ATE333455T1 - Substituierte, ringkondensierte imidazolderivate: gabaa-rezeptorliganden - Google Patents

Substituierte, ringkondensierte imidazolderivate: gabaa-rezeptorliganden

Info

Publication number: ATE333455T1
Authority: AT; Austria
Prior art keywords: sub; receptors; substituted ring; imidazole derivatives; gaba
Prior art date: 2002-05-17

Application number

AT03736638T

Other languages

English (en)

Inventor

George D Maynard

Jun Yuan

George P Luke

Kevin Currie

Original Assignee

Neurogen Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-17

Filing date

2003-05-15

Publication date

2006-08-15

2003-05-15 Application filed by Neurogen Corp filed Critical Neurogen Corp

2006-08-15 Application granted granted Critical

2006-08-15 Publication of ATE333455T1 publication Critical patent/ATE333455T1/de

Links

239000003446 ligand Substances 0.000 title abstract 3
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 2
RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
102000027484 GABAA receptors Human genes 0.000 title 1
108091008681 GABAA receptors Proteins 0.000 title 1
210000003169 central nervous system Anatomy 0.000 abstract 4
229960003692 gamma aminobutyric acid Drugs 0.000 abstract 3
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 3
241001465754 Metazoa Species 0.000 abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
244000144972 livestock Species 0.000 abstract 1
230000004807 localization Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

AT03736638T 2002-05-17 2003-05-15 Substituierte, ringkondensierte imidazolderivate: gabaa-rezeptorliganden ATE333455T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US38130202P	2002-05-17	2002-05-17

Publications (1)

Publication Number	Publication Date
ATE333455T1 true ATE333455T1 (de)	2006-08-15

Family

ID=29550099

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03736638T ATE333455T1 (de)	2002-05-17	2003-05-15	Substituierte, ringkondensierte imidazolderivate: gabaa-rezeptorliganden

Country Status (9)

Country	Link
US (1)	US6916827B2 (de)
EP (1)	EP1506194B1 (de)
JP (1)	JP2006502974A (de)
AT (1)	ATE333455T1 (de)
AU (1)	AU2003237881A1 (de)
CA (1)	CA2486339A1 (de)
DE (1)	DE60306918T2 (de)
ES (1)	ES2273008T3 (de)
WO (1)	WO2003097643A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1648899E (pt) *	2003-07-25	2007-03-30	Neurogen Corp	Imidazo-pirimidinas e triazolo-pirimidinas: ligandos do receptor de benzodiazepina
MXPA06014909A (es) *	2004-06-18	2007-02-28	Chiron Corp	Derivados de n-(1-(1-bencil -4-fenil-1h -imidazol -2-il)-2, 2-dimetilpropil) benzamida y compuestos relacionados como inhibidores de proteina de huso de cinesina (ksp) para el tratamiento del cancer.
CN101622247A (zh)	2007-01-05	2010-01-06	诺瓦提斯公司	作为驱动蛋白纺锤体蛋白抑制剂的咪唑衍生物
US20150374705A1 (en)	2012-02-14	2015-12-31	Shanghai Institues for Biological Sciences	Substances for treatment or relief of pain

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4812462A (en)	1986-04-01	1989-03-14	Warner-Lambert Company	4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
CA2004911A1 (en) *	1988-12-22	1990-06-22	Mitsuaki Ohta	4,5,6,7-tetrahydrobenzimidazole derivatives
US5362732A (en)	1989-12-20	1994-11-08	University Of North Carolina At Chapel Hill	Boronated compounds
US5130302A (en)	1989-12-20	1992-07-14	Boron Bilogicals, Inc.	Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
US5262537A (en) *	1993-03-19	1993-11-16	Anaquest, Inc.	Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid
WO1996039404A1 (en) *	1995-06-05	1996-12-12	Neurogen Corporation	Novel substituted aryl and cycloalkyl imidazolones; a new class of gaba brain receptor ligands
US5637725A (en) *	1995-06-05	1997-06-10	Neurogen Corporation	Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
US6211365B1 (en) *	1996-01-19	2001-04-03	Neurogen Corporation	Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
US5804686A (en) *	1996-01-19	1998-09-08	Neurogen Corporation	fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
US5789416B1 (en)	1996-08-27	1999-10-05	Cv Therapeutics Inc	N6 mono heterocyclic substituted adenosine derivatives
JP3619017B2 (ja)	1998-06-24	2005-02-09	日本臓器製薬株式会社	新規アラビノシルアデニン誘導体
WO2002002557A2 (en)	2000-06-30	2002-01-10	Neurogen Corporation	2-phenylimidazo[1,2-a]pyridine derivatives: a new class of gaba brain receptor ligands
PA8535601A1 (es) *	2000-12-21	2002-11-28	Pfizer	Derivados benzimidazol y piridilimidazol como ligandos para gabaa

2003
- 2003-05-15 AU AU2003237881A patent/AU2003237881A1/en not_active Abandoned
- 2003-05-15 AT AT03736638T patent/ATE333455T1/de not_active IP Right Cessation
- 2003-05-15 DE DE60306918T patent/DE60306918T2/de not_active Expired - Fee Related
- 2003-05-15 ES ES03736638T patent/ES2273008T3/es not_active Expired - Lifetime
- 2003-05-15 EP EP03736638A patent/EP1506194B1/de not_active Expired - Lifetime
- 2003-05-15 CA CA002486339A patent/CA2486339A1/en not_active Abandoned
- 2003-05-15 JP JP2004505375A patent/JP2006502974A/ja active Pending
- 2003-05-15 WO PCT/US2003/015578 patent/WO2003097643A1/en active IP Right Grant
- 2003-05-15 US US10/438,496 patent/US6916827B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20040014780A1 (en)	2004-01-22
JP2006502974A (ja)	2006-01-26
DE60306918T2 (de)	2007-03-01
US6916827B2 (en)	2005-07-12
WO2003097643A1 (en)	2003-11-27
EP1506194B1 (de)	2006-07-19
AU2003237881A1 (en)	2003-12-02
EP1506194A1 (de)	2005-02-16
DE60306918D1 (de)	2006-08-31
ES2273008T3 (es)	2007-05-01
CA2486339A1 (en)	2003-11-27

Legal Events

Date	Code	Title	Description
2007-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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