ATE397063T1 - Fibroblasten-wachstumsfaktor-19 - Google Patents

Fibroblasten-wachstumsfaktor-19

Info

Publication number
ATE397063T1
ATE397063T1 AT98961795T AT98961795T ATE397063T1 AT E397063 T1 ATE397063 T1 AT E397063T1 AT 98961795 T AT98961795 T AT 98961795T AT 98961795 T AT98961795 T AT 98961795T AT E397063 T1 ATE397063 T1 AT E397063T1
Authority
AT
Austria
Prior art keywords
polypeptides
present
methods
treatment
diagnosis
Prior art date
Application number
AT98961795T
Other languages
English (en)
Inventor
David Botstein
Audrey Goddard
Austin Gurney
Kenneth Hillan
David Lawrence
Margaret Roy
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE397063T1 publication Critical patent/ATE397063T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT98961795T 1997-11-25 1998-11-25 Fibroblasten-wachstumsfaktor-19 ATE397063T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6684097P 1997-11-25 1997-11-25
US15834298A 1998-09-21 1998-09-21

Publications (1)

Publication Number Publication Date
ATE397063T1 true ATE397063T1 (de) 2008-06-15

Family

ID=26747212

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98961795T ATE397063T1 (de) 1997-11-25 1998-11-25 Fibroblasten-wachstumsfaktor-19

Country Status (11)

Country Link
EP (1) EP1032668B1 (de)
JP (1) JP3653469B2 (de)
KR (2) KR20050009764A (de)
AT (1) ATE397063T1 (de)
AU (1) AU733222B2 (de)
CA (1) CA2309783C (de)
DE (1) DE69839571D1 (de)
DK (1) DK1032668T3 (de)
IL (2) IL136055A0 (de)
NZ (1) NZ504425A (de)
WO (1) WO1999027100A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6605441B1 (en) 1995-06-05 2003-08-12 Human Genome Sciences, Inc. Antibodies against fibroblast growth factor 11
US6787640B2 (en) 1995-06-05 2004-09-07 Human Genome Sciences, Inc. Fibroblast growth factor 14
US20050043234A1 (en) 1996-10-16 2005-02-24 Deisher Theresa A. Novel FGF homologs
DK1032668T3 (da) * 1997-11-25 2008-09-29 Genentech Inc Fibroblast vækstfaktor 19
WO2000056890A1 (en) * 1999-03-19 2000-09-28 Chiron Corporation Human fgf gene and gene expression products
EP1657256B1 (de) * 1999-06-09 2009-10-07 Genentech, Inc. Zusammensetzungen und Verfahren für die Tumor-Behandlung
US7459540B1 (en) * 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
IL148188A0 (en) * 1999-09-08 2002-09-12 Genentech Inc Fibroblast growth factor-19 (fgf-19) nucleic acids and polypeptides and methods of use for the treatment of obesity
CA2384089A1 (en) * 1999-09-08 2001-03-15 Genentech, Inc. Fibroblast growth factor-19 (fgf-19) nucleic acids and polypeptides and methods of use for the treatment of obesity
US6716626B1 (en) 1999-11-18 2004-04-06 Chiron Corporation Human FGF-21 nucleic acids
EP2163626A1 (de) * 1999-11-18 2010-03-17 Novartis Vaccines and Diagnostics, Inc. Menschliches FGF-21 Gen und Genexpressionsprodukte
EP1246843A1 (de) * 2000-01-05 2002-10-09 ZymoGenetics, Inc. Neues fgf homolog zfgf12
AU2631001A (en) * 2000-01-05 2001-07-16 Zymogenetics Inc. Novel fgf homolog zfgf11
CA2398603A1 (en) * 2000-02-15 2001-08-23 Amgen, Inc. Fibroblast growth factor-23 molecules and uses thereof
EP1947182A1 (de) * 2000-02-15 2008-07-23 Amgen Inc. Fibroblastenwachstumsfaktor-23-Moleküle und ihre Verwendung
CN1311212A (zh) * 2000-03-02 2001-09-05 上海博德基因开发有限公司 一种新的多肽——人成纤维细胞生长因子14和编码这种多肽的多核苷酸
EP1286704B1 (de) * 2000-06-02 2014-07-23 Board of Regents, The University of Texas System ETHYLENEDICYSTEINE (EC)-Glucose Analoge KONJUGATE
US20030045489A1 (en) * 2000-11-22 2003-03-06 Murphy John E. Methods for modulating angiogenesis
FI20011542A (fi) * 2001-07-13 2003-01-14 Fit Biotech Oyj Plc Urosognaasigeenin monistuman käyttö
CA2486252C (en) 2002-06-07 2012-07-24 Genentech, Inc. Methods for screening for agents that modulate hepatocellular carcinoma development
CA2500742C (en) 2002-10-07 2014-02-18 Zymogenetics, Inc. Compositions of fgf-18 and hyaluronic acid for stimulating cartilage production and treating osteoarthritis
TWI388568B (zh) 2006-02-10 2013-03-11 Genentech Inc 抗ｆｇｆ１９抗體及其使用方法
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
US8236307B2 (en) 2007-08-03 2012-08-07 Genentech, Inc. Humanized anti-FGF19 antagonists and methods using same
CA2715628A1 (en) 2008-02-21 2009-08-27 Dexcom, Inc. Systems and methods for processing, transmitting and displaying sensor data
JOP20190083A1 (ar) 2008-06-04 2017-06-16 Amgen Inc بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
EA032727B1 (ru) 2008-10-10 2019-07-31 Амген Инк. Мутантный резистентный к протеолизу полипептид fgf21 и его применение
EP2358790B2 (de) 2008-12-16 2016-09-21 Dow Corning Corporation Herstellung von siloxanen
US20120052069A1 (en) 2009-05-05 2012-03-01 Amgen Inc Fgf21 mutants and uses thereof
SG10201402038WA (en) 2009-05-05 2014-07-30 Amgen Inc FGF21 Mutants And Uses Thereof
EP2443145A1 (de) * 2009-06-17 2012-04-25 Amgen, Inc Chimäre fgf19-polypeptide und ihreverwendung
CA2777717C (en) * 2009-10-15 2021-05-25 Genentech, Inc. Chimeric fibroblast growth factors with altered receptor specificity
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
TWI670283B (zh) 2013-12-23 2019-09-01 美商建南德克公司 抗體及使用方法
EP3108893A1 (de) 2015-06-25 2016-12-28 Universite Claude Bernard - Lyon 1 Neuartige therapeutische verwendung von fgf19
KR102315601B1 (ko) 2020-05-13 2021-10-21 전남대학교산학협력단 재조합 벡터 및 이를 이용한 재조합 섬유아세포 성장인자 19의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999014327A2 (en) * 1997-09-17 1999-03-25 Genentech, Inc. Genes amplified in tumours, antibodies against the proteins coded thereby, and their use in diagnosis and treatment of cancer
ATE447583T1 (de) * 1997-09-17 2009-11-15 Genentech Inc Polypeptide und dafür kodierende nukleinsäure
DK1032668T3 (da) * 1997-11-25 2008-09-29 Genentech Inc Fibroblast vækstfaktor 19
AU5816799A (en) * 1998-09-10 2000-04-03 Genentech Inc. Compositions and methods for the treatment of tumor
IL141535A0 (en) * 1998-09-16 2002-03-10 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same

Also Published As

Publication number Publication date
EP1032668A1 (de) 2000-09-06
AU733222B2 (en) 2001-05-10
KR20010032405A (ko) 2001-04-16
CA2309783C (en) 2011-06-28
KR20050009764A (ko) 2005-01-25
WO1999027100A9 (en) 2000-05-11
IL193366A0 (en) 2009-02-11
WO1999027100A1 (en) 1999-06-03
DK1032668T3 (da) 2008-09-29
JP3653469B2 (ja) 2005-05-25
EP1032668B1 (de) 2008-05-28
DE69839571D1 (de) 2008-07-10
JP2002503446A (ja) 2002-02-05
CA2309783A1 (en) 1999-06-03
KR100506786B1 (ko) 2005-08-08
AU1703399A (en) 1999-06-15
IL136055A0 (en) 2001-05-20
NZ504425A (en) 2001-10-26

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Legal Events

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