ATE231143T1 - Triarylimidazole - Google Patents
TriarylimidazoleInfo
- Publication number
- ATE231143T1 ATE231143T1 AT00930101T AT00930101T ATE231143T1 AT E231143 T1 ATE231143 T1 AT E231143T1 AT 00930101 T AT00930101 T AT 00930101T AT 00930101 T AT00930101 T AT 00930101T AT E231143 T1 ATE231143 T1 AT E231143T1
- Authority
- AT
- Austria
- Prior art keywords
- triarylimidazole
- andone
- 6alkyl
- chr
- pharmaceuticals
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12868799P | 1999-04-09 | 1999-04-09 | |
PCT/US2000/009147 WO2000061576A1 (en) | 1999-04-09 | 2000-04-06 | Triarylimidazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE231143T1 true ATE231143T1 (de) | 2003-02-15 |
Family
ID=22436501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00930101T ATE231143T1 (de) | 1999-04-09 | 2000-04-06 | Triarylimidazole |
Country Status (9)
Country | Link |
---|---|
US (1) | US6465493B1 (de) |
EP (1) | EP1169317B1 (de) |
JP (1) | JP2002541253A (de) |
AT (1) | ATE231143T1 (de) |
AU (1) | AU4798000A (de) |
CO (1) | CO5031285A1 (de) |
DE (1) | DE60001229T2 (de) |
ES (1) | ES2187473T3 (de) |
WO (1) | WO2000061576A1 (de) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0007405D0 (en) * | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
JP2004510696A (ja) * | 2000-05-19 | 2004-04-08 | アメリカ合衆国 | 線維症の防止および創傷治癒の改善のためのSmad3の阻害 |
WO2002040468A1 (en) * | 2000-11-16 | 2002-05-23 | Smithkline Beecham Corporation | Compounds |
GB0100762D0 (en) * | 2001-01-11 | 2001-02-21 | Smithkline Beecham Plc | Novel use |
GB0102665D0 (en) * | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
GB0102672D0 (en) * | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
IL158512A0 (en) | 2001-05-24 | 2004-05-12 | Lilly Co Eli | Novel pyrrole derivatives as pharmaceutical agents |
GB0127430D0 (en) * | 2001-11-15 | 2002-01-09 | Smithkline Beecham Corp | Compounds |
AR039241A1 (es) * | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
ATE343572T1 (de) | 2002-08-09 | 2006-11-15 | Lilly Co Eli | Benzimidazole und benzothiazole als inhibitoren der map-kinase |
UA80295C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Pyrazolopyridines and using the same |
CA2499429C (en) | 2002-09-18 | 2010-09-21 | Pfizer Products Inc. | Novel oxazole and thiazole compounds as transforming growth factor (tgf) inhibitors |
AU2003260810A1 (en) | 2002-09-18 | 2004-04-08 | Pfizer Products Inc. | Triazole derivatives as transforming growth factor (tgf) inhibitors |
CA2496295C (en) | 2002-09-18 | 2010-11-23 | Michael John Munchhof | Novels pyrazole compounds as transforming growth factor (tgf) inhibitors |
AP2005003262A0 (en) | 2002-09-18 | 2005-03-31 | Pfizer Prod Inc | Novel isothiazole and isoxazole compounds as tranforming growth factor (TGF) inhibitors. |
KR20050057392A (ko) | 2002-09-18 | 2005-06-16 | 화이자 프로덕츠 인크. | 전환성장인자(tgf) 억제제로서의 신규한 이미다졸 화합물 |
US20040192583A1 (en) * | 2002-12-19 | 2004-09-30 | Satyanarayana Medicherla | Treatment of obesity and associated conditions with TGF-beta inhibitors |
WO2004060362A2 (en) * | 2003-01-02 | 2004-07-22 | Millennium Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING TGF-β |
PA8595001A1 (es) | 2003-03-04 | 2004-09-28 | Pfizer Prod Inc | Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf) |
JPWO2004108160A1 (ja) * | 2003-06-05 | 2006-07-27 | 日本新薬株式会社 | 骨形成促進増強剤及びそのスクリーニング方法 |
AU2004274326B2 (en) | 2003-09-17 | 2011-11-17 | Sumitomo Chemical Company, Limited | Cinnamoyl derivatives and use thereof |
JP4815773B2 (ja) * | 2003-09-17 | 2011-11-16 | 住友化学株式会社 | シンナモイル化合物及びその用途 |
JP2006104061A (ja) * | 2003-09-17 | 2006-04-20 | Sumitomo Chemical Co Ltd | シンナモイル化合物含有i型コラーゲン遺伝子転写抑制組成物。 |
RU2367661C2 (ru) | 2004-03-05 | 2009-09-20 | Тайсо Фармасьютикал Ко., Лтд. | Производные тиазола |
KR100749566B1 (ko) * | 2004-04-21 | 2007-08-16 | 이화여자대학교 산학협력단 | Alk5 및/또는 alk4 억제제로 유효한 2-피리딜이치환된 이미다졸 유도체 |
US20080319012A1 (en) | 2004-04-21 | 2008-12-25 | In2Gen Co., Ltd. | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors |
US7429604B2 (en) * | 2004-06-15 | 2008-09-30 | Bristol Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
AU2005280496B2 (en) * | 2004-07-29 | 2009-10-08 | Schering-Plough Pty. Limited | Use of ALK 5 inhibitors to modulate or inhibit myostatin activity leading to increased lean tissue accretion in animals |
JP2009501236A (ja) | 2005-07-14 | 2009-01-15 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
KR100694181B1 (ko) * | 2005-11-25 | 2007-03-12 | 연세대학교 산학협력단 | 근원세포 또는 근섬유로부터 신경세포 분화를 유도하는화합물, 이를 포함하는 약학적 조성물, 신경세포 분화를유도하는 방법 및 신경세포 분화를 유도하는 화합물을검색하는 스크리닝 방법 |
EP2077838B1 (de) | 2006-10-25 | 2013-04-03 | The Rockefeller University | Verfahren zur behandlung von amyloid-beta verwandten erkrankungen und zusammensetzungen dafür |
WO2008071605A2 (en) * | 2006-12-15 | 2008-06-19 | F. Hoffmann-La Roche Ag | Methods of treating inflammatory diseases |
WO2008094556A2 (en) * | 2007-01-30 | 2008-08-07 | Biogen Idec Ma Inc. | Imidazolone compounds as tgf-beta family type i receptors, alk5 and/or alk4 antagonists |
CA2686318A1 (en) * | 2007-05-04 | 2008-11-13 | Jana Pickova | Compound feed for aquaculture |
GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
MX2009012558A (es) | 2007-08-03 | 2010-04-21 | Biomarin Iga Ltd | Combinaciones de farmacos para el tratamiento de distrofia muscular de duchenne. |
WO2009047163A1 (en) * | 2007-10-10 | 2009-04-16 | F. Hoffmann-La Roche Ag | Methods of treating inflammatory diseases |
AU2012203026B2 (en) * | 2008-03-21 | 2014-06-12 | Novartis Ag | Novel heterocyclic compounds and uses thereof |
US8865732B2 (en) | 2008-03-21 | 2014-10-21 | Novartis Ag | Heterocyclic compounds and uses thereof |
US8513222B2 (en) | 2010-06-29 | 2013-08-20 | EWHA University—Industry Collaboration Foundation | Methods of treating fibrosis, cancer and vascular injuries |
US8080568B1 (en) | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
USRE47141E1 (en) | 2010-06-29 | 2018-11-27 | EWHA University—Industry Collaboration Foundation | Methods of treating fibrosis, cancer and vascular injuries |
US9446175B2 (en) * | 2011-06-03 | 2016-09-20 | Yale University | Compositions and methods for treating and preventing neointimal stenosis |
KR101938368B1 (ko) | 2011-07-13 | 2019-01-14 | 주식회사 티움바이오 | Alk5 및/또는 alk4 억제제로서의 2-피리딜-치환된 이미다졸 |
US9637723B2 (en) | 2012-05-30 | 2017-05-02 | Cornell University Q | Generation of functional and durable endothelial cells from human amniotic fluid-derived cells |
SI2880053T1 (sl) | 2012-08-01 | 2020-08-31 | Ikaika Therapeutics, Llc | Blažitev poškodbe tkiva in fibroze s protitelesom proti-LTBP4 |
US20140242595A1 (en) | 2013-02-22 | 2014-08-28 | Cellular Dynamics International, Inc. | Hepatocyte production via forward programming by combined genetic and chemical engineering |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
CA2914615C (en) | 2013-06-05 | 2023-10-17 | Biotime, Inc. | Compositions and methods for induced tissue regeneration in mammalian species |
BR112016016098A2 (pt) | 2014-01-09 | 2017-08-08 | Intracellular Therapies Inc | Compostos orgânicos |
US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
EP3133149B1 (de) | 2014-04-18 | 2022-06-22 | Kyoto Prefectural Public University Corporation | Verfahren zur herstellung von osteoblasten und osteoblasteninduktor |
US20170107486A1 (en) | 2014-04-21 | 2017-04-20 | Cellular Dynamics International, Inc. | Hepatocyte production via forward programming by combined genetic and chemical engineering |
US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
EP3741397A1 (de) | 2015-12-11 | 2020-11-25 | Research Institute at Nationwide Children's Hospital | Systeme und verfahren für optimierte patientenspezifische gewebegezüchtete gefässtransplantate |
EP3897689A1 (de) | 2018-12-21 | 2021-10-27 | Northwestern University | Verwendung von annexinen zur vorbeugung und behandlung von muskelmembranverletzungen |
WO2020139977A1 (en) | 2018-12-26 | 2020-07-02 | Northwestern University | Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder |
CN115052663A (zh) | 2020-01-08 | 2022-09-13 | 辛瑟斯治疗股份有限公司 | Alk5抑制剂缀合物及其用途 |
US20240018122A1 (en) | 2020-07-15 | 2024-01-18 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
BR112023000592A2 (pt) | 2020-07-15 | 2023-01-31 | Chiesi Farm Spa | Derivados de pirido oxazina amino como inibidores de alk5 |
WO2023208986A1 (en) | 2022-04-27 | 2023-11-02 | Chiesi Farmaceutici S.P.A. | Imidazole derivatives as alk5 inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB138101A (de) | ||||
CH561202A5 (de) * | 1971-05-10 | 1975-04-30 | Ciba Geigy Ag | |
US5656644A (en) | 1994-07-20 | 1997-08-12 | Smithkline Beecham Corporation | Pyridyl imidazoles |
DE69433501T2 (de) | 1993-11-08 | 2004-11-04 | Smithkline Beecham Corp. | Oxazole zur behandlung von zytokinvermittelten erkrankungen |
US5776954A (en) * | 1996-10-30 | 1998-07-07 | Merck & Co., Inc. | Substituted pyridyl pyrroles, compositions containing such compounds and methods of use |
CA2271893A1 (en) | 1996-11-20 | 1998-05-28 | Linda L. Chang | Triaryl substituted imidazoles as glucagon antagonists |
JPH11180958A (ja) * | 1997-12-24 | 1999-07-06 | Yamanouchi Pharmaceut Co Ltd | 新規アミン誘導体 |
-
2000
- 2000-04-06 EP EP00930101A patent/EP1169317B1/de not_active Expired - Lifetime
- 2000-04-06 AT AT00930101T patent/ATE231143T1/de not_active IP Right Cessation
- 2000-04-06 AU AU47980/00A patent/AU4798000A/en not_active Abandoned
- 2000-04-06 WO PCT/US2000/009147 patent/WO2000061576A1/en active IP Right Grant
- 2000-04-06 DE DE60001229T patent/DE60001229T2/de not_active Expired - Fee Related
- 2000-04-06 JP JP2000610849A patent/JP2002541253A/ja not_active Withdrawn
- 2000-04-06 ES ES00930101T patent/ES2187473T3/es not_active Expired - Lifetime
- 2000-04-06 US US09/958,639 patent/US6465493B1/en not_active Expired - Fee Related
- 2000-04-10 CO CO00026001A patent/CO5031285A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
DE60001229D1 (de) | 2003-02-20 |
WO2000061576A1 (en) | 2000-10-19 |
US6465493B1 (en) | 2002-10-15 |
CO5031285A1 (es) | 2001-04-27 |
JP2002541253A (ja) | 2002-12-03 |
EP1169317A1 (de) | 2002-01-09 |
AU4798000A (en) | 2000-11-14 |
EP1169317B1 (de) | 2003-01-15 |
DE60001229T2 (de) | 2003-10-30 |
ES2187473T3 (es) | 2003-06-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE231143T1 (de) | Triarylimidazole | |
CO5280078A1 (es) | Compuestos | |
AP1614A (en) | New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents. | |
BG106586A (en) | Pyrazolopyramidines as therapeutic agents | |
MXPA03002911A (es) | Compuestos quimicos. | |
DE60230127D1 (de) | Inhibitoren von integrin alpha-v-beta-6 | |
AU2001266575A1 (en) | Chemical compounds | |
MXPA02012076A (es) | Compuestos quimicos. | |
TR200002605T2 (tr) | Nitrik oksit sentaz inhibitörleri olarak faydalı halojene amidino amino asit türevleri | |
GEP20053626B (en) | Substituted 8-Arylquinoline Phosphodiesterase-4 Inhibitors, Pharmaceutical Composition Containing Them and Use Thereof | |
TR200201128T2 (tr) | PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri. | |
DE60112960D1 (de) | Kondensierte pyridoindolderivate | |
CA2412596A1 (en) | Cyclic gmp-specific phosphodiesterase inhibitors | |
MXPA02004441A (es) | Derivados de isoxazol como inhibidores de la fosfodiesterasa. | |
ATE213241T1 (de) | Amidin- und isothioharnstoffderivate als inhibitoren der stickstoffoxid-synthase | |
ATE330958T1 (de) | Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate | |
HRP20010885B1 (en) | Ethanesulfonyl-piperidine derivatives | |
ATE286887T1 (de) | Antibakterielle mittel | |
SE9901901D0 (sv) | Compounds | |
TR200001122T2 (tr) | Farmasötikler olarak bifenil türevleri. | |
IL159493A0 (en) | Pharmaceutical formulation containing an ltb4 antagonist | |
SE9603284D0 (sv) | New compounds | |
SE9802650D0 (sv) | Compounds | |
TR200100476T2 (tr) | N-İkameli azabisikloheptan türevlerinin üretimleri ve kullanımları. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |