ATE371727T1 - Kdr, ein menschlicher tyrosin kinase rezeptor - Google Patents

Kdr, ein menschlicher tyrosin kinase rezeptor

Info

Publication number
ATE371727T1
ATE371727T1 AT98931318T AT98931318T ATE371727T1 AT E371727 T1 ATE371727 T1 AT E371727T1 AT 98931318 T AT98931318 T AT 98931318T AT 98931318 T AT98931318 T AT 98931318T AT E371727 T1 ATE371727 T1 AT E371727T1
Authority
AT
Austria
Prior art keywords
kdr
tyrosine kinase
kinase receptor
human
human tyrosine
Prior art date
Application number
AT98931318T
Other languages
English (en)
Inventor
Richard Kendall
Kenneth Thomas
Xianzhi Mao
Andrew Tebben
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21968566&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE371727(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE371727T1 publication Critical patent/ATE371727T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT98931318T 1997-06-18 1998-06-17 Kdr, ein menschlicher tyrosin kinase rezeptor ATE371727T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5096297P 1997-06-18 1997-06-18

Publications (1)

Publication Number Publication Date
ATE371727T1 true ATE371727T1 (de) 2007-09-15

Family

ID=21968566

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98931318T ATE371727T1 (de) 1997-06-18 1998-06-17 Kdr, ein menschlicher tyrosin kinase rezeptor

Country Status (8)

Country Link
US (4) US6204011B1 (de)
EP (1) EP1009814B1 (de)
JP (1) JP4405597B2 (de)
AT (1) ATE371727T1 (de)
CA (1) CA2293723A1 (de)
DE (1) DE69838334T2 (de)
ES (1) ES2292204T3 (de)
WO (1) WO1998058053A1 (de)

Families Citing this family (41)

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US20030108545A1 (en) * 1994-02-10 2003-06-12 Patricia Rockwell Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist
US6448077B1 (en) * 1994-02-10 2002-09-10 Imclone Systems, Inc. Chimeric and humanized monoclonal antibodies specific to VEGF receptors
US6891082B2 (en) * 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
JP4404479B2 (ja) 1997-12-09 2010-01-27 チルドレンズ・メディカル・センター・コーポレイション 血管内皮増殖因子の可溶性インヒビターおよびその使用
US6852533B1 (en) * 1998-01-23 2005-02-08 Cornell Research Foundation, Inc. Purified populations of stem cells
CN1342077A (zh) * 1998-11-06 2002-03-27 诺尔股份公司 抑制血管渗透性过高的形成
US7396810B1 (en) * 2000-08-14 2008-07-08 Oregon Health Sciences University Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
US7625859B1 (en) * 2000-02-16 2009-12-01 Oregon Health & Science University HER-2 binding antagonists
US7393823B1 (en) 1999-01-20 2008-07-01 Oregon Health And Science University HER-2 binding antagonists
GB9918057D0 (en) * 1999-07-30 1999-10-06 Univ Bristol Therapeutic agents
WO2001094624A1 (en) 2000-06-07 2001-12-13 Ortho-Mcneil Pharmaceutical, Inc. Method to detect modulators of vegf kinase domain
US20040247597A1 (en) * 2001-06-20 2004-12-09 Peter Carmeliet Method of treating atherosclerosis and other inflammatory diseases
US6734017B2 (en) * 2001-09-28 2004-05-11 Isis Pharmaceuticals, Inc. Antisense modulation of vascular endothelial growth factor receptor-2 expression
GB0124317D0 (en) 2001-10-10 2001-11-28 Celltech R&D Ltd Biological products
US7261876B2 (en) * 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US20050250700A1 (en) * 2002-03-01 2005-11-10 Sato Aaron K KDR and VEGF/KDR binding peptides
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7666979B2 (en) * 2002-03-01 2010-02-23 Bracco International B.V. Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7985402B2 (en) * 2002-03-01 2011-07-26 Bracco Suisse Sa Targeting vector-phospholipid conjugates
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
ATE510561T1 (de) * 2002-03-04 2011-06-15 Imclone Llc Kdr-spezifische menschliche antikörper und ihre verwendung
GB0206072D0 (en) * 2002-03-15 2002-04-24 Astrazeneca Ab Epitope
ES2327040T3 (es) 2002-09-12 2009-10-23 Oncotherapy Science, Inc. Peptidos kdr y vacunas que los contienen.
CA2512624A1 (en) * 2003-01-29 2004-08-19 Merck & Co., Inc. Rat receptor tyrosine kinase, kdr
EP1603935A4 (de) 2003-03-03 2007-03-21 Dyax Corp SPEZIFISCH AN HGF-REZEPTOR (cMet) BINDENDE PEPTIDE UND DEREN VERWENDUNG
EP1626988A2 (de) * 2003-05-16 2006-02-22 Receptor Biologix, Inc. Intron fusionproteinen und methoden deren identifizierung und verwendung
US7582726B2 (en) * 2003-11-10 2009-09-01 Ghc Research Development Corporation VEGF receptor antagonists
EP1745073A2 (de) * 2004-05-14 2007-01-24 Receptor Biologix, Inc. Isoformen eines zelloberflächenrezeptors und verfahren zu deren identifizierung und anwendung
CN101094688B (zh) 2004-09-13 2013-05-01 建新公司 多聚构建体
CA2583230A1 (en) * 2004-10-05 2006-04-20 Oregon Health And Science University Compositions and methods for treating disease
WO2006120762A1 (ja) * 2005-05-11 2006-11-16 Murata Manufacturing Co., Ltd. アンテナ構造およびそれを備えた無線通信機
US20090170769A1 (en) * 2005-05-13 2009-07-02 Pei Jin Cell surface receptor isoforms and methods of identifying and using the same
UA96139C2 (uk) 2005-11-08 2011-10-10 Дженентек, Інк. Антитіло до нейропіліну-1 (nrp1)
WO2008061104A2 (en) * 2006-11-13 2008-05-22 Invitrogen Corporation Methods and kits for detecting prostate cancer biomarkers
TW201109029A (en) 2009-06-11 2011-03-16 Oncotherapy Science Inc Vaccine therapy for choroidal neovascularization
WO2012006503A1 (en) 2010-07-09 2012-01-12 Genentech, Inc. Anti-neuropilin antibodies and methods of use
PL2601214T3 (pl) 2010-08-06 2018-05-30 Genzyme Corporation Kompozycje antagonistyczne wobec VEGF oraz ich zastosowania
US9534222B2 (en) 2011-11-15 2017-01-03 University Of Utah Research Foundation Morpholinos, morpholino upregulating, and associated methods
US9506069B2 (en) 2012-04-19 2016-11-29 University Of Utah Research Foundation Morpholino-mediated increase in soluble Flt-1 expression results in decreased ocular and tumor neovascularization

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240848A (en) 1988-11-21 1993-08-31 Monsanto Company Dna sequences encoding human vascular permeability factor having 189 amino acids
US5332671A (en) 1989-05-12 1994-07-26 Genetech, Inc. Production of vascular endothelial cell growth factor and DNA encoding same
DE69232718T2 (de) * 1991-02-22 2003-04-03 American Cyanamid Co Identifizierung eines menschlichen rezeptor-tyrosinkinasegens
EP0506477B1 (de) 1991-03-28 1999-06-23 Merck & Co. Inc. Untereinheit-C des vaskulären endothelialen Zellwachstumsfaktors
US5861301A (en) 1992-02-20 1999-01-19 American Cayanamid Company Recombinant kinase insert domain containing receptor and gene encoding same
US6177401B1 (en) * 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
CN1173991C (zh) * 1992-11-13 2004-11-03 马克斯普朗克科学促进协会 作为血管内皮生长因子受体的f1k-1

Also Published As

Publication number Publication date
US6841367B2 (en) 2005-01-11
JP4405597B2 (ja) 2010-01-27
DE69838334D1 (de) 2007-10-11
WO1998058053A9 (en) 1999-04-08
EP1009814B1 (de) 2007-08-29
US6359115B1 (en) 2002-03-19
US6841382B2 (en) 2005-01-11
WO1998058053A1 (en) 1998-12-23
CA2293723A1 (en) 1998-12-23
DE69838334T2 (de) 2008-06-12
ES2292204T3 (es) 2008-03-01
US20030055239A1 (en) 2003-03-20
US20030032160A1 (en) 2003-02-13
JP2002507119A (ja) 2002-03-05
US6204011B1 (en) 2001-03-20
EP1009814A1 (de) 2000-06-21
EP1009814A4 (de) 2001-12-12

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