DE69836626D1 - Proteine mit lecithin-cholesterin acetyltransferase-ähnlicher aktivität, deren herstellung und verwendung - Google Patents

Proteine mit lecithin-cholesterin acetyltransferase-ähnlicher aktivität, deren herstellung und verwendung

Info

Publication number
DE69836626D1
DE69836626D1 DE69836626T DE69836626T DE69836626D1 DE 69836626 D1 DE69836626 D1 DE 69836626D1 DE 69836626 T DE69836626 T DE 69836626T DE 69836626 T DE69836626 T DE 69836626T DE 69836626 D1 DE69836626 D1 DE 69836626D1
Authority
DE
Germany
Prior art keywords
protein
salt
partial peptide
proteins
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69836626T
Other languages
English (en)
Other versions
DE69836626T2 (de
Inventor
Yoshio Taniyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69836626D1 publication Critical patent/DE69836626D1/de
Publication of DE69836626T2 publication Critical patent/DE69836626T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01043—Phosphatidylcholine-sterol O-acyltransferase (2.3.1.43), i.e. lecithin-cholesterol acyltransferase or LCAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69836626T 1997-04-11 1998-04-09 Proteine mit lecithin-cholesterin acetyltransferase-ähnlicher aktivität, deren herstellung und verwendung Expired - Lifetime DE69836626T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP9335597 1997-04-11
JP9335597 1997-04-11
JP18488597 1997-07-10
JP18488597 1997-07-10
JP1028998 1998-01-22
JP1028998 1998-01-22
PCT/JP1998/001643 WO1998046767A1 (en) 1997-04-11 1998-04-09 Proteins having lecithin-cholesterol acyltransferase-like activity, their production and use

Publications (2)

Publication Number Publication Date
DE69836626D1 true DE69836626D1 (de) 2007-01-25
DE69836626T2 DE69836626T2 (de) 2007-04-05

Family

ID=27278908

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69836626T Expired - Lifetime DE69836626T2 (de) 1997-04-11 1998-04-09 Proteine mit lecithin-cholesterin acetyltransferase-ähnlicher aktivität, deren herstellung und verwendung

Country Status (8)

Country Link
US (2) US6498019B1 (de)
EP (1) EP0973914B1 (de)
JP (1) JP2008148708A (de)
AT (1) ATE348171T1 (de)
AU (1) AU6748198A (de)
CA (1) CA2284832A1 (de)
DE (1) DE69836626T2 (de)
WO (1) WO1998046767A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030104559A1 (en) * 1998-03-27 2003-06-05 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6940003B1 (en) 1998-12-03 2005-09-06 E. I. Du Pont De Nemours And Company Plan lecithin: cholesterol acyltransferases
AU2163000A (en) * 1998-12-03 2000-06-19 E.I. Du Pont De Nemours And Company Plan lecithin:cholesterol acyltransferases
WO2002102998A1 (fr) * 2001-05-22 2002-12-27 Takeda Chemical Industries, Ltd. Animal avec hypoexpression genetique
WO2003062416A1 (fr) * 2002-01-21 2003-07-31 Takeda Chemical Industries, Ltd. Procede de criblage d'agents preventifs et de remedes pour l'arteriosclerose
WO2003078624A1 (fr) * 2002-03-18 2003-09-25 Takeda Chemical Industries, Ltd. Gene llpl et nouvelle utilisation de ses produits geniques
EP2037928B1 (de) * 2006-06-26 2012-01-11 Amgen Inc. Verfahren zur behandlung von atherosklerose
EP2489730B1 (de) * 2007-07-26 2015-12-30 Amgen, Inc Modifizierte Lecithin-Cholesterin-Acyltransferase-Enzyme
JP2011526916A (ja) * 2008-06-30 2011-10-20 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 全身性紅斑性狼瘡を同定および処置するための診断標的および治療標的としてのリソソームホスホリパーゼａ２（ｌｐｌａ２）活性
GB2463925A (en) * 2008-07-11 2010-04-07 Eisai London Res Lab Ltd Screening for agents for the treatment of Alzheimers Disease
CA2797126C (en) * 2010-05-06 2020-06-02 Alphacore Pharma Llc Delivery of cholesteryl ester to steroidogenic tissues
CN104220460A (zh) * 2011-12-08 2014-12-17 安姆根有限公司 激动人lcat抗原结合蛋白和它们在疗法中的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51129293A (en) * 1975-05-02 1976-11-10 Nippon Shoji Kk Measurement method of activity of lecithin cholesteral acyl transferas e
US4163011A (en) * 1978-08-28 1979-07-31 Orts Richard J Peptide compounds and compositions
US5049488A (en) 1985-11-08 1991-09-17 Genentech, Inc. Method and nucleic acid for the preparation of lecithin:cholesterol acyltransferase
JPH08176007A (ja) 1994-12-27 1996-07-09 Snow Brand Milk Prod Co Ltd 脂質代謝異常治療剤
FR2731710B1 (fr) 1995-03-14 1997-04-30 Rhone Poulenc Rorer Sa Virus recombinants exprimant la lecithine cholesterol acyltransferase et utilisations en therapie genique
EP0871713B1 (de) * 1995-11-09 2007-02-14 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Verwendung von lezithin-cholesterin-azetyltransferase für die behandlung von atherosklerose

Also Published As

Publication number Publication date
US7157259B2 (en) 2007-01-02
DE69836626T2 (de) 2007-04-05
EP0973914A1 (de) 2000-01-26
ATE348171T1 (de) 2007-01-15
EP0973914B1 (de) 2006-12-13
JP2008148708A (ja) 2008-07-03
US6498019B1 (en) 2002-12-24
US20030175905A1 (en) 2003-09-18
CA2284832A1 (en) 1998-10-22
AU6748198A (en) 1998-11-11
WO1998046767A1 (en) 1998-10-22

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