UA96122C2 - Антитело или его антигенсвязующий фрагмент, которое специфически связывается с il-22ra, и его применение - Google Patents

Антитело или его антигенсвязующий фрагмент, которое специфически связывается с il-22ra, и его применение

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Publication number
UA96122C2
UA96122C2 UAA200705409A UAA200705409A UA96122C2 UA 96122 C2 UA96122 C2 UA 96122C2 UA A200705409 A UAA200705409 A UA A200705409A UA A200705409 A UAA200705409 A UA A200705409A UA 96122 C2 UA96122 C2 UA 96122C2
Authority
UA
Ukraine
Prior art keywords
methods
antibody
antigen binding
binding fragment
antagonizing
Prior art date
Application number
UAA200705409A
Other languages
English (en)
Ukrainian (uk)
Inventor
Веньфен Сюй
Уейн Р. Киндсфогель
Джасмин А. Чандрасехер
Стейси Р. Диллон
Джойс М. Ленер
Энтони У. Сядак
Палавур В. Сивакумар
Маргарет Д. Мур
Original Assignee
Займодженетикс, Инк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Займодженетикс, Инк filed Critical Займодженетикс, Инк
Publication of UA96122C2 publication Critical patent/UA96122C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к антителу или его антигенсвязующему фрагменту, которое специфически связывается с человеческим IL-22RA и экспрессируется гибридомным клоном 280.46.3.4, депонированным в Американской коллекции культур АТСС под номером РТА-6284. Изобретение также относится к фармацевтической композиции, которая содержит очеловеченное антитело, полученное из заявленного антитела, иммуноконъюгату и способу лечения млекопитающего, пораженного воспалительным заболеванием, в котором определенную роль играет IL-22RA.
UAA200705409A 2004-10-22 2005-10-21 Антитело или его антигенсвязующий фрагмент, которое специфически связывается с il-22ra, и его применение UA96122C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62155304P 2004-10-22 2004-10-22

Publications (1)

Publication Number Publication Date
UA96122C2 true UA96122C2 (ru) 2011-10-10

Family

ID=35871017

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200705409A UA96122C2 (ru) 2004-10-22 2005-10-21 Антитело или его антигенсвязующий фрагмент, которое специфически связывается с il-22ra, и его применение

Country Status (22)

Country Link
US (5) US7537761B2 (ru)
EP (1) EP1812476B1 (ru)
JP (1) JP4898691B2 (ru)
KR (1) KR101238684B1 (ru)
CN (1) CN101198625A (ru)
AT (1) ATE474856T1 (ru)
AU (1) AU2005299809B2 (ru)
BR (1) BRPI0516975A (ru)
CA (1) CA2584157C (ru)
CY (1) CY1110843T1 (ru)
DE (1) DE602005022475D1 (ru)
DK (1) DK1812476T3 (ru)
EA (1) EA015706B1 (ru)
ES (1) ES2347672T3 (ru)
HK (1) HK1110333A1 (ru)
IL (2) IL182503A (ru)
MX (1) MX2007004770A (ru)
NO (1) NO20072602L (ru)
PT (1) PT1812476E (ru)
UA (1) UA96122C2 (ru)
WO (1) WO2006047249A1 (ru)
ZA (1) ZA200704125B (ru)

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Also Published As

Publication number Publication date
MX2007004770A (es) 2007-11-22
CA2584157C (en) 2014-10-14
HK1110333A1 (en) 2008-07-11
BRPI0516975A (pt) 2008-09-30
US8536309B2 (en) 2013-09-17
US20090220519A1 (en) 2009-09-03
CN101198625A (zh) 2008-06-11
US20130315919A1 (en) 2013-11-28
KR101238684B1 (ko) 2013-03-04
US7537761B2 (en) 2009-05-26
PT1812476E (pt) 2010-11-08
DE602005022475D1 (de) 2010-09-02
US20060141582A1 (en) 2006-06-29
ATE474856T1 (de) 2010-08-15
US8124088B2 (en) 2012-02-28
ES2347672T3 (es) 2010-11-03
WO2006047249A1 (en) 2006-05-04
US20120156210A1 (en) 2012-06-21
AU2005299809B2 (en) 2010-12-02
EP1812476B1 (en) 2010-07-21
IL182503A0 (en) 2007-09-20
DK1812476T3 (da) 2010-10-25
US7871616B2 (en) 2011-01-18
EA200700916A1 (ru) 2007-10-26
AU2005299809A2 (en) 2006-05-04
EP1812476A1 (en) 2007-08-01
JP2008517922A (ja) 2008-05-29
CY1110843T1 (el) 2015-06-10
CA2584157A1 (en) 2006-05-04
EA015706B1 (ru) 2011-10-31
IL207146A0 (en) 2010-12-30
IL207146A (en) 2012-06-28
KR20070084486A (ko) 2007-08-24
ZA200704125B (en) 2008-09-25
US20100210825A1 (en) 2010-08-19
JP4898691B2 (ja) 2012-03-21
NO20072602L (no) 2007-07-23
IL182503A (en) 2012-01-31
AU2005299809A1 (en) 2006-05-04

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