HUP1500098A2 - 8-hidroxikinolin származékok új enantiomerjei és szintézisük - Google Patents

8-hidroxikinolin származékok új enantiomerjei és szintézisük

Info

Publication number
HUP1500098A2
HUP1500098A2 HU1500098A HUP1500098A HUP1500098A2 HU P1500098 A2 HUP1500098 A2 HU P1500098A2 HU 1500098 A HU1500098 A HU 1500098A HU P1500098 A HUP1500098 A HU P1500098A HU P1500098 A2 HUP1500098 A2 HU P1500098A2
Authority
HU
Hungary
Prior art keywords
synthesis
hydroxyquinoline derivatives
enantiomers
new
new enantiomers
Prior art date
Application number
HU1500098A
Other languages
English (en)
Inventor
Laszlo Puskas
Ivan Kanizsai
Pillot Thierry
Mario Gyuris
Andras Szabo
Ferenc Takacs
Laszlo Hackler
Original Assignee
Avidin Kft
Ubichem Kft
Synaging Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avidin Kft, Ubichem Kft, Synaging Sas filed Critical Avidin Kft
Priority to HU1500098A priority Critical patent/HUP1500098A2/hu
Priority to EP16733177.6A priority patent/EP3268357A1/en
Priority to BR112017019404-0A priority patent/BR112017019404A2/pt
Priority to AU2016246107A priority patent/AU2016246107A1/en
Priority to CA2979121A priority patent/CA2979121A1/en
Priority to CN201680026883.0A priority patent/CN108137540A/zh
Priority to MX2017011542A priority patent/MX2017011542A/es
Priority to JP2017566218A priority patent/JP2018512447A/ja
Priority to PCT/HU2016/000012 priority patent/WO2016162706A1/en
Priority to KR1020177028545A priority patent/KR20180051430A/ko
Priority to US15/065,385 priority patent/US10287265B2/en
Publication of HUP1500098A2 publication Critical patent/HUP1500098A2/hu
Priority to HK18115742.9A priority patent/HK1257486A1/zh
Priority to US16/410,776 priority patent/US20190330188A1/en
Priority to JP2021079571A priority patent/JP2021120391A/ja
Priority to JP2023122264A priority patent/JP2023153894A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/30—Metal salts; Chelates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
HU1500098A 2015-03-09 2015-03-09 8-hidroxikinolin származékok új enantiomerjei és szintézisük HUP1500098A2 (hu)

Priority Applications (15)

Application Number Priority Date Filing Date Title
HU1500098A HUP1500098A2 (hu) 2015-03-09 2015-03-09 8-hidroxikinolin származékok új enantiomerjei és szintézisük
JP2017566218A JP2018512447A (ja) 2015-03-09 2016-03-07 ８−ヒドロキシキノリン誘導体のエナンチオマーとその合成
PCT/HU2016/000012 WO2016162706A1 (en) 2015-03-09 2016-03-07 Enantiomers of 8-hydroxy quinoline derivatives and the synthesis thereof
AU2016246107A AU2016246107A1 (en) 2015-03-09 2016-03-07 Enantiomers of 8-hydroxy quinoline derivatives and the synthesis thereof
CA2979121A CA2979121A1 (en) 2015-03-09 2016-03-07 Stereoselective synthesis of enantiomers of 8-hydroxyquinoline derivati ves
CN201680026883.0A CN108137540A (zh) 2015-03-09 2016-03-07 8-羟基喹啉衍生物的对映异构体及其合成
MX2017011542A MX2017011542A (es) 2015-03-09 2016-03-07 Enantiómeros novedosos de derivados de 8-hidroxiquinolina y la síntesis de los mismos.
EP16733177.6A EP3268357A1 (en) 2015-03-09 2016-03-07 Enantiomers of 8-hydroxy quinoline derivatives and the synthesis thereof
BR112017019404-0A BR112017019404A2 (pt) 2015-03-09 2016-03-07 enantiômeros de derivados de 8-hidróxi quinolina e a síntese destes
KR1020177028545A KR20180051430A (ko) 2015-03-09 2016-03-07 8-히드록시 퀴놀린 유도체의 에난티오머 및 그의 합성
US15/065,385 US10287265B2 (en) 2015-03-09 2016-03-09 Enantiomers of 8-hydroxyquinoline derivatives and the synthesis thereof
HK18115742.9A HK1257486A1 (zh) 2015-03-09 2018-12-07 8-羥基喹啉衍生物的對映異構體及其合成
US16/410,776 US20190330188A1 (en) 2015-03-09 2019-05-13 Enantiomers of 8-hydroxyquinoline derivatives and the synthesis thereof
JP2021079571A JP2021120391A (ja) 2015-03-09 2021-05-10 ８−ヒドロキシキノリン誘導体のエナンチオマーとその合成
JP2023122264A JP2023153894A (ja) 2015-03-09 2023-07-27 ８－ヒドロキシキノリン誘導体のエナンチオマーの合成

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1500098A HUP1500098A2 (hu) 2015-03-09 2015-03-09 8-hidroxikinolin származékok új enantiomerjei és szintézisük

Publications (1)

Publication Number Publication Date
HUP1500098A2 true HUP1500098A2 (hu) 2016-09-28

Family

ID=89991754

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1500098A HUP1500098A2 (hu) 2015-03-09 2015-03-09 8-hidroxikinolin származékok új enantiomerjei és szintézisük

Country Status (12)

Country Link
US (2) US10287265B2 (hu)
EP (1) EP3268357A1 (hu)
JP (3) JP2018512447A (hu)
KR (1) KR20180051430A (hu)
CN (1) CN108137540A (hu)
AU (1) AU2016246107A1 (hu)
BR (1) BR112017019404A2 (hu)
CA (1) CA2979121A1 (hu)
HK (1) HK1257486A1 (hu)
HU (1) HUP1500098A2 (hu)
MX (1) MX2017011542A (hu)
WO (1) WO2016162706A1 (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106749184B (zh) * 2016-11-15 2020-07-17 中山大学 8-氨基喹啉-羟基咔唑杂联体，其制备方法及其药物组合物
JPWO2022158323A1 (hu) 2021-01-22 2022-07-28

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6863895B2 (en) * 2001-04-20 2005-03-08 The Regents Of The University Of California Mycobacterial sulfation pathway proteins and methods of use thereof
AU2002950217A0 (en) 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
AU2007280984A1 (en) * 2006-07-25 2008-02-07 Envivo Pharmaceutical Inc. Quinoline derivatives
BRPI0715872A2 (pt) * 2006-08-23 2014-08-26 Wyeth Corp Composto; composição farmacêutica; método de preparação do composto; composto preparado pelo método; e método de tratamento de um transtorno em um mamífero necessitado
EP2139460A4 (en) * 2007-03-20 2011-09-07 Univ Brandeis COMPOSITIONS AND METHODS FOR THE DIAGNOSIS, TREATMENT AND PREVENTION OF AMYOTROPHER LATERAL SCLEROSIS AND ASSOCIATED NEUROLOGICAL DISEASES
WO2008153760A1 (en) 2007-05-25 2008-12-18 Burnham Institute For Medical Research Inhibitors of thapsigargin-induced cell death
EP2350012B1 (en) 2008-10-06 2017-06-28 The Johns Hopkins University Quinoline compounds as inhibitors of angiogenesis, human methionine aminopeptidase, and sirt1, and methods of treating disorders
WO2010068767A1 (en) * 2008-12-10 2010-06-17 The Trustees Of The University Of Pennsylvania Small molecule activators of mitochondrial function
AR077892A1 (es) * 2009-08-20 2011-09-28 Vifor Int Ag Quinolinas antagonistas de la hepcidina
WO2011022721A1 (en) * 2009-08-21 2011-02-24 Microbiotix, Inc Inhibitors of botulinum neurotoxins
US8658170B2 (en) * 2010-01-06 2014-02-25 Joseph P. Errico Combination therapy with MDM2 and EFGR inhibitors
CN104592090A (zh) * 2010-02-23 2015-05-06 康奈尔大学 脯氨酰羟化酶抑制剂及其使用方法
HUP1000243A2 (en) * 2010-05-06 2012-01-30 Avidin Kft 8-hidroxy-quinoline derivatives
JP2013526576A (ja) * 2010-05-18 2013-06-24 アメリカ合衆国 ヒト１２−リポキシゲナーゼ阻害剤
CA2853722A1 (en) 2011-10-27 2013-05-02 Mayo Foundation For Medical Education And Research Inhibiting g protein coupled receptor 6 kinase polypeptides
CN102786420B (zh) * 2012-08-22 2014-03-05 浙江大学 手性胺的制备方法
WO2016020892A1 (en) * 2014-08-07 2016-02-11 University Of Cape Town Small molecule inhibitors for cancer therapy
CN104744439A (zh) * 2015-02-10 2015-07-01 南开大学 8-羟基喹啉类ntr1小分子拮抗剂及应用

Also Published As

Publication number Publication date
HK1257486A1 (zh) 2019-10-25
WO2016162706A1 (en) 2016-10-13
JP2018512447A (ja) 2018-05-17
BR112017019404A2 (pt) 2019-02-19
AU2016246107A1 (en) 2017-10-26
CN108137540A (zh) 2018-06-08
JP2023153894A (ja) 2023-10-18
WO2016162706A9 (en) 2016-11-17
US20170197936A1 (en) 2017-07-13
US10287265B2 (en) 2019-05-14
KR20180051430A (ko) 2018-05-16
JP2021120391A (ja) 2021-08-19
MX2017011542A (es) 2018-11-29
US20190330188A1 (en) 2019-10-31
EP3268357A1 (en) 2018-01-17
CA2979121A1 (en) 2016-10-13

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