ATE209251T1 - Knochen- und knorpel-bildung hervorrufende proteine - Google Patents

Knochen- und knorpel-bildung hervorrufende proteine

Info

Publication number
ATE209251T1
ATE209251T1 AT91911087T AT91911087T ATE209251T1 AT E209251 T1 ATE209251 T1 AT E209251T1 AT 91911087 T AT91911087 T AT 91911087T AT 91911087 T AT91911087 T AT 91911087T AT E209251 T1 ATE209251 T1 AT E209251T1
Authority
AT
Austria
Prior art keywords
cartilage formation
proteins
producing bone
proteins producing
bone
Prior art date
Application number
AT91911087T
Other languages
English (en)
Inventor
Rodney M Hewick
Jack H Wang
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst filed Critical Genetics Inst
Application granted granted Critical
Publication of ATE209251T1 publication Critical patent/ATE209251T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT91911087T 1990-05-16 1991-05-15 Knochen- und knorpel-bildung hervorrufende proteine ATE209251T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52535790A 1990-05-16 1990-05-16
US64120491A 1991-01-15 1991-01-15
PCT/US1991/003388 WO1991018098A1 (en) 1990-05-16 1991-05-15 Bone and cartilage inductive proteins

Publications (1)

Publication Number Publication Date
ATE209251T1 true ATE209251T1 (de) 2001-12-15

Family

ID=27061763

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91911087T ATE209251T1 (de) 1990-05-16 1991-05-15 Knochen- und knorpel-bildung hervorrufende proteine

Country Status (8)

Country Link
EP (1) EP0536186B1 (de)
JP (2) JPH06500991A (de)
AT (1) ATE209251T1 (de)
CA (1) CA2082941A1 (de)
DE (1) DE69132823T2 (de)
DK (1) DK0536186T3 (de)
ES (1) ES2168091T3 (de)
WO (1) WO1991018098A1 (de)

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US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
KR100255415B1 (ko) * 1991-06-25 2000-05-01 브루스 엠. 에이센 비엠피-9 조성물
ATE238417T1 (de) * 1991-11-04 2003-05-15 Inst Genetics Llc Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
KR100231640B1 (ko) * 1993-05-12 1999-12-01 토마스 제이 데스로저 Bmp-10 조성물
EP2272959A1 (de) * 1993-05-12 2011-01-12 Genetics Institute, LLC BMP-11 Zusammenstellungen
US5399677A (en) * 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
US6027919A (en) * 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
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US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
US5846770A (en) * 1994-11-22 1998-12-08 Genetics Institute, Inc. DNA molecules encoding human chordin
US5645084A (en) * 1995-06-07 1997-07-08 Danek Medical, Inc. Method for spinal fusion without decortication
US5635372A (en) * 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
HU222664B1 (hu) 1995-06-05 2003-09-29 Genetics Institute, Llc Csont morfogenetikus protein (BMP) alkalmazása csont és ín vagy szalag funkcionális összeköttetésének regenerálására
US5902785A (en) * 1995-06-06 1999-05-11 Genetics Institute, Inc. Cartilage induction by bone morphogenetic proteins
EP0885308A4 (de) * 1996-02-28 2002-02-27 Univ Vanderbilt Verbindungen und methoden zur herstellung embryonaler stammzellen
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
US5965403A (en) * 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
DE69814352T3 (de) 1997-02-07 2009-08-13 Stryker Corp., Kalamazoo Matrixlose osteogene vorrichtungen und implantate und verfahren zu deren verwendung
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
EP0980252B1 (de) 1997-05-05 2004-10-06 Curis, Inc. Therapien zur behandlung von akutem nierenversagen
EP0985149A1 (de) 1997-05-30 2000-03-15 Creative Biomolecules, Inc. Verfahren zur bestimmung der gewebemorphogenese und morphogenesische tätigkeit
US20020052026A1 (en) 1997-10-08 2002-05-02 Steven M. Vicik Methods of refolding proteins
US6027917A (en) 1997-12-10 2000-02-22 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-17 and BMP-18 compositions
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
US6849255B2 (en) 1998-08-18 2005-02-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods and compositions for enhancing cartilage repair
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
EP2374870B1 (de) 1998-10-06 2014-04-23 Stryker Corporation Zusammensetzung enthaltend ein osteogenes Protein ausgewählt aus OP-2, OP-3, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-9, BMP-10, BMP-11, BMP-15, BMP-3B, DPP, Vg-1, Vgr-1, 60A Protein, GDF-1, GDF-2, GDF-3, GDF-6, GDF-7, GDF-8, GDF-9, GDF-10 und GDF-11 zur Verwendung zur Wiederherstellung eines defekten Locus in einem Nicht-Gelenkknorpelgewebe
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
JP4703926B2 (ja) 1999-10-15 2011-06-15 ジェネティクス インスティテュート,エルエルシー 骨形成蛋白をデリバリーするためのヒアルロン酸の処方
TW200526779A (en) 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
KR20050010778A (ko) 2002-05-03 2005-01-28 밀레늄 바이올로직스 인코포레이티드 결합조직 자극 펩티드
EP1529061B1 (de) 2002-08-06 2008-02-13 Sanofi-Aventis Deutschland GmbH Verfahren zur isolierung eines intestilanen cholesterin bindenproteins
CA2504768A1 (en) * 2002-11-14 2004-05-27 Adherex Technologies, Inc. Compounds and methods for modulating functions of classical cadherins
EP1675608B1 (de) 2003-09-12 2007-03-21 Wyeth Injizierbare feste calciumphosphat-stäbe zur abgabe von osteogenen proteinen
US7575751B2 (en) 2004-04-27 2009-08-18 Research Development Foundation Activin-A mutants
CA2567405A1 (en) 2004-05-25 2005-12-08 Stryker Corporation Use of morphogenic proteins for treating cartilage defects
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
WO2007092622A2 (en) 2006-02-09 2007-08-16 Biomimetic Therapeutics, Inc. Compositions and methods for treating bone
US9011930B2 (en) 2006-05-01 2015-04-21 Zycal Bioceuticals Healthcare Company, Inc. Nutritional supplement and use thereof
US20090298761A1 (en) 2006-05-17 2009-12-03 Donald Engelman Methods of treating cartilage defects using a soluble morphogenic protein complex
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
JP5484047B2 (ja) 2006-06-30 2014-05-07 バイオミメティック セラピューティクス, エルエルシー 回旋筋腱板傷害を処置するためのpdgf−生体マトリックス組成物および方法
US8524265B2 (en) 2006-08-17 2013-09-03 Warsaw Orthopedic, Inc. Medical implant sheets useful for tissue regeneration
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
CA2674384C (en) * 2007-01-22 2016-11-15 Acologix, Inc. A peptide composition and a method of promoting cartilage formation
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
EP2187932B1 (de) 2007-08-07 2015-01-28 DePuy Synthes Products, LLC Proteinformulierungen mit gdf-5 in wässriger saurer lösung
CA2720845A1 (en) 2008-04-14 2009-10-22 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered gdf-5 formulations
BRPI0918611B8 (pt) 2008-09-09 2021-06-22 Biomimetic Therapeutics Inc composição que compreende uma matriz biocompatível e um fator de crescimento derivado de plaqueta e kit
US8609127B2 (en) 2009-04-03 2013-12-17 Warsaw Orthopedic, Inc. Medical implant with bioactive material and method of making the medical implant
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
CN107080834A (zh) 2010-02-22 2017-08-22 生物模拟治疗有限责任公司 用于治疗腱病的血小板衍生生长因子组合物和方法
US10034945B2 (en) 2012-07-13 2018-07-31 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
JP2016204292A (ja) * 2015-04-21 2016-12-08 国立大学法人 熊本大学 Bmp7変異体とアルブミンとの融合体、及び該融合体を含む腎疾患治療剤
US11578110B2 (en) 2015-08-25 2023-02-14 Histide Ag Compounds for inducing tissue formation and uses thereof
EP3349777A2 (de) * 2015-09-17 2018-07-25 Histide AG Pharmazeutische assoziation mit einem an einen bioaktiven träger konjugierten wachstumsfaktorrezeptoragonisten zur umwandlung einer neoplastischen zelle in eine nicht-neoplastische zelle und deren verwendungen
US10780171B2 (en) 2015-10-26 2020-09-22 President And Fellows Of Harvard College Reduced and oxidized polysaccharides and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010409A1 (en) * 1988-04-08 1989-11-02 Genetics Institute, Inc. Bone and cartilage inductive compositions
ATE162223T1 (de) * 1989-03-28 1998-01-15 Genetics Inst Osteoinduktive zusammensetzungen
DE69129865T2 (de) * 1990-10-18 1999-03-04 Stryker Corp., Kalamazoo, Mich. Osteogene peptide

Also Published As

Publication number Publication date
JPH06500991A (ja) 1994-01-27
EP0536186B1 (de) 2001-11-21
ES2168091T3 (es) 2002-06-01
DK0536186T3 (da) 2002-05-21
WO1991018098A1 (en) 1991-11-28
EP0536186A1 (de) 1993-04-14
CA2082941A1 (en) 1991-11-17
JP2001245682A (ja) 2001-09-11
DE69132823T2 (de) 2002-07-18
DE69132823D1 (de) 2002-01-03

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee