ATE272114T1 - Rezeptoren für il-18 - Google Patents
Rezeptoren für il-18Info
- Publication number
- ATE272114T1 ATE272114T1 AT99904222T AT99904222T ATE272114T1 AT E272114 T1 ATE272114 T1 AT E272114T1 AT 99904222 T AT99904222 T AT 99904222T AT 99904222 T AT99904222 T AT 99904222T AT E272114 T1 ATE272114 T1 AT E272114T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor
- polypeptide
- receptors
- multimeric
- fragment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7230198P | 1998-01-23 | 1998-01-23 | |
US7883598P | 1998-03-20 | 1998-03-20 | |
US9446998P | 1998-07-28 | 1998-07-28 | |
PCT/US1999/001419 WO1999037772A1 (en) | 1998-01-23 | 1999-01-22 | Il-18 receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE272114T1 true ATE272114T1 (de) | 2004-08-15 |
Family
ID=27372056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99904222T ATE272114T1 (de) | 1998-01-23 | 1999-01-22 | Rezeptoren für il-18 |
Country Status (13)
Country | Link |
---|---|
US (4) | US6589764B1 (de) |
EP (1) | EP1047781B1 (de) |
JP (1) | JP4271850B2 (de) |
AT (1) | ATE272114T1 (de) |
AU (1) | AU737592B2 (de) |
CA (1) | CA2318482C (de) |
DE (1) | DE69918946T2 (de) |
DK (1) | DK1047781T3 (de) |
ES (1) | ES2226335T3 (de) |
IL (2) | IL137178A0 (de) |
NZ (1) | NZ505880A (de) |
PT (1) | PT1047781E (de) |
WO (1) | WO1999037772A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6326472B1 (en) | 1997-10-15 | 2001-12-04 | Schering Corporation | Human receptor proteins; related reagents and methods |
US6927044B2 (en) | 1998-09-25 | 2005-08-09 | Regeneron Pharmaceuticals, Inc. | IL-1 receptor based cytokine traps |
US7083949B2 (en) | 1998-09-25 | 2006-08-01 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
US6472179B2 (en) * | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
US20020155526A1 (en) | 1998-09-30 | 2002-10-24 | Busfield Samantha J. | Novel secreted immunomodulatory proteins and uses thereof |
US7122632B2 (en) | 1999-12-23 | 2006-10-17 | Zymogenetics, Inc. | Soluble Interleukin-20 receptor |
ATE407950T1 (de) * | 1999-12-23 | 2008-09-15 | Zymogenetics Inc | Löslicher interleukin-20 rezeptor |
US6610286B2 (en) | 1999-12-23 | 2003-08-26 | Zymogenetics, Inc. | Method for treating inflammation using soluble receptors to interleukin-20 |
NZ520392A (en) | 2000-02-10 | 2005-04-29 | Abbott Lab | Antibodies that bind human interleukin-18 and methods of making and using |
US20020025317A1 (en) * | 2000-07-20 | 2002-02-28 | Schering Ag | Bispecific monoclonal antibodies to IL-12 and IL-18 |
US20020052475A1 (en) * | 2000-07-20 | 2002-05-02 | Schering Ag | High affinity soluble interleukin-18 receptor |
DE60123998T2 (de) | 2000-08-08 | 2007-09-06 | Zymogenetics, Inc., Seattle | Lösliche zcyctor 11 cytokinrezeptoren |
ATE460429T1 (de) | 2000-09-15 | 2010-03-15 | Zymogenetics Inc | Polypeptide enthaltend extrazellulären domäne von il-20ra und/oderr il-20rb |
WO2002031115A2 (en) * | 2000-10-11 | 2002-04-18 | Viron Therapeutics, Inc. | Nucleic acid molecules and polypeptides for immune modulation |
US7718368B2 (en) * | 2000-12-04 | 2010-05-18 | Viron Therapeutics Inc. | Immunomodulatory protein and useful embodiments thereof |
GB2375604A (en) * | 2001-05-18 | 2002-11-20 | Warner Lambert Co | Methods for screening using interleukin soluble trimolecular complex |
SG2011076551A (en) | 2001-06-26 | 2015-08-28 | Amgen Inc | Antibodies to opgl |
EP1293566A1 (de) * | 2001-09-17 | 2003-03-19 | Societe Des Produits Nestle S.A. | Ein löslicher Toll-ähnlicher Rezeptor |
EP1531843B1 (de) | 2001-12-17 | 2011-08-24 | ZymoGenetics, Inc. | Verfahren zur behandlung von gebärmutterhalskrebs |
EP1545578A4 (de) | 2002-08-28 | 2010-07-07 | Immunex Corp | Zusammensetzungen und verfahren zur behandlung von herz-kreislauf-erkrankungen |
CN1909926A (zh) | 2002-10-08 | 2007-02-07 | 阿雷斯贸易股份有限公司 | 能够结合il-18bp和抑制第二细胞因子活性的细胞因子的用途 |
KR20110091598A (ko) | 2003-03-24 | 2011-08-11 | 지모제넥틱스, 인코포레이티드 | 항-il-22ra 항체 및 결합 파트너 및 염증에 있어서의 사용 방법 |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
JP4991307B2 (ja) | 2003-11-21 | 2012-08-01 | ザイモジェネティクス, インコーポレイテッド | 抗il−20抗体および結合パートナーならびに炎症において用いる方法 |
US7141382B1 (en) | 2004-10-12 | 2006-11-28 | Parikh Chirag R | Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality |
UA96122C2 (ru) | 2004-10-22 | 2011-10-10 | Займодженетикс, Инк | Антитело или его антигенсвязующий фрагмент, которое специфически связывается с il-22ra, и его применение |
CA2597584A1 (en) * | 2005-02-15 | 2006-08-24 | Apollo Life Sciences Limited | Molecules and chimeric molecules thereof |
JP2009527535A (ja) * | 2006-02-22 | 2009-07-30 | ユニバーシティ オブ チューリッヒ | 自己免疫疾患又は脱髄疾患を処置するための可溶性受容体及び方法 |
US7932055B2 (en) | 2006-06-22 | 2011-04-26 | Novo Nordisk A/S | Soluble heterodimeric CD94/NKG2 receptors fusion proteins |
BRPI0811857A2 (pt) * | 2007-05-14 | 2014-10-21 | Biogen Idec Inc | Regiões fc (scfc) de cadeia simples, polipeptídeos de aglutinação que as compreendem e métodos relacionados. |
CL2008002153A1 (es) | 2007-07-24 | 2009-06-05 | Amgen Inc | Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r. |
BR112012021576A2 (pt) | 2010-02-26 | 2016-10-25 | Novo Nordisk As | composições estáveis contendo anticorpo. |
WO2011147921A1 (en) | 2010-05-28 | 2011-12-01 | Novo Nordisk A/S | Stable multi-dose compositions comprising an antibody and a preservative |
AU2011274423B2 (en) * | 2010-07-09 | 2016-02-11 | Bioverativ Therapeutics Inc. | Chimeric clotting factors |
KR101603001B1 (ko) | 2010-08-25 | 2016-03-11 | 에프. 호프만-라 로슈 아게 | Il-18r1에 대한 항체 및 그의 용도 |
JOP20200308A1 (ar) | 2012-09-07 | 2017-06-16 | Novartis Ag | جزيئات إرتباط il-18 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989004838A1 (en) | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
EP0533006A1 (de) * | 1991-09-18 | 1993-03-24 | F.Hoffmann-La Roche & Co. Aktiengesellschaft | Chimäre Interleukin 5-Rezeptor/Immunoglobulin-Polypeptide |
US5470952A (en) | 1993-10-20 | 1995-11-28 | Regeneron Pharmaceuticals, Inc. | CNTF and IL-6 antagonists |
WO1996013593A2 (en) * | 1994-10-26 | 1996-05-09 | Procept, Inc. | Soluble single chain t cell receptors |
US5853721A (en) | 1995-01-31 | 1998-12-29 | Hoffmann-La Roche Inc. | Antibody to interleukin-12 receptor |
EP0759466B1 (de) * | 1995-08-01 | 2005-12-28 | F. Hoffmann-La Roche Ag | Interleukin-12-beta-Rezeptoren mit niedriger Bindungsaffinität |
US5776731A (en) | 1996-02-21 | 1998-07-07 | Immunex Corporation | DNA encoding type-I interleukin-I receptor-like protein designated 2F1 |
US7141393B2 (en) | 1996-12-26 | 2006-11-28 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18-receptor proteins |
US6087116A (en) | 1997-03-12 | 2000-07-11 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18 (IL-18) receptor polypeptides and their uses |
US6326472B1 (en) | 1997-10-15 | 2001-12-04 | Schering Corporation | Human receptor proteins; related reagents and methods |
US6280955B1 (en) * | 1997-12-16 | 2001-08-28 | Tularik Inc. | Interleukin-1 receptor accessory proteins, nucleic acids and methods |
US6472179B2 (en) | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
US20020052475A1 (en) | 2000-07-20 | 2002-05-02 | Schering Ag | High affinity soluble interleukin-18 receptor |
-
1999
- 1999-01-22 CA CA2318482A patent/CA2318482C/en not_active Expired - Fee Related
- 1999-01-22 WO PCT/US1999/001419 patent/WO1999037772A1/en active IP Right Grant
- 1999-01-22 DK DK99904222T patent/DK1047781T3/da active
- 1999-01-22 EP EP99904222A patent/EP1047781B1/de not_active Expired - Lifetime
- 1999-01-22 PT PT99904222T patent/PT1047781E/pt unknown
- 1999-01-22 DE DE69918946T patent/DE69918946T2/de not_active Expired - Lifetime
- 1999-01-22 AT AT99904222T patent/ATE272114T1/de active
- 1999-01-22 AU AU24668/99A patent/AU737592B2/en not_active Ceased
- 1999-01-22 JP JP2000528679A patent/JP4271850B2/ja not_active Expired - Fee Related
- 1999-01-22 ES ES99904222T patent/ES2226335T3/es not_active Expired - Lifetime
- 1999-01-22 NZ NZ505880A patent/NZ505880A/xx not_active IP Right Cessation
- 1999-01-22 IL IL13717899A patent/IL137178A0/xx active IP Right Grant
-
2000
- 2000-07-05 IL IL137178A patent/IL137178A/en not_active IP Right Cessation
- 2000-07-21 US US09/621,502 patent/US6589764B1/en not_active Expired - Fee Related
-
2003
- 2003-05-15 US US10/439,458 patent/US7169581B2/en not_active Expired - Fee Related
-
2007
- 2007-01-29 US US11/699,676 patent/US7704945B2/en not_active Expired - Fee Related
-
2010
- 2010-03-03 US US12/716,993 patent/US8053233B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NZ505880A (en) | 2003-06-30 |
DE69918946D1 (de) | 2004-09-02 |
CA2318482C (en) | 2010-04-13 |
EP1047781B1 (de) | 2004-07-28 |
US20070135625A1 (en) | 2007-06-14 |
AU737592B2 (en) | 2001-08-23 |
US20030199040A1 (en) | 2003-10-23 |
EP1047781A1 (de) | 2000-11-02 |
DE69918946T2 (de) | 2005-07-28 |
IL137178A0 (en) | 2001-07-24 |
JP2002500886A (ja) | 2002-01-15 |
US8053233B2 (en) | 2011-11-08 |
DK1047781T3 (da) | 2004-12-06 |
US7704945B2 (en) | 2010-04-27 |
US6589764B1 (en) | 2003-07-08 |
AU2466899A (en) | 1999-08-09 |
US20100190211A1 (en) | 2010-07-29 |
ES2226335T3 (es) | 2005-03-16 |
CA2318482A1 (en) | 1999-07-29 |
IL137178A (en) | 2007-06-17 |
US7169581B2 (en) | 2007-01-30 |
JP4271850B2 (ja) | 2009-06-03 |
WO1999037772A1 (en) | 1999-07-29 |
PT1047781E (pt) | 2004-11-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
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