DK25691D0 - Bivalente ligandforbindelser og deres anvendelse til blokering af cholesterol-o-acyltransferaseenzymet (acat) - Google Patents

Bivalente ligandforbindelser og deres anvendelse til blokering af cholesterol-o-acyltransferaseenzymet (acat)

Info

Publication number: DK25691D0
Authority: DK; Denmark
Prior art keywords: acat; cholesterol; bival; block; ligand compounds
Prior art date: 1988-08-16

Application number

DK025691A

Other languages

English (en)

Other versions

DK25691A (da

Inventor

Ronald B Gammill

Frank P Bell

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-16

Filing date

1991-02-14

Publication date

1991-02-14

1991-02-14 Application filed by Upjohn Co filed Critical Upjohn Co

1991-02-14 Publication of DK25691D0 publication Critical patent/DK25691D0/da

1991-02-14 Publication of DK25691A publication Critical patent/DK25691A/da

Links

150000001875 compounds Chemical class 0.000 title abstract 3
239000003446 ligand Substances 0.000 title abstract 2
102000004357 Transferases Human genes 0.000 title 1
108090000992 Transferases Proteins 0.000 title 1
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
201000001320 Atherosclerosis Diseases 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000004060 metabolic process Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

DK025691A 1988-08-16 1991-02-14 Bivalente ligandforbindelser og deres anvendelse til blokering af cholesterol-o-acyltransferaseenzymet (acat) DK25691A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US23293188A	1988-08-16	1988-08-16
PCT/US1989/002572 WO1990002129A1 (en)	1988-08-16	1989-06-16	Bivalent ligands effective for blocking acat enzyme

Publications (2)

Publication Number	Publication Date
DK25691D0 true DK25691D0 (da)	1991-02-14
DK25691A DK25691A (da)	1991-02-14

Family

ID=22875168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK025691A DK25691A (da)	1988-08-16	1991-02-14	Bivalente ligandforbindelser og deres anvendelse til blokering af cholesterol-o-acyltransferaseenzymet (acat)

Country Status (7)

Country	Link
EP (1)	EP0429464B1 (da)
JP (1)	JPH04500506A (da)
KR (1)	KR900701792A (da)
AT (1)	ATE114311T1 (da)
DE (1)	DE68919475T2 (da)
DK (1)	DK25691A (da)
WO (1)	WO1990002129A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5304548A (en) *	1988-08-16	1994-04-19	The Upjohn Company	Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol
US5180717A (en) *	1988-08-16	1993-01-19	The Upjohn Company	Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol
WO1995027964A1 (en) *	1994-04-12	1995-10-19	Qualcomm Incorporated	Method and apparatus for freight transportation using a satellite navigation system
JPWO2009038064A1 (ja) *	2007-09-19	2011-01-06	株式会社医薬分子設計研究所	Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有する複素環誘導体
PL2268644T3 (pl)	2008-03-05	2012-01-31	Boehringer Ingelheim Int	Tricykliczne pochodne piperydyny, leki zawierające te związki, ich zastosowanie i sposoby ich wytwarzania
SG183321A1 (en)	2010-02-19	2012-09-27	Boehringer Ingelheim Int	Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
EP2760868B1 (en)	2011-08-17	2018-04-25	Boehringer Ingelheim International GmbH	Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation
CN107021940A (zh) *	2017-05-03	2017-08-08	天津国际生物医药联合研究院	一种双哌嗪类化合物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU529561B2 (en) *	1979-02-13	1983-06-09	Upjohn Company, The	Antiatherogenic 6-halofurochromones
US4412071A (en) *	1982-05-17	1983-10-25	The Upjohn Company	Antiatherosclerotic compositions

1989
- 1989-06-16 WO PCT/US1989/002572 patent/WO1990002129A1/en active IP Right Grant
- 1989-06-16 JP JP1507138A patent/JPH04500506A/ja active Pending
- 1989-06-16 DE DE68919475T patent/DE68919475T2/de not_active Expired - Fee Related
- 1989-06-16 AT AT89907579T patent/ATE114311T1/de not_active IP Right Cessation
- 1989-06-16 KR KR1019900700773A patent/KR900701792A/ko not_active Application Discontinuation
- 1989-06-16 EP EP89907579A patent/EP0429464B1/en not_active Expired - Lifetime
1991
- 1991-02-14 DK DK025691A patent/DK25691A/da unknown

Also Published As

Publication number	Publication date
DE68919475T2 (de)	1995-05-11
EP0429464B1 (en)	1994-11-23
EP0429464A1 (en)	1991-06-05
ATE114311T1 (de)	1994-12-15
JPH04500506A (ja)	1992-01-30
WO1990002129A1 (en)	1990-03-08
KR900701792A (ko)	1990-12-04
AU631801B2 (en)	1992-12-10
DE68919475D1 (de)	1995-01-05
DK25691A (da)	1991-02-14
AU3835889A (en)	1990-03-23

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