ATE234102T1 - Bindung von e-selectin, p-selectin oder l- selectin an sialyl-lewisx oder an sialyl-lewisa - Google Patents

Bindung von e-selectin, p-selectin oder l- selectin an sialyl-lewisx oder an sialyl-lewisa

Info

Publication number
ATE234102T1
ATE234102T1 AT95918365T AT95918365T ATE234102T1 AT E234102 T1 ATE234102 T1 AT E234102T1 AT 95918365 T AT95918365 T AT 95918365T AT 95918365 T AT95918365 T AT 95918365T AT E234102 T1 ATE234102 T1 AT E234102T1
Authority
AT
Austria
Prior art keywords
alkyl
selectin
sialyl
group
mco2h
Prior art date
Application number
AT95918365T
Other languages
English (en)
Inventor
Timothy P Kogan
Brian Dupre
Ian L Scott
Karin Keller
Huong Dao
Pamela J Beck
Original Assignee
Texas Biotechnology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas Biotechnology Corp filed Critical Texas Biotechnology Corp
Application granted granted Critical
Publication of ATE234102T1 publication Critical patent/ATE234102T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
AT95918365T 1994-04-29 1995-04-28 Bindung von e-selectin, p-selectin oder l- selectin an sialyl-lewisx oder an sialyl-lewisa ATE234102T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/235,293 US5444050A (en) 1994-04-29 1994-04-29 Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa
PCT/US1995/005463 WO1995029682A1 (en) 1994-04-29 1995-04-28 BINDING OF E-SELECTIN, P-SELECTIN OR L-SELECTIN TO SIALYL-LEWISx OR SIALYL-LEWIS?a¿

Publications (1)

Publication Number Publication Date
ATE234102T1 true ATE234102T1 (de) 2003-03-15

Family

ID=22884899

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95918365T ATE234102T1 (de) 1994-04-29 1995-04-28 Bindung von e-selectin, p-selectin oder l- selectin an sialyl-lewisx oder an sialyl-lewisa

Country Status (13)

Country Link
US (1) US5444050A (de)
EP (1) EP0758243B1 (de)
JP (1) JPH09512560A (de)
CN (1) CN1151117A (de)
AT (1) ATE234102T1 (de)
AU (1) AU691920B2 (de)
BR (1) BR9507561A (de)
CA (1) CA2189013A1 (de)
CZ (1) CZ314396A3 (de)
DE (1) DE69529892T2 (de)
NO (1) NO964566L (de)
PL (1) PL316994A1 (de)
WO (1) WO1995029682A1 (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710123A (en) * 1992-12-18 1998-01-20 Centocor, Inc. Peptide inhibitors of selectin binding
JPH0899989A (ja) * 1994-09-30 1996-04-16 Akira Hasegawa 新規糖脂質誘導体およびその製造用中間体
US20020040008A1 (en) * 1995-01-24 2002-04-04 Wagner Denisa D. Method for treating and preventing atherosclerosis
JP4046351B2 (ja) * 1995-06-29 2008-02-13 テキサス・バイオテクノロジー・コーポレイション ２価および３価の小分子セレクチン阻害薬
EP0859005A1 (de) * 1995-10-26 1998-08-19 Kanebo, Ltd. Fucose-derivate, medikamente, die diese als wirkstoff enthalten, und zwischenprodukte für ihre herstellung
US5919768A (en) * 1996-06-26 1999-07-06 Texas Biotechnology Corporation Di- and trivalent small molecule selectin inhibitors
WO1998031697A1 (en) * 1997-01-15 1998-07-23 Sankyo Company, Limited Aryl c-glycoside compounds and sulfated esters thereof
ATE287895T1 (de) * 1997-08-08 2005-02-15 Aventis Pharma Gmbh Substituierte tetrahydropyranderivate sowie verfahren zu deren herstellung
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
US6515117B2 (en) * 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
GB9924990D0 (en) * 1999-10-21 1999-12-22 Glaxo Group Ltd Medicaments
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6683056B2 (en) * 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6936590B2 (en) * 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
ATE318272T1 (de) 2001-04-11 2006-03-15 Bristol Myers Squibb Co Aminosäurekomplexe von c-arylglycosiden zur behandlung von diabetes und verfahren
US7060685B2 (en) 2002-05-16 2006-06-13 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
CA2490703A1 (en) * 2002-07-03 2004-01-15 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
JP2007524658A (ja) * 2003-11-19 2007-08-30 グリコミメティクス， インコーポレイテッド Ｅ−およびｐ−セレクチンの両方のための糖模倣物アンタゴニスト
WO2005051920A2 (en) * 2003-11-19 2005-06-09 Glycomimetics, Inc. Specific antagonist for both e- and p-selectins
EP1577289A1 (de) 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Nicht-glykosylierte/-glykosidische/-peptidische keine Moleküle als Selektininhibitoren für die Behandlung entzündlicher Erkrankungen.
WO2006127906A1 (en) * 2005-05-25 2006-11-30 Glycomimetics, Inc. Heterobifunctional compounds for selectin inhibition
CA2618638C (en) * 2005-08-09 2014-03-11 Glycomimetics, Inc. Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
JP5209476B2 (ja) 2005-09-02 2013-06-12 グリコミメティクス， インコーポレイテッド ヘテロ二官能性全セレクチン阻害剤
EP1764096A1 (de) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue Phloroglucinolderivate mit Selectin-Ligand-Aktivität
EP1764093A1 (de) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue aromatische Verbindungen und deren medizinische Verwendung
EP1764095A1 (de) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue Nitrocatecholderivate mit Selectin-Ligand-Activität
US20090176717A1 (en) * 2006-06-01 2009-07-09 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
JP5298020B2 (ja) 2006-10-12 2013-09-25 グリコミメティクス， インコーポレイテッド ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換
NZ598863A (en) * 2007-02-09 2013-11-29 Glycomimetics Inc Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
US8039442B2 (en) * 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
WO2009067493A2 (en) * 2007-11-19 2009-05-28 Envivo Pharmaceuticals, Inc. 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
JP2011507909A (ja) 2007-12-20 2011-03-10 エンビボ ファーマシューティカルズ インコーポレイテッド 四置換ベンゼン
CA2709664A1 (en) 2007-12-26 2009-07-02 Eisai R&D Management Co., Ltd. Method for manufacturing heterocycle substituted pyridine derivatives
US8895510B2 (en) 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
FR2930942B1 (fr) * 2008-05-07 2011-03-04 Centre Nat Rech Scient Nouvelles utilisations de derives de d-mannopyranose activateurs de l'angiogenese
WO2009152245A1 (en) * 2008-06-13 2009-12-17 Glycomimetics, Inc. Treatment of cancers of the blood using selected glycomimetic compounds
WO2010042652A2 (en) 2008-10-08 2010-04-15 Amira Pharmaceuticals, Inc. Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors
WO2010126888A1 (en) * 2009-05-01 2010-11-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
EP2960247A1 (de) * 2009-12-14 2015-12-30 University of Basel Mannosederivate als antagonisten von bakterieller haftung
EP2566580A1 (de) * 2010-05-07 2013-03-13 Revotar Biopharmaceuticals AG Verfahren zur herstellung von bimosiamose
EP2423181A1 (de) 2010-07-28 2012-02-29 Prous Institute For Biomedical Research S.A. Substituierte Multitarget-Biphenyl-Diol-Derivate
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
ES2655443T7 (es) * 2011-12-22 2021-03-22 Glycomimetics Inc Compuestos antagonistas de E-selectina
CA2891514C (en) 2012-12-07 2020-08-25 Glycomimetics, Inc. Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
CN103804403B (zh) * 2014-02-24 2016-05-18 蚌埠中实化学技术有限公司 一种制备2-羟基苯硼酸的方法
CN103896974B (zh) * 2014-04-11 2017-01-04 北京乐威泰克医药技术有限公司 2-羟基苯硼酸的制备方法
CN107108679B (zh) 2014-12-03 2020-10-23 糖模拟物有限公司 E-选择蛋白和cxcr4趋化因子受体的异双官能抑制剂
CA3009836A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
WO2018045142A1 (en) * 2016-09-02 2018-03-08 Polaris Pharmaceuticals, Inc. Immune checkpoint inhibitors, compositions and methods thereof
JP7069136B2 (ja) 2016-10-07 2022-05-17 グリコミメティクス， インコーポレイテッド 極めて強力な多量体ｅ－セレクチンアンタゴニスト
JP7272956B2 (ja) 2017-03-15 2023-05-12 グリコミメティクス， インコーポレイテッド Ｅ－セレクチンアンタゴニストとしてのガラクトピラノシル－シクロヘキシル誘導体
US11773127B2 (en) 2017-11-08 2023-10-03 Washington University Compounds and methods for treating bacterial infections
US11712446B2 (en) 2017-11-30 2023-08-01 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
CN111566117A (zh) 2017-12-29 2020-08-21 糖模拟物有限公司 E-选择蛋白和半乳凝素-3的异双功能抑制剂
AU2019230013A1 (en) 2018-03-05 2020-09-10 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212298A (en) * 1989-08-16 1993-05-18 Monsanto Company Method for producing synthetic N-linked glycoconjugates
US5280113A (en) * 1989-08-16 1994-01-18 Monsanto Company Method for producing synthetic N-linked glycoconjugates
US5318890A (en) * 1991-05-06 1994-06-07 The Regents Of The University Of California Assays for inhibitors of leukocyte adhesion
US5268364A (en) * 1991-12-12 1993-12-07 The Biomembrane Institute Method for inhibiting selectin-dependent adhesion of leukocytes and platelets by O-glycosylation modification
WO1994000477A1 (en) * 1992-06-29 1994-01-06 Glycomed Incorporated Substituted lactose derivatives as cell adhesion inhibitors
HUT77345A (hu) * 1994-04-29 1998-03-30 Texas Biotechnology Corporation E-szelektin, P-szelektin vagy L-szelektin szialil-Lewis x-hez vagy szialil-Lewis a-hoz kapcsolódását gátló mannopiranoziloxi-bifenil származékok és ezeket tartalmazó gyógyszerkészítmények

Also Published As

Publication number Publication date
PL316994A1 (en) 1997-03-03
CN1151117A (zh) 1997-06-04
JPH09512560A (ja) 1997-12-16
EP0758243A1 (de) 1997-02-19
DE69529892T2 (de) 2004-02-05
CZ314396A3 (en) 1997-05-14
US5444050A (en) 1995-08-22
EP0758243A4 (de) 1997-08-20
NO964566L (no) 1996-12-30
WO1995029682A1 (en) 1995-11-09
CA2189013A1 (en) 1995-11-09
AU691920B2 (en) 1998-05-28
BR9507561A (pt) 1997-08-05
NO964566D0 (no) 1996-10-28
DE69529892D1 (de) 2003-04-17
EP0758243B1 (de) 2003-03-12
AU2432995A (en) 1995-11-29

Similar Documents

Publication Publication Date Title
DE69529892D1 (de) BINDUNG VON E-SELECTIN, P-SELECTIN ODER L-SELECTIN AN SIALYL-LEWISx ODER AN SIALYL-LEWISa
MY132056A (en) Methods of inhibiting physiological conditions associated with an excess of neuropeptide y.
GB2248449B (en) Piperazine derivatives
EP1153924A3 (de) Substutuierte 1,3-Oxathiolane mit antiviralen Eigenschaften
ATE189227T1 (de) Polyanionische benzyl-glykosiden als inhibitoren zur glatten-muskelzellen-proliferation
ES2147399T3 (es) Nuevos derivados de 2,3,5-trimetil-4-hidroxianilidas, su preparacion y su aplicacion terapeutica.
NO20014240D0 (no) C16-umettede FP-selektive prostaglandinanaloger
ZW9791A1 (en) New heterocyclic chemistry
NZ296459A (en) Smooth muscle cell proliferation inhibitors
RU94045271A (ru) Применение 2-фенил-3-ароилбензотиофенов для ингибирования синдрома тернера
FI934680A0 (fi) Arylmorfolin, framstaellning och anvaending
ATE99934T1 (de) Heteroaryl-3-oxo-propannitril-derivate, nuetzlich zur behandlung von rheumatoider arthritis und anderen autoimmunkrankheiten.
NZ287551A (en) N-hydroxyureas that inhibit the 5-lipoxygenase enzyme as anti-inflammatory agents
FI954138A (fi) Hydroksimetyylifuratsaanikarboksyylihappojohdannaiset ja niiden käyttö sydänverisuonitautien käsittelyssä
AU2068895A (en) Dl- di- or tri-hydroxyphenylglycine alkyl esters for the treatment of inflammatory and allergic conditions
DK0871611T3 (da) Hidtil ukendte glycylanilidderivater, deres fremstilling og deres terapeutiske anvendelse
ES501744A0 (es) Procedimiento para la obtencion de bis (fenoxiacetatos sus- tituidos)de n-alcohil-dialcanolaminas

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties