ATE408005T1 - Makroeingekapselte sekretorische zellen - Google Patents
Makroeingekapselte sekretorische zellenInfo
- Publication number
- ATE408005T1 ATE408005T1 AT06004970T AT06004970T ATE408005T1 AT E408005 T1 ATE408005 T1 AT E408005T1 AT 06004970 T AT06004970 T AT 06004970T AT 06004970 T AT06004970 T AT 06004970T AT E408005 T1 ATE408005 T1 AT E408005T1
- Authority
- AT
- Austria
- Prior art keywords
- encapsuled
- macro
- secretory cells
- agarose
- coated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0012—Cell encapsulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/76—Agarose, agar-agar
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physiology (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Developmental Biology & Embryology (AREA)
- Nutrition Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18126994A | 1994-01-13 | 1994-01-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE408005T1 true ATE408005T1 (de) | 2008-09-15 |
Family
ID=22663563
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95906814T ATE275194T1 (de) | 1994-01-13 | 1995-01-12 | Makroeingekapselte sekretorische zellen |
AT03028476T ATE320482T1 (de) | 1994-01-13 | 1995-01-12 | Makroeingekapselte sekretorische zellen |
AT06004970T ATE408005T1 (de) | 1994-01-13 | 1995-01-12 | Makroeingekapselte sekretorische zellen |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95906814T ATE275194T1 (de) | 1994-01-13 | 1995-01-12 | Makroeingekapselte sekretorische zellen |
AT03028476T ATE320482T1 (de) | 1994-01-13 | 1995-01-12 | Makroeingekapselte sekretorische zellen |
Country Status (19)
Country | Link |
---|---|
US (3) | US5643569A (de) |
EP (3) | EP1418228B1 (de) |
JP (4) | JP3948742B2 (de) |
KR (1) | KR100474803B1 (de) |
CN (1) | CN1087779C (de) |
AT (3) | ATE275194T1 (de) |
AU (1) | AU681240C (de) |
CA (1) | CA2181156C (de) |
DE (3) | DE69534865T2 (de) |
DK (2) | DK1418228T3 (de) |
ES (3) | ES2260568T3 (de) |
FI (1) | FI118853B (de) |
HK (1) | HK1084693A1 (de) |
IL (1) | IL112330A (de) |
NO (2) | NO323228B1 (de) |
NZ (3) | NZ278809A (de) |
PT (3) | PT1418228E (de) |
RU (2) | RU2177503C2 (de) |
WO (1) | WO1995019430A1 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5834005A (en) * | 1992-02-24 | 1998-11-10 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
US5830492A (en) * | 1992-02-24 | 1998-11-03 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
US5824331A (en) * | 1992-02-24 | 1998-10-20 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
US6231881B1 (en) | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
RU2177503C2 (ru) * | 1994-01-13 | 2001-12-27 | Рогозин Институт | Макрогранула с секреторными клетками, способ ее получения и способ лечения заболеваний, вызванных нарушением функционирования секреторных клеток |
USRE39542E1 (en) * | 1994-01-13 | 2007-04-03 | The Rogosin Institute | Preparation of agarose coated, solid agarose-collagen beads containing secretory cells |
US5916790A (en) * | 1995-03-03 | 1999-06-29 | Metabolex, Inc. | Encapsulation compositions, and methods |
AU705108B2 (en) * | 1995-03-03 | 1999-05-13 | Metabolex, Inc. | Novel encapsulation process by a gelling polymer |
US5965125A (en) | 1995-10-25 | 1999-10-12 | Transkaryotic Therapies, Inc. | Hybrid matrix implants and explants |
US6419920B1 (en) | 1995-10-25 | 2002-07-16 | Trans Karyotic Therapies, Inc. | Hybrid matrix implants and explants |
EP0822857A1 (de) * | 1996-02-23 | 1998-02-11 | Circe Biomedical, Inc. | Neuartige künstliche bauchspeicheldrüse |
US7297331B2 (en) | 1996-04-03 | 2007-11-20 | The Rogosin Institute | Beads containing restricted cancer cells producing material suppressing cancer cell proliferation |
KR100477296B1 (ko) * | 1996-04-03 | 2005-05-16 | 더 로고신 인스티튜트 | 확산성의생물학적산물생산세포를함유하는이식가능한아가로오스-콜라겐비드,및그의용도 |
ATE250858T1 (de) * | 1996-04-03 | 2003-10-15 | Rogosin Inst | Implantierbare agarose-kollagenkügelchen enthaltende zellen, die ein diffusionsfähiges biologisches produkt bilden und ihre verwendung |
US6303151B1 (en) * | 1996-04-03 | 2001-10-16 | The Rogosin Institute | Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment |
US5888497A (en) * | 1996-04-03 | 1999-03-30 | The Rogosin Institute | Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation |
US6224912B1 (en) * | 1996-04-03 | 2001-05-01 | The Rogo Institute | Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment |
RU2179034C2 (ru) | 1996-09-13 | 2002-02-10 | Транскариотик Терапиз, Инк. | ЛЕЧЕНИЕ В СЛУЧАЕ ДЕФИЦИТА α-ГАЛАКТОЗИДАЗЫ А |
AU8577498A (en) * | 1997-07-22 | 1999-02-16 | General Hospital Corporation, The | Modulation of multicellular aggregates by solid stress |
US5922339A (en) * | 1998-01-27 | 1999-07-13 | Usala; Anton-Lewis | Compositions and methods for biocompatible implants |
US6303355B1 (en) | 1999-03-22 | 2001-10-16 | Duke University | Method of culturing, cryopreserving and encapsulating pancreatic islet cells |
US6365385B1 (en) * | 1999-03-22 | 2002-04-02 | Duke University | Methods of culturing and encapsulating pancreatic islet cells |
US6391576B1 (en) * | 1999-10-13 | 2002-05-21 | Japan Bioindustry Association | Method for isolating a microbe |
US6279656B1 (en) | 1999-11-03 | 2001-08-28 | Santrol, Inc. | Downhole chemical delivery system for oil and gas wells |
US7700660B2 (en) | 2000-05-31 | 2010-04-20 | Encelle, Inc. | Method of treating chronic ulcers |
CA2450650C (en) * | 2002-12-24 | 2007-08-28 | An-Go-Gen Inc. | Encapsulated cell therapy |
WO2004075855A2 (en) * | 2003-02-26 | 2004-09-10 | Biomed Solutions, Llc | Process for in vivo treatment of specific biological targets in bodily fluid |
US20050053586A1 (en) | 2003-09-04 | 2005-03-10 | Bryan Conn | Entrapped stem cells and uses thereof |
WO2006053052A2 (en) * | 2004-11-11 | 2006-05-18 | The Rogosin Institute | Method for treating patients with implants of islets which have been kept in long term, in vitro culture |
PT1928249E (pt) * | 2005-09-26 | 2012-05-25 | Rogosin Inst Inc | Macrocontas contendo células secretoras compreendendo agarose seakem gold e utilizações destas |
US20070116680A1 (en) * | 2005-11-18 | 2007-05-24 | Rensselaer Polytechnic Institute | Stem cells within gel microenvironments |
EP2029727B1 (de) | 2006-06-16 | 2012-04-11 | FMC Biopolymer AS | Alginatbeschichtete collagenmatrix-zellvorrichtung, herstellungsverfahren dafür und verwendungen davon |
JP2010516273A (ja) * | 2007-01-24 | 2010-05-20 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 培養細胞を処理する方法 |
CA2698212A1 (en) | 2007-08-23 | 2009-02-26 | Intrexon Corporation | Methods and compositions for diagnosing disease |
CN101868241A (zh) * | 2007-09-28 | 2010-10-20 | 英特瑞克斯顿股份有限公司 | 表达生物治疗分子的治疗基因开关构建物和生物反应器以及它们的应用 |
DE102010040687A1 (de) | 2010-09-14 | 2012-03-15 | Hamilton Bonaduz Ag | Verfahren zum Herstellen von Wirkstoff-Beads |
US10655120B2 (en) | 2011-03-21 | 2020-05-19 | The University Of Newcastle Upon Tyne | Transport of cells in hydrogels |
DE102011050024A1 (de) | 2011-04-29 | 2012-10-31 | Hamilton Bonaduz Ag | Analysevorrichtung für eine berührungslose Analyse der Ausformung eines transparenten Körpers und Verfahren zur Durchführung der berührungslosen Analyse |
PT2809782T (pt) * | 2012-01-31 | 2017-12-01 | The Rogosin Inst Inc | Método melhorado para o fabrico de macro esferas |
KR101327630B1 (ko) * | 2012-03-05 | 2013-11-13 | 울산대학교 산학협력단 | 아텔로콜라겐을 이용한 췌도세포 이식용 담체의 제조방법 그리고 이를 이용하여 제조된 인공췌장 |
UY38389A (es) | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
WO2024081309A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
WO2024081310A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4352883A (en) * | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
US4391909A (en) * | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
US4409331A (en) * | 1979-03-28 | 1983-10-11 | Damon Corporation | Preparation of substances with encapsulated cells |
SE441009B (sv) * | 1982-03-08 | 1985-09-02 | Kjell Nilsson | Sett att immobilisera levande biomaterial i perlformiga polymerer |
US4798786A (en) * | 1982-05-06 | 1989-01-17 | Stolle Research And Development Corporation | Living cells encapsulated in crosslinked protein |
CA1196862A (en) * | 1983-06-01 | 1985-11-19 | Anthony M.F. Sun | Microencapsulation of living tissue and cells |
US4663286A (en) * | 1984-02-13 | 1987-05-05 | Damon Biotech, Inc. | Encapsulation of materials |
US4997443A (en) * | 1985-08-26 | 1991-03-05 | Hana Biologics, Inc. | Transplantable artificial tissue and process |
US4902295A (en) * | 1985-08-26 | 1990-02-20 | Hana Biologics, Inc. | Transplantable artificial tissue |
SE8604684L (sv) * | 1986-11-03 | 1988-05-04 | Excorim Kommanditbolag | Sett att belegga fasta partiklar med en hydrofil gel samt genom settet belagda partiklar |
US5053332A (en) * | 1989-07-24 | 1991-10-01 | Cook Richard B | Agarose beads, preferably incorporating biological materials |
US5227298A (en) * | 1990-08-17 | 1993-07-13 | The Trustees Of Columbia University In The City Of New York | Method for microencapuslation of cells or tissue |
FR2686250A1 (fr) * | 1992-01-16 | 1993-07-23 | Coletica | Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques. |
WO1993024076A1 (en) * | 1992-05-29 | 1993-12-09 | The Regents Of The University Of California | Coated transplant and method for making same |
AU5728994A (en) * | 1992-11-24 | 1994-06-22 | Clover Consolidated, Limited | Cytoprotective, biocompatible, retrievable macrocapsules |
RU2177503C2 (ru) * | 1994-01-13 | 2001-12-27 | Рогозин Институт | Макрогранула с секреторными клетками, способ ее получения и способ лечения заболеваний, вызванных нарушением функционирования секреторных клеток |
US5888497A (en) * | 1996-04-03 | 1999-03-30 | The Rogosin Institute | Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation |
US6224912B1 (en) * | 1996-04-03 | 2001-05-01 | The Rogo Institute | Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment |
-
1995
- 1995-01-12 RU RU96115926/13A patent/RU2177503C2/ru active
- 1995-01-12 JP JP51910195A patent/JP3948742B2/ja not_active Expired - Lifetime
- 1995-01-12 PT PT03028476T patent/PT1418228E/pt unknown
- 1995-01-12 AT AT95906814T patent/ATE275194T1/de active
- 1995-01-12 DK DK03028476T patent/DK1418228T3/da active
- 1995-01-12 RU RU2001117583/13A patent/RU2208636C2/ru active
- 1995-01-12 ES ES03028476T patent/ES2260568T3/es not_active Expired - Lifetime
- 1995-01-12 EP EP03028476A patent/EP1418228B1/de not_active Expired - Lifetime
- 1995-01-12 ES ES95906814T patent/ES2227544T3/es not_active Expired - Lifetime
- 1995-01-12 DE DE69534865T patent/DE69534865T2/de not_active Expired - Lifetime
- 1995-01-12 WO PCT/US1995/000400 patent/WO1995019430A1/en active IP Right Grant
- 1995-01-12 EP EP95906814A patent/EP0742818B1/de not_active Expired - Lifetime
- 1995-01-12 DE DE69535842T patent/DE69535842D1/de not_active Expired - Lifetime
- 1995-01-12 NZ NZ278809A patent/NZ278809A/en not_active IP Right Cessation
- 1995-01-12 AT AT03028476T patent/ATE320482T1/de active
- 1995-01-12 PT PT06004970T patent/PT1666585E/pt unknown
- 1995-01-12 DE DE69533437T patent/DE69533437T2/de not_active Expired - Lifetime
- 1995-01-12 KR KR10-2002-7006924A patent/KR100474803B1/ko not_active IP Right Cessation
- 1995-01-12 AU AU15267/95A patent/AU681240C/en not_active Expired
- 1995-01-12 DK DK06004970T patent/DK1666585T3/da active
- 1995-01-12 AT AT06004970T patent/ATE408005T1/de active
- 1995-01-12 CA CA002181156A patent/CA2181156C/en not_active Expired - Lifetime
- 1995-01-12 CN CN95191589A patent/CN1087779C/zh not_active Expired - Lifetime
- 1995-01-12 ES ES06004970T patent/ES2309849T3/es not_active Expired - Lifetime
- 1995-01-12 PT PT95906814T patent/PT742818E/pt unknown
- 1995-01-12 NZ NZ509363A patent/NZ509363A/en not_active IP Right Cessation
- 1995-01-12 NZ NZ329619A patent/NZ329619A/en not_active IP Right Cessation
- 1995-01-12 EP EP06004970A patent/EP1666585B1/de not_active Expired - Lifetime
- 1995-01-13 IL IL11233095A patent/IL112330A/en not_active IP Right Cessation
- 1995-06-07 US US08/483,728 patent/US5643569A/en not_active Ceased
-
1996
- 1996-07-12 FI FI962841A patent/FI118853B/fi not_active IP Right Cessation
- 1996-07-15 NO NO19962955A patent/NO323228B1/no not_active IP Right Cessation
-
1999
- 1999-06-30 US US09/345,196 patent/USRE38027E1/en not_active Expired - Lifetime
-
2004
- 2004-11-01 US US10/979,527 patent/USRE40555E1/en not_active Expired - Lifetime
-
2005
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2006
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