ATE247630T1 - Verfahren zur herstellung von n,n'-bis,2,3- dihydroxypropyl)-5-((hydroxyacetyl)methylamino) 2,4,6-triiodo-1,3-benzenedicarboxamide - Google Patents

Verfahren zur herstellung von n,n'-bis,2,3- dihydroxypropyl)-5-((hydroxyacetyl)methylamino) 2,4,6-triiodo-1,3-benzenedicarboxamide

Info

Publication number: ATE247630T1
Authority: AT; Austria
Prior art keywords: triiodo; hydroxyacetyl; dihydroxypropyl; methylamino; bis
Prior art date: 1998-11-27

Application number

AT99973018T

Other languages

English (en)

Inventor

Laura Alessandroni

Patrizia Ambrosetti

Maria Argese

Renato Geremia

Enrico Moretti

Vittorio Valle

Giorgio Ripa

Marcella Murru

Original Assignee

Bracco Int Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-27

Filing date

1999-11-25

Publication date

2003-09-15

1999-11-25 Application filed by Bracco Int Bv filed Critical Bracco Int Bv

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE247630T1 publication Critical patent/ATE247630T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Polyamides (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT99973018T 1998-11-27 1999-11-25 Verfahren zur herstellung von n,n'-bis,2,3- dihydroxypropyl)-5-((hydroxyacetyl)methylamino) 2,4,6-triiodo-1,3-benzenedicarboxamide ATE247630T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1998MI002574A IT1303797B1 (it)	1998-11-27	1998-11-27	Processo per la preparazione di n,n'-bis(2,3-diidrossipropil)-5-((idrossiacetil)metilammino)-2,4,6-triiodo-1,3-benzendicarbossammide.
PCT/EP1999/009118 WO2000032561A1 (en)	1998-11-27	1999-11-25	A process for the preparation of n,n'-bis[2, 3-dihydroxypropyl] -5-[ (hydroxyacetyl) methylamino]-2, 4,6-triiodo-1, 3-benzenedi carboxamide

Publications (1)

Publication Number	Publication Date
ATE247630T1 true ATE247630T1 (de)	2003-09-15

Family

ID=11381150

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99973018T ATE247630T1 (de)	1998-11-27	1999-11-25	Verfahren zur herstellung von n,n'-bis,2,3- dihydroxypropyl)-5-((hydroxyacetyl)methylamino) 2,4,6-triiodo-1,3-benzenedicarboxamide

Country Status (24)

Country	Link
US (1)	US6420603B1 (de)
EP (1)	EP1133466B1 (de)
JP (1)	JP4439123B2 (de)
KR (1)	KR100630400B1 (de)
CN (1)	CN1163474C (de)
AT (1)	ATE247630T1 (de)
AU (1)	AU753601B2 (de)
BR (1)	BR9915608B1 (de)
CA (1)	CA2351717C (de)
CZ (1)	CZ296096B6 (de)
DE (1)	DE69910609T2 (de)
EA (1)	EA003253B1 (de)
ES (1)	ES2205949T3 (de)
HK (1)	HK1040988B (de)
HR (1)	HRP20010393B1 (de)
HU (1)	HU229092B1 (de)
IL (1)	IL143150A0 (de)
IT (1)	IT1303797B1 (de)
ME (2)	MEP8809A (de)
NO (1)	NO327037B1 (de)
RS (1)	RS50038B (de)
SK (1)	SK285050B6 (de)
TR (1)	TR200101439T2 (de)
WO (1)	WO2000032561A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2093206A1 (de) *	2008-02-20	2009-08-26	BRACCO IMAGING S.p.A.	Verfahren zur Iodierung aromatischer Verbindungen
EP2243767A1 (de)	2009-04-21	2010-10-27	Bracco Imaging S.p.A	Verfahren zur Iodierung aromatischer Verbindungen
ES2443149T3 (es)	2009-07-07	2014-02-18	Bracco Imaging Spa	Proceso para la preparación de un agente de yodación
EP2277846A1 (de) *	2009-07-21	2011-01-26	GE Healthcare AS	Erhalt freien Iods bei der Herstellung von wässrigem Iodchlorid durch Zugabe von Iodid
EP2394984A1 (de)	2010-06-10	2011-12-14	Bracco Imaging S.p.A	Verfahren zur Iodinierung von Phenol-Derivaten
IT1403988B1 (it) *	2010-07-15	2013-11-08	Bracco Imaging Spa	Processo per la preparazione di agenti di contrasto.
WO2012136813A2 (en)	2011-04-07	2012-10-11	Universitetet I Oslo	Agents for medical radar diagnosis
KR101833334B1 (ko) *	2016-04-29	2018-02-28	(주)유케이케미팜	신규 중간체 화합물 및 이를 이용한 이오메프롤의 제조방법
KR102128423B1 (ko)	2018-09-17	2020-07-01	(주)유케이케미팜	조영제 이오메프롤의 제조방법
WO2023046815A1 (en)	2021-09-24	2023-03-30	Bracco Imaging Spa	Electrochemical iodination of n,n'-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide
WO2023209165A1 (en)	2022-04-29	2023-11-02	Bracco Imaging Spa	Process for the preparation of 2,4,6-triiodophenol derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1196363B (it) *	1984-12-10	1988-11-16	Bracco Ind Chimica Spa	Derivati dell'acido 5-alcossi-2,4,6-triiodo- o -tribromo-isoftalico,metodo per la loro preparazione e relativi mezzi di contrasto radiologici
CA1327600C (en)	1987-05-22	1994-03-08	Ernest Felder	Process for the preparation of 5-acylamino-2,4,6- triiodo-or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process

1998
- 1998-11-27 IT IT1998MI002574A patent/IT1303797B1/it active
1999
- 1999-11-25 RS YUP-371/01A patent/RS50038B/sr unknown
- 1999-11-25 BR BRPI9915608-3A patent/BR9915608B1/pt not_active IP Right Cessation
- 1999-11-25 EP EP99973018A patent/EP1133466B1/de not_active Expired - Lifetime
- 1999-11-25 SK SK705-2001A patent/SK285050B6/sk not_active IP Right Cessation
- 1999-11-25 HU HU0104507A patent/HU229092B1/hu unknown
- 1999-11-25 KR KR1020017006458A patent/KR100630400B1/ko active IP Right Grant
- 1999-11-25 IL IL14315099A patent/IL143150A0/xx not_active IP Right Cessation
- 1999-11-25 ME MEP-88/09A patent/MEP8809A/xx unknown
- 1999-11-25 DE DE69910609T patent/DE69910609T2/de not_active Expired - Lifetime
- 1999-11-25 CZ CZ20011833A patent/CZ296096B6/cs not_active IP Right Cessation
- 1999-11-25 ES ES99973018T patent/ES2205949T3/es not_active Expired - Lifetime
- 1999-11-25 EA EA200100462A patent/EA003253B1/ru not_active IP Right Cessation
- 1999-11-25 ME MEP-2009-88A patent/ME00606B/me unknown
- 1999-11-25 TR TR2001/01439T patent/TR200101439T2/xx unknown
- 1999-11-25 US US09/856,554 patent/US6420603B1/en not_active Expired - Lifetime
- 1999-11-25 WO PCT/EP1999/009118 patent/WO2000032561A1/en active IP Right Grant
- 1999-11-25 AT AT99973018T patent/ATE247630T1/de active
- 1999-11-25 AU AU13862/00A patent/AU753601B2/en not_active Expired
- 1999-11-25 CA CA2351717A patent/CA2351717C/en not_active Expired - Lifetime
- 1999-11-25 JP JP2000585203A patent/JP4439123B2/ja not_active Expired - Lifetime
- 1999-11-25 CN CNB998136514A patent/CN1163474C/zh not_active Expired - Lifetime
2001
- 2001-05-23 HR HR20010393A patent/HRP20010393B1/xx not_active IP Right Cessation
- 2001-05-23 NO NO20012547A patent/NO327037B1/no not_active IP Right Cessation
2002
- 2002-04-12 HK HK02102762.0A patent/HK1040988B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO327037B1 (no)	2009-04-06
NO20012547D0 (no)	2001-05-23
IT1303797B1 (it)	2001-02-23
HUP0104507A2 (hu)	2002-04-29
IL143150A0 (en)	2002-04-21
SK285050B6 (sk)	2006-05-04
KR100630400B1 (ko)	2006-10-02
AU1386200A (en)	2000-06-19
HK1040988A1 (en)	2002-06-28
ES2205949T3 (es)	2004-05-01
HRP20010393B1 (en)	2004-04-30
US6420603B1 (en)	2002-07-16
EP1133466A1 (de)	2001-09-19
NO20012547L (no)	2001-07-25
DE69910609T2 (de)	2004-03-18
HU229092B1 (en)	2013-07-29
MEP8809A (en)	2011-12-20
HUP0104507A3 (en)	2004-07-28
WO2000032561A1 (en)	2000-06-08
KR20010101053A (ko)	2001-11-14
EA003253B1 (ru)	2003-02-27
JP4439123B2 (ja)	2010-03-24
EA200100462A1 (ru)	2001-12-24
TR200101439T2 (tr)	2001-10-22
SK7052001A3 (en)	2001-12-03
YU37101A (sh)	2003-04-30
RS50038B (sr)	2008-11-28
AU753601B2 (en)	2002-10-24
BR9915608B1 (pt)	2010-11-16
HRP20010393A2 (en)	2002-06-30
CN1163474C (zh)	2004-08-25
CZ296096B6 (cs)	2006-01-11
JP2002531432A (ja)	2002-09-24
DE69910609D1 (de)	2003-09-25
CN1328539A (zh)	2001-12-26
CA2351717C (en)	2010-10-05
ITMI982574A1 (it)	2000-05-27
BR9915608A (pt)	2001-08-14
EP1133466B1 (de)	2003-08-20
HK1040988B (zh)	2005-04-29
CZ20011833A3 (cs)	2001-10-17
CA2351717A1 (en)	2000-06-08
ME00606B (me)	2011-12-20

Legal Events

Date

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Title

Description

2004-03-15

UEP

Publication of translation of european patent specification

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Publication	Publication Date	Title
ATE247630T1 (de)	2003-09-15	Verfahren zur herstellung von n,n'-bis,2,3- dihydroxypropyl)-5-((hydroxyacetyl)methylamino) 2,4,6-triiodo-1,3-benzenedicarboxamide
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DE69919382D1 (de)	2004-09-16	Herstellung von 5-amino-isophthalamiden
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DE50205026D1 (de)	2005-12-29	Verfahren zur herstellung von n-substituierten 2,6-dialkylmorpholinen
SI1133466T1 (en)	2003-12-31	A process for the preparation of n,n'-bis 2, 3-dihydroxypropyl) -5-((hydroxyacetyl) methylamino)-2, 4,6-triiodo-1, 3-benzenedi carboxamide