EP1066320A4 - Zellkern waisenrezeptor - Google Patents

Zellkern waisenrezeptor

Info

Publication number
EP1066320A4
EP1066320A4 EP99914221A EP99914221A EP1066320A4 EP 1066320 A4 EP1066320 A4 EP 1066320A4 EP 99914221 A EP99914221 A EP 99914221A EP 99914221 A EP99914221 A EP 99914221A EP 1066320 A4 EP1066320 A4 EP 1066320A4
Authority
EP
European Patent Office
Prior art keywords
nuclear receptor
orphan nuclear
orphan
receptor
nuclear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99914221A
Other languages
English (en)
French (fr)
Other versions
EP1066320A1 (de
Inventor
Steven Anthony Kliewer
Timothy Mark Willson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of EP1066320A1 publication Critical patent/EP1066320A1/de
Publication of EP1066320A4 publication Critical patent/EP1066320A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP99914221A 1998-03-27 1999-03-26 Zellkern waisenrezeptor Withdrawn EP1066320A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7959398P 1998-03-27 1998-03-27
US79593P 1998-03-27
PCT/US1999/006737 WO1999048915A1 (en) 1998-03-27 1999-03-26 Orphan nuclear receptor

Publications (2)

Publication Number Publication Date
EP1066320A1 EP1066320A1 (de) 2001-01-10
EP1066320A4 true EP1066320A4 (de) 2005-03-16

Family

ID=22151520

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99914221A Withdrawn EP1066320A4 (de) 1998-03-27 1999-03-26 Zellkern waisenrezeptor

Country Status (4)

Country Link
EP (1) EP1066320A4 (de)
JP (1) JP2002535241A (de)
AU (1) AU3211699A (de)
WO (1) WO1999048915A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756491B2 (en) 1998-01-09 2004-06-29 The Salk Institute For Biological Studies Steroid-activated nuclear receptors and uses therefor
US6984773B1 (en) 1998-01-09 2006-01-10 The Salk Institute For Biological Studies Transgenic mice expressing a human SXR receptor polypeptide
AUPP135698A0 (en) 1998-01-15 1998-02-05 Commonwealth Scientific And Industrial Research Organisation Insectical modalities
US7238491B1 (en) 1998-03-27 2007-07-03 Smithkline Beecham Corporation Pregnane X receptor method
AUPP362898A0 (en) 1998-05-21 1998-06-11 University Of Sydney, The Xenobiotic induction of gene expression
NZ516439A (en) * 1999-07-01 2002-12-20 Commw Scient Ind Res Org Novel genetic sequences encoding steroid and juvenile hormone receptor polypeptides and uses therefor
EP1088900A1 (de) * 1999-09-10 2001-04-04 Epidauros Biotechnologie AG Polymorphismen des menschlichen CYP3A4, CYP3A7 und hPXR Gene, und ihre Anwendung in Diagnose und Therapie
AU2006200258B2 (en) * 1999-12-09 2009-04-09 The Salk Institute For Biological Studies Novel steroid-activated nuclear receptors and uses therefor
EP1250432A2 (de) * 2000-01-28 2002-10-23 Incyte Genomics, Inc. Nukleären hormonrezeptoren
MXPA02009869A (es) * 2000-04-12 2005-02-17 Judy Raucy Composiciones y metodos para induccion de proteinas involucradas en metabolismo xenobiotico.
JP2003535912A (ja) * 2000-06-21 2003-12-02 グラクソ グループ リミテッド 核内オーファン受容体
AU2001285842A1 (en) * 2000-07-25 2002-02-05 Epidauros Biotechnologie Ag Assay for screening compounds for inducing drug metabolizing enzymes
AU2001293778A1 (en) * 2000-08-28 2002-03-13 Lion Bioscience Ag Novel cofactors of the pregnane x receptor and methods of use
AUPR116100A0 (en) 2000-11-01 2000-11-23 University Of Sydney, The P450 gene regulation
AU2002213660A1 (en) * 2000-11-01 2002-05-15 The University Of Sydney Transgenic animals for analysing CYP3A4 cytochrome P450 gene regulation
JP2005503776A (ja) * 2001-05-24 2005-02-10 スミスクライン ビーチャム コーポレーション 比較薬理学に用いるための非ヒトプレグナンｘ受容体配列
EP3209671B8 (de) 2014-10-21 2019-07-31 Council of Scientific and Industrial Research Alkyliden-phosphonat-ester als p-glycoproteininduktoren

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999019354A1 (en) * 1997-10-14 1999-04-22 Pharmacia & Upjohn Ab Novel vitamin d receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof
WO1999031129A1 (en) * 1997-12-12 1999-06-24 Merck & Co., Inc. DNA MOLECULES ENCODING HUMAN NUCLEAR RECEPTOR PROTEINS, nNR7 AND nNR7-1
WO1999035246A1 (en) * 1998-01-09 1999-07-15 The Salk Institute For Biological Studies Novel steroid-activated nuclear receptors and uses therefor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999019354A1 (en) * 1997-10-14 1999-04-22 Pharmacia & Upjohn Ab Novel vitamin d receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof
WO1999031129A1 (en) * 1997-12-12 1999-06-24 Merck & Co., Inc. DNA MOLECULES ENCODING HUMAN NUCLEAR RECEPTOR PROTEINS, nNR7 AND nNR7-1
WO1999035246A1 (en) * 1998-01-09 1999-07-15 The Salk Institute For Biological Studies Novel steroid-activated nuclear receptors and uses therefor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KLIEWER S A ET AL: "AN ORPHAN NUCLEAR RECEPTOR ACTIVATED BY PREGNANES DEFINES A NOVEL STEROID SIGNALING PATHWAY", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 92, 9 January 1998 (1998-01-09), pages 73 - 82, XP000918927, ISSN: 0092-8674 *
LEHMANN J M ET AL: "The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 102, no. 5, 1 September 1998 (1998-09-01), pages 1016 - 1023, XP000909297, ISSN: 0021-9738 *
See also references of WO9948915A1 *

Also Published As

Publication number Publication date
EP1066320A1 (de) 2001-01-10
JP2002535241A (ja) 2002-10-22
WO1999048915A9 (en) 1999-11-18
AU3211699A (en) 1999-10-18
WO1999048915A1 (en) 1999-09-30

Similar Documents

Publication Publication Date Title
PL348375A1 (en) Pyrrolidine derivatives-ccr-3 receptor antagonists
HU9603525D0 (en) Vironectin receptor antagonists
IL133235A0 (en) 1-Amino-alkylcyclohexane nmda receptor antagonists
PL345247A1 (en) Retinoid-associated receptor regulators
EP1066320A4 (de) Zellkern waisenrezeptor
EP1086066A4 (de) Muskarinrezeptorantagonisten
GB9826359D0 (en) Novel receptors
IL133920A0 (en) Trail receptor
IL146151A0 (en) Human-g-protein receptor
EP1084142A4 (de) Gpr35a-rezeptor
EP0973800A4 (de) Neuartiger rezeptor
GB9819420D0 (en) Novel receptor
EP1131335A4 (de) 7tm rezeptor hlwar77
AU2001284343A1 (en) An orphan nuclear receptor
EP1071766A4 (de) MENSCHLICHER, AN EIN G-PROTEIN GEKOPPELTER REZEPTOR MIT DER BEZEICHNUNG GPR6sb.
IL137327A0 (en) Orphan receptors
EP1083909A4 (de) hCEPR REZEPTOR
GB9816742D0 (en) Pressuriser device
GB9913649D0 (en) Estrogen receptor
IL140987A0 (en) Orphan cytokine receptor
EP1109565A4 (de) Gabab1aa rezeptor
GB9607532D0 (en) Orphan receptor
GB9605550D0 (en) Orphan receptor
GB9609576D0 (en) Orphan receptor
GB9825849D0 (en) Receptor

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000925

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20050131

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Effective date: 20050418