ATE427317T1 - Auf heparansulfat-proteoglycane gerichtete hybridproteine mit neuregulin-heparin- bindungsdomane - Google Patents
Auf heparansulfat-proteoglycane gerichtete hybridproteine mit neuregulin-heparin- bindungsdomaneInfo
- Publication number
- ATE427317T1 ATE427317T1 AT02756777T AT02756777T ATE427317T1 AT E427317 T1 ATE427317 T1 AT E427317T1 AT 02756777 T AT02756777 T AT 02756777T AT 02756777 T AT02756777 T AT 02756777T AT E427317 T1 ATE427317 T1 AT E427317T1
- Authority
- AT
- Austria
- Prior art keywords
- neuregulin
- targeted
- heparin binding
- proteoglycan
- hybrid proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30856301P | 2001-07-31 | 2001-07-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE427317T1 true ATE427317T1 (de) | 2009-04-15 |
Family
ID=23194471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02756777T ATE427317T1 (de) | 2001-07-31 | 2002-07-31 | Auf heparansulfat-proteoglycane gerichtete hybridproteine mit neuregulin-heparin- bindungsdomane |
Country Status (8)
Country | Link |
---|---|
US (1) | US7527794B2 (de) |
EP (1) | EP1456239B1 (de) |
JP (1) | JP4314113B2 (de) |
AT (1) | ATE427317T1 (de) |
AU (1) | AU2002322762B2 (de) |
CA (1) | CA2455830C (de) |
DE (1) | DE60231833D1 (de) |
WO (1) | WO2003012045A2 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4955548B2 (ja) * | 2004-07-09 | 2012-06-20 | ウェイン・ステイト・ユニバーシティ | 標的化のためのErbB4細胞外ドメインおよびニューレグリンヘパリン結合ドメインを有するハイブリッドタンパク質 |
WO2009072005A2 (en) * | 2007-10-15 | 2009-06-11 | Centre National De La Recherche Scientifique - C.N.R.S. | Cxcl12 gamma a chemokine and uses thereof |
EP2346526A2 (de) | 2008-09-22 | 2011-07-27 | Massachusetts Institute of Technology | Zusammensetzungen und verfahren zur verwendung von liganden-dimeren |
EP2555788B1 (de) | 2010-03-24 | 2017-10-11 | Massachusetts Institute of Technology | Neuregulin dimer für einen erbb/her rezeptor für die verwendung in reduzierung der kardiotoxizität |
CN103118698A (zh) * | 2010-05-28 | 2013-05-22 | 意识-Nrg公司 | 神经调节素同种型,神经调节素多肽和其使用 |
WO2012177653A2 (en) * | 2011-06-20 | 2012-12-27 | St. Louis University | Targeting the neuromuscular junction for treatment |
US20130058871A1 (en) * | 2011-07-28 | 2013-03-07 | Howard Hughes Medical Institute | Method and system for mapping synaptic connectivity using light microscopy |
CA2877886A1 (en) | 2012-06-25 | 2014-01-03 | The Brigham And Women's Hospital, Inc. | Targeted therapeutics comprising heparin binding protein |
US9790264B2 (en) | 2012-06-25 | 2017-10-17 | The Brigham And Women's Hospital, Inc. | Compounds and methods for modulating pharmacokinetics |
US20170333529A1 (en) * | 2015-01-20 | 2017-11-23 | Universiteit Antwerpen | Neuregulin in the treatment of fibrotic disorders |
US11143659B2 (en) | 2015-01-27 | 2021-10-12 | Arterez, Inc. | Biomarkers of vascular disease |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992007935A1 (en) | 1990-11-01 | 1992-05-14 | The Scripps Research Institute | Glycosaminoglycan-targeted fusion proteins, their design, construction and compositions |
US5367060A (en) * | 1991-05-24 | 1994-11-22 | Genentech, Inc. | Structure, production and use of heregulin |
WO1993022424A1 (en) * | 1992-04-29 | 1993-11-11 | Amgen Inc. | RECOMBINANT STIMULATING FACTOR OF THE neu RECEPTOR |
JPH08502168A (ja) | 1992-09-29 | 1996-03-12 | プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | ニューロン細胞においてイオンチャンネル誘導活性をもつ栄養因子 |
US6037329A (en) * | 1994-03-15 | 2000-03-14 | Selective Genetics, Inc. | Compositions containing nucleic acids and ligands for therapeutic treatment |
WO1997009051A1 (en) | 1995-09-05 | 1997-03-13 | Cambridge Neuroscience, Inc. | Analogs for specific oligosaccharide-neuregulin interactions and uses thereof |
US6344436B1 (en) * | 1996-01-08 | 2002-02-05 | Baylor College Of Medicine | Lipophilic peptides for macromolecule delivery |
DE69740038D1 (de) | 1996-07-12 | 2010-12-16 | Genentech Inc | |
CA2257839C (en) * | 1996-07-12 | 2012-10-23 | Genentech, Inc. | Gamma-heregulin |
KR100195886B1 (ko) | 1996-11-01 | 1999-06-15 | 김상조 | 당뇨병 치료용 의약조성물 |
WO1998043649A2 (en) | 1997-03-28 | 1998-10-08 | Otsuka Pharmaceutical Co., Ltd. | Age production inhibitory composition comprising a maillard reaction inhibitor and vitamin b¿6? |
AU4469997A (en) | 1997-09-17 | 1999-04-05 | Urs Eppenberger | Heregulin-gamma |
WO1999055351A1 (en) | 1998-04-23 | 1999-11-04 | Vladimir Leko | Herbal composition and medicament against diabetes mellitus type ii manufactured thereof |
ES2267494T3 (es) | 1999-01-29 | 2007-03-16 | Kaneka Corporation | Procedimiento para la preparacion de derivados de treo-1,2-epoxi-3-amino-4-fenilbutano. |
-
2002
- 2002-07-31 AU AU2002322762A patent/AU2002322762B2/en not_active Ceased
- 2002-07-31 DE DE60231833T patent/DE60231833D1/de not_active Expired - Lifetime
- 2002-07-31 US US10/485,206 patent/US7527794B2/en not_active Expired - Lifetime
- 2002-07-31 AT AT02756777T patent/ATE427317T1/de not_active IP Right Cessation
- 2002-07-31 EP EP02756777A patent/EP1456239B1/de not_active Expired - Lifetime
- 2002-07-31 WO PCT/US2002/024053 patent/WO2003012045A2/en active Application Filing
- 2002-07-31 CA CA2455830A patent/CA2455830C/en not_active Expired - Fee Related
- 2002-07-31 JP JP2003517223A patent/JP4314113B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2002322762B2 (en) | 2008-10-16 |
EP1456239A4 (de) | 2005-04-27 |
US20050107601A1 (en) | 2005-05-19 |
JP4314113B2 (ja) | 2009-08-12 |
DE60231833D1 (de) | 2009-05-14 |
CA2455830A1 (en) | 2003-02-13 |
JP2005500052A (ja) | 2005-01-06 |
WO2003012045A3 (en) | 2004-07-01 |
EP1456239B1 (de) | 2009-04-01 |
EP1456239A2 (de) | 2004-09-15 |
CA2455830C (en) | 2012-10-09 |
WO2003012045A2 (en) | 2003-02-13 |
US7527794B2 (en) | 2009-05-05 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |