DE69839571D1 - Fibroblasten-wachstumsfaktor-19 - Google Patents

Fibroblasten-wachstumsfaktor-19

Info

Publication number
DE69839571D1
DE69839571D1 DE69839571T DE69839571T DE69839571D1 DE 69839571 D1 DE69839571 D1 DE 69839571D1 DE 69839571 T DE69839571 T DE 69839571T DE 69839571 T DE69839571 T DE 69839571T DE 69839571 D1 DE69839571 D1 DE 69839571D1
Authority
DE
Germany
Prior art keywords
polypeptides
present
methods
treatment
diagnosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69839571T
Other languages
English (en)
Inventor
David Botstein
Audrey Goddard
Austin L Gurney
Kenneth J Hillan
David A Lawrence
Margaret Ann Roy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE69839571D1 publication Critical patent/DE69839571D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69839571T 1997-11-25 1998-11-25 Fibroblasten-wachstumsfaktor-19 Expired - Lifetime DE69839571D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6684097P 1997-11-25 1997-11-25
US15834298A 1998-09-21 1998-09-21
PCT/US1998/025190 WO1999027100A1 (en) 1997-11-25 1998-11-25 Fibroblast growth factor-19

Publications (1)

Publication Number Publication Date
DE69839571D1 true DE69839571D1 (de) 2008-07-10

Family

ID=26747212

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839571T Expired - Lifetime DE69839571D1 (de) 1997-11-25 1998-11-25 Fibroblasten-wachstumsfaktor-19

Country Status (11)

Country Link
EP (1) EP1032668B1 (de)
JP (1) JP3653469B2 (de)
KR (2) KR20050009764A (de)
AT (1) ATE397063T1 (de)
AU (1) AU733222B2 (de)
CA (1) CA2309783C (de)
DE (1) DE69839571D1 (de)
DK (1) DK1032668T3 (de)
IL (2) IL136055A0 (de)
NZ (1) NZ504425A (de)
WO (1) WO1999027100A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6605441B1 (en) 1995-06-05 2003-08-12 Human Genome Sciences, Inc. Antibodies against fibroblast growth factor 11
US6787640B2 (en) 1995-06-05 2004-09-07 Human Genome Sciences, Inc. Fibroblast growth factor 14
US20050043234A1 (en) 1996-10-16 2005-02-24 Deisher Theresa A. Novel FGF homologs
ATE397063T1 (de) * 1997-11-25 2008-06-15 Genentech Inc Fibroblasten-wachstumsfaktor-19
WO2000056890A1 (en) * 1999-03-19 2000-09-28 Chiron Corporation Human fgf gene and gene expression products
ATE440109T1 (de) * 1999-06-09 2009-09-15 Genentech Inc Methoden zur diagnose von tumoren
US7459540B1 (en) * 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
DE60028054T2 (de) * 1999-09-08 2006-12-21 Genentech, Inc., South San Francisco Fibroblasten-wachstumsfaktor-19 (fgf-19) nukleinsäure und polypeptide und verfahren zu deren verwendung für behandlung von fettleibigkeit
DK1214409T3 (da) * 1999-09-08 2006-09-04 Genentech Inc Fibroblast vækstfaktor-19 (FGF-19) nucleinsyrer og polypeptider samt anvendelsesmetoder til behandling af fedme
US6716626B1 (en) 1999-11-18 2004-04-06 Chiron Corporation Human FGF-21 nucleic acids
ATE446365T1 (de) * 1999-11-18 2009-11-15 Novartis Vaccines & Diagnostic Menschliches fgf-21 gen und genexpressionsprodukte
AU2631001A (en) * 2000-01-05 2001-07-16 Zymogenetics Inc. Novel fgf homolog zfgf11
WO2001049740A1 (en) * 2000-01-05 2001-07-12 Zymogenetics, Inc. Novel fgf homolog zfgf12
EP1257645A2 (de) * 2000-02-15 2002-11-20 Amgen Inc. Fibroblasten wachstumfaktor-23 moleküle und ihre verwendungen
EP1947182A1 (de) * 2000-02-15 2008-07-23 Amgen Inc. Fibroblastenwachstumsfaktor-23-Moleküle und ihre Verwendung
CN1311212A (zh) * 2000-03-02 2001-09-05 上海博德基因开发有限公司 一种新的多肽——人成纤维细胞生长因子14和编码这种多肽的多核苷酸
JP5448284B2 (ja) * 2000-06-02 2014-03-19 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム エチレンジシステイン（ｅｃ）−薬物結合体
US20030045489A1 (en) * 2000-11-22 2003-03-06 Murphy John E. Methods for modulating angiogenesis
FI20011542A (fi) * 2001-07-13 2003-01-14 Fit Biotech Oyj Plc Urosognaasigeenin monistuman käyttö
AU2003243400B2 (en) 2002-06-07 2009-10-29 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
AU2003279835B2 (en) 2002-10-07 2009-09-10 Zymogenetics, Inc. Methods of administering FGF18
AR059432A1 (es) 2006-02-10 2008-04-09 Genentech Inc Anticuerpos anti-fgf19 y metodos que usan estos
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
ES2622107T3 (es) 2007-08-03 2017-07-05 Genentech, Inc. Antagonistas anti-FGF19 humanizados y métodos de uso de los mismos
CA2715628A1 (en) 2008-02-21 2009-08-27 Dexcom, Inc. Systems and methods for processing, transmitting and displaying sensor data
JOP20190083A1 (ar) 2008-06-04 2017-06-16 Amgen Inc بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
EA201990619A1 (ru) 2008-10-10 2019-07-31 Амген Инк. Fgf21 мутанты и их применение
EP2358790B2 (de) 2008-12-16 2016-09-21 Dow Corning Corporation Herstellung von siloxanen
US8188040B2 (en) 2009-05-05 2012-05-29 Amgen Inc. FGF21 mutants and uses thereof
AU2010246038A1 (en) 2009-05-05 2011-12-01 Amgen Inc. FGF21 mutants and uses thereof
AU2010262927A1 (en) * 2009-06-17 2012-01-19 Amgen Inc. Chimeric FGF19 polypeptides and uses thereof
JP6016636B2 (ja) * 2009-10-15 2016-10-26 ジェネンテック， インコーポレイテッド 改変したレセプター特異性を持つキメラ線維芽細胞増殖因子
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
TWI728373B (zh) 2013-12-23 2021-05-21 美商建南德克公司 抗體及使用方法
EP3108893A1 (de) 2015-06-25 2016-12-28 Universite Claude Bernard - Lyon 1 Neuartige therapeutische verwendung von fgf19
KR102315601B1 (ko) 2020-05-13 2021-10-21 전남대학교산학협력단 재조합 벡터 및 이를 이용한 재조합 섬유아세포 성장인자 19의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999014327A2 (en) * 1997-09-17 1999-03-25 Genentech, Inc. Genes amplified in tumours, antibodies against the proteins coded thereby, and their use in diagnosis and treatment of cancer
CA2303834A1 (en) * 1997-09-17 1999-03-25 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
ATE397063T1 (de) * 1997-11-25 2008-06-15 Genentech Inc Fibroblasten-wachstumsfaktor-19
EP1109833A2 (de) * 1998-09-10 2001-06-27 Genentech, Inc. Zusammensetzungen und verfahren zur behandlung von tumoren
AU5922999A (en) * 1998-09-16 2000-04-03 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same

Also Published As

Publication number Publication date
KR20010032405A (ko) 2001-04-16
JP3653469B2 (ja) 2005-05-25
ATE397063T1 (de) 2008-06-15
IL193366A0 (en) 2009-02-11
CA2309783A1 (en) 1999-06-03
AU1703399A (en) 1999-06-15
DK1032668T3 (da) 2008-09-29
WO1999027100A1 (en) 1999-06-03
KR100506786B1 (ko) 2005-08-08
IL136055A0 (en) 2001-05-20
EP1032668A1 (de) 2000-09-06
JP2002503446A (ja) 2002-02-05
NZ504425A (en) 2001-10-26
EP1032668B1 (de) 2008-05-28
AU733222B2 (en) 2001-05-10
CA2309783C (en) 2011-06-28
KR20050009764A (ko) 2005-01-25
WO1999027100A9 (en) 2000-05-11

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