ATE193286T1 - 10- deacetylbaccatin iii und 10- deacetyl 14 beta hydroxybaccatin iii derivaten, verfahren zu deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen - Google Patents

10- deacetylbaccatin iii und 10- deacetyl 14 beta hydroxybaccatin iii derivaten, verfahren zu deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen

Info

Publication number: ATE193286T1
Authority: AT; Austria
Prior art keywords: iii; deacetyl; beta; production; pharmaceutical compositions
Prior art date: 1995-03-17

Application number

AT96904100T

Other languages

English (en)

Inventor

Ezio Bombardelli

Bellis Paolo De

Bruno Gabetta

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-17

Filing date

1996-03-04

Publication date

2000-06-15

1996-03-04 Application filed by Indena Spa filed Critical Indena Spa

2000-06-15 Application granted granted Critical

2000-06-15 Publication of ATE193286T1 publication Critical patent/ATE193286T1/de

Links

YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 title abstract 3
FNZPZCTVRVPPAB-YZSQHPIKSA-N (2ar,4s,4as,6r,9r,10s,11r,12s,12ar,12bs)-12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,10,11-pentahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5h-cyclodeca[3,4]benz[1,2-b]oxet-5-one Chemical class O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)[C@H](O)[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 FNZPZCTVRVPPAB-YZSQHPIKSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical group NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
229940123237 Taxane Drugs 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
231100000433 cytotoxic Toxicity 0.000 abstract 1
230000001472 cytotoxic effect Effects 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
125000000468 ketone group Chemical group 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrane Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT96904100T 1995-03-17 1996-03-04 10- deacetylbaccatin iii und 10- deacetyl 14 beta hydroxybaccatin iii derivaten, verfahren zu deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen ATE193286T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT95MI000533A IT1275936B1 (it)	1995-03-17	1995-03-17	Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
PCT/EP1996/000904 WO1996029321A1 (en)	1995-03-17	1996-03-04	10-DEACETYLBACCATINE III AND 10-DEACETYL 14β-HYDROXYBACCATINE III DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number	Publication Date
ATE193286T1 true ATE193286T1 (de)	2000-06-15

Family

ID=11370949

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96904100T ATE193286T1 (de)	1995-03-17	1996-03-04	10- deacetylbaccatin iii und 10- deacetyl 14 beta hydroxybaccatin iii derivaten, verfahren zu deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen

Country Status (18)

Country	Link
US (2)	US5750562A (de)
EP (1)	EP0815095B1 (de)
JP (4)	JP4101289B2 (de)
KR (2)	KR100388877B1 (de)
CN (2)	CN100335470C (de)
AT (1)	ATE193286T1 (de)
AU (1)	AU705923B2 (de)
CA (1)	CA2215682C (de)
DE (1)	DE69608548T2 (de)
DK (1)	DK0815095T3 (de)
ES (1)	ES2146389T3 (de)
GR (1)	GR3033742T3 (de)
HK (1)	HK1005242A1 (de)
IT (1)	IT1275936B1 (de)
NO (1)	NO317056B1 (de)
PT (1)	PT815095E (de)
RU (1)	RU2152936C1 (de)
WO (1)	WO1996029321A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1283633B1 (it) *	1996-05-10	1998-04-23	Indena Spa	Derivati tassanici loro sintesi e formulazioni che li contengono
ITMI991483A1 (it) *	1999-07-06	2001-01-06	Indena Spa	Derivati tassanici e procedimenti per la loro preparazione
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
IT1318678B1 (it)	2000-08-10	2003-08-27	Indena Spa	Procedimento per la preparazione di derivati della baccatina iii.
ITMI20012186A1 (it)	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012185A1 (it) *	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20021921A1 (it) *	2002-09-10	2004-03-11	Indena Spa	Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
WO2005030150A2 (en)	2003-09-25	2005-04-07	Tapestry Pharmaceuticals, Inc.	9,10-α,α-OH-TAXANE ANALOGS AND METHODS FOR PRODUCTION THEREOF
US20070225510A1 (en) *	2006-03-27	2007-09-27	Henri John T	Convergent Process for the Synthesis of Taxane Derivatives
WO2007143839A1 (en) *	2006-06-12	2007-12-21	6570763 Canada Inc.	Semi-synthetic route for the preparation of paclitaxel, docetaxel and 10-deacetylbaccatin iii from 9-dihydro-13-acetylbaccatin iii
US7847111B2 (en)	2006-06-19	2010-12-07	Canada Inc.	Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
WO2008106621A1 (en)	2007-02-28	2008-09-04	Tapestry Pharmaceuticals, Inc	Taxane analogs for the treatment of brain cancer
US11786504B2 (en)	2006-09-28	2023-10-17	Tapestry Pharmaceuticals, Inc.	Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en)	2007-03-28	2008-10-09	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration
US11873308B2 (en)	2006-11-06	2024-01-16	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration
EP2080764B1 (de)	2008-01-18	2012-08-22	INDENA S.p.A.	Feste Formen von Ortataxel

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5380916A (en) *	1990-11-02	1995-01-10	University Of Florida	Method for the isolation and purification of taxane derivatives
IT1254517B (it) *	1992-03-06	1995-09-25	Indena Spa	14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
US5200534A (en) *	1992-03-13	1993-04-06	University Of Florida	Process for the preparation of taxol and 10-deacetyltaxol
PL174374B1 (pl) *	1992-07-01	1998-07-31	Bristol Myers Squibb Co	Fluorotaksole
US5319112A (en) *	1992-08-18	1994-06-07	Virgnia Tech Intellectual Properties, Inc.	Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
MX9307777A (es) *	1992-12-15	1994-07-29	Upjohn Co	7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
CA2111527C (en) *	1992-12-24	2000-07-18	Jerzy Golik	Phosphonooxymethyl ethers of taxane derivatives
US5475011A (en) *	1993-03-26	1995-12-12	The Research Foundation Of State University Of New York	Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IT1261667B (it) *	1993-05-20	1996-05-29		Tassano ad attivita' antitumorale.
DK0703909T3 (da) *	1993-06-11	2000-09-11	Upjohn Co	Delta6,7-taxoler, antineoplastisk anvendelse og farmaceutiske præparater indeholdende dem
IL109926A (en) *	1993-06-15	2000-02-29	Bristol Myers Squibb Co	Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
FR2707293A1 (fr) *	1993-07-08	1995-01-13	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur préparation et les compositions pharmaceutiques qui les contiennent.

1995
- 1995-03-17 IT IT95MI000533A patent/IT1275936B1/it active IP Right Grant
- 1995-06-06 US US08/471,137 patent/US5750562A/en not_active Expired - Lifetime
1996
- 1996-03-04 AU AU48320/96A patent/AU705923B2/en not_active Expired
- 1996-03-04 JP JP52801996A patent/JP4101289B2/ja not_active Expired - Lifetime
- 1996-03-04 PT PT96904100T patent/PT815095E/pt unknown
- 1996-03-04 US US08/913,861 patent/US5973163A/en not_active Expired - Lifetime
- 1996-03-04 DK DK96904100T patent/DK0815095T3/da active
- 1996-03-04 EP EP96904100A patent/EP0815095B1/de not_active Expired - Lifetime
- 1996-03-04 DE DE69608548T patent/DE69608548T2/de not_active Expired - Lifetime
- 1996-03-04 WO PCT/EP1996/000904 patent/WO1996029321A1/en active IP Right Grant
- 1996-03-04 CN CNB961926074A patent/CN100335470C/zh not_active Expired - Lifetime
- 1996-03-04 RU RU97117166/04A patent/RU2152936C1/ru active
- 1996-03-04 AT AT96904100T patent/ATE193286T1/de active
- 1996-03-04 ES ES96904100T patent/ES2146389T3/es not_active Expired - Lifetime
- 1996-03-04 CA CA002215682A patent/CA2215682C/en not_active Expired - Lifetime
- 1996-03-04 CN CNB01137067XA patent/CN1176914C/zh not_active Expired - Lifetime
- 1996-03-04 KR KR10-2002-7014226A patent/KR100388877B1/ko not_active IP Right Cessation
- 1996-03-04 KR KR1019970706439A patent/KR100388878B1/ko not_active IP Right Cessation
1997
- 1997-09-16 NO NO19974266A patent/NO317056B1/no not_active IP Right Cessation
1998
- 1998-05-12 HK HK98104095A patent/HK1005242A1/xx not_active IP Right Cessation
2000
- 2000-06-22 GR GR20000401437T patent/GR3033742T3/el unknown
2007
- 2007-02-28 JP JP2007049738A patent/JP2007137898A/ja not_active Withdrawn
2010
- 2010-12-06 JP JP2010271599A patent/JP2011046744A/ja active Pending
2012
- 2012-04-13 JP JP2012091985A patent/JP2012140465A/ja active Pending

Also Published As

Publication number	Publication date
KR100388878B1 (ko)	2003-10-04
CA2215682A1 (en)	1996-09-26
AU4832096A (en)	1996-10-08
HK1005242A1 (en)	1998-12-31
RU2152936C1 (ru)	2000-07-20
DK0815095T3 (da)	2000-08-07
JP4101289B2 (ja)	2008-06-18
DE69608548T2 (de)	2001-02-01
US5973163A (en)	1999-10-26
JPH11502206A (ja)	1999-02-23
JP2011046744A (ja)	2011-03-10
EP0815095B1 (de)	2000-05-24
CN1178528A (zh)	1998-04-08
NO317056B1 (no)	2004-08-02
PT815095E (pt)	2000-09-29
KR19980703031A (ko)	1998-09-05
US5750562A (en)	1998-05-12
ES2146389T3 (es)	2000-08-01
GR3033742T3 (en)	2000-10-31
JP2007137898A (ja)	2007-06-07
JP2012140465A (ja)	2012-07-26
DE69608548D1 (de)	2000-06-29
CN1176914C (zh)	2004-11-24
KR100388877B1 (ko)	2003-06-25
EP0815095A1 (de)	1998-01-07
AU705923B2 (en)	1999-06-03
NO974266D0 (no)	1997-09-16
CN1410421A (zh)	2003-04-16
NO974266L (no)	1997-09-16
CN100335470C (zh)	2007-09-05
CA2215682C (en)	2008-01-29
IT1275936B1 (it)	1997-10-24
ITMI950533A1 (it)	1996-09-17
ITMI950533A0 (it)	1995-03-17
WO1996029321A1 (en)	1996-09-26

Legal Events

Date	Code	Title	Description
2000-11-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
ATE193286T1 (de)	2000-06-15	10- deacetylbaccatin iii und 10- deacetyl 14 beta hydroxybaccatin iii derivaten, verfahren zu deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen
HUT76829A (en)	1997-11-28	Semi-synthetic taxanes, process for producing them and pharmaceutical compositions containing them
DE69604653D1 (de)	1999-11-18	Taxol derivate, deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen
ES2158093T3 (es)	2001-09-01	Compuesto del 9-desoxotaxano.
DE59303365D1 (de)	1996-09-05	Derivate in der vitamin d-reihe mit modifikationen in der 20 position, verfahren zu ihrer herstellung, zwischenprodukte für dieses verfahren, diese derivate enthaltende pharmazeutische präparate sowie deren verwendung zur herstellung von arzneimitteln
NO964433D0 (no)	1996-10-18	Farmasöytiske preparater på basis av derivater av taxanklassen
FI955424A0 (fi)	1995-11-10	Syklodekstriinien kanssa muodostettuja taksoli- ja taksoteeri- tai Taxus-uuteinkluusiokomplekseja ja niiden valmistus ja käyttö
ATE195312T1 (de)	2000-08-15	Prozess für die herstellung von 10-deacethyl- 14beta-hydroxybaccatin iii derivaten und kompositionen, welche diese beinhalten
ATE172976T1 (de)	1998-11-15	3-aminochroman-spiroderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE3770726D1 (de)	1991-07-18	Decahydrochinolinderivate, verfahren zu ihrer herstellung und zwischenprodukte davon, ihre verwendung als arzneimittel und ihre pharmazeutischen zusammensetzungen.
DE68918597D1 (de)	1994-11-03	Neues S-Timolol Derivat und Verfahren zu seiner Herstellung.
FR2701952B1 (fr)	1995-03-31	Nouveaux dérivés cyclopeptidiques de l'angiopeptine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1278108B1 (it)	1997-11-17	Secotassani dotati di attivita' antitumorale.
IT1274356B (it)	1997-07-17	Tassani semisintetici odtati di attivita' antitumorale
CA2558908A1 (en)	1996-09-26	10-deacetylbaccatine iii and 10-deacetyl 14.beta.-hydroxybaccatine iii derivatives and intermediates useful in the preparation thereof