ATE260274T1 - Furanonderivate als inhibitoren von cathepsin s - Google Patents
Furanonderivate als inhibitoren von cathepsin sInfo
- Publication number
- ATE260274T1 ATE260274T1 AT00929721T AT00929721T ATE260274T1 AT E260274 T1 ATE260274 T1 AT E260274T1 AT 00929721 T AT00929721 T AT 00929721T AT 00929721 T AT00929721 T AT 00929721T AT E260274 T1 ATE260274 T1 AT E260274T1
- Authority
- AT
- Austria
- Prior art keywords
- cathepsin
- inhibitors
- furanone derivatives
- furanone
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9911417.5A GB9911417D0 (en) | 1999-05-18 | 1999-05-18 | Furanone derivatives as inhibitors of cathepsin s |
PCT/GB2000/001894 WO2000069855A2 (en) | 1999-05-18 | 2000-05-18 | Furanone derivatives as inhibitors of cathepsin s |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE260274T1 true ATE260274T1 (de) | 2004-03-15 |
Family
ID=10853598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00929721T ATE260274T1 (de) | 1999-05-18 | 2000-05-18 | Furanonderivate als inhibitoren von cathepsin s |
Country Status (16)
Country | Link |
---|---|
EP (2) | EP1413580A1 (de) |
JP (1) | JP2002544274A (de) |
AR (1) | AR024040A1 (de) |
AT (1) | ATE260274T1 (de) |
AU (1) | AU763694B2 (de) |
BR (1) | BR0010553A (de) |
CA (1) | CA2374297A1 (de) |
DE (1) | DE60008524T2 (de) |
DK (1) | DK1178986T3 (de) |
ES (1) | ES2215048T3 (de) |
GB (1) | GB9911417D0 (de) |
IL (2) | IL146409A0 (de) |
MX (1) | MXPA01011872A (de) |
MY (1) | MY130768A (de) |
PT (1) | PT1178986E (de) |
WO (1) | WO2000069855A2 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001258543A1 (en) * | 2000-05-17 | 2001-11-26 | Medivir Uk Limited | Branched amino acids |
CA2429001A1 (en) * | 2000-11-17 | 2002-11-07 | Medivir Ab | Cysteine protease inhibitors |
US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
EP1383748A2 (de) | 2000-12-22 | 2004-01-28 | Axys Pharmaceuticals, Inc. | Neue verbindungen und zusammensetzungen als cathepsin-inhibitoren |
US7425562B2 (en) * | 2001-01-17 | 2008-09-16 | Amura Therapeutics Ltd. | Inhibitors of cruzipain and other cysteine proteases |
CA2435117A1 (en) * | 2001-01-17 | 2002-07-25 | Amura Therapeutics Limited | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases |
CA2434068A1 (en) * | 2001-01-17 | 2002-07-25 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
US7132449B2 (en) | 2001-01-17 | 2006-11-07 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
JP2005504078A (ja) * | 2001-09-14 | 2005-02-10 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | カテプシン阻害剤としての新規化合物および組成物 |
JP2005508979A (ja) * | 2001-10-29 | 2005-04-07 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | システインプロテアーゼの可逆性インヒビターとして有用な化合物 |
EP1446392A1 (de) | 2001-11-14 | 2004-08-18 | Aventis Pharmaceuticals, Inc. | Oligopeptide und diese enthaltende zusammensetzungen als cathepsininhibitoren |
US7087604B2 (en) | 2002-03-08 | 2006-08-08 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
ATE424401T1 (de) * | 2002-07-16 | 2009-03-15 | Amura Therapeutics Ltd | Pyrrolderivate als hemmstoffe von cystein proteasen |
KR20080103117A (ko) | 2002-09-24 | 2008-11-26 | 노파르티스 아게 | 탈수초성 장애의 치료에 있어서의 스핑고신-1-포스페이트 수용체 아고니스트 |
US7297714B2 (en) * | 2003-10-21 | 2007-11-20 | Irm Llc | Inhibitors of cathepsin S |
WO2005082876A1 (en) * | 2004-03-01 | 2005-09-09 | Medivir Uk Ltd | C-5 substituted furanone dipeptide cathepsin s inhibitors |
WO2006064286A1 (en) * | 2004-12-13 | 2006-06-22 | Medivir Uk Ltd | Cathepsin s inhibitors |
GB0614042D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
EP1916248A1 (de) * | 2006-10-24 | 2008-04-30 | Medivir Ab | Furanonderivate als Inhibitoren der Cysteinprotease |
CA2678717A1 (en) | 2007-02-28 | 2008-09-04 | Sanofi-Aventis | Imaging probes |
JP5587790B2 (ja) | 2008-01-09 | 2014-09-10 | アミュラ セラピューティクス リミティド | 化合物 |
CN104800196A (zh) | 2008-06-20 | 2015-07-29 | 诺华股份有限公司 | 用于治疗多发性硬化的儿科组合物 |
EP3946332A1 (de) | 2019-04-05 | 2022-02-09 | Université de Bretagne Occidentale | Protease-aktivierte rezeptor-2-inhibitoren zur behandlung einer sensorischen neuropathie, die durch eine marine neurotoxische vergiftung induziert wird |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2111930A1 (en) * | 1992-12-25 | 1994-06-26 | Ryoichi Ando | Aminoketone derivatives |
AU723447B2 (en) * | 1996-04-22 | 2000-08-24 | Brigham And Women's Hospital | Suppression of immune response via inhibition of cathepsin S |
AR013079A1 (es) * | 1997-05-06 | 2000-12-13 | Smithkline Beecham Corp | Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios |
-
1999
- 1999-05-18 GB GBGB9911417.5A patent/GB9911417D0/en not_active Ceased
-
2000
- 2000-05-17 MY MYPI20002178A patent/MY130768A/en unknown
- 2000-05-18 IL IL14640988A patent/IL146409A0/xx unknown
- 2000-05-18 MX MXPA01011872A patent/MXPA01011872A/es active IP Right Grant
- 2000-05-18 EP EP20040002432 patent/EP1413580A1/de not_active Withdrawn
- 2000-05-18 PT PT00929721T patent/PT1178986E/pt unknown
- 2000-05-18 BR BR0010553-8A patent/BR0010553A/pt not_active Withdrawn
- 2000-05-18 JP JP2000618272A patent/JP2002544274A/ja active Pending
- 2000-05-18 AU AU47722/00A patent/AU763694B2/en not_active Ceased
- 2000-05-18 CA CA002374297A patent/CA2374297A1/en not_active Abandoned
- 2000-05-18 ES ES00929721T patent/ES2215048T3/es not_active Expired - Lifetime
- 2000-05-18 IL IL14640900A patent/IL146409A/xx not_active IP Right Cessation
- 2000-05-18 EP EP00929721A patent/EP1178986B1/de not_active Expired - Lifetime
- 2000-05-18 DE DE60008524T patent/DE60008524T2/de not_active Expired - Fee Related
- 2000-05-18 AT AT00929721T patent/ATE260274T1/de not_active IP Right Cessation
- 2000-05-18 DK DK00929721T patent/DK1178986T3/da active
- 2000-05-18 WO PCT/GB2000/001894 patent/WO2000069855A2/en active IP Right Grant
- 2000-05-19 AR ARP000102445A patent/AR024040A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2000069855A2 (en) | 2000-11-23 |
AR024040A1 (es) | 2002-09-04 |
ES2215048T3 (es) | 2004-10-01 |
MXPA01011872A (es) | 2003-09-04 |
IL146409A (en) | 2005-11-20 |
MY130768A (en) | 2007-07-31 |
DE60008524T2 (de) | 2004-12-23 |
IL146409A0 (en) | 2002-07-25 |
EP1413580A1 (de) | 2004-04-28 |
GB9911417D0 (en) | 1999-07-14 |
AU4772200A (en) | 2000-12-05 |
PT1178986E (pt) | 2004-07-30 |
EP1178986B1 (de) | 2004-02-25 |
EP1178986A2 (de) | 2002-02-13 |
AU763694B2 (en) | 2003-07-31 |
DE60008524D1 (de) | 2004-04-01 |
JP2002544274A (ja) | 2002-12-24 |
WO2000069855A3 (en) | 2001-02-08 |
DK1178986T3 (da) | 2004-07-05 |
CA2374297A1 (en) | 2000-11-23 |
BR0010553A (pt) | 2002-07-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1178986 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |