DE726075T1 - Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung - Google Patents

Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung

Info

Publication number
DE726075T1
DE726075T1 DE0726075T DE95101681T DE726075T1 DE 726075 T1 DE726075 T1 DE 726075T1 DE 0726075 T DE0726075 T DE 0726075T DE 95101681 T DE95101681 T DE 95101681T DE 726075 T1 DE726075 T1 DE 726075T1
Authority
DE
Germany
Prior art keywords
saline solutions
endonasal administration
inorganic pharmaceutical
endonasal
pharmaceutical saline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE0726075T
Other languages
English (en)
Inventor
Paolo Alberto Veronesi
Emanuela Peschechera
Anna Maria Veronesi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Therapicon SRL
Original Assignee
Therapicon SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therapicon SRL filed Critical Therapicon SRL
Publication of DE726075T1 publication Critical patent/DE726075T1/de
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/23Calcitonins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/585Calcitonins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Otolaryngology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE0726075T 1995-02-08 1995-02-08 Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung Pending DE726075T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95101681A EP0726075A1 (de) 1995-02-08 1995-02-08 Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung

Publications (1)

Publication Number Publication Date
DE726075T1 true DE726075T1 (de) 1996-12-12

Family

ID=8218965

Family Applications (4)

Application Number Title Priority Date Filing Date
DE0726075T Pending DE726075T1 (de) 1995-02-08 1995-02-08 Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung
DE69607749T Expired - Fee Related DE69607749T2 (de) 1995-02-08 1996-02-02 Analoge des calcitonin aus lachs, ihre herstellung und ihre verwendung als medizin und als analytische reagentien
DE29622959U Expired - Lifetime DE29622959U1 (de) 1995-02-08 1996-02-02 Analoge des Lachs-Calcitonin
DE69620393T Expired - Lifetime DE69620393T2 (de) 1995-02-08 1996-02-08 PHARMAZEUTISCHE NICHTINORGANISCHE SALZLÖSUNGEN FÜR ENDONASALE VERABREICHUNG EINEs CALCITONINs

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE69607749T Expired - Fee Related DE69607749T2 (de) 1995-02-08 1996-02-02 Analoge des calcitonin aus lachs, ihre herstellung und ihre verwendung als medizin und als analytische reagentien
DE29622959U Expired - Lifetime DE29622959U1 (de) 1995-02-08 1996-02-02 Analoge des Lachs-Calcitonin
DE69620393T Expired - Lifetime DE69620393T2 (de) 1995-02-08 1996-02-08 PHARMAZEUTISCHE NICHTINORGANISCHE SALZLÖSUNGEN FÜR ENDONASALE VERABREICHUNG EINEs CALCITONINs

Country Status (17)

Country Link
US (2) US6087338A (de)
EP (3) EP0726075A1 (de)
JP (2) JPH11506416A (de)
KR (2) KR100430101B1 (de)
AT (2) ATE191719T1 (de)
AU (2) AU4787996A (de)
BR (1) BR9607410A (de)
CA (2) CA2210664A1 (de)
DE (4) DE726075T1 (de)
ES (2) ES2146869T3 (de)
GB (1) GB9523442D0 (de)
HU (1) HUP9600266A3 (de)
PE (1) PE28397A1 (de)
PL (1) PL183398B1 (de)
PT (2) PT809654E (de)
WO (2) WO1996024618A1 (de)
ZA (2) ZA96779B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0726075A1 (de) * 1995-02-08 1996-08-14 Therapicon Srl Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung
US6034064A (en) * 1995-04-07 2000-03-07 Hoechst Pharmaceuticals & Chemicals K.K. Peptides and therapeutic agent for autoimmune diseases containing the same
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
IT1298780B1 (it) * 1998-03-24 2000-02-02 Therapicon Srl Preparazioni parenterali a base di calcitonina
US6734162B2 (en) 2000-01-24 2004-05-11 Minimed Inc. Mixed buffer system for stabilizing polypeptide formulations
AU783952B2 (en) * 2000-02-04 2006-01-05 Unigene Laboratories, Inc. Nasal calcitonin formulations
DE10024451A1 (de) * 2000-05-18 2001-11-29 Asta Medica Ag Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung
US6737401B2 (en) 2001-06-28 2004-05-18 Metronic Minimed, Inc. Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom
JP4225416B2 (ja) * 2001-06-29 2009-02-18 旭化成ファーマ株式会社 タンパク質製剤の安定性を改善する方法
US20090035260A1 (en) * 2002-07-29 2009-02-05 Therapicon Srl Enhanced nasal composition of active peptide
ITMI20021684A1 (it) * 2002-07-29 2004-01-29 Therapicon Srl Composizione farmaceutica di peptide nasale
US7812120B2 (en) * 2003-03-21 2010-10-12 Par Pharmaceutical, Inc. Nasal calcitonin formulations containing chlorobutanol
ITMI20040235A1 (it) * 2004-02-13 2004-05-13 Therapicon Srl Preparazione farmaceutica per il cavo orale
GB0422644D0 (en) * 2004-10-12 2004-11-10 Novartis Ag Organic compounds
TW200722518A (en) 2005-03-31 2007-06-16 Chugai Pharmaceutical Co Ltd Sc(fv)2 structural isomers
US9241994B2 (en) 2005-06-10 2016-01-26 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical compositions containing sc(Fv)2
AU2006256041B2 (en) * 2005-06-10 2012-03-29 Chugai Seiyaku Kabushiki Kaisha Stabilizer for protein preparation comprising meglumine and use thereof
CN100349611C (zh) * 2005-11-25 2007-11-21 中国药科大学 鲑降钙素吸入粉雾剂及其制备方法
AU2010206614B2 (en) * 2009-01-22 2015-03-26 Keybioscience Ag Treatment for obesity
US9533022B2 (en) 2011-11-02 2017-01-03 KeyBioscience A/S Peptide analogs for treating diseases and disorders
US9006172B2 (en) 2011-11-02 2015-04-14 Keybioscience Ag Peptide analogs for treating diseases and disorders

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3926938A (en) * 1974-08-12 1975-12-16 Armour Pharma Synthesis of salmon calcitonin
US4217268A (en) * 1978-07-20 1980-08-12 Hughes John L Synthesis of peptides
CH657779A5 (de) * 1982-10-05 1986-09-30 Sandoz Ag Galenische zusammensetzungen enthaltend calcitonin.
GB2127689B (en) * 1982-10-05 1986-07-09 Sandoz Ltd Calcitonin inhalation compositions
JPS59163313A (ja) * 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
US4659804A (en) * 1984-11-01 1987-04-21 Armour Pharmaceutical Company (Bis-1,7-S-acetamidomethyl-L-cysteine)salmon calcitonin
JPS61267528A (ja) * 1984-11-26 1986-11-27 Yamanouchi Pharmaceut Co Ltd 吸収促進剤を含有するカルシトニン経鼻剤
US4622386A (en) * 1985-03-28 1986-11-11 Armour Pharmaceutical Company [1,7-di-alanine]calcitonin
US4639510A (en) * 1985-10-04 1987-01-27 Armour Pharmaceutical Company (1-S-acetamidomethyl cysteine, 7-alanine)calcitonin
HUT44794A (en) * 1985-12-04 1988-04-28 Sandoz Ag Process for production of calcitonine-derivatives and medical preparatives containing such compounds
ES2052642T3 (es) * 1987-07-08 1994-07-16 Mitsubishi Petrochemical Co Nuevo derivado de calcitonina y su sal.
US5059587A (en) * 1987-08-03 1991-10-22 Toyo Jozo Company, Ltd. Physiologically active peptide composition for nasal administration
EP0327756B1 (de) * 1987-11-13 1994-01-26 Smithkline Beecham Farmaceutici S.p.A. Ein Calcitonin sowie ein Glycyrrhizinat als Absorptionsförderer enthaltende Arzneimittel
AU629552B2 (en) * 1988-06-16 1992-10-08 Teijin Limited S-sulfonated calcitonin derivatives
JPH0694851B2 (ja) * 1988-06-27 1994-11-24 株式会社日立製作所 蒸発燃料制御装置
US5026825A (en) * 1988-09-08 1991-06-25 Rhone-Poulenc Rorer Pharmaceuticals Inc. Intranasal calcitonin formulations
JPH02104531A (ja) * 1988-10-14 1990-04-17 Toyo Jozo Co Ltd 経鼻投与用生理活性ペプチド組成物
JPH0643339B2 (ja) * 1990-05-25 1994-06-08 旭化成工業株式会社 カルシトニン類水溶液組成物の安定化法
IT1248725B (it) * 1990-06-12 1995-01-26 Sclavo Spa Composizione farmaceutica in polvere per somministrazione per via nasale contenente essenzialmente calcitonina ed un eccipiente idrosolubile
JPH078806B2 (ja) * 1990-08-16 1995-02-01 旭化成工業株式会社 カルシトニン類含有経鼻投与用乳剤
JP3179538B2 (ja) * 1990-12-11 2001-06-25 ノバルティス アクチエンゲゼルシャフト 安定なヒトカルシトニンの水性溶液
IT1244500B (it) * 1991-03-21 1994-07-15 Pulitzer Italiana Impiego di sali minerali di trometamina in composizioni farmaceutiche a base di calcitonina somministrabili per via rettale in terapia umana
IT1251685B (it) * 1991-10-11 1995-05-19 Isf Spa Composizioni farmaceutiche contenenti una calcitonina
US5571788A (en) * 1991-12-09 1996-11-05 Ciba-Geigy Corporation Stable calcitonin pharmaceutical compositions
IT1255895B (it) * 1992-10-20 1995-11-17 Laura Chiodini Composizioni farmaceutiche contenenti una calcitonina
EP0726075A1 (de) * 1995-02-08 1996-08-14 Therapicon Srl Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung

Also Published As

Publication number Publication date
HUP9600266A3 (en) 2000-09-28
KR960030948A (ko) 1996-09-17
DE29622959U1 (de) 1998-03-05
EP0809654A1 (de) 1997-12-03
EP0726075A1 (de) 1996-08-14
HU9600266D0 (en) 1996-04-29
CA2212520A1 (en) 1996-08-15
EP0809512B1 (de) 2002-04-03
BR9607410A (pt) 1998-07-07
JPH11506416A (ja) 1999-06-08
ES2173267T3 (es) 2002-10-16
JPH08245417A (ja) 1996-09-24
PT809512E (pt) 2002-09-30
ATE191719T1 (de) 2000-04-15
JP4123309B2 (ja) 2008-07-23
EP0809654B1 (de) 2000-04-12
AU4787996A (en) 1996-08-27
DE69620393D1 (de) 2002-05-08
ES2146869T3 (es) 2000-08-16
CA2210664A1 (en) 1996-08-15
KR19980702091A (ko) 1998-07-15
DE69607749D1 (de) 2000-05-18
PL312683A1 (en) 1996-08-19
WO1996024370A1 (en) 1996-08-15
GB9523442D0 (en) 1996-01-17
PE28397A1 (es) 1997-08-22
US6107277A (en) 2000-08-22
KR100430101B1 (ko) 2006-02-13
DE69607749T2 (de) 2000-07-27
ATE215381T1 (de) 2002-04-15
KR100397034B1 (ko) 2003-11-13
ZA96835B (en) 1996-08-19
EP0809512A1 (de) 1997-12-03
ZA96779B (en) 1996-08-29
HUP9600266A2 (en) 1997-06-30
AU4786396A (en) 1996-08-27
PL183398B1 (pl) 2002-06-28
DE69620393T2 (de) 2003-01-16
US6087338A (en) 2000-07-11
PT809654E (pt) 2000-10-31
WO1996024618A1 (en) 1996-08-15

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