ATE324444T1 - Tek-antagonisten - Google Patents

Tek-antagonisten

Info

Publication number
ATE324444T1
ATE324444T1 AT00938207T AT00938207T ATE324444T1 AT E324444 T1 ATE324444 T1 AT E324444T1 AT 00938207 T AT00938207 T AT 00938207T AT 00938207 T AT00938207 T AT 00938207T AT E324444 T1 ATE324444 T1 AT E324444T1
Authority
AT
Austria
Prior art keywords
tek antagonists
methods
tek
antagonists
angiogenesis
Prior art date
Application number
AT00938207T
Other languages
English (en)
Inventor
Douglas P Cerretti
Luis G Borges
William C Fanslow Iii
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22479496&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE324444(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunex Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of ATE324444T1 publication Critical patent/ATE324444T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT00938207T 1999-06-07 2000-06-07 Tek-antagonisten ATE324444T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13788999P 1999-06-07 1999-06-07

Publications (1)

Publication Number Publication Date
ATE324444T1 true ATE324444T1 (de) 2006-05-15

Family

ID=22479496

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00938207T ATE324444T1 (de) 1999-06-07 2000-06-07 Tek-antagonisten

Country Status (14)

Country Link
US (2) US6413932B1 (de)
EP (1) EP1187918B9 (de)
JP (1) JP4587626B2 (de)
AT (1) ATE324444T1 (de)
AU (1) AU783960B2 (de)
CA (1) CA2374851A1 (de)
CY (1) CY1105078T1 (de)
DE (1) DE60027564T3 (de)
DK (1) DK1187918T4 (de)
ES (1) ES2262518T5 (de)
IL (2) IL146482A0 (de)
NZ (1) NZ516258A (de)
PT (1) PT1187918E (de)
WO (1) WO2000075323A1 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1239869B1 (de) 1999-12-20 2013-08-28 Immunex Corporation Tweak rezeptor
EP1427829A4 (de) * 2001-08-31 2005-10-12 Abmaxis Inc Multivalentes proteinkonjugat mit mehreren ligandenbindungsrezeptordomänen
US7658924B2 (en) 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US7138370B2 (en) * 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7205275B2 (en) * 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
CN1315536C (zh) * 2002-09-13 2007-05-16 李进 肿瘤抗原疫苗及其制备方法和疫苗组合物
CA2525969A1 (en) * 2003-05-16 2005-02-24 Receptor Biologix, Inc. Intron fusion proteins, and methods of identifying and using same
PL1648998T3 (pl) 2003-07-18 2015-03-31 Amgen Inc Specyficzne czynniki wiążące czynnik wzrostu hepatocytów
US20060286102A1 (en) * 2004-05-14 2006-12-21 Pei Jin Cell surface receptor isoforms and methods of identifying and using the same
US20070280947A1 (en) * 2004-06-25 2007-12-06 Licentia, Ltd. Tie Receptor and Tie Ligand Materials and Methods for Modulating Female Fertility
US7507748B2 (en) * 2004-07-22 2009-03-24 Amgen Inc. Substituted aryl-amine derivatives and methods of use
US20080119367A1 (en) * 2004-12-17 2008-05-22 Mayo Foundation For Medical Education And Research Prognosis of Renal Cell Carcinoma
US7973140B2 (en) * 2004-12-21 2011-07-05 Medimmune Limited Antibodies directed to angiopoietin-2 and uses thereof
US20090170769A1 (en) * 2005-05-13 2009-07-02 Pei Jin Cell surface receptor isoforms and methods of identifying and using the same
AR059066A1 (es) * 2006-01-27 2008-03-12 Amgen Inc Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
PE20121506A1 (es) 2006-07-14 2012-11-26 Amgen Inc Compuestos triazolopiridinas como inhibidores de c-met
US8217177B2 (en) 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
MX2009008531A (es) 2007-02-16 2009-08-26 Amgen Inc Cetonas de heterociclilo que contienen nitrogeno y su uso como inhibidores de c-met.
TWI595005B (zh) 2007-08-21 2017-08-11 安健股份有限公司 人類c-fms抗原結合蛋白質
US8574577B2 (en) 2008-01-03 2013-11-05 The Scripps Research Institute VEGF antibodies comprising modular recognition domains
US8557242B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute ERBB2 antibodies comprising modular recognition domains
US8557243B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute EFGR antibodies comprising modular recognition domains
US8454960B2 (en) 2008-01-03 2013-06-04 The Scripps Research Institute Multispecific antibody targeting and multivalency through modular recognition domains
EA201500156A3 (ru) 2008-01-03 2017-09-29 Дзе Скриппс Рисерч Инститьют Доставка антител посредством модульного домена распознавания
MX2010008099A (es) 2008-01-28 2010-08-04 Medimmune Ltd Anticuerpos y angiopoyetina-2 estabilizados y sus usos.
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
WO2009158432A2 (en) 2008-06-27 2009-12-30 Amgen Inc. Ang-2 inhibition to treat multiple sclerosis
US20120100166A1 (en) 2010-07-15 2012-04-26 Zyngenia, Inc. Ang-2 Binding Complexes and Uses Thereof
KR101606250B1 (ko) 2011-03-23 2016-03-24 암젠 인크 Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제
AU2012258637B2 (en) 2011-05-24 2017-07-20 Zyngenia, Inc. Multivalent and monovalent multispecific complexes and their uses
WO2013025939A2 (en) 2011-08-16 2013-02-21 Indiana University Research And Technology Corporation Compounds and methods for treating cancer by inhibiting the urokinase receptor
AU2012299195B9 (en) 2011-08-19 2018-05-10 Regeneron Pharmaceuticals, Inc Anti-Tie2 antibodies uses thereof
US10316105B2 (en) 2011-08-19 2019-06-11 Regeneron Pharmaceuticals, Inc. Anti-TIE2 antibodies and uses thereof
AR090263A1 (es) 2012-03-08 2014-10-29 Hoffmann La Roche Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
WO2014036022A1 (en) 2012-08-29 2014-03-06 Amgen Inc. Quinazolinone compounds and derivatives thereof
GB201223053D0 (en) 2012-12-20 2013-02-06 Medical Res Council Receptor
EP2968541A4 (de) 2013-03-15 2017-02-08 Zyngenia, Inc. Multivalente und monovalente multispezifische komplexe und deren verwendungen
TW201605896A (zh) 2013-08-30 2016-02-16 安美基股份有限公司 Gitr抗原結合蛋白
CA3016894A1 (en) 2016-03-08 2017-09-14 Janssen Biotech, Inc. Gitr antibodies, methods, and uses
KR102592246B1 (ko) 2016-12-22 2023-10-23 암젠 인크 폐암, 췌장암 또는 대장암을 치료하기 위한 kras g12c 억제제로서의 벤즈이소티아졸, 이소티아졸로[3,4-b]피리딘, 퀴나졸린, 프탈라진, 피리도[2,3-d]피리다진 및 피리도[2,3-d]피리미딘 유도체
JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
EP4141005B1 (de) 2017-09-08 2024-04-03 Amgen Inc. Inhibitoren von kras g12c und verfahren zur verwendung davon
AU2019262589B2 (en) 2018-05-04 2022-07-07 Amgen Inc. KRAS G12C inhibitors and methods of using the same
MA52496A (fr) 2018-05-04 2021-03-10 Amgen Inc Inhibiteurs de kras g12c et leurs procédés d'utilisation
MX2020011907A (es) 2018-05-10 2021-01-29 Amgen Inc Inhibidores de kras g12c para el tratamiento de cancer.
ES2938987T3 (es) 2018-06-01 2023-04-18 Amgen Inc Inhibidores de KRAS G12c y métodos de uso de los mismos
MA52780A (fr) 2018-06-11 2021-04-14 Amgen Inc Inhibiteurs de kras g12c pour le traitement du cancer
US11285156B2 (en) 2018-06-12 2022-03-29 Amgen Inc. Substituted piperazines as KRAS G12C inhibitors
CN108888756A (zh) * 2018-07-25 2018-11-27 韩曙 C16多肽和血管生成素Ang1的应用和应用二者的药物
JP2020090482A (ja) 2018-11-16 2020-06-11 アムジエン・インコーポレーテツド Kras g12c阻害剤化合物の重要な中間体の改良合成法
EP3883565A1 (de) 2018-11-19 2021-09-29 Amgen Inc. Kras-g12c-inhibitoren und verfahren zu deren verwendung
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
US20220073504A1 (en) 2018-12-20 2022-03-10 Amgen Inc. Kif18a inhibitors
MA54543A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
WO2020132649A1 (en) 2018-12-20 2020-06-25 Amgen Inc. Heteroaryl amides useful as kif18a inhibitors
US20220002311A1 (en) 2018-12-20 2022-01-06 Amgen Inc. Kif18a inhibitors
KR20210146287A (ko) 2019-03-01 2021-12-03 레볼루션 메디슨즈, 인크. 이환식 헤테로아릴 화합물 및 이의 용도
EP3930845A1 (de) 2019-03-01 2022-01-05 Revolution Medicines, Inc. Bicyclische heterocyclyl-verbindungen und ihre verwendung
EP3738593A1 (de) 2019-05-14 2020-11-18 Amgen, Inc Dosierung von kras-inhibitor zur behandlung von krebserkrankungen
US11236091B2 (en) 2019-05-21 2022-02-01 Amgen Inc. Solid state forms
EP3990476A1 (de) * 2019-06-25 2022-05-04 Gilead Sciences, Inc. Flt3l-fc-fusionsproteine und verfahren zur verwendung
MX2022001296A (es) 2019-08-02 2022-02-22 Amgen Inc Inhibidores de kif18a.
CA3146693A1 (en) 2019-08-02 2021-02-11 Amgen Inc. Kif18a inhibitors
EP4007756A1 (de) 2019-08-02 2022-06-08 Amgen Inc. Kif18a-inhibitoren
US20220372018A1 (en) 2019-08-02 2022-11-24 Amgen Inc. Kif18a inhibitors
EP4031542A4 (de) 2019-09-18 2023-10-25 Merck Sharp & Dohme LLC Kleinmolekülige inhibitoren der kras-g12c-mutante
EP4048671A1 (de) 2019-10-24 2022-08-31 Amgen Inc. Pyridopyrimidinderivate als kras-sg12c- und kras-g12d-inhibitoren zur behandlung von krebs
EP4051678A1 (de) 2019-10-28 2022-09-07 Merck Sharp & Dohme Corp. Kleinmolekülige inhibitoren der kras-g12c-mutante
US20230023023A1 (en) 2019-10-31 2023-01-26 Taiho Pharmaceutical Co., Ltd. 4-aminobut-2-enamide derivatives and salts thereof
WO2021091967A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
KR20220109407A (ko) 2019-11-04 2022-08-04 레볼루션 메디슨즈, 인크. Ras 억제제
TW202132316A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ras抑制劑
JP2023500328A (ja) 2019-11-08 2023-01-05 レボリューション メディシンズ インコーポレイテッド 二環式ヘテロアリール化合物及びその使用
WO2021097212A1 (en) 2019-11-14 2021-05-20 Amgen Inc. Improved synthesis of kras g12c inhibitor compound
EP4058432A1 (de) 2019-11-14 2022-09-21 Amgen Inc. Verbesserte synthese einer kras-g12c-hemmenden verbindung
EP4065231A1 (de) 2019-11-27 2022-10-05 Revolution Medicines, Inc. Kovalente ras-inhibitoren und verwendungen davon
WO2021106231A1 (en) 2019-11-29 2021-06-03 Taiho Pharmaceutical Co., Ltd. A compound having inhibitory activity against kras g12d mutation
IL294484A (en) 2020-01-07 2022-09-01 Revolution Medicines Inc Dosage for shp2 inhibitor and methods for treating cancer
WO2021215544A1 (en) 2020-04-24 2021-10-28 Taiho Pharmaceutical Co., Ltd. Kras g12d protein inhibitors
US20230181536A1 (en) 2020-04-24 2023-06-15 Taiho Pharmaceutical Co., Ltd. Anticancer combination therapy with n-(1-acryloyl-azetidin-3-yl)-2-((1h-indazol-3-yl)amino)methyl)-1h-imidazole-5-carboxamide inhibitor of kras-g12c
CA3183032A1 (en) 2020-06-18 2021-12-23 Mallika Singh Methods for delaying, preventing, and treating acquired resistance to ras inhibitors
JP7373664B2 (ja) 2020-07-15 2023-11-02 大鵬薬品工業株式会社 腫瘍の治療に使用されるピリミジン化合物を含む組み合わせ
CA3187757A1 (en) 2020-09-03 2022-03-24 Ethan AHLER Use of sos1 inhibitors to treat malignancies with shp2 mutations
CA3194067A1 (en) 2020-09-15 2022-03-24 Revolution Medicines, Inc. Ras inhibitors
EP4267250A1 (de) 2020-12-22 2023-11-01 Qilu Regor Therapeutics Inc. Sos1-inhibitoren und verwendungen davon
IL308193A (en) 2021-05-05 2024-01-01 Revolution Medicines Inc RAS inhibitors
CN117616031A (zh) 2021-05-05 2024-02-27 锐新医药公司 用于治疗癌症的ras抑制剂
CN117500811A (zh) 2021-05-05 2024-02-02 锐新医药公司 共价ras抑制剂及其用途
CN117769554A (zh) 2021-05-28 2024-03-26 大鹏药品工业株式会社 Kras突变蛋白的小分子抑制剂
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
WO2023114954A1 (en) 2021-12-17 2023-06-22 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
EP4227307A1 (de) 2022-02-11 2023-08-16 Genzyme Corporation Pyrazolopyrazinverbindungen als shp2-inhibitoren
WO2023172940A1 (en) 2022-03-08 2023-09-14 Revolution Medicines, Inc. Methods for treating immune refractory lung cancer
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2024081916A1 (en) 2022-10-14 2024-04-18 Black Diamond Therapeutics, Inc. Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1411092A (en) * 1991-01-31 1992-09-07 Cor Therapeutics, Inc. Domains of extracellular region of human platelet derived growth factor receptor polypeptides
US5955291A (en) 1992-01-09 1999-09-21 Alitalo; Kari Antibodies recognizing tie receptor tyrosine kinase and uses thereof
CA2127540A1 (en) 1992-01-09 1993-07-22 Juha Partanen Tie, a novel endothelial cell receptor tyrosine kinase
WO1994000469A1 (en) 1992-06-26 1994-01-06 Immunex Corporation Novel tyrosine kinase
US5681714A (en) 1992-07-30 1997-10-28 Mount Sinai Hospital Corporation Nucleic acid encoding tek receptor tyrosine kinase
JPH06315382A (ja) 1993-05-06 1994-11-15 Toshio Suda Tie−2受容体をコードするdna及びtie−2受容体
AU8143094A (en) * 1993-11-12 1995-05-29 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. (tie-2), a novel receptor tyrosine kinase
AUPM379494A0 (en) * 1994-02-10 1994-03-03 Ludwig Institute For Cancer Research Immunointeractive molecules - ii
US5814464A (en) 1994-10-07 1998-09-29 Regeneron Pharma Nucleic acids encoding TIE-2 ligand-2
EP0854185A3 (de) 1994-12-23 1998-10-21 Ludwig Institute For Cancer Research Rezeptor-Proteine zu Bestimmungszwecke und Liganden
JP4122056B2 (ja) * 1995-04-06 2008-07-23 リジエネロン ファーマシューティカルズ,インコーポレイテッド Tie−2リガンド、その作製方法および使用方法
US6033903A (en) * 1995-06-02 2000-03-07 Applied Research Systems, ARS Holding N.V. Method of expressing and secreting soluble extracellular domains of human gonadotropin hormone receptors
EP0965637B1 (de) * 1996-05-02 2005-07-20 Mochida Pharmaceutical Co., Ltd. Fas ANTIGEN-DERIVATE
WO1998018914A1 (en) * 1996-10-31 1998-05-07 Duke University Soluble tie2 receptor
US6376653B1 (en) 1998-09-28 2002-04-23 Smithkline Beecham Plc Tie2 antagonist antibodies

Also Published As

Publication number Publication date
DK1187918T3 (da) 2006-08-21
JP4587626B2 (ja) 2010-11-24
AU783960B2 (en) 2006-01-05
ES2262518T5 (es) 2009-05-08
WO2000075323A1 (en) 2000-12-14
DE60027564D1 (de) 2006-06-01
US20070025993A1 (en) 2007-02-01
CY1105078T1 (el) 2009-11-04
US6413932B1 (en) 2002-07-02
AU5328200A (en) 2000-12-28
IL146482A (en) 2010-11-30
DK1187918T4 (da) 2009-02-23
EP1187918B9 (de) 2009-08-19
NZ516258A (en) 2004-02-27
CA2374851A1 (en) 2000-12-14
EP1187918A1 (de) 2002-03-20
EP1187918B1 (de) 2006-04-26
DE60027564T3 (de) 2009-07-23
EP1187918B2 (de) 2009-01-14
PT1187918E (pt) 2006-08-31
ES2262518T3 (es) 2006-12-01
IL146482A0 (en) 2002-07-25
DE60027564T2 (de) 2007-05-10
JP2003501090A (ja) 2003-01-14

Similar Documents

Publication Publication Date Title
ATE324444T1 (de) Tek-antagonisten
NO20034056D0 (no) Proliferative sykdommer
ATE293989T1 (de) Verwendung von eph-rezeptor-antagonisten und agonisten zur behandlung von vaskulären krankheiten
CY1107074T1 (el) Συνθεση εναντιομερων 4-αμινο-θαλιδομιδης
HRP20080467A2 (en) 5-beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia
DK1202736T3 (da) Nikotin i terapeutisk angiogenese og vasculogenese
BR9707819A (pt) Imunogenos peptidicos
NO20001598D0 (no) Apolipoprotein A-1-agonister og deres anvendelse for Õ behandle dyslipidemiske forstyrrelser
WO2006015060A3 (en) Isoindoline compounds and methods of their use
DE60231439D1 (de) Mitotische kinesinhemmer
DE60234278D1 (de) Mitotische kinesin-hemmer
DK1346041T3 (da) Terapeutiske midler og fremgangsmåder til anvendelse deraf til behandling af en amyloidogen sygdom
DE60137337D1 (de) Vorbeugende und therapeutsche monoklonale antikörper gegen vacciniavirusantigene
ATE333882T1 (de) Zusammensetzungen zur hemmung der angiogenese
DE59708265D1 (de) Neue in 6-position substituierte phenanthridine
DE60031714D1 (de) Thrombopoietin-mimetika
IL153680A0 (en) Aplidine derivatives and methods for the preparation thereof
PT1109571E (pt) Metodos de tratamento da hipertensao e composicoes para utilizacao nesses metodos
TW200640944A (en) VGF polypeptides and methods of treating VGF-related disorders
DK1220852T3 (da) Substituerede diazepaner
DE60108626D1 (de) Verwendung von 5-thio, sulfinyl- und sulfonylpyrazolo 3,4-b] pyridinen als cyclin-abhängige kinase-hemmer
AP9801202A0 (en) Atropisomers of 3-heteroaryl-4(3H)-quinazolinones.
DK1196442T3 (da) VGF-polypeptider og fremgangsmåder til behandling af VGF-relaterede lidelser
TR200200278T2 (tr) Kalsilitik bileşimler
NO20015673L (no) IL6RIL6 kimaere for behandlingen av nevrodegenerative sykdommer

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1187918

Country of ref document: EP

UEP Publication of translation of european patent specification

Ref document number: 1187918

Country of ref document: EP

REN Ceased due to non-payment of the annual fee