DE69837606D1 - Cystein-reiche rezeptoren-train - Google Patents

Cystein-reiche rezeptoren-train

Info

Publication number
DE69837606D1
DE69837606D1 DE69837606T DE69837606T DE69837606D1 DE 69837606 D1 DE69837606 D1 DE 69837606D1 DE 69837606 T DE69837606 T DE 69837606T DE 69837606 T DE69837606 T DE 69837606T DE 69837606 D1 DE69837606 D1 DE 69837606D1
Authority
DE
Germany
Prior art keywords
train
cystein rich
receptors
rich receptors
cystein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69837606T
Other languages
English (en)
Other versions
DE69837606T2 (de
Inventor
Jurg Tschopp
Catherine Hession
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotech R & D SA
Biogen Inc
Biogen MA Inc
Original Assignee
Apotech R & D SA
Biogen Idec Inc
Biogen Idec MA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotech R & D SA, Biogen Idec Inc, Biogen Idec MA Inc filed Critical Apotech R & D SA
Publication of DE69837606D1 publication Critical patent/DE69837606D1/de
Application granted granted Critical
Publication of DE69837606T2 publication Critical patent/DE69837606T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE69837606T 1997-09-12 1998-09-11 Cystein-reiche rezeptoren-train Expired - Lifetime DE69837606T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5863197P 1997-09-12 1997-09-12
US58631P 1997-09-12
US8442298P 1998-05-06 1998-05-06
US84422P 1998-05-06
PCT/US1998/019030 WO1999013078A1 (en) 1997-09-12 1998-09-11 Cysteine rich receptors-train

Publications (2)

Publication Number Publication Date
DE69837606D1 true DE69837606D1 (de) 2007-05-31
DE69837606T2 DE69837606T2 (de) 2008-02-14

Family

ID=26737837

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69837606T Expired - Lifetime DE69837606T2 (de) 1997-09-12 1998-09-11 Cystein-reiche rezeptoren-train

Country Status (10)

Country Link
US (4) US7223852B2 (de)
EP (2) EP1012282B1 (de)
JP (1) JP4357738B2 (de)
AT (1) ATE360032T1 (de)
AU (2) AU9386398A (de)
CA (1) CA2301173C (de)
DE (1) DE69837606T2 (de)
ES (1) ES2286856T3 (de)
HK (1) HK1028417A1 (de)
WO (2) WO1999013078A1 (de)

Families Citing this family (34)

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US7528239B1 (en) 1997-02-13 2009-05-05 Immunex Corporation Receptor that binds trail
US6072047A (en) 1997-02-13 2000-06-06 Immunex Corporation Receptor that binds trail
PT990703E (pt) * 1997-02-27 2008-08-27 Ono Pharmaceutical Co Novo polipéptido, o adn que codifica o mesmo e a sua utilização
US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
WO1999013078A1 (en) 1997-09-12 1999-03-18 Biogen, Inc. Cysteine rich receptors-train
JP2002508934A (ja) * 1997-12-29 2002-03-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｔｎｆレセプターに対して相同性を有する、新規な核酸およびポリペプチド
JP2002528046A (ja) * 1998-01-27 2002-09-03 ミレニアム・フアーマシユーチカルズ・インコーポレーテツド 新規レセプタースーパーファミリー分子およびそれについての用途
EP1710299A3 (de) * 1998-12-30 2007-01-10 Millennium Pharmaceuticals, Inc. Sekretierte Proteine und dafür kodierende Polynukleotide
AU2574200A (en) * 1999-02-19 2000-09-04 Toshio Kitamura Novel tnf receptor-like proteins
EP1210425B2 (de) 1999-08-17 2015-06-17 Biogen MA Inc. Baff rezeptor (bcma), ein immunoregulatorisches mittel
JP2003507064A (ja) * 1999-08-25 2003-02-25 ゲノム セラピューティックス コーポレーション 膜結合タンパク質単離用膜貫通トラップ
WO2001030850A1 (en) 1999-10-22 2001-05-03 Zymogenetics, Inc. Umlr polypeptides
GB9927681D0 (en) * 1999-11-23 2000-01-19 Glaxo Group Ltd Protein
WO2001058954A2 (en) * 2000-02-11 2001-08-16 Genetics Institute, Llc. Trade molecules and uses related thereto
US6900185B1 (en) 2000-04-12 2005-05-31 University Of Iowa Research Foundation Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer
US7476383B2 (en) 2000-05-02 2009-01-13 The Uab Research Foundation Antibody selective for DR4 and uses thereof
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
US7279160B2 (en) 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
AU2001297702A1 (en) * 2000-11-08 2002-10-15 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
AU2002309647C1 (en) 2001-05-25 2008-09-11 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
CA2560742A1 (en) 2004-03-23 2005-10-06 Biogen Idec Ma Inc. Receptor coupling agents and therapeutic uses thereof
JP5060293B2 (ja) 2004-08-03 2012-10-31 バイオジェン・アイデック・エムエイ・インコーポレイテッド 神経機能におけるｔａｊ
US8129124B2 (en) 2005-02-02 2012-03-06 The Uab Research Foundation Agents and methods related to reducing resistance to apoptosis-inducing death receptor agonists
JP4898126B2 (ja) * 2005-02-28 2012-03-14 中外製薬株式会社 Ｔｒｏｙシグナルが阻害されたトランスジェニック非ヒト動物
PE20071101A1 (es) 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
US7888044B2 (en) 2006-04-10 2011-02-15 Trustees Of Boston University Melanoma biomarker and methods of uses
US9527915B2 (en) 2009-11-05 2016-12-27 The Uab Research Foundation Treating basal-like genotype cancers
US8703712B2 (en) 2010-03-18 2014-04-22 The Uab Research Foundation Targeting cancer stem cells with DR5 agonists
ES2675847T3 (es) 2010-10-29 2018-07-13 Daiichi Sankyo Company, Limited Nuevo anticuerpo anti-DR5
JP6141827B2 (ja) 2011-04-15 2017-06-07 デックスコム・インコーポレーテッド 検体を測定するシステムの作動方法及び該方法を実施するべく構成されたセンサシステム
US9700253B2 (en) 2012-03-16 2017-07-11 Dexcom, Inc. Systems and methods for processing analyte sensor data
US20190120785A1 (en) 2017-10-24 2019-04-25 Dexcom, Inc. Pre-connected analyte sensors
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
US5965388A (en) 1996-07-09 1999-10-12 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO2002000690A2 (en) 2000-06-23 2002-01-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
WO1998030693A2 (en) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. Tumor necrosis factor receptor 5
US6072047A (en) * 1997-02-13 2000-06-06 Immunex Corporation Receptor that binds trail
PT990703E (pt) * 1997-02-27 2008-08-27 Ono Pharmaceutical Co Novo polipéptido, o adn que codifica o mesmo e a sua utilização
ES2281126T3 (es) * 1997-03-17 2007-09-16 Human Genome Sciences, Inc. Receptor 5 que contiene un dominio de muerte.
WO1999011791A2 (en) 1997-09-05 1999-03-11 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
WO1999013078A1 (en) * 1997-09-12 1999-03-18 Biogen, Inc. Cysteine rich receptors-train
US20030027272A1 (en) * 1997-09-18 2003-02-06 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2001520033A (ja) 1997-10-18 2001-10-30 ジェネティックス・インスチチュート・インコーポレーテッド 分泌蛋白およびそれらをコードするポリヌクレオチド
JP2002508934A (ja) 1997-12-29 2002-03-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｔｎｆレセプターに対して相同性を有する、新規な核酸およびポリペプチド
WO1999033980A2 (en) 1997-12-30 1999-07-08 Chiron Corporation Members of tnf and tnfr families
JP2002528046A (ja) 1998-01-27 2002-09-03 ミレニアム・フアーマシユーチカルズ・インコーポレーテツド 新規レセプタースーパーファミリー分子およびそれについての用途
EP1093516A2 (de) 1998-07-06 2001-04-25 Schering Corporation Säugergenen; dendritische zellen prostaglandin- förmigen transporterprotein (dc-pgt), hdtea84, hsljd37r und rankl, hcc5 chemokine, deubiquitine 11 und 12 (dub11, dub12), md-1, md2 und cyclin e2, zugehörige reagenzien und verfahren
JP2000098232A (ja) * 1998-09-25 2000-04-07 Canon Inc 光学素子及びそれを用いた光学系
AU2574200A (en) 1999-02-19 2000-09-04 Toshio Kitamura Novel tnf receptor-like proteins
JP2004516227A (ja) 1999-03-08 2004-06-03 ジェネンテック・インコーポレーテッド 免疫関連疾患を治療するための組成物と方法
GB9927681D0 (en) 1999-11-23 2000-01-19 Glaxo Group Ltd Protein
WO2001058954A2 (en) 2000-02-11 2001-08-16 Genetics Institute, Llc. Trade molecules and uses related thereto
AU6802801A (en) 2000-03-01 2001-09-24 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU6531101A (en) 2000-06-02 2001-12-17 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1354040A2 (de) 2000-07-20 2003-10-22 Genentech, Inc. Ausgeschiedene und transmembran-polypeptide und nukleinsäuren, welche für diese kodieren
CA2416538A1 (en) 2000-07-20 2002-01-31 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
AU2002328173A1 (en) 2001-08-07 2003-02-24 Genset S.A. Omoxin agonists and antagonists for use in the treatment of metabolic disorders
US8067664B2 (en) 2003-12-16 2011-11-29 Genentech, Inc. PRO224 gene disruptions, and methods related thereto
JP5060293B2 (ja) 2004-08-03 2012-10-31 バイオジェン・アイデック・エムエイ・インコーポレイテッド 神経機能におけるｔａｊ
WO2007092777A2 (en) 2006-02-02 2007-08-16 Wyeth Cloning, characterization, and application of tnfrsf19 in neurological disorders

Also Published As

Publication number Publication date
EP1012282A1 (de) 2000-06-28
US20030219860A1 (en) 2003-11-27
WO1999013078A1 (en) 1999-03-18
US20060233792A1 (en) 2006-10-19
HK1028417A1 (en) 2001-02-16
JP4357738B2 (ja) 2009-11-04
AU738688B2 (en) 2001-09-27
JP2002505843A (ja) 2002-02-26
WO1999012963A3 (en) 1999-05-06
ATE360032T1 (de) 2007-05-15
US7402658B2 (en) 2008-07-22
US7838639B2 (en) 2010-11-23
CA2301173A1 (en) 1999-03-18
CA2301173C (en) 2015-04-14
EP1012282B1 (de) 2007-04-18
US20110158993A1 (en) 2011-06-30
US7223852B2 (en) 2007-05-29
AU9230398A (en) 1999-03-29
WO1999012963A2 (en) 1999-03-18
AU9386398A (en) 1999-03-29
DE69837606T2 (de) 2008-02-14
ES2286856T3 (es) 2007-12-01
EP1012179A2 (de) 2000-06-28
US20090004188A1 (en) 2009-01-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition