ATE250043T1 - Tetrazolylphenylborsäureintermediate zur synthese von aii rezeptor antagonisten - Google Patents
Tetrazolylphenylborsäureintermediate zur synthese von aii rezeptor antagonistenInfo
- Publication number
- ATE250043T1 ATE250043T1 AT93900550T AT93900550T ATE250043T1 AT E250043 T1 ATE250043 T1 AT E250043T1 AT 93900550 T AT93900550 T AT 93900550T AT 93900550 T AT93900550 T AT 93900550T AT E250043 T1 ATE250043 T1 AT E250043T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- tetrazolylphenylboric
- synthesis
- acid intermediate
- aii receptor
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 1
- -1 biphenyl tetrazole compound Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/793,514 US5130439A (en) | 1991-11-18 | 1991-11-18 | Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists |
US07/911,813 US5206374A (en) | 1991-11-18 | 1992-07-10 | Process for preparing tetrazolylphenylboronic acid intermediates |
US07/911,812 US5310928A (en) | 1991-11-18 | 1992-07-10 | Process for preparing biphenyltetrazole compounds |
PCT/US1992/009979 WO1993010106A1 (en) | 1991-11-18 | 1992-11-18 | Tetrazolylphenylboronic acid intermediates for the synthesis of aii receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE250043T1 true ATE250043T1 (de) | 2003-10-15 |
Family
ID=27419904
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03018662T ATE395341T1 (de) | 1991-11-18 | 1992-11-18 | 2-(2'-triphenylmethyl-2'h-tetrazol-5'- yl)phenylborsäure als zwischenprodukt zur synthese von a ii receptorenantagonisten |
AT93900550T ATE250043T1 (de) | 1991-11-18 | 1992-11-18 | Tetrazolylphenylborsäureintermediate zur synthese von aii rezeptor antagonisten |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03018662T ATE395341T1 (de) | 1991-11-18 | 1992-11-18 | 2-(2'-triphenylmethyl-2'h-tetrazol-5'- yl)phenylborsäure als zwischenprodukt zur synthese von a ii receptorenantagonisten |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP0643704B1 (de) |
JP (1) | JPH08500323A (de) |
KR (2) | KR100212257B1 (de) |
AT (2) | ATE395341T1 (de) |
AU (1) | AU665388B2 (de) |
CA (1) | CA2123900C (de) |
CZ (1) | CZ283954B6 (de) |
DE (2) | DE69233208T2 (de) |
DK (1) | DK0643704T3 (de) |
ES (1) | ES2203614T3 (de) |
FI (1) | FI112945B (de) |
NO (1) | NO307932B1 (de) |
SK (1) | SK280887B6 (de) |
WO (1) | WO1993010106A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4319041A1 (de) * | 1992-10-23 | 1994-04-28 | Bayer Ag | Trisubstituierte Biphenyle |
US5965738A (en) * | 1994-09-20 | 1999-10-12 | Wakunaga Seiyaku Kabushiki Kaisha | Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same |
WO1998018787A1 (en) * | 1996-10-29 | 1998-05-07 | Merck & Co., Inc. | Process for the crystallization of losartan |
IT1295405B1 (it) | 1997-09-30 | 1999-05-12 | Merck Sharp & Dohme Italia S P | Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di |
DE19916222A1 (de) | 1999-04-10 | 2000-10-19 | Aventis Res & Tech Gmbh & Co | Verfahren zur Herstellung von Biarylen |
JP4507294B2 (ja) * | 1999-05-27 | 2010-07-21 | チッソ株式会社 | ビアリール誘導体の製造方法 |
JP2001226372A (ja) | 1999-12-06 | 2001-08-21 | Sumika Fine Chemicals Co Ltd | ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法 |
HU222773B1 (hu) * | 2000-04-21 | 2003-10-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás egy ismert tetrazolszármazék előállítására |
SK722003A3 (en) * | 2001-05-18 | 2003-12-02 | Aurobindo Pharma Ltd | Process for the crystallization of losartan potassium |
SI1589966T1 (sl) * | 2003-01-30 | 2011-06-30 | Lek Pharmaceuticals D.D. | Postopek čiščenja losartana |
US7345071B2 (en) | 2003-05-07 | 2008-03-18 | Ipca Laboratories Limited | Process for the synthesis of Losartan potassium |
EP1660463B1 (de) * | 2003-08-08 | 2007-12-05 | Dipharma Francis S.r.l. | Verfahren zur herstellung von phenyltetrazolderivaten |
ITMI20032069A1 (it) * | 2003-10-23 | 2005-04-24 | Dinamite Dipharma S P A In Forma A Bbreviata Diph | Procedimento per la preparazione di derivati benzilmidazolici. |
DE102004060699A1 (de) * | 2004-12-16 | 2006-06-22 | Ratiopharm Gmbh | Verfahren zur Herstellung von Candesartan |
FR2879601B1 (fr) * | 2004-12-22 | 2007-01-19 | Galderma Res & Dev | Nouveaux composes derives d'acide phenyl-boronique et leur procede de preparation |
EP1833801B9 (de) * | 2004-12-22 | 2009-02-25 | Algry Quimica, S.L | Zwischenprodukte für die herstellung von antagonisten des angiotensin-ii-rezeptors |
US20070117987A1 (en) * | 2005-07-05 | 2007-05-24 | Viviana Braude | Process for preparing valsartan |
ES2300175B1 (es) * | 2006-02-14 | 2009-06-08 | Inke, S.A. | Procedimiento para la obtencion de intermedios utiles en la obtencion de un compuesto farmaceuticamente activo. |
CN101812029B (zh) * | 2010-04-29 | 2012-02-15 | 南通市华峰化工有限责任公司 | 5-卤代直链烷基四氮唑的生产方法 |
CN105906614A (zh) * | 2016-05-12 | 2016-08-31 | 山东罗欣药业集团股份有限公司 | 一种奥美沙坦酯的制备方法 |
WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4820843A (en) * | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
US5039814A (en) * | 1990-05-02 | 1991-08-13 | Merck & Co., Inc. | Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes |
IE914572A1 (en) * | 1991-01-17 | 1992-07-29 | Zeneca Ltd | Chemical process |
US5164403A (en) * | 1991-04-05 | 1992-11-17 | G. D. Searle & Co. | N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders |
US5155117A (en) * | 1991-04-12 | 1992-10-13 | G. D. Searle & Co. | 1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders |
US5149699A (en) * | 1991-10-24 | 1992-09-22 | American Home Products Corporation | Substituted pyridopyrimidines useful as antgiotensin II antagonists |
TW226375B (de) * | 1991-10-24 | 1994-07-11 | American Home Prod | |
FR2688507B1 (fr) * | 1992-03-16 | 1994-05-06 | Synthelabo | Derives de l'acide tetrazolylbenzeneboronique, leur preparation et leur utilisation comme intermediaires de synthese. |
FR2688505B1 (fr) * | 1992-03-16 | 1994-05-06 | Synthelabo | Nouveau procede de preparation de 4-pyrimidinones. |
US5655009A (en) * | 1992-03-19 | 1997-08-05 | Fujitsu Limited | Modem unit |
-
1992
- 1992-11-18 JP JP5509518A patent/JPH08500323A/ja not_active Expired - Lifetime
- 1992-11-18 CZ CZ941205A patent/CZ283954B6/cs not_active IP Right Cessation
- 1992-11-18 DE DE69233208T patent/DE69233208T2/de not_active Expired - Lifetime
- 1992-11-18 EP EP93900550A patent/EP0643704B1/de not_active Expired - Lifetime
- 1992-11-18 DK DK93900550T patent/DK0643704T3/da active
- 1992-11-18 ES ES93900550T patent/ES2203614T3/es not_active Expired - Lifetime
- 1992-11-18 AT AT03018662T patent/ATE395341T1/de active
- 1992-11-18 SK SK579-94A patent/SK280887B6/sk not_active IP Right Cessation
- 1992-11-18 KR KR1019940701677A patent/KR100212257B1/ko not_active IP Right Cessation
- 1992-11-18 CA CA002123900A patent/CA2123900C/en not_active Expired - Lifetime
- 1992-11-18 AU AU31792/93A patent/AU665388B2/en not_active Expired
- 1992-11-18 DE DE69233734T patent/DE69233734D1/de not_active Expired - Lifetime
- 1992-11-18 EP EP03018662A patent/EP1384717B1/de not_active Expired - Lifetime
- 1992-11-18 AT AT93900550T patent/ATE250043T1/de active
- 1992-11-18 WO PCT/US1992/009979 patent/WO1993010106A1/en active IP Right Grant
-
1994
- 1994-05-17 FI FI942282A patent/FI112945B/fi not_active IP Right Cessation
- 1994-05-18 NO NO941857A patent/NO307932B1/no not_active IP Right Cessation
-
1999
- 1999-01-25 KR KR1019997000625A patent/KR100212405B1/ko active
Also Published As
Publication number | Publication date |
---|---|
JPH08500323A (ja) | 1996-01-16 |
DE69233734D1 (de) | 2008-06-26 |
NO941857L (no) | 1994-07-18 |
CZ283954B6 (cs) | 1998-07-15 |
WO1993010106A1 (en) | 1993-05-27 |
KR100212257B1 (ko) | 1999-08-02 |
CA2123900C (en) | 1998-07-14 |
EP0643704A4 (en) | 1995-04-12 |
SK280887B6 (sk) | 2000-09-12 |
NO307932B1 (no) | 2000-06-19 |
DE69233208D1 (de) | 2003-10-23 |
FI112945B (fi) | 2004-02-13 |
FI942282A (fi) | 1994-05-17 |
FI942282A0 (fi) | 1994-05-17 |
DE69233208T2 (de) | 2004-07-08 |
NO941857D0 (no) | 1994-05-18 |
AU3179293A (en) | 1993-06-15 |
ATE395341T1 (de) | 2008-05-15 |
SK57994A3 (en) | 1995-02-08 |
CZ120594A3 (en) | 1995-02-15 |
CA2123900A1 (en) | 1993-05-27 |
EP0643704B1 (de) | 2003-09-17 |
ES2203614T3 (es) | 2004-04-16 |
EP0643704A1 (de) | 1995-03-22 |
EP1384717A3 (de) | 2004-02-04 |
EP1384717B1 (de) | 2008-05-14 |
EP1384717A2 (de) | 2004-01-28 |
KR100212405B1 (ko) | 2000-03-15 |
DK0643704T3 (da) | 2004-01-19 |
AU665388B2 (en) | 1996-01-04 |
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Legal Events
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UEP | Publication of translation of european patent specification |
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