ATE13302T1 - 3-o-demethyl-derivate von verbindungen der istamycin b-serie und ihre herstellung. - Google Patents

3-o-demethyl-derivate von verbindungen der istamycin b-serie und ihre herstellung.

Info

Publication number
ATE13302T1
ATE13302T1 AT81303758T AT81303758T ATE13302T1 AT E13302 T1 ATE13302 T1 AT E13302T1 AT 81303758 T AT81303758 T AT 81303758T AT 81303758 T AT81303758 T AT 81303758T AT E13302 T1 ATE13302 T1 AT E13302T1
Authority
AT
Austria
Prior art keywords
istamycin
compounds
production
series compounds
demethyl
Prior art date
Application number
AT81303758T
Other languages
English (en)
Inventor
Hamao Umezawa
Shinichi Kondo
Yoshiro Okami
Original Assignee
Microbial Chem Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chem Res Found filed Critical Microbial Chem Res Found
Application granted granted Critical
Publication of ATE13302T1 publication Critical patent/ATE13302T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT81303758T 1980-09-11 1981-08-18 3-o-demethyl-derivate von verbindungen der istamycin b-serie und ihre herstellung. ATE13302T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP55125334A JPS5750996A (en) 1980-09-11 1980-09-11 3-o-demthylistamycin b derivative
EP81303758A EP0048549B1 (de) 1980-09-11 1981-08-18 3-O-Demethyl-Derivate von Verbindungen der Istamycin B-Serie und ihre Herstellung

Publications (1)

Publication Number Publication Date
ATE13302T1 true ATE13302T1 (de) 1985-06-15

Family

ID=14907532

Family Applications (1)

Application Number Title Priority Date Filing Date
AT81303758T ATE13302T1 (de) 1980-09-11 1981-08-18 3-o-demethyl-derivate von verbindungen der istamycin b-serie und ihre herstellung.

Country Status (11)

Country Link
US (1) US4499083A (de)
EP (1) EP0048549B1 (de)
JP (1) JPS5750996A (de)
KR (1) KR840001622B1 (de)
AT (1) ATE13302T1 (de)
AU (1) AU548292B2 (de)
CA (1) CA1188313A (de)
DE (1) DE3170503D1 (de)
ES (2) ES8302021A1 (de)
HU (1) HU188079B (de)
ZA (1) ZA815449B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58128395A (ja) * 1982-01-27 1983-07-30 Microbial Chem Res Found ３−０−デメチルイスタマイシンｂの低毒性誘導体
AU1937583A (en) * 1982-10-08 1984-04-12 Abbott Laboratories O-demethylation of aminoglycosides
JPS5984899A (ja) * 1982-11-05 1984-05-16 Microbial Chem Res Found ３−デメトキシイスタマイシンｂ誘導体
SI8611592A8 (en) * 1986-09-12 1995-04-30 Pliva Pharm & Chem Works Process for preparing complexes of N-methyl-11-aza-10-deoxo-10-dihydroeritromicine A and 11-aza-10-deoxo-10-dihydroeritromicine A with metals
ZA923818B (en) * 1991-05-30 1993-11-25 Bristol Myers Squibb Co Chemical modification of 2"-amino group in elsamicin A
US5237055A (en) * 1991-05-30 1993-08-17 Bristol-Myers Squibb Company Chemical modification of 2"-amino group in elsamicin A
US9035032B2 (en) * 2005-12-13 2015-05-19 Solux Corporation Method for preparing 4-demethyldaunorubicin

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124756A (en) * 1976-12-27 1978-11-07 Abbott Laboratories 3-DE-O-Methylfortimicins
SE447386B (sv) * 1978-10-18 1986-11-10 Kowa Co Aminoglykosider, komposition innehallande dem samt forfarande for framstellning av dem
US4242503A (en) * 1979-03-29 1980-12-30 Abbott Laboratories Process for O-demethylating fortimicins
US4330673A (en) * 1979-03-29 1982-05-18 Abbott Laboratories Process for producing 3-O-demethylaminoglycoside and novel 3-O-demethylfortimicin derivatives
NL8001842A (nl) * 1979-05-01 1980-11-04 Microbial Chem Res Found Nieuwe antibiotica die istamycinen zijn genoemd, werk- wijzen voor de bereiding van deze antibiotica, alsmede farmaceutische preparaten met werkzaamheid tegen bacterien die deze antibiotica bevatten en werkwijze voor het remmen van de groei van bacterien.
US4283529A (en) * 1980-03-03 1981-08-11 Abbott Laboratories 3-O-Demethyl derivatives of Sannamycin C and antibiotic AX-127B-1
US4382926A (en) * 1980-04-01 1983-05-10 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Formimidoyl A and B useful as semi-synthetic aminoglycosidic antibiotics
DE3160643D1 (en) * 1980-05-22 1983-08-25 Kowa Co Novel aminoglycosides, and antibiotic use thereof

Also Published As

Publication number Publication date
EP0048549A1 (de) 1982-03-31
JPS5750996A (en) 1982-03-25
ES505430A0 (es) 1983-01-01
CA1188313A (en) 1985-06-04
KR830006326A (ko) 1983-09-24
ES515015A0 (es) 1983-06-01
EP0048549B1 (de) 1985-05-15
US4499083A (en) 1985-02-12
ES8306766A1 (es) 1983-06-01
JPS632271B2 (de) 1988-01-18
DE3170503D1 (en) 1985-06-20
KR840001622B1 (ko) 1984-10-12
AU7436481A (en) 1982-03-18
AU548292B2 (en) 1985-12-05
ES8302021A1 (es) 1983-01-01
HU188079B (en) 1986-03-28
ZA815449B (en) 1982-09-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time