ATA130287A - Verfahren zur herstellung neuer 1-(hydroxystyryl)-5h-2,3-benzodiazepin-derivate - Google Patents

Verfahren zur herstellung neuer 1-(hydroxystyryl)-5h-2,3-benzodiazepin-derivate

Info

Publication number
ATA130287A
ATA130287A AT0130287A AT130287A ATA130287A AT A130287 A ATA130287 A AT A130287A AT 0130287 A AT0130287 A AT 0130287A AT 130287 A AT130287 A AT 130287A AT A130287 A ATA130287 A AT A130287A
Authority
AT
Austria
Prior art keywords
hydroxystyryl
producing new
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
AT0130287A
Other languages
English (en)
Other versions
AT395009B (de
Inventor
Tibor Chem Ing Dr Lang
Jenoe Chem Ing Dr Koroesi
Gyoergy Dr Rabloczky
Tamas Chem Ing Hamori
Maria Kuhar
Istvan Dr Polgari
Istvan Dr Elekes
Gabor Chem Ing Dr Zolyomi
Krisztina Dr Heltai
Judit Sarossy
Zsuzsanna Dr Lang
Imre Chem Ing Moravcsik
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ATA130287A publication Critical patent/ATA130287A/de
Application granted granted Critical
Publication of AT395009B publication Critical patent/AT395009B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT0130287A 1986-05-21 1987-05-21 Verfahren zur herstellung neuer 1-(hydroxystyryl)-5h-2,3-benzodiazepin-derivate AT395009B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862140A HU195788B (en) 1986-05-21 1986-05-21 Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
ATA130287A true ATA130287A (de) 1992-01-15
AT395009B AT395009B (de) 1992-08-25

Family

ID=10957976

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0130287A AT395009B (de) 1986-05-21 1987-05-21 Verfahren zur herstellung neuer 1-(hydroxystyryl)-5h-2,3-benzodiazepin-derivate

Country Status (24)

Country Link
US (1) US4840948A (de)
JP (1) JPS6322082A (de)
AT (1) AT395009B (de)
BE (1) BE1000573A4 (de)
BG (1) BG46003A3 (de)
CA (1) CA1280748C (de)
CH (1) CH671226A5 (de)
CS (1) CS262690B2 (de)
DD (1) DD268943A5 (de)
DE (1) DE3717080C2 (de)
DK (1) DK258187A (de)
ES (1) ES2005582A6 (de)
FI (1) FI91964C (de)
FR (1) FR2599034B1 (de)
GB (1) GB2190677B (de)
HU (1) HU195788B (de)
IL (1) IL82613A (de)
IT (1) IT1205665B (de)
NL (1) NL8701213A (de)
PL (1) PL147687B1 (de)
PT (1) PT84923B (de)
SE (1) SE468560B (de)
SU (1) SU1503681A3 (de)
YU (1) YU46675B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380721A (en) * 1990-09-10 1995-01-10 Sterling Winthrop Inc. Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents
HU224435B1 (hu) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
SK283859B6 (sk) * 1995-02-09 2004-03-02 EGIS Gyógyszergyár Rt. 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie
EP0726256A1 (de) * 1995-02-09 1996-08-14 Egis Gyogyszergyar Rt. 1-Arylvinyl-3,4-dihydro-5H-2,3-benzodiazepinderivative verwendbar zur Behandlung von Erkrankungen des Zentralnervensystems
ES2111493B1 (es) * 1996-02-08 1999-08-01 Egyt Gyogyszervegyeszeti Gyar Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes.
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US7745431B2 (en) * 2002-12-03 2010-06-29 Vela Acquisition Corporation Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5H-2,3-benzodiazepine and uses thereof
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
MXPA05005893A (es) * 2002-12-03 2006-02-08 Vela Pharmaceuticals Inc Composicion farmaceutica de 1-(3-hidroxi -4-metoxifenil) -4-metil-5 -etil-7, 8-dimetoxi- 5h-2, 3-benzodiazepina y usos de la misma.
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines

Also Published As

Publication number Publication date
HUT44521A (en) 1988-03-28
PT84923A (en) 1987-06-01
IL82613A (en) 1991-03-10
PL265812A1 (en) 1988-05-12
FI91964B (fi) 1994-05-31
CS262690B2 (en) 1989-03-14
NL8701213A (nl) 1987-12-16
CA1280748C (en) 1991-02-26
PT84923B (pt) 1990-02-08
SE8702120D0 (sv) 1987-05-21
DD268943A5 (de) 1989-06-14
FR2599034B1 (fr) 1989-06-09
GB2190677A (en) 1987-11-25
CS369087A2 (en) 1988-08-16
BG46003A3 (en) 1989-09-15
SU1503681A3 (ru) 1989-08-23
CH671226A5 (de) 1989-08-15
YU90687A (en) 1988-08-31
ES2005582A6 (es) 1989-03-16
HU195788B (en) 1988-07-28
US4840948A (en) 1989-06-20
PL147687B1 (en) 1989-07-31
FR2599034A1 (fr) 1987-11-27
FI91964C (fi) 1994-09-12
DK258187D0 (da) 1987-05-21
AT395009B (de) 1992-08-25
SE8702120L (sv) 1987-11-22
IT1205665B (it) 1989-03-31
DE3717080A1 (de) 1987-11-26
GB2190677B (en) 1990-01-10
DK258187A (da) 1987-11-22
FI872255A0 (fi) 1987-05-21
BE1000573A4 (fr) 1989-02-07
IL82613A0 (en) 1987-11-30
YU46675B (sh) 1994-01-20
DE3717080C2 (de) 1996-02-08
GB8712005D0 (en) 1987-06-24
IT8720619A0 (it) 1987-05-21
FI872255A (fi) 1987-11-22
JPS6322082A (ja) 1988-01-29
SE468560B (sv) 1993-02-08

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
ELJ Ceased due to non-payment of the annual fee