DE3780506D1 - Reinigung des einkettigen und zweikettigen gewebeplasminogenaktivators. - Google Patents

Reinigung des einkettigen und zweikettigen gewebeplasminogenaktivators.

Info

Publication number
DE3780506D1
DE3780506D1 DE8787304077T DE3780506T DE3780506D1 DE 3780506 D1 DE3780506 D1 DE 3780506D1 DE 8787304077 T DE8787304077 T DE 8787304077T DE 3780506 T DE3780506 T DE 3780506T DE 3780506 D1 DE3780506 D1 DE 3780506D1
Authority
DE
Germany
Prior art keywords
cleaning
tissue plasminogen
plasminogen activators
chain tissue
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787304077T
Other languages
English (en)
Other versions
DE3780506T2 (de
Inventor
Mitsuyoshi Morii
Toshihiko Suzuki
Masaharu Mitsui Toatsu I Ohoka
Katsuyuki Suzuki
Nobuhiro Kawashima
Kunizo Mitsui Toatsu Iimi Mori
Noriko Morii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP10320086A external-priority patent/JPH0779692B2/ja
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Application granted granted Critical
Publication of DE3780506D1 publication Critical patent/DE3780506D1/de
Publication of DE3780506T2 publication Critical patent/DE3780506T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8787304077T 1986-05-07 1987-05-07 Reinigung des einkettigen und zweikettigen gewebeplasminogenaktivators. Expired - Fee Related DE3780506T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10320086A JPH0779692B2 (ja) 1986-05-07 1986-05-07 一本鎖ｔ−ＰＡと二本鎖ｔ−ＰＡを分離する方法
JP18685086 1986-08-11

Publications (2)

Publication Number Publication Date
DE3780506D1 true DE3780506D1 (de) 1992-08-27
DE3780506T2 DE3780506T2 (de) 1993-01-07

Family

ID=26443851

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787304077T Expired - Fee Related DE3780506T2 (de) 1986-05-07 1987-05-07 Reinigung des einkettigen und zweikettigen gewebeplasminogenaktivators.

Country Status (8)

Country Link
US (1) US4898825A (de)
EP (1) EP0245100B1 (de)
AU (1) AU590840B2 (de)
CA (1) CA1284961C (de)
DE (1) DE3780506T2 (de)
DK (1) DK173151B1 (de)
FI (1) FI96211C (de)
NO (1) NO173287C (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001355A (en) * 1982-12-14 1999-12-14 Dowdle; Eugene Bernard Davey Pro-tPA for the treatment of thrombosis, embolism and related conditions
JP2507339B2 (ja) * 1986-08-11 1996-06-12 三井東圧化学株式会社 粗ｔＰＡの精製方法
US4898826A (en) * 1987-12-10 1990-02-06 Invitron Corporation Method to solubilize tissue plasminogen activator
DE3832898A1 (de) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh Praeparat von in prokaryonten exprimiertem plasminogenaktivator
US5676947A (en) * 1989-02-07 1997-10-14 Boehringer Manneheim Gmbh Method for treating thromboembolic conditions using thrombolytically active proteins
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat
US6326155B1 (en) 1995-03-20 2001-12-04 Dyax Corp. Engineering affinity ligands for macromolecules
US5612473A (en) * 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
US5731186A (en) * 1996-02-05 1998-03-24 Schering Aktiengesellschaft Method for the production of rDSPA α1
AU715608B2 (en) * 1996-03-20 2000-02-03 Morphosys Ag Purification of tissue plasminogen activator (tPA)
WO2016073668A1 (en) * 2014-11-06 2016-05-12 The Regents Of The University Of Colorado Identification of novel disease states using viscoelastic analysis in the presence of a thrombolytic agent
WO2016200765A1 (en) 2015-06-08 2016-12-15 The Regents Of The University Of Colorado, A Body Corporate Time independent viscoelastic analysis parameter for prediction of patient outcome
EP3455366A4 (de) 2016-05-11 2020-02-26 Michael P. Chapman Viskoelastische analyse bei patienten mit krankheiten in zusammenhang mit dem kardiovaskulären system

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
EP0112122B1 (de) * 1982-12-14 1991-08-28 South African Inventions Development Corporation Plasminogenaktivator
GR80966B (en) * 1983-11-21 1985-03-15 Ciba Geigy Ag Synthesis of fibrinolytic agents by yeast
AU606582B2 (en) * 1985-09-06 1991-02-14 Codon Methods for the recovery of tissue plasminogen activator

Also Published As

Publication number Publication date
EP0245100B1 (de) 1992-07-22
AU7241887A (en) 1987-11-12
EP0245100A3 (en) 1988-01-07
DE3780506T2 (de) 1993-01-07
FI96211C (fi) 1996-05-27
NO871883D0 (no) 1987-05-06
DK233787D0 (da) 1987-05-07
DK233787A (da) 1987-11-08
CA1284961C (en) 1991-06-18
FI871948A0 (fi) 1987-05-04
FI96211B (fi) 1996-02-15
NO173287C (no) 1993-11-24
DK173151B1 (da) 2000-02-14
FI871948A (fi) 1987-11-08
NO173287B (no) 1993-08-16
NO871883L (no) 1987-11-09
EP0245100A2 (de) 1987-11-11
AU590840B2 (en) 1989-11-16
US4898825A (en) 1990-02-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MITSUI CHEMICALS, INC., TOKIO/TOKYO, JP

8327 Change in the person/name/address of the patent owner

Owner name: SCHERING AG, 13353 BERLIN, DE

8339 Ceased/non-payment of the annual fee