DK2154250T3 - Ikke-humant transgent dyr til xenobiotisk relateret induktion af genudtryk af cytokrom CYP3A4 - Google Patents

Ikke-humant transgent dyr til xenobiotisk relateret induktion af genudtryk af cytokrom CYP3A4

Info

Publication number: DK2154250T3
Authority: DK; Denmark
Prior art keywords: xenobiotic; gene expression; transgenic animal; seq; human transgenic
Prior art date: 1998-05-21

Application number

DK09177085.9T

Other languages

English (en)

Inventor

Bryan James Goodwin

Christopher Liddle

Original Assignee

Univ Sydney

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-21

Filing date

1999-05-20

Publication date

2013-06-17

1999-05-20 Application filed by Univ Sydney filed Critical Univ Sydney

2013-06-17 Application granted granted Critical

2013-06-17 Publication of DK2154250T3 publication Critical patent/DK2154250T3/da

Links

230000014509 gene expression Effects 0.000 title abstract 2
101150116544 CYP3A4 gene Proteins 0.000 title 1
108010052832 Cytochromes Proteins 0.000 title 1
102000018832 Cytochromes Human genes 0.000 title 1
230000006698 induction Effects 0.000 title 1
230000009261 transgenic effect Effects 0.000 title 1
239000002676 xenobiotic agent Substances 0.000 title 1
230000002034 xenobiotic effect Effects 0.000 title 1
102000004328 Cytochrome P-450 CYP3A Human genes 0.000 abstract 2
108010081668 Cytochrome P-450 CYP3A Proteins 0.000 abstract 2
230000002068 genetic effect Effects 0.000 abstract 2
239000002773 nucleotide Substances 0.000 abstract 2
125000003729 nucleotide group Chemical group 0.000 abstract 2
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
108020005029 5' Flanking Region Proteins 0.000 abstract 1
108091027981 Response element Proteins 0.000 abstract 1
239000003623 enhancer Substances 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000002103 transcriptional effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

DK09177085.9T 1998-05-21 1999-05-20 Ikke-humant transgent dyr til xenobiotisk relateret induktion af genudtryk af cytokrom CYP3A4 DK2154250T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPP3628A AUPP362898A0 (en)	1998-05-21	1998-05-21	Xenobiotic induction of gene expression
EP99923306A EP1082437B1 (en)	1998-05-21	1999-05-20	Xenobiotic related induction of gene expression of cytochrome P450 CYP3A4

Publications (1)

Publication Number	Publication Date
DK2154250T3 true DK2154250T3 (da)	2013-06-17

Family

ID=3807879

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK99923306.7T DK1082437T3 (da)	1998-05-21	1999-05-20	Xenobiotisk inducering af genekspression af cytochrom P450 CYP3A4
DK09177085.9T DK2154250T3 (da)	1998-05-21	1999-05-20	Ikke-humant transgent dyr til xenobiotisk relateret induktion af genudtryk af cytokrom CYP3A4

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK99923306.7T DK1082437T3 (da)	1998-05-21	1999-05-20	Xenobiotisk inducering af genekspression af cytochrom P450 CYP3A4

Country Status (10)

Country	Link
US (3)	US6984489B1 (da)
EP (2)	EP1082437B1 (da)
JP (1)	JP4446603B2 (da)
AT (1)	ATE452193T1 (da)
AU (2)	AUPP362898A0 (da)
CA (1)	CA2333016C (da)
DE (1)	DE69941813D1 (da)
DK (2)	DK1082437T3 (da)
ES (1)	ES2337967T3 (da)
WO (1)	WO1999061622A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6984773B1 (en)	1998-01-09	2006-01-10	The Salk Institute For Biological Studies	Transgenic mice expressing a human SXR receptor polypeptide
US6756491B2 (en)	1998-01-09	2004-06-29	The Salk Institute For Biological Studies	Steroid-activated nuclear receptors and uses therefor
AUPP362898A0 (en)	1998-05-21	1998-06-11	University Of Sydney, The	Xenobiotic induction of gene expression
AU2006200258B2 (en) *	1999-12-09	2009-04-09	The Salk Institute For Biological Studies	Novel steroid-activated nuclear receptors and uses therefor
MXPA02009869A (es) *	2000-04-12	2005-02-17	Judy Raucy	Composiciones y metodos para induccion de proteinas involucradas en metabolismo xenobiotico.
AU2001285842A1 (en) *	2000-07-25	2002-02-05	Epidauros Biotechnologie Ag	Assay for screening compounds for inducing drug metabolizing enzymes
WO2002014554A2 (en) *	2000-08-11	2002-02-21	City Of Hope	The anti-neoplastic agent et-743 inhibits trans activation by sxr
SE0003393D0 (sv) *	2000-09-22	2000-09-22	Pharmacia & Upjohn Ab	Promoter sequences
AUPR116100A0 (en)	2000-11-01	2000-11-23	University Of Sydney, The	P450 gene regulation
AU2002213660A1 (en) *	2000-11-01	2002-05-15	The University Of Sydney	Transgenic animals for analysing CYP3A4 cytochrome P450 gene regulation
WO2002088305A2 (en)	2001-04-12	2002-11-07	Xenogen Corporation	Isolation and identification of mouse and human transcription control elements associated with cytochrome expression
WO2003085112A1 (en) *	2002-04-09	2003-10-16	Universität Basel	Enhancer sequence of the 5-aminolevulinic synthase gene
EP1827087B8 (en) *	2004-12-13	2012-09-12	ITI Scotland Limited	Transgenic animals for assessing drug metabolism and toxicity
CN108271422A (zh)	2015-06-25	2018-07-10	株式会社国际电气通信基础技术研究所	基于器官间串扰***的预测装置及预测程序
US11180539B2 (en)	2016-03-29	2021-11-23	Karydo Therapeutix, Inc.	Pharmaceutical composition or food composition, and method for assessing effect of active ingredient in vivo

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5851819A (en) *	1987-06-16	1998-12-22	National Institutes Of Health	Vectors carrying MDR1 cDNA which confer multidrug resistance on transduced cells
US4997757A (en) *	1987-12-23	1991-03-05	Genebiomed, Inc.	Process for detecting potential carcinogens
US5429948A (en)	1988-03-02	1995-07-04	Gentest Corporation	Human cell line stably expressing 5cDNAS encoding procarcinogen-activating enzymes and related mutagenicity assays
GB9308271D0 (en)	1993-04-21	1993-06-02	Univ Edinburgh	Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method
US6620593B1 (en)	1993-07-20	2003-09-16	Sumitomo Chemical Company, Limited	Method for safety evaluation of chemical compound using recombinant yeast expressing human cytochrome P450
US6432639B1 (en) *	1997-09-10	2002-08-13	Dna Sciences Laboratories, Inc.	Isolated CYP3A4 nucleic acid molecules and detection methods
US6756491B2 (en)	1998-01-09	2004-06-29	The Salk Institute For Biological Studies	Steroid-activated nuclear receptors and uses therefor
WO1999048915A1 (en)	1998-03-27	1999-09-30	Glaxo Group Limited	Orphan nuclear receptor
AUPP362898A0 (en)	1998-05-21	1998-06-11	University Of Sydney, The	Xenobiotic induction of gene expression
DE69933471T2 (de) *	1998-12-17	2007-08-30	Xenogen Corp., Alameda	Unblutige bestimmung einer physiologischen reaktion in einem säugetier
EP1206906A4 (en)	1999-08-13	2004-12-29	Kirin Brewery	MOUSE CONTAINING A HUMAN P450 CYTOCHROME
EP1088900A1 (en)	1999-09-10	2001-04-04	Epidauros Biotechnologie AG	Polymorphisms in the human CYP3A4, CYP3A7 and hPXR genes and their use in diagnostic and therapeutic applications
MXPA02009869A (es)	2000-04-12	2005-02-17	Judy Raucy	Composiciones y metodos para induccion de proteinas involucradas en metabolismo xenobiotico.
AU2001285842A1 (en)	2000-07-25	2002-02-05	Epidauros Biotechnologie Ag	Assay for screening compounds for inducing drug metabolizing enzymes
JP4884640B2 (ja)	2000-09-21	2012-02-29	ベイラーカレッジオブメディスン	生体異物代謝の調節物質を同定するためのスクリーニングシステムおよび方法
US20020150915A1 (en) *	2000-09-22	2002-10-17	Anders Berkenstam	Promoter sequences
AU2002213660A1 (en)	2000-11-01	2002-05-15	The University Of Sydney	Transgenic animals for analysing CYP3A4 cytochrome P450 gene regulation
US6734582B2 (en)	2001-04-10	2004-05-11	International Business Machines Corporation	Linear actuator using a rotating motor
WO2002088305A2 (en)	2001-04-12	2002-11-07	Xenogen Corporation	Isolation and identification of mouse and human transcription control elements associated with cytochrome expression
AUPR446701A0 (en)	2001-04-18	2001-05-17	Gene Stream Pty Ltd	Transgenic mammals for pharmacological and toxicological studies

1998
- 1998-05-21 AU AUPP3628A patent/AUPP362898A0/en not_active Abandoned
1999
- 1999-05-20 JP JP2000551006A patent/JP4446603B2/ja not_active Expired - Lifetime
- 1999-05-20 DE DE69941813T patent/DE69941813D1/de not_active Expired - Lifetime
- 1999-05-20 ES ES99923306T patent/ES2337967T3/es not_active Expired - Lifetime
- 1999-05-20 DK DK99923306.7T patent/DK1082437T3/da active
- 1999-05-20 WO PCT/AU1999/000381 patent/WO1999061622A1/en active IP Right Grant
- 1999-05-20 DK DK09177085.9T patent/DK2154250T3/da active
- 1999-05-20 AU AU40232/99A patent/AU758087B2/en not_active Ceased
- 1999-05-20 EP EP99923306A patent/EP1082437B1/en not_active Expired - Lifetime
- 1999-05-20 AT AT99923306T patent/ATE452193T1/de active
- 1999-05-20 EP EP09177085A patent/EP2154250B1/en not_active Expired - Lifetime
- 1999-05-20 CA CA2333016A patent/CA2333016C/en not_active Expired - Fee Related
- 1999-05-20 US US09/700,991 patent/US6984489B1/en not_active Expired - Fee Related
2006
- 2006-01-04 US US11/324,921 patent/US7638614B2/en not_active Expired - Fee Related
2009
- 2009-12-02 US US12/629,186 patent/US9029336B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP2154250B1 (en)	2013-03-20
DK1082437T3 (da)	2010-04-12
JP2002516107A (ja)	2002-06-04
ATE452193T1 (de)	2010-01-15
WO1999061622A1 (en)	1999-12-02
AUPP362898A0 (en)	1998-06-11
DE69941813D1 (de)	2010-01-28
ES2337967T3 (es)	2010-04-30
EP1082437B1 (en)	2009-12-16
EP1082437A4 (en)	2003-03-19
US7638614B2 (en)	2009-12-29
JP4446603B2 (ja)	2010-04-07
CA2333016A1 (en)	1999-12-02
US9029336B2 (en)	2015-05-12
US20100146652A1 (en)	2010-06-10
US20060105385A1 (en)	2006-05-18
EP1082437A1 (en)	2001-03-14
US6984489B1 (en)	2006-01-10
CA2333016C (en)	2011-08-09
AU4023299A (en)	1999-12-13
AU758087B2 (en)	2003-03-13
EP2154250A1 (en)	2010-02-17

Publication	Publication Date	Title
DK2154250T3 (da)	2013-06-17	Ikke-humant transgent dyr til xenobiotisk relateret induktion af genudtryk af cytokrom CYP3A4
DK1334200T3 (da)	2011-07-18	Multipelt inducerbart genreguleringssystem
DK0522880T3 (da)	2001-07-16	Gensekvenser som koder for flavonoid pathway enzymer og anvendelse
DK0581848T3 (da)	2003-10-27	Lukkede antisense- og sense-oligonukleotider og deres anvendelser
ATE528405T1 (de)	2011-10-15	Auf dem virus der infektiösen pferdeanämie (eiav) basierende vektoren
DK1034262T3 (da)	2005-11-28	Sammensætninger og fremgangsmåder til genetisk modifikation af planter
DE69527654T2 (de)	2003-04-03	Cytoplasmatische inhibition des genexpression
DK0599868T3 (da)	2000-06-26	Polyphenoloxidase-gener
DK0521621T4 (da)	2006-02-13	Modifikation af stivelsesproduktion
ATE342366T1 (de)	2006-11-15	Rekombinantes konstrukt für eine erhöhte expression von genen in pflanzen.
BR0015100A (pt)	2003-07-15	Camundongos transgênicos contendo rompimentos do gene trp
FR2701960B1 (fr)	2002-09-13	Polyribozyme apte à conférer, aux plantes, une résistance aux virus et plantes résistantes produisant ce polyribozyme.
ATE500338T1 (de)	2011-03-15	Verwendung des adenoviralen e2-late-promotors
ATE339508T1 (de)	2006-10-15	Mites-ähnliches element und an trankriptionsaktivierung beteiligtes element
DE69739936D1 (de)	2010-08-26	Genexpressionsregulator-dna, expressionskassette, expressionsvektor und transgene pflanze
WO1999060140A3 (en)	2000-06-15	Geminivirus inducible promoter sequences and the uses thereof
DE69938427D1 (de)	2008-05-08	Tes gen und dessen verwendung