ATE114311T1 - Bivalente liganden, wirksam für die blockierung des enzyms acat. - Google Patents

Bivalente liganden, wirksam für die blockierung des enzyms acat.

Info

Publication number: ATE114311T1
Authority: AT; Austria
Prior art keywords: blocking; bivalent ligands; acat; ligands effective; enzyme acat
Prior art date: 1988-08-16

Application number

AT89907579T

Other languages

English (en)

Inventor

Ronald B Gammill

Frank P Bell

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-16

Filing date

1989-06-16

Publication date

1994-12-15

1989-06-16 Application filed by Upjohn Co filed Critical Upjohn Co

1994-12-15 Application granted granted Critical

1994-12-15 Publication of ATE114311T1 publication Critical patent/ATE114311T1/de

Links

102000004190 Enzymes Human genes 0.000 title abstract 2
108090000790 Enzymes Proteins 0.000 title abstract 2
230000000903 blocking effect Effects 0.000 title abstract 2
239000003446 ligand Substances 0.000 title abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
201000001320 Atherosclerosis Diseases 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000004060 metabolic process Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Plural Heterocyclic Compounds (AREA)

AT89907579T 1988-08-16 1989-06-16 Bivalente liganden, wirksam für die blockierung des enzyms acat. ATE114311T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US23293188A	1988-08-16	1988-08-16

Publications (1)

Publication Number	Publication Date
ATE114311T1 true ATE114311T1 (de)	1994-12-15

Family

ID=22875168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89907579T ATE114311T1 (de)	1988-08-16	1989-06-16	Bivalente liganden, wirksam für die blockierung des enzyms acat.

Country Status (7)

Country	Link
EP (1)	EP0429464B1 (de)
JP (1)	JPH04500506A (de)
KR (1)	KR900701792A (de)
AT (1)	ATE114311T1 (de)
DE (1)	DE68919475T2 (de)
DK (1)	DK25691A (de)
WO (1)	WO1990002129A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5304548A (en) *	1988-08-16	1994-04-19	The Upjohn Company	Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol
US5180717A (en) *	1988-08-16	1993-01-19	The Upjohn Company	Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol
WO1995027964A1 (en) *	1994-04-12	1995-10-19	Qualcomm Incorporated	Method and apparatus for freight transportation using a satellite navigation system
WO2009038064A1 (ja) *	2007-09-19	2009-03-26	Institute Of Medicinal Molecular Design, Inc.	Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有する複素環誘導体
AU2009221179A1 (en) *	2008-03-05	2009-09-11	Boehringer Ingelheim International Gmbh	Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
SG183321A1 (en)	2010-02-19	2012-09-27	Boehringer Ingelheim Int	Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
WO2013024130A1 (en)	2011-08-17	2013-02-21	Boehringer Ingelheim International Gmbh	Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation
CN107021940A (zh) *	2017-05-03	2017-08-08	天津国际生物医药联合研究院	一种双哌嗪类化合物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU529561B2 (en) *	1979-02-13	1983-06-09	Upjohn Company, The	Antiatherogenic 6-halofurochromones
US4412071A (en) *	1982-05-17	1983-10-25	The Upjohn Company	Antiatherosclerotic compositions

1989
- 1989-06-16 WO PCT/US1989/002572 patent/WO1990002129A1/en active IP Right Grant
- 1989-06-16 AT AT89907579T patent/ATE114311T1/de not_active IP Right Cessation
- 1989-06-16 KR KR1019900700773A patent/KR900701792A/ko not_active Application Discontinuation
- 1989-06-16 JP JP1507138A patent/JPH04500506A/ja active Pending
- 1989-06-16 EP EP89907579A patent/EP0429464B1/de not_active Expired - Lifetime
- 1989-06-16 DE DE68919475T patent/DE68919475T2/de not_active Expired - Fee Related
1991
- 1991-02-14 DK DK025691A patent/DK25691A/da unknown

Also Published As

Publication number	Publication date
AU3835889A (en)	1990-03-23
EP0429464B1 (de)	1994-11-23
DK25691D0 (da)	1991-02-14
AU631801B2 (en)	1992-12-10
EP0429464A1 (de)	1991-06-05
DE68919475D1 (de)	1995-01-05
DE68919475T2 (de)	1995-05-11
JPH04500506A (ja)	1992-01-30
KR900701792A (ko)	1990-12-04
DK25691A (da)	1991-02-14
WO1990002129A1 (en)	1990-03-08

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Legal Events

Date	Code	Title	Description
1996-09-15	REN	Ceased due to non-payment of the annual fee