ATA224988A - Wasserloesliche monoester als solubilisatoren fuer pharmakologische wirkstoffe und pharmazeutische hilfsstoffe - Google Patents

Wasserloesliche monoester als solubilisatoren fuer pharmakologische wirkstoffe und pharmazeutische hilfsstoffe

Info

Publication number
ATA224988A
ATA224988A AT0224988A AT224988A ATA224988A AT A224988 A ATA224988 A AT A224988A AT 0224988 A AT0224988 A AT 0224988A AT 224988 A AT224988 A AT 224988A AT A224988 A ATA224988 A AT A224988A
Authority
AT
Austria
Prior art keywords
solubilizers
water
substances
pharmacological active
pharmaceutical auxiliary
Prior art date
Application number
AT0224988A
Other languages
English (en)
Other versions
AT395819B (de
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of ATA224988A publication Critical patent/ATA224988A/de
Application granted granted Critical
Publication of AT395819B publication Critical patent/AT395819B/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
AT0224988A 1987-09-15 1988-09-14 Wasserloesliche monoester als solubilisatoren fuer pharmakologische wirkstoffe und pharmazeutische hilfsstoffe AT395819B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3730909 1987-09-15
DE3802355 1988-01-27

Publications (2)

Publication Number Publication Date
ATA224988A true ATA224988A (de) 1992-08-15
AT395819B AT395819B (de) 1993-03-25

Family

ID=25859774

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0224988A AT395819B (de) 1987-09-15 1988-09-14 Wasserloesliche monoester als solubilisatoren fuer pharmakologische wirkstoffe und pharmazeutische hilfsstoffe

Country Status (24)

Country Link
JP (1) JP3090666B2 (de)
KR (1) KR0131084B1 (de)
AT (1) AT395819B (de)
AU (1) AU628787B2 (de)
BE (1) BE1001204A5 (de)
CA (1) CA1338775C (de)
CH (1) CH683672A5 (de)
DK (1) DK175132B1 (de)
ES (1) ES2012118A6 (de)
FI (1) FI94837C (de)
FR (1) FR2620336B1 (de)
GB (1) GB2209671B (de)
GR (1) GR1002243B (de)
HU (1) HU205010B (de)
IE (1) IE61195B1 (de)
IL (1) IL87746A (de)
IT (1) IT1224886B (de)
LU (1) LU87335A1 (de)
MY (1) MY103769A (de)
NL (1) NL195094C (de)
NO (1) NO179434C (de)
NZ (1) NZ226163A (de)
PT (1) PT88492B (de)
SE (1) SE503279C2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
GR1000466B (el) * 1989-01-28 1992-07-30 Sandoz Ag Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης.
BE1003009A5 (fr) * 1989-02-09 1991-10-22 Sandoz Sa Nouvelles compositions pharmaceutiques a base de cyclosporines.
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
ES2098739T3 (es) 1992-05-13 1997-05-01 Sandoz Ltd Composiciones oftalmicas conteniendo una cyclosporin.
EP0589843B1 (de) 1992-09-25 2001-11-28 Novartis AG Cyclosporin enthaltende pharmazeutische Zusammensetzungen
ATE398448T1 (de) * 1993-09-28 2008-07-15 Scherer Gmbh R P Herstellung von weichgelatinekapseln
RU2158601C2 (ru) 1994-11-03 2000-11-10 Новартис Аг Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
TW414696B (en) * 1996-07-01 2000-12-11 Mitsubishi Kagaku Foods Kk Anti-bacteria agent
NZ336900A (en) 1997-01-30 2001-06-29 Novartis Ag Hard gelatine capsules containing pharmaceutical compositions comprising cyclosporin A and being substantially free of any oil
GB2326337A (en) * 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
EP1558215A4 (de) * 2003-10-14 2007-09-12 Wockhardt Ltd Sterile geliermittel
JP5422871B2 (ja) * 2006-10-24 2014-02-19 不二製油株式会社 イソフラボン類組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE624258A (de) * 1961-10-31
GB1134878A (en) * 1966-05-12 1968-11-27 Suga Kazuo Improvements in and relating to oryzanol solutions and compositions
FR5986M (de) * 1966-11-22 1968-06-21
BE787842A (fr) * 1971-08-25 1972-12-18 Sumito Chemical Cy Ltd Procede de preparation d'une suspension aqueuse de cristaux stables du type non beta d'esters d'acides gras superieurs du chloramphenicol
JPS53107408A (en) * 1977-02-28 1978-09-19 Yamanouchi Pharmaceut Co Ltd Micellar preparation for rectal infusion
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
JPS57128634A (en) * 1981-02-03 1982-08-10 Eisai Co Ltd Elastase-containing compound increasing absorption
EP0179583A1 (de) * 1984-10-04 1986-04-30 Merck & Co. Inc. System zur Verbesserung der Auflösungsgeschwindigkeit in Wasser und der Löslichkeit von schwer löslichen Arzneimitteln
JPS61280435A (ja) * 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤

Also Published As

Publication number Publication date
MY103769A (en) 1993-09-30
KR0131084B1 (ko) 1998-04-17
GB2209671B (en) 1991-11-13
JPH01151526A (ja) 1989-06-14
NO179434B (no) 1996-07-01
FI94837C (fi) 1995-11-10
AU2217288A (en) 1989-04-27
NL8802275A (nl) 1989-04-03
AT395819B (de) 1993-03-25
IL87746A0 (en) 1989-02-28
NO179434C (no) 1996-10-09
DK511188D0 (da) 1988-09-14
SE8803221L (sv) 1989-03-16
FI884192A0 (fi) 1988-09-13
NO884052L (no) 1989-03-16
IE882772L (en) 1989-03-15
LU87335A1 (fr) 1989-04-06
AU628787B2 (en) 1992-09-24
CH683672A5 (de) 1994-04-29
DK175132B1 (da) 2004-06-14
FR2620336A1 (fr) 1989-03-17
GR880100602A (el) 1989-06-22
IT8848349A0 (it) 1988-09-14
NZ226163A (en) 1991-08-27
IT1224886B (it) 1990-10-24
PT88492B (pt) 1993-03-31
GR1002243B (en) 1996-04-22
JP3090666B2 (ja) 2000-09-25
SE503279C2 (sv) 1996-05-13
PT88492A (pt) 1988-10-01
IL87746A (en) 1992-07-15
NL195094C (nl) 2003-12-17
SE8803221D0 (sv) 1988-09-13
CA1338775C (en) 1996-12-10
DK511188A (da) 1989-03-16
HU205010B (en) 1992-03-30
GB8821443D0 (en) 1988-10-12
GB2209671A (en) 1989-05-24
HUT49494A (en) 1989-10-30
ES2012118A6 (es) 1990-03-01
BE1001204A5 (fr) 1989-08-16
FI94837B (fi) 1995-07-31
NO884052D0 (no) 1988-09-13
FI884192A (fi) 1989-03-16
IE61195B1 (en) 1994-10-19
FR2620336B1 (fr) 1991-10-25
KR890004694A (ko) 1989-05-09

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