ATE360423T1 - Verwendung von chymase hemmern gegen vaskuläre lipidablagerung - Google Patents

Verwendung von chymase hemmern gegen vaskuläre lipidablagerung

Info

Publication number
ATE360423T1
ATE360423T1 AT00971729T AT00971729T ATE360423T1 AT E360423 T1 ATE360423 T1 AT E360423T1 AT 00971729 T AT00971729 T AT 00971729T AT 00971729 T AT00971729 T AT 00971729T AT E360423 T1 ATE360423 T1 AT E360423T1
Authority
AT
Austria
Prior art keywords
inhibitors against
against vascular
chymase inhibitors
lipid deposit
vascular lipid
Prior art date
Application number
AT00971729T
Other languages
English (en)
Inventor
Harukazu Fukami
Hidenori Urata
Original Assignee
Daiichi Asubio Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Asubio Pharma Co Ltd filed Critical Daiichi Asubio Pharma Co Ltd
Application granted granted Critical
Publication of ATE360423T1 publication Critical patent/ATE360423T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00971729T 1999-11-01 2000-11-01 Verwendung von chymase hemmern gegen vaskuläre lipidablagerung ATE360423T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP31125799 1999-11-01

Publications (1)

Publication Number Publication Date
ATE360423T1 true ATE360423T1 (de) 2007-05-15

Family

ID=18014979

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00971729T ATE360423T1 (de) 1999-11-01 2000-11-01 Verwendung von chymase hemmern gegen vaskuläre lipidablagerung

Country Status (11)

Country Link
US (1) US6921766B1 (de)
EP (1) EP1142586B1 (de)
KR (1) KR20010100004A (de)
CN (1) CN1335778A (de)
AT (1) ATE360423T1 (de)
AU (1) AU784467B2 (de)
CA (1) CA2358314A1 (de)
DE (1) DE60034545T2 (de)
ES (1) ES2281358T3 (de)
HU (1) HUP0104952A3 (de)
WO (1) WO2001032214A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0201284A3 (en) 2000-02-22 2003-02-28 Daiichi Asubio Pharma Co Ltd Preventive or therapeutic drugs for fibrosis containing quinazolindione derivative chymase inhibitors as the active ingredient
CA2365606A1 (en) 2000-02-22 2001-08-30 Suntory Limited Medicament for prevention or treatment of various diseases involving an increase in eosinophils chymase inhibitor as effective ingredient
EP1192950B1 (de) 2000-02-22 2006-07-26 Daiichi Asubio Pharma Co., Ltd. Arzneimittel mit chymaseinhibitoren als wirksames mittel zur behandlung von dermatitis mit zweiphasigen hautreaktionen
WO2003007964A1 (fr) * 2001-07-18 2003-01-30 Nippon Kayaku Kabushiki Kaisha Remede ou agent preventif de cardiopathie ou d'anevrysme contenant un compose d'inhibition de la chymase
US20060276455A1 (en) * 2003-02-13 2006-12-07 Lindsberg Perttu J Use of a mast cell activation or degranulation blocking agent in the manufacture of a medicament for the treatment of cerebral ischemia
EP2463268B1 (de) 2004-12-02 2013-08-28 Daiichi Sankyo Company, Limited 4-(Aminomethyl)benzoesäuren als Zwischenverbindungen für die Herstellung von Chymase-hemmende 1,4-Diazepan-2,5-dion-Verbindungen
US8049006B2 (en) 2006-05-31 2011-11-01 Daiichi Sankyo Company, Limited 7-membered ring compound and method of production and pharmaceutical application thereof
CN101925585B (zh) * 2008-01-30 2013-04-17 新丰制药株式会社 喹唑啉-2,4-二酮衍生物及含有所述衍生物的用于预防和治疗脑神经疾病的药物组合物
JP6364362B2 (ja) * 2015-02-17 2018-07-25 学校法人福岡大学 ヒトキマーゼ阻害剤および機能性食品、並びにヒトキマーゼの活性を阻害する方法
AU2017416068A1 (en) 2017-05-24 2019-10-31 The Provost, Fellows, Foundation Scholars, And Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Novel compounds and uses

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5199279A (en) 1991-08-13 1993-04-06 Reynolds Martin M Drum contact freezer system and method
JP2982454B2 (ja) 1991-12-20 1999-11-22 王子製紙株式会社 感熱記録体
CA2137832C (en) 1992-06-12 2000-09-26 Dennis J. Hoover Inhibitors of angiotensin i chymase(s) including human heart chymase
AU3086095A (en) 1994-07-29 1996-03-04 Suntory Limited Imidazolidine derivative and use thereof
CA2219364A1 (en) 1995-04-27 1996-10-31 Hideki Okunishi Heterocyclic amide compounds and pharmaceutical use thereof
US5596111A (en) 1995-06-05 1997-01-21 North Dakota State University Method for preparation of carboxylic acids
DE69622148T2 (de) 1995-09-28 2002-10-31 Suntory Ltd Osaka Chinazozin derivate und deren verwendung
JP4073489B2 (ja) 1996-05-24 2008-04-09 ニューロサーチ・アクティーゼルスカブ 酸性基を有するフエニル誘導体、その製造方法及びそれをクロライドチャンネル遮断剤として使用する方法
AUPO062696A0 (en) * 1996-06-24 1996-07-18 Fujisawa Pharmaceutical Co., Ltd. Novel compounds
KR20000052775A (ko) 1996-10-25 2000-08-25 가마쿠라 아키오 신규한 헤테로사이클릭 아미드 화합물 및 의약으로서의 그의 용도
CA2321146A1 (en) * 1998-02-17 1999-08-19 Nippon Kayaku Kabushiki Kaisha Novel acetamide derivative and use thereof
ATE326451T1 (de) * 1998-08-21 2006-06-15 Daiichi Asubio Pharma Co Ltd Chinazolin derivate und therapeutische verwendungen davon
EP1136488A4 (de) * 1998-12-01 2002-06-12 Meiji Seika Kaisha Sf2809-i, ii, iii. vi, v und vi-verbindungen mit chymase-inhibierender wirkung

Also Published As

Publication number Publication date
AU1053601A (en) 2001-05-14
HUP0104952A2 (en) 2002-06-29
KR20010100004A (ko) 2001-11-09
AU784467B2 (en) 2006-04-06
DE60034545T2 (de) 2007-10-25
WO2001032214A1 (fr) 2001-05-10
HUP0104952A3 (en) 2006-02-28
ES2281358T3 (es) 2007-10-01
US6921766B1 (en) 2005-07-26
DE60034545D1 (de) 2007-06-06
CN1335778A (zh) 2002-02-13
EP1142586A1 (de) 2001-10-10
CA2358314A1 (en) 2001-05-10
EP1142586A4 (de) 2003-03-19
EP1142586B1 (de) 2007-04-25

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Legal Events

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