BR9813296A - Molécula isolada de ácido nucleico, processo para identificar uma molécula de ácido nucleico codificando um polipeptìdeo de endoglucuronidase de mamìfero, vetor de expressão, peptìdeo de heparanase isolado, polipeptìdeo recombinante ou isolado, molécula de anticorpo, processo para identificar um modulador da atividade de heparanase, uso de um oligossacarìdeo sulfatado, um sulfonato ou hspg compreendendo os mesmos, processos para tratamento de uma condição fisiológica ou médica em um sujeito humano ou animal em que a atividade de heparanase no referido sujeito é elevada, para intensificar a cura de feridas em um sujeito humano ou animal e para diagnosticar uma condição fisiológica ou médica associada com a super-expressão de heparanase, e, célula - Google Patents

Molécula isolada de ácido nucleico, processo para identificar uma molécula de ácido nucleico codificando um polipeptìdeo de endoglucuronidase de mamìfero, vetor de expressão, peptìdeo de heparanase isolado, polipeptìdeo recombinante ou isolado, molécula de anticorpo, processo para identificar um modulador da atividade de heparanase, uso de um oligossacarìdeo sulfatado, um sulfonato ou hspg compreendendo os mesmos, processos para tratamento de uma condição fisiológica ou médica em um sujeito humano ou animal em que a atividade de heparanase no referido sujeito é elevada, para intensificar a cura de feridas em um sujeito humano ou animal e para diagnosticar uma condição fisiológica ou médica associada com a super-expressão de heparanase, e, célula

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Publication number
BR9813296A
BR9813296A BR9813296-2A BR9813296A BR9813296A BR 9813296 A BR9813296 A BR 9813296A BR 9813296 A BR9813296 A BR 9813296A BR 9813296 A BR9813296 A BR 9813296A
Authority
BR
Brazil
Prior art keywords
heparanase
subject
human
isolated
physiological
Prior art date
Application number
BR9813296-2A
Other languages
English (en)
Inventor
Craig Geoffrey Freeman
Mark Darren Hulett
Christopher Richard Parish
Brenton James Hamdorf
Original Assignee
Univ Australian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPP006297 external-priority patent/AUPO006297A0/xx
Priority claimed from AUPP0812A external-priority patent/AUPP081297A0/en
Application filed by Univ Australian filed Critical Univ Australian
Publication of BR9813296A publication Critical patent/BR9813296A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01166—Heparanase (3.2.1.166)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"MOLéCULA ISOLADA DE áCIDO NUCLEICO, PROCESSO PARA IDENTIFICAR UMA MOLéCULA DE áCIDO NUCLEICO CODIFICANDO UM POLIPEPTìDEO DE ENDOGLUCURONIDASE DE MAMìFERO, VETOR DE EXPRESSãO, PEPTìDEO DE HEPARANASE ISOLADO, POLIPEPTìDEO RECOMBINANTE OU ISOLADO, MOLéCULA DE ANTICORPO, PROCESSO PARA IDENTIFICAR UM MODULADOR DA ATIVIDADE DE HEPARANASE, USO DE UM OLIGOSSACARìDEO SULFATADO, UM SULFONATO OU HSPG COMPREENDENDO OS MESMOS, PROCESSOS PARA TRATAMENTO DE UMA CONDIçãO FISIOLóGICA OU MéDICA EM UM SUJEITO HUMANO OU ANIMAL EM QUE A ATIVIDADE DE HEPARANASE NO REFERIDO SUJEITO é ELEVADA, PARA INTENSIFICAR A CURA DE FERIDAS EM UM SUJEITO HUMANO OU ANIMAL E PARA DIAGNOSTICAR UMA CONDIçãO FISIOLóGICA OU MéDICA ASSOCIADA COM A SUPER-EXPRESSãO DE HEPARANASE, E, CéLULA" A presente invenção refere-se a enzimas, polipeptídeos e peptídeos isolados ou recombinantes de endoglucuronidase de mamífero, em particular a heparanases humanas, murinos e de rato, a sequências genéticas codificando os mesmos, e a seus usos, por exemplo, na determinação e na caracterização de compostos químicos, proteínas, polipeptídeos, pequenas moléculas e macromoléculas capazes de inibir metástase, angiogênese, restenose induzida por angioplastia, ateroesclerose, inflamação, promover cura de feridas e, de outra forma, modular processos fisiológicos que envolvem a clivagem de heparanase do sulfato de heparano. A invenção também se refere a um processo para alterar, modificar ou, de outra forma, modular o nível de expressão da heparanase de mamífero em uma célula. Um outro aspecto da invenção refere-se a moléculas imunorreativas capazes de ligar-se a, e/ou inibir, a heparanase de mamífero. Em particular anticorpos monoclonais. Um outro aspecto adicional da invenção trata do uso de heparanase como um agente para promover os processos da cura de feridas.
BR9813296-2A 1997-10-28 1998-10-28 Molécula isolada de ácido nucleico, processo para identificar uma molécula de ácido nucleico codificando um polipeptìdeo de endoglucuronidase de mamìfero, vetor de expressão, peptìdeo de heparanase isolado, polipeptìdeo recombinante ou isolado, molécula de anticorpo, processo para identificar um modulador da atividade de heparanase, uso de um oligossacarìdeo sulfatado, um sulfonato ou hspg compreendendo os mesmos, processos para tratamento de uma condição fisiológica ou médica em um sujeito humano ou animal em que a atividade de heparanase no referido sujeito é elevada, para intensificar a cura de feridas em um sujeito humano ou animal e para diagnosticar uma condição fisiológica ou médica associada com a super-expressão de heparanase, e, célula BR9813296A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPP006297 AUPO006297A0 (en) 1997-10-28 1997-10-28 Isolated nucleic acid molecule encoding mammalian endoglucuronidase and uses therefor
AUPP0812A AUPP081297A0 (en) 1997-12-09 1997-12-09 Isolated nucleic acid molecule encoding mammalian endoglucuronidase and uses therfor ii
PCT/AU1998/000898 WO1999021975A1 (en) 1997-10-28 1998-10-28 Isolated nucleic acid molecule encoding mammalian endoglucuronidase and uses therefor

Publications (1)

Publication Number Publication Date
BR9813296A true BR9813296A (pt) 2000-08-22

Family

ID=25645639

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813296-2A BR9813296A (pt) 1997-10-28 1998-10-28 Molécula isolada de ácido nucleico, processo para identificar uma molécula de ácido nucleico codificando um polipeptìdeo de endoglucuronidase de mamìfero, vetor de expressão, peptìdeo de heparanase isolado, polipeptìdeo recombinante ou isolado, molécula de anticorpo, processo para identificar um modulador da atividade de heparanase, uso de um oligossacarìdeo sulfatado, um sulfonato ou hspg compreendendo os mesmos, processos para tratamento de uma condição fisiológica ou médica em um sujeito humano ou animal em que a atividade de heparanase no referido sujeito é elevada, para intensificar a cura de feridas em um sujeito humano ou animal e para diagnosticar uma condição fisiológica ou médica associada com a super-expressão de heparanase, e, célula

Country Status (9)

Country Link
US (1) US6242238B1 (pt)
EP (1) EP1032656A4 (pt)
JP (1) JP2002510462A (pt)
CN (1) CN1280613A (pt)
AU (1) AU744655B2 (pt)
BR (1) BR9813296A (pt)
CA (1) CA2307830A1 (pt)
IL (1) IL135823A0 (pt)
WO (1) WO1999021975A1 (pt)

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Publication number Priority date Publication date Assignee Title
US6562950B2 (en) * 1997-09-02 2003-05-13 Insight Strategy & Marketing Ltd. Heparanase activity neutralizing anti-heparanase monoclonal antibody
US6699672B1 (en) 1997-09-02 2004-03-02 Insight Biopharmaceuticals Ltd. Heparanase specific molecular probes and their use research and medical applications
US20030161823A1 (en) * 1998-08-31 2003-08-28 Neta Ilan Therapeutic and cosmetic uses of heparanases
US20010006630A1 (en) * 1997-09-02 2001-07-05 Oron Yacoby-Zeevi Introducing a biological material into a patient
US6348344B1 (en) * 1997-09-02 2002-02-19 Insight Strategy & Marketing Ltd. Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same
US20020088019A1 (en) * 1997-09-02 2002-07-04 Oron Yacoby-Zeevi Methods of and pharmaceutical compositions for improving implantation of embryos
US5968822A (en) * 1997-09-02 1999-10-19 Pecker; Iris Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells
US6177545B1 (en) 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
US20040213789A1 (en) * 1997-09-02 2004-10-28 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
GB9802725D0 (en) 1998-02-09 1998-04-08 Ciba Geigy Ag Organic compounds
US20020068054A1 (en) * 2000-09-11 2002-06-06 Insight Strategy & Marketing Ltd. And Hadasit Medical Research Services And Development Ltd. Therapeutic and cosmetic uses of heparanases
WO2000052178A1 (en) * 1999-03-01 2000-09-08 Insight Strategy & Marketing Ltd. Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
CN1370178A (zh) * 1999-06-25 2002-09-18 洞察战略及销售有限公司 多核苷酸及其编码的与乙酰肝素酶同源较远的多肽
EP1214423A1 (en) * 1999-09-23 2002-06-19 MERCK PATENT GmbH Heparanase-2, a member of the heparanase protein family
WO2001046392A2 (en) * 1999-12-22 2001-06-28 Oxford Glycosciences (Uk) Ltd. Homologues of human heparanase and splice variants thereof
JP2003518381A (ja) * 1999-12-23 2003-06-10 シエーリング アクチエンゲゼルシャフト ヒトヘパラナーゼ関連ポリペプチド及び核酸
GB0008912D0 (en) * 2000-04-11 2000-05-31 Janssen Pharmaceutica Nv Mammalian heparanase
PL366012A1 (en) 2000-09-15 2005-01-24 Reddy Us Therapeutics, Inc. Methods and compositions for glycosidase assays
US6677137B2 (en) * 2000-09-20 2004-01-13 Insight Strategy & Marketing Ltd. Avian and reptile derived polynucleotide encoding a polypeptide having heparanase activity
EP1333862A4 (en) * 2000-10-17 2004-08-18 Insight Strategy & Marketing PHARMACEUTICAL METHODS AND COMPOSITIONS FOR IMPROVING THE ESTABLISHMENT OF EMBRYOS
EP1379139A4 (en) * 2000-12-19 2004-12-01 Insight Strategy & Marketing USE OF ECM DEGRADING ENZYME TO IMPROVE CELL TRANSPLANTATION
US6630295B2 (en) * 2001-01-04 2003-10-07 Insight Strategy & Marketing Ltd. High throughput assay for monitoring polycation or polyanion molecular weight, degradation or synthesis
US20040247577A1 (en) * 2001-07-13 2004-12-09 Peter Bohlen Method and composition for inhibiting heparanase activity
JP2005521379A (ja) * 2001-07-13 2005-07-21 イムクローン システムズ インコーポレイティド ヘパラナーゼ活性を阻害するための方法及び組成物
WO2003042366A2 (en) * 2001-11-13 2003-05-22 Albert Einstein College Of Medicine Of Yeshiva University A novel saitohin gene and uses of same
US20030234212A1 (en) * 2002-06-21 2003-12-25 Sanden Corporation Mineral water making apparatus
WO2004043989A2 (en) * 2002-11-07 2004-05-27 Medarex, Inc. Human monoclonal antibodies to heparanase
EP1479764A1 (en) 2003-05-19 2004-11-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Heparanase-derived peptides for vaccination of tumor patients
IL162276A0 (en) * 2004-06-01 2005-11-20 Hadasit Med Res Service Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof
CN100462432C (zh) * 2006-03-15 2009-02-18 中国人民解放军军事医学科学院野战输血研究所 杂交瘤细胞株及其产生的抗人肝素酶单克隆抗体
CN114793437A (zh) * 2019-04-30 2022-07-26 Encodia 公司 用于从多肽上切割n端氨基酸的方法和试剂

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EP0532695A1 (en) 1990-05-31 1993-03-24 Board Of Regents, The University Of Texas System Immunochemical localization of heparanase in mouse and human melanomas
AU7368994A (en) * 1993-07-29 1995-02-28 Upjohn Company, The Use of heparanase to identify and isolate anti-heparanase compound
TW565614B (en) 1996-07-18 2003-12-11 Univ Australian Detection of mammalian heparanase activity and purification of mammalian heparanase
US5968822A (en) 1997-09-02 1999-10-19 Pecker; Iris Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells

Also Published As

Publication number Publication date
US6242238B1 (en) 2001-06-05
AU744655B2 (en) 2002-02-28
EP1032656A1 (en) 2000-09-06
CA2307830A1 (en) 1999-05-06
WO1999021975A1 (en) 1999-05-06
AU1010999A (en) 1999-05-17
CN1280613A (zh) 2001-01-17
EP1032656A4 (en) 2002-10-29
IL135823A0 (en) 2001-05-20
JP2002510462A (ja) 2002-04-09

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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