ATE246808T1 - Peptide, die den transport über gewebe erhöhen und verfahren zu ihrer identifizierung und verwendung - Google Patents

Peptide, die den transport über gewebe erhöhen und verfahren zu ihrer identifizierung und verwendung

Info

Publication number
ATE246808T1
ATE246808T1 AT96938439T AT96938439T ATE246808T1 AT E246808 T1 ATE246808 T1 AT E246808T1 AT 96938439 T AT96938439 T AT 96938439T AT 96938439 T AT96938439 T AT 96938439T AT E246808 T1 ATE246808 T1 AT E246808T1
Authority
AT
Austria
Prior art keywords
phage
transported
site
peptide
transport
Prior art date
Application number
AT96938439T
Other languages
English (en)
Inventor
Daniel Joseph O'mahony
Original Assignee
Elan Corp Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IE950864A external-priority patent/IE80466B1/en
Application filed by Elan Corp Plc filed Critical Elan Corp Plc
Application granted granted Critical
Publication of ATE246808T1 publication Critical patent/ATE246808T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT96938439T 1995-11-10 1996-11-11 Peptide, die den transport über gewebe erhöhen und verfahren zu ihrer identifizierung und verwendung ATE246808T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IE950864A IE80466B1 (en) 1995-11-10 1995-11-10 Peptides which enhance transport across tissues and methods of identifying and using the same
US646195P 1995-11-13 1995-11-13
PCT/IE1996/000072 WO1997017613A1 (en) 1995-11-10 1996-11-11 Peptides which enhance transport across tissues and methods of identifying and using the same

Publications (1)

Publication Number Publication Date
ATE246808T1 true ATE246808T1 (de) 2003-08-15

Family

ID=26319862

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96938439T ATE246808T1 (de) 1995-11-10 1996-11-11 Peptide, die den transport über gewebe erhöhen und verfahren zu ihrer identifizierung und verwendung

Country Status (11)

Country Link
EP (3) EP0859959B1 (de)
JP (3) JP3830525B2 (de)
AT (1) ATE246808T1 (de)
AU (2) AU705816B2 (de)
CA (2) CA2234685A1 (de)
DE (1) DE69629385T2 (de)
DK (1) DK0859959T3 (de)
ES (1) ES2203722T3 (de)
NZ (2) NZ322174A (de)
PT (1) PT859959E (de)
WO (2) WO1997017614A1 (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9700291D0 (sv) * 1997-01-31 1997-01-31 Pharmacia & Upjohn Ab Selection method and prodcts resulting therefrom
JP4129298B2 (ja) * 1997-05-15 2008-08-06 サイトジェン コーポレーション 胃腸管（ｇｉｔ）輸送受容体に結合するランダムペプチド、及び関連した方法
US6787523B1 (en) 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US6750324B1 (en) 1997-12-02 2004-06-15 Neuralab Limited Humanized and chimeric N-terminal amyloid beta-antibodies
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6743427B1 (en) 1997-12-02 2004-06-01 Neuralab Limited Prevention and treatment of amyloidogenic disease
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US20030147882A1 (en) 1998-05-21 2003-08-07 Alan Solomon Methods for amyloid removal using anti-amyloid antibodies
US7087236B1 (en) 1998-09-01 2006-08-08 Merrion Research I Limited Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
EP1109897A1 (de) * 1998-09-07 2001-06-27 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verfahren zur selektion von peptiden für zielgerichteten pharma- und markertransport und peptide damit entdeckt
DE69926531T2 (de) * 1998-11-19 2006-03-30 Elan Corp. Plc Gegen gastrointestinale transport rezeptoren gerichtete retro-invertierte peptide und deren verwendung
JP2002535246A (ja) * 1998-11-19 2002-10-22 エラン コーポレーシヨン ピーエルシー Ｇｉｔレセプターを標的とするペプチドに対する抗体および関連する方法
US6787637B1 (en) 1999-05-28 2004-09-07 Neuralab Limited N-Terminal amyloid-β antibodies
UA81216C2 (en) 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
EP1212619B1 (de) * 1999-09-14 2007-05-23 Xenoport, Inc. Substrate und screeningverfahren für transportproteine
CA2392477A1 (en) 1999-11-30 2001-06-07 Mayo Foundation For Medical Education And Research B7-h1, a novel immunoregulatory molecule
JP2003516745A (ja) * 1999-12-13 2003-05-20 ケンブリッジ アンティボディー テクノロジー リミティド 脳特定結合性メンバー
US7030219B2 (en) 2000-04-28 2006-04-18 Johns Hopkins University B7-DC, Dendritic cell co-stimulatory molecules
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
AU2002326070A1 (en) * 2001-07-02 2003-01-21 Elan Corporation, Plc Peyers's patch and/or m-celle targeting ligands
EP2289941A3 (de) 2002-02-25 2012-01-18 Elan Pharmaceuticals Inc. Verabreichung von Wirkstoffen zur Behandlung von Entzündungen
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
WO2010011999A2 (en) 2008-07-25 2010-01-28 The Regents Of The University Of California Methods and compositions for eliciting an amyloid-selective immune response
US7432351B1 (en) 2002-10-04 2008-10-07 Mayo Foundation For Medical Education And Research B7-H1 variants
US8506959B2 (en) 2002-11-01 2013-08-13 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
WO2008103472A2 (en) 2007-02-23 2008-08-28 Elan Pharmaceuticals, Inc. Prevention and treatment of synucleinopathic and amyloidogenic disease
TW200509968A (en) 2002-11-01 2005-03-16 Elan Pharm Inc Prevention and treatment of synucleinopathic disease
PE20050627A1 (es) 2003-05-30 2005-08-10 Wyeth Corp Anticuerpos humanizados que reconocen el peptido beta amiloideo
US20070134762A1 (en) 2003-12-17 2007-06-14 Arumugham Rasappa G Immunogenic peptide carrier conjugates and methods of producing same
TWI357414B (en) 2003-12-17 2012-02-01 Wyeth Llc Aβ immunogenic peptide carrier conjugates and meth
EA013752B1 (ru) 2004-08-09 2010-06-30 Элан Фармасьютикалз, Инк. Предупреждение и лечение синуклеинопатических и амилоидогенных заболеваний
AU2005295038B2 (en) 2004-10-06 2012-05-17 Mayo Foundation For Medical Education And Research B7-H1 and methods of diagnosis, prognosis, and treatment of cancer
US8916165B2 (en) 2004-12-15 2014-12-23 Janssen Alzheimer Immunotherapy Humanized Aβ antibodies for use in improving cognition
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
EP2035448A4 (de) 2006-06-01 2010-11-03 Elan Pharm Inc Neuroaktive fragmente von app
KR100866925B1 (ko) 2006-08-28 2008-11-04 주식회사 인실리코텍 경구 파지 디스플레이 방법으로 동정된 소장 상피세포흡수촉진 유도 펩타이드 및 이를 이용한 경구투약 시스템
WO2008083169A2 (en) 2006-12-26 2008-07-10 The Johns Hopkins University Compositions and methods for the treatment of immunologic disorders
US7989173B2 (en) 2006-12-27 2011-08-02 The Johns Hopkins University Detection and diagnosis of inflammatory disorders
JP2011502954A (ja) 2006-12-27 2011-01-27 ザ ジョンズ ホプキンス ユニバーシティー 免疫応答を刺激する組成物および方法
WO2008084899A1 (en) * 2007-01-10 2008-07-17 Insilicotech Co., Ltd. The enterocyte-transcytotic, tissue target and m cell target peptide identified by the phage display process and drug delivery systems using the same
EP3067066B1 (de) 2007-02-23 2019-03-27 Prothena Biosciences Limited Verhinderung und behandlung synukleinopathischer und amyloidogener krankheiten
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
PL2182983T3 (pl) 2007-07-27 2014-10-31 Janssen Alzheimer Immunotherap Leczenie chorób amyloidowych z wykorzystaniem humanizowanych przeciwciał specyficznych względem Abeta
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
US8619257B2 (en) * 2007-12-13 2013-12-31 Kimberley-Clark Worldwide, Inc. Recombinant bacteriophage for detection of nosocomial infection
US8779088B2 (en) 2007-12-17 2014-07-15 Marfl Ab Vaccine for the treatment of Mycobacterium related disorders
US7928203B2 (en) 2007-12-28 2011-04-19 Elan Pharmaceuticals, Inc. Chimeric, humanized, or human antibody 2A4
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
EP2473523A2 (de) 2009-08-31 2012-07-11 Amplimmune, Inc. Verfahren und zusammensetzungen zur hemmung von transplantatabstossung
WO2011046983A2 (en) 2009-10-12 2011-04-21 Smith Holdings, Llc Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro
CN109265543B (zh) 2011-09-19 2022-04-26 阿克松神经***科学公司 阿尔茨海默病中的tau蛋白介导病变的基于蛋白质的疗法和诊断
US9302005B2 (en) 2013-03-14 2016-04-05 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
US10259875B2 (en) 2013-10-01 2019-04-16 Mayo Foundation For Medical Education And Research Methods for treating cancer in patients with elevated levels of BIM
JP2017501848A (ja) 2013-11-19 2017-01-19 プロセナ バイオサイエンシーズ リミテッド 便秘症状からのレビー小体病の免疫療法のモニター
US10302653B2 (en) 2014-05-22 2019-05-28 Mayo Foundation For Medical Education And Research Distinguishing antagonistic and agonistic anti B7-H1 antibodies
EP3171896A4 (de) 2014-07-23 2018-03-21 Mayo Foundation for Medical Education and Research Abzielung auf dna-pkcs und b7-h1 zur behandlung von krebs
WO2017075045A2 (en) 2015-10-30 2017-05-04 Mayo Foundation For Medical Education And Research Antibodies to b7-h1
WO2017176829A1 (en) * 2016-04-08 2017-10-12 Cold Spring Harbor Laboratory Multiplexed analysis of neuron projections by sequencing
JP7335265B2 (ja) 2018-04-09 2023-08-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ある種のプラジエノライド化合物及び使用方法
CN112368270B (zh) 2018-04-12 2023-10-13 卫材R&D管理有限公司 作为用于治疗癌症的剪接体靶向剂的普拉二烯内酯衍生物
IL279062B2 (en) 2018-06-01 2024-02-01 Eisai R&D Man Co Ltd Antibody drug conjugates of splicing modulators and methods of use
MX2020012940A (es) 2018-06-01 2021-03-25 Eisai R&D Man Co Ltd Metodos de uso de moduladores de empalme.
JP7365766B2 (ja) 2018-11-16 2023-10-20 住友重機械工業株式会社 偏心揺動型減速装置
AU2019397062A1 (en) 2018-12-13 2021-05-06 Eisai R&D Management Co., Ltd. Herboxidiene antibody-drug conjugates and methods of use
EP4028040A2 (de) 2019-09-09 2022-07-20 Axon Neuroscience SE Biomarker und behandlungen von morbus alzheimer und milder kognitiver beeinträchtigung
CN113136372B (zh) * 2021-05-28 2023-08-01 广西大学 一种重组噬菌体的构建方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750373A (en) * 1990-12-03 1998-05-12 Genentech, Inc. Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
IT1270939B (it) * 1993-05-11 1997-05-26 Angeletti P Ist Richerche Bio Procedimento per la preparazione di immunogeni e reagenti diagnostici,e immunogeni e reagenti diagnostici cosi' ottenibili.
JPH08510325A (ja) * 1993-05-28 1996-10-29 カイロン コーポレイション 生物学的に活性なペプチド配列の選択方法

Also Published As

Publication number Publication date
EP0876615A1 (de) 1998-11-11
AU7585396A (en) 1997-05-29
ES2203722T3 (es) 2004-04-16
WO1997017613A1 (en) 1997-05-15
EP0859959B1 (de) 2003-08-06
EP1281718A3 (de) 2005-01-19
NZ322174A (en) 1999-02-25
NZ322175A (en) 1999-02-25
CA2234685A1 (en) 1997-05-15
JP4135978B2 (ja) 2008-08-20
CA2235226A1 (en) 1997-05-15
JP4126055B2 (ja) 2008-07-30
AU7585296A (en) 1997-05-29
JP2006117686A (ja) 2006-05-11
AU705688B2 (en) 1999-05-27
JP3830525B2 (ja) 2006-10-04
EP0859959A1 (de) 1998-08-26
EP1281718A2 (de) 2003-02-05
DE69629385D1 (de) 2003-09-11
JP2002504072A (ja) 2002-02-05
PT859959E (pt) 2003-12-31
AU705816B2 (en) 1999-06-03
WO1997017614A1 (en) 1997-05-15
DK0859959T3 (da) 2003-11-24
DE69629385T2 (de) 2004-06-09
JP2002515967A (ja) 2002-05-28

Similar Documents

Publication Publication Date Title
ATE246808T1 (de) Peptide, die den transport über gewebe erhöhen und verfahren zu ihrer identifizierung und verwendung
Barker Peptides: roles in neuronal excitability.
DE59009462D1 (de) Implantierbare Vorrichtung zur dosierten Abgabe von Medikamenten in den menschlichen Körper.
ATE123943T1 (de) Mittel zur behandlung und vorbeugung von bauchentzündungen, die als wirkstoff zink-l- carnosin-salze oder -komplexe enthalten.
DE726075T1 (de) Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung
DE69614375T2 (de) Dermatologische zubereitung zur behandlung von aktinischen keratosen
SE9504505D0 (sv) Förvaringslösning
US20080318869A1 (en) Method to Promote Wound Healing
CA2074166A1 (en) Method for treating intestinal diseases
Mulford Use of a surgical skin stapler to quickly close incisions in striped bass
Geary et al. Exotic myiasis with Lund's fly (Cordylobia rodhaini)
DK68690A (da) Fremgangsmaade til ekstraktion af en fysiologisk aktiv substans fra fyrrekogler og anti-kontagioest laegemiddel fremstillet paa basis af denne substans
EA199901061A1 (ru) Новые соли врс-пептидов с органопротективной активностью, способ их получения и их использование в терапии
Norström et al. Effect of suckling and parturition on axonal transport and turnover of neurohypophysial proteins of the rat
Henry et al. Immobilizing trapped European wild hogs with cap-chur-barb
Larsen et al. Evaluation of modified techniques for immobilization of wild ring-tailed lemurs (Lemur catta)
Wadhwa et al. Effects of strontium on the absorption of calcium, magnesium and phosphate ions from the ovine reticulo-rumen
Pass et al. Factors affecting gallbladder motility in sheep
Buchanan et al. Gastric ulceration in rats induced by self-imposed immobilization or physical restraint
RU94003799A (ru) Способ лечения псороптозов животных
Wray Jr et al. Effect of continuous load on the mechanical properties of tendon adhesions
SU906472A1 (ru) Способ стимулировани репродуктивной функции молодых самок соболей
RU2001106744A (ru) Способ профилактики и лечения мастита у коров
DE886053C (de) Verfahren zur Inaktivierung von Virusproteinen
Banik Risk factors of snake bite and health seeking behaviour of the people on North 24 Parganas

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0859959

Country of ref document: EP

EEIH Change in the person of patent owner