ES8609468A1 - Un procedimiento para preparar un derivado de una enzima fibronolitica - Google Patents

Un procedimiento para preparar un derivado de una enzima fibronolitica

Info

Publication number
ES8609468A1
ES8609468A1 ES539000A ES539000A ES8609468A1 ES 8609468 A1 ES8609468 A1 ES 8609468A1 ES 539000 A ES539000 A ES 539000A ES 539000 A ES539000 A ES 539000A ES 8609468 A1 ES8609468 A1 ES 8609468A1
Authority
ES
Spain
Prior art keywords
enzyme
preparation
pharmaceutical use
protein conjugate
fibrinolytic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539000A
Other languages
English (en)
Other versions
ES539000A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES539000A0 publication Critical patent/ES539000A0/es
Publication of ES8609468A1 publication Critical patent/ES8609468A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PREPARACION DE UN DERIVADO DE UNA ENZIMA FIBRINOLITICA. SE HACE REACCIONAR UNA PROTEINA HUMANA OPCIONALMENTE MODIFICADA PARA INCLUIR UN GRUPO DE UNION A LA PROTEINA CON UNA ENZIMA FIBRINOLITICA Y CON UN AGENTE ENLAZANTE QUE TIENE UN RESTO CAPAZ DE REACCIONAR CON EL SITIO CATALITICO DE LA ENZIMA Y UN RESTO CAPAZ DE REACCIONAR CON UN GRUPO AMINO DE UNA PROTEINA O UN GRUPO DE UNION A LA PROTEINA PARA FORMAR UN GRUPO ENLAZANTE REVERSIBLE. EL SITIO CATALITICO DE LA ENZIMA RESPONSABLE DE LA ACCION FIBRINOLITICA ESTA BLOQUEADO POR UNA PROTEINA HUMANA UNIDA A ELLA POR UN GRUPO ENLAZANTE REVERSIBLE QUE LE CONFIERE ACTIVIDAD PARA SU EMPLEO EN ENFERMEDADES TROMBOTICAS.
ES539000A 1983-12-24 1984-12-21 Un procedimiento para preparar un derivado de una enzima fibronolitica Expired ES8609468A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838334499A GB8334499D0 (en) 1983-12-24 1983-12-24 Derivatives

Publications (2)

Publication Number Publication Date
ES539000A0 ES539000A0 (es) 1986-09-01
ES8609468A1 true ES8609468A1 (es) 1986-09-01

Family

ID=10553871

Family Applications (2)

Application Number Title Priority Date Filing Date
ES539000A Expired ES8609468A1 (es) 1983-12-24 1984-12-21 Un procedimiento para preparar un derivado de una enzima fibronolitica
ES546739A Expired ES8605476A1 (es) 1983-12-24 1985-09-05 Un procedimiento para preparar un derivado de acido benzoico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES546739A Expired ES8605476A1 (es) 1983-12-24 1985-09-05 Un procedimiento para preparar un derivado de acido benzoico.

Country Status (12)

Country Link
US (3) US4600580A (es)
EP (2) EP0283563B1 (es)
JP (1) JPH0829085B2 (es)
AU (1) AU580747B2 (es)
CA (1) CA1271718A (es)
DE (2) DE3484655D1 (es)
ES (2) ES8609468A1 (es)
GB (1) GB8334499D0 (es)
GR (1) GR82558B (es)
MX (1) MX7663E (es)
NZ (1) NZ210696A (es)
ZA (1) ZA849927B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650270A (en) * 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
US4880776A (en) * 1983-12-24 1989-11-14 Beecham Group P.L.C. Plasmin A-chain urokinase B-chain hybrid protein
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
GB8430253D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
US4916070A (en) * 1986-04-14 1990-04-10 The General Hospital Corporation Fibrin-specific antibodies and method of screening for the antibodies
GB8707369D0 (en) * 1987-03-27 1987-04-29 Beecham Group Plc Enzyme derivatives
US5217705A (en) * 1987-09-25 1993-06-08 Neorx Corporation Method of diagnosing blood clots using fibrin-binding proteins
US5151359A (en) * 1988-05-19 1992-09-29 Mitsui Toatsu Chemicals Incorporated Method for producing of human tissue type plasminogen activator
US5609869A (en) * 1988-08-19 1997-03-11 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
US5811265A (en) * 1988-08-19 1998-09-22 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
US5183754A (en) * 1988-10-04 1993-02-02 Mitsui Toatsu Chemicals, Incorporated Method for production of human tissue type plasminogen activator
US5272076A (en) * 1991-06-13 1993-12-21 Eli Lilly And Company Compounds and methods for treatment of thromboembolic disorders using an adduct of t-PA
US6608204B1 (en) * 1994-12-13 2003-08-19 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
EP1028752B1 (en) * 1996-10-21 2004-12-15 Quadrant Drug Delivery Limited Platelet substitutes and conjugation methods suitable for their preparation
EP0973384A4 (en) * 1997-02-13 2004-10-13 Sky High Llc ORGAN PRESERVATION SOLUTION
WO2004082640A2 (en) * 2003-03-19 2004-09-30 New Century Pharmaceuticals, Inc. Human serum albumin conjugates with therapeutic compounds
US7541159B2 (en) * 2004-04-14 2009-06-02 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Molecular-specific urokinase antibodies
US10878790B1 (en) 2020-03-13 2020-12-29 Aspire Precision Instruments, LLC Device and method for amplitude modulated optical pickup for a stringed instrument

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US428593A (en) * 1890-05-27 Sleigh
US4464468A (en) * 1968-03-29 1984-08-07 Agence Nationale De Valorisation De La Recherche (Anvar) Immobilization of active protein by cross-linking to inactive protein
GB1463513A (en) * 1974-08-13 1977-02-02 Beecham Group Ltd Enzymes
CS181417B1 (en) * 1975-03-27 1978-03-31 Miroslav Bleha Method for preparing insoluble biologically active compounds
DE2621974A1 (de) * 1976-05-18 1977-11-24 Max Planck Gesellschaft Verfahren zur herstellung eines zur kovalenten bindung mit biologisch aktivem material befaehigten traegermaterials
US4082612A (en) * 1976-09-24 1978-04-04 Michael Reese Research Foundation Plasminogen activator complex
US4134792A (en) * 1976-12-06 1979-01-16 Miles Laboratories, Inc. Specific binding assay with an enzyme modulator as a labeling substance
SE427505B (sv) * 1977-03-04 1983-04-11 Pharmacia Diagnostics Ab Reagens till anvendning vid immunkemiska bestemningsmetoder
SE430062B (sv) * 1977-03-04 1983-10-17 Pharmacia Fine Chemicals Ab Kopplings- eller tioleringsreagens
US4233401A (en) * 1977-07-14 1980-11-11 Syva Company Antienzyme homogeneous competitive binding assay
US4275000A (en) * 1977-08-22 1981-06-23 National Research Development Corporation Peptide macromolecular complexes
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions
SE446184B (sv) * 1979-01-12 1986-08-18 Toyo Jozo Kk Polyfunktionell disulfidforening anvendbar som tverbindande medel
US4305926A (en) * 1979-09-13 1981-12-15 Johannes Everse Immobilization of Streptokinase
US4286964A (en) * 1979-10-12 1981-09-01 Seed Brian S Polyfunctional epoxides and halohydrins used as bridging groups to bind aromatic amine group-containing alcohols and thiols to hydroxyl bearing substrates
FR2470773B1 (es) * 1979-11-28 1983-01-28 Pasteur Institut
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
SE450834B (sv) * 1980-11-19 1987-08-03 Biocompat Inc Sett att binda ett protein till en berare innehallande hydroxylgrupper
SE8102193L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och dess anvendning
US4429008B1 (en) * 1981-12-10 1995-05-16 Univ California Thiol reactive liposomes
EP0091240B1 (en) * 1982-04-07 1985-12-27 Beecham Group Plc Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them
US4536391A (en) * 1982-11-17 1985-08-20 Otsuka Pharmaceutical Co. Process for preparing urokinase complex
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
US4542225A (en) * 1984-08-29 1985-09-17 Dana-Farber Cancer Institute, Inc. Acid-cleavable compound

Also Published As

Publication number Publication date
DE3477469D1 (en) 1989-05-03
EP0155388B1 (en) 1989-03-29
US4741903A (en) 1988-05-03
GR82558B (en) 1985-04-23
EP0283563B1 (en) 1991-05-29
ES8605476A1 (es) 1986-03-16
US4600580A (en) 1986-07-15
EP0283563A3 (en) 1988-11-23
EP0155388A3 (en) 1986-12-10
JPH0829085B2 (ja) 1996-03-27
AU580747B2 (en) 1989-02-02
MX7663E (es) 1990-06-19
JPS60178864A (ja) 1985-09-12
ES546739A0 (es) 1986-03-16
EP0155388A2 (en) 1985-09-25
NZ210696A (en) 1989-04-26
ES539000A0 (es) 1986-09-01
CA1271718A (en) 1990-07-17
US4730050A (en) 1988-03-08
ZA849927B (en) 1986-04-30
AU3707284A (en) 1985-07-04
EP0283563A2 (en) 1988-09-28
GB8334499D0 (en) 1984-02-01
DE3484655D1 (de) 1991-07-04

Similar Documents

Publication Publication Date Title
ES8609468A1 (es) Un procedimiento para preparar un derivado de una enzima fibronolitica
EP0152736A3 (en) Enzyme-protein conjugate, process for its preparation and pharmaceutical composition
MY114889A (en) 1-phenyl-3-dimethylamino-propane derivatives having pharmacological activity
MY101593A (en) Sustained release preparation.
PT82575A (fr) Procede de preparation d'un produit conjugue constitue d'une adhesine de s.mutans de nature proteique d'une composition a activite immunogene et d'un polysaccharide de s.mutans et son utilisation notamment dans des vaccins anti-caries
AU649605B2 (en) Retinal, derivatives and their therapeutic use
AU1917095A (en) 6-substituted mycophenolic and derivatives with immunosuppressive activity
NO891380L (no) Anti-inflammatorisk hudfuktingspreparat og fremgangsmaate for fremstilling derav.
EP0211592A3 (en) Pharmaceutical dosage unit
EP0233013A3 (en) Modified enzyme
DK159652C (da) Cholecalciferolderivater, disse derivater til brug som terapeutisk aktive substanser, fremgangsmaade til fremstilling deraf samt farmaceutisk praeparat baseret paa disse cholecalciferolderivater
NO854942L (no) Fremgangsmaate for fremstilling av terapeutisk aktive, benzotiofener og benzofuraner.
NO862534L (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-oxy-4h-3,1-benzoxazin-4-on-derivater og beslektede forbindelser.
DE3776620D1 (de) 3-propenylcephemderivate, ihre herstellung, zwischenverbindungen, pharmazeutische praeparate und anwendung.
NO892798D0 (no) Pyrazolyleterderivater, fremgangsmaate for fremstilling avdisse, preparater og anvendelse derav.
AU5668286A (en) Carbohydrate derivatives and compositions thereof for therapeutic or diagnostic use, and methods for their use
NO901396L (no) Fytosanitaere preparater, deres fremstilling og deres anvendelse for behandling av kryptogame sykdommer.
IT8423896A0 (it) Diacilderivati della glicerilfosforilcolina ad attivita' terapeutica, procedimento per laloro preparazione e relative composizioni farmaceutiche.
AU8282187A (en) 5-hydroxyethyl derivatives of oxazolidinone-2, their preparation and their therapeutic uses
EP0270682A4 (en) NEW COMPLEXES, PROCESS FOR THEIR PREPARATION, AND THEIR MEDICINAL USE.
HU912742D0 (en) T-pa pro-stabilization
EP0184363A3 (en) Enzyme conjugates and their therapeutical use
NO168055C (no) Fremgangsmaate for fremstilling av human vevplasminogenaktivator og urokinase-type plasminogenaktivator.
NO166280C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive n,n'-disubstituerte ureaer.
NO871634D0 (no) Plantevernmidler og fremgangsmaate for deres fremstilling.

Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506