ATE348171T1 - Proteine mit lecithin-cholesterin acetyltransferase-ähnlicher aktivität, deren herstellung und verwendung - Google Patents

Proteine mit lecithin-cholesterin acetyltransferase-ähnlicher aktivität, deren herstellung und verwendung

Info

Publication number
ATE348171T1
ATE348171T1 AT98912745T AT98912745T ATE348171T1 AT E348171 T1 ATE348171 T1 AT E348171T1 AT 98912745 T AT98912745 T AT 98912745T AT 98912745 T AT98912745 T AT 98912745T AT E348171 T1 ATE348171 T1 AT E348171T1
Authority
AT
Austria
Prior art keywords
protein
salt
partial peptide
lecithin
activity
Prior art date
Application number
AT98912745T
Other languages
English (en)
Inventor
Yoshio Taniyama
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of ATE348171T1 publication Critical patent/ATE348171T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01043—Phosphatidylcholine-sterol O-acyltransferase (2.3.1.43), i.e. lecithin-cholesterol acyltransferase or LCAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT98912745T 1997-04-11 1998-04-09 Proteine mit lecithin-cholesterin acetyltransferase-ähnlicher aktivität, deren herstellung und verwendung ATE348171T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9335597 1997-04-11
JP18488597 1997-07-10
JP1028998 1998-01-22

Publications (1)

Publication Number Publication Date
ATE348171T1 true ATE348171T1 (de) 2007-01-15

Family

ID=27278908

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98912745T ATE348171T1 (de) 1997-04-11 1998-04-09 Proteine mit lecithin-cholesterin acetyltransferase-ähnlicher aktivität, deren herstellung und verwendung

Country Status (8)

Country Link
US (2) US6498019B1 (de)
EP (1) EP0973914B1 (de)
JP (1) JP2008148708A (de)
AT (1) ATE348171T1 (de)
AU (1) AU6748198A (de)
CA (1) CA2284832A1 (de)
DE (1) DE69836626T2 (de)
WO (1) WO1998046767A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030104559A1 (en) * 1998-03-27 2003-06-05 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6940003B1 (en) 1998-12-03 2005-09-06 E. I. Du Pont De Nemours And Company Plan lecithin: cholesterol acyltransferases
AU2163000A (en) * 1998-12-03 2000-06-19 E.I. Du Pont De Nemours And Company Plan lecithin:cholesterol acyltransferases
DE60239099D1 (de) * 2001-05-22 2011-03-17 Takeda Pharmaceutical Tier mit gen-hypoexpression
WO2003062416A1 (fr) * 2002-01-21 2003-07-31 Takeda Chemical Industries, Ltd. Procede de criblage d'agents preventifs et de remedes pour l'arteriosclerose
WO2003078624A1 (fr) * 2002-03-18 2003-09-25 Takeda Chemical Industries, Ltd. Gene llpl et nouvelle utilisation de ses produits geniques
CA2787343C (en) * 2006-06-26 2016-08-02 Amgen Inc. Compositions comprising modified lcat and uses thereof
EP2522721B1 (de) 2007-07-26 2016-05-04 Amgen, Inc Modifizierte Lecithin-Cholesterin-Acyltransferase-Enzyme
WO2010002895A2 (en) * 2008-06-30 2010-01-07 The Regents Of The University Of Michigan Lysosomal phospholipase a2 (lpla2) activity as a diagnostic and therapeutic target for identifying and treating systemic lupus erythematosis
GB2463925A (en) * 2008-07-11 2010-04-07 Eisai London Res Lab Ltd Screening for agents for the treatment of Alzheimers Disease
EP2566505B1 (de) * 2010-05-06 2019-10-16 Alphacore Pharma LLC Verabreichung von cholesterylester an steroidogene gewebe
JP6635655B2 (ja) * 2011-12-08 2020-01-29 アムジエン・インコーポレーテツド ヒトｌｃａｔ抗原結合タンパク質および治療法におけるそれらの使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51129293A (en) * 1975-05-02 1976-11-10 Nippon Shoji Kk Measurement method of activity of lecithin cholesteral acyl transferas e
US4163011A (en) * 1978-08-28 1979-07-31 Orts Richard J Peptide compounds and compositions
US5049488A (en) * 1985-11-08 1991-09-17 Genentech, Inc. Method and nucleic acid for the preparation of lecithin:cholesterol acyltransferase
JPH08176007A (ja) * 1994-12-27 1996-07-09 Snow Brand Milk Prod Co Ltd 脂質代謝異常治療剤
FR2731710B1 (fr) * 1995-03-14 1997-04-30 Rhone Poulenc Rorer Sa Virus recombinants exprimant la lecithine cholesterol acyltransferase et utilisations en therapie genique
ATE353957T1 (de) * 1995-11-09 2007-03-15 Us Gov Health & Human Serv Verwendung von lezithin-cholesterin- azetyltransferase für die behandlung von atherosklerose

Also Published As

Publication number Publication date
US6498019B1 (en) 2002-12-24
DE69836626T2 (de) 2007-04-05
DE69836626D1 (de) 2007-01-25
EP0973914B1 (de) 2006-12-13
US7157259B2 (en) 2007-01-02
WO1998046767A1 (en) 1998-10-22
US20030175905A1 (en) 2003-09-18
EP0973914A1 (de) 2000-01-26
AU6748198A (en) 1998-11-11
JP2008148708A (ja) 2008-07-03
CA2284832A1 (en) 1998-10-22

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