US20020150915A1 (en) *	2000-09-22	2002-10-17	Anders Berkenstam	Promoter sequences
JP2004512054A (ja)	2000-11-01	2004-04-22	ザ・ユニバーシティ・オブ・シドニー	Ｃｙｐ３ａ４シトクロムｐ４５０遺伝子調節を分析するためのトランスジェニック動物
US6734582B2 (en)	2001-04-10	2004-05-11	International Business Machines Corporation	Linear actuator using a rotating motor
US7449567B2 (en) *	2001-04-12	2008-11-11	Xenogen Corporation	Isolation and identification of mouse and human transcription control elements associated with cytochrome expression
AUPR446701A0 (en)	2001-04-18	2001-05-17	Gene Stream Pty Ltd	Transgenic mammals for pharmacological and toxicological studies

1998
- 1998-05-21 AU AUPP3628A patent/AUPP362898A0/en not_active Abandoned
1999
- 1999-05-20 ES ES99923306T patent/ES2337967T3/es not_active Expired - Lifetime
- 1999-05-20 AU AU40232/99A patent/AU758087B2/en not_active Ceased
- 1999-05-20 JP JP2000551006A patent/JP4446603B2/ja not_active Expired - Lifetime
- 1999-05-20 AT AT99923306T patent/ATE452193T1/de active
- 1999-05-20 WO PCT/AU1999/000381 patent/WO1999061622A1/en active IP Right Grant
- 1999-05-20 DK DK99923306.7T patent/DK1082437T3/da active
- 1999-05-20 DE DE69941813T patent/DE69941813D1/de not_active Expired - Lifetime
- 1999-05-20 EP EP99923306A patent/EP1082437B1/de not_active Expired - Lifetime
- 1999-05-20 DK DK09177085.9T patent/DK2154250T3/da active
- 1999-05-20 EP EP09177085A patent/EP2154250B1/de not_active Expired - Lifetime
- 1999-05-20 US US09/700,991 patent/US6984489B1/en not_active Expired - Fee Related
- 1999-05-20 CA CA2333016A patent/CA2333016C/en not_active Expired - Fee Related
2006
- 2006-01-04 US US11/324,921 patent/US7638614B2/en not_active Expired - Fee Related
2009
- 2009-12-02 US US12/629,186 patent/US9029336B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2333016A1 (en)	1999-12-02
EP1082437A4 (de)	2003-03-19
EP1082437A1 (de)	2001-03-14
ES2337967T3 (es)	2010-04-30
EP1082437B1 (de)	2009-12-16
US7638614B2 (en)	2009-12-29
US6984489B1 (en)	2006-01-10
AUPP362898A0 (en)	1998-06-11
AU4023299A (en)	1999-12-13
US20100146652A1 (en)	2010-06-10
JP2002516107A (ja)	2002-06-04
EP2154250A1 (de)	2010-02-17
DK2154250T3 (da)	2013-06-17
WO1999061622A1 (en)	1999-12-02
EP2154250B1 (de)	2013-03-20
DK1082437T3 (da)	2010-04-12
AU758087B2 (en)	2003-03-13
US20060105385A1 (en)	2006-05-18
JP4446603B2 (ja)	2010-04-07
US9029336B2 (en)	2015-05-12
DE69941813D1 (de)	2010-01-28
CA2333016C (en)	2011-08-09

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2010-06-15

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Publication	Publication Date	Title
DE69941813D1 (de)	2010-01-28	Xenobiotische Induzierung der Genexpression von Zytochrom P450 CYP3A4
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DE69224902T2 (de)	1998-07-30	Hefepromoter und seine verwendung
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