AT379800B - Verfahren zur herstellung von neuen 2-oxazetidin-derivaten - Google Patents

Verfahren zur herstellung von neuen 2-oxazetidin-derivaten

Info

Publication number: AT379800B
Authority: AT; Austria
Prior art keywords: amino group; chem; acylated; derivatives; oxacetidine
Prior art date: 1980-12-05

Application number

AT0520781A

Other languages

English (en)

Other versions

ATA520781A (de

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-12-05

Filing date

1981-12-04

Publication date

1986-02-25

1980-12-05 Priority claimed from PCT/JP1980/000296 external-priority patent/WO1982001872A1/ja

1981-04-30 Priority claimed from PCT/JP1981/000102 external-priority patent/WO1982003858A1/ja

1981-08-25 Priority claimed from PCT/JP1981/000192 external-priority patent/WO1983000690A1/ja

1981-12-04 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1984-05-23 Priority to AT0170384A priority Critical patent/AT380471B/de

1985-07-15 Publication of ATA520781A publication Critical patent/ATA520781A/de

1986-02-25 Application granted granted Critical

1986-02-25 Publication of AT379800B publication Critical patent/AT379800B/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
125000003277 amino group Chemical group 0.000 abstract 4
CDFGMYLBUSYTKQ-UHFFFAOYSA-N 2-oxoazetidine-1-sulfonic acid Chemical class OS(=O)(=O)N1CCC1=O CDFGMYLBUSYTKQ-UHFFFAOYSA-N 0.000 abstract 1
108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
230000000845 anti-microbial effect Effects 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
102000006635 beta-lactamase Human genes 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT0520781A 1980-12-05 1981-12-04 Verfahren zur herstellung von neuen 2-oxazetidin-derivaten AT379800B (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
AT0170384A AT380471B (de)	1980-12-05	1984-05-23	Verfahren zur herstellung von neuen 2-oxoazetidin-derivate

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
PCT/JP1980/000296 WO1982001872A1 (en)	1980-12-05	1980-12-05	Azetidine derivatives and process for their preparation
PCT/JP1981/000102 WO1982003858A1 (fr)	1981-04-30	1981-04-30	Derives d'azetidine et procede de preparation
PCT/JP1981/000192 WO1983000690A1 (en)	1981-08-25	1981-08-25	Azetidine derivatives and process for their preparation

Publications (2)

Publication Number	Publication Date
ATA520781A ATA520781A (de)	1985-07-15
AT379800B true AT379800B (de)	1986-02-25

Family

ID=27303167

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT81110154T ATE13178T1 (de)	1980-12-05	1981-12-04	2-oxoazetidin-derivate, ihre herstellung und verwendung.
AT0520781A AT379800B (de)	1980-12-05	1981-12-04	Verfahren zur herstellung von neuen 2-oxazetidin-derivaten
AT0170384A AT380471B (de)	1980-12-05	1984-05-23	Verfahren zur herstellung von neuen 2-oxoazetidin-derivate

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT81110154T ATE13178T1 (de)	1980-12-05	1981-12-04	2-oxoazetidin-derivate, ihre herstellung und verwendung.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT0170384A AT380471B (de)	1980-12-05	1984-05-23	Verfahren zur herstellung von neuen 2-oxoazetidin-derivate

Country Status (26)

Country	Link
US (1)	US4822790A (de)
EP (1)	EP0053815B1 (de)
JP (1)	JPS57131759A (de)
KR (1)	KR880001564B1 (de)
AT (3)	ATE13178T1 (de)
AU (1)	AU551463B2 (de)
CH (1)	CH656122A5 (de)
DE (2)	DE3148020A1 (de)
DK (1)	DK534381A (de)
ES (2)	ES507716A0 (de)
FI (1)	FI79528C (de)
FR (1)	FR2495612A1 (de)
GB (1)	GB2091723B (de)
HU (1)	HU189545B (de)
IE (1)	IE53451B1 (de)
IL (1)	IL64314A (de)
IT (1)	IT1146726B (de)
LU (1)	LU83820A1 (de)
MX (1)	MX7096E (de)
NL (1)	NL8105468A (de)
NO (1)	NO160297C (de)
NZ (1)	NZ199168A (de)
PT (1)	PT74087B (de)
SE (1)	SE8107273L (de)
SU (2)	SU1662348A3 (de)
WO (1)	WO1982002042A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ199828A (en) *	1981-03-30	1985-11-08	Squibb & Sons Inc	4-substituted mercapto-2-oxo-1-azetidine-sulphonic acid derivatives and pharmaceutical compositions
US4734496A (en) *	1981-05-29	1988-03-29	E. R. Squibb & Sons, Inc.	4-amino derivatives of 2-oxo-1-azetidinesulfonic acid salts
JPS588060A (ja) *	1981-06-29	1983-01-18	イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド	アリ−ルチオアゼチジノンスルホン酸塩類
IT1157292B (it) *	1981-07-16	1987-02-11	Squibb & Sons Inc	Derivati 4-sostituiti dei sali dell'acido 2-osso-1-azetidinsolfonico e procedimento per la loro preparazione
ATE24726T1 (de) *	1981-10-05	1987-01-15	Squibb & Sons Inc	4-aether-derivate von 2-azetidinon-1-sulfonsaeuren.
AU564150B2 (en) *	1982-04-30	1987-08-06	Takeda Chemical Industries Ltd.	1-sulfo-2-azetidinone derivatives
JPS58210060A (ja) *	1982-05-31	1983-12-07	Takeda Chem Ind Ltd	２−オキソアゼチジン誘導体、その製造法および用途
JPS5916888A (ja) *	1982-07-20	1984-01-28	Takeda Chem Ind Ltd	１−スルホ−２−アゼチジノン誘導体およびその製造法
US4681937A (en) *	1982-09-27	1987-07-21	E. R. Squibb & Sons, Inc.	3-acylamino-2-oxo-1-azetidinyl esters of phosphonic acids, phosphoric acid and phosphoric acid esters
JPS59101485A (ja) *	1982-11-29	1984-06-12	Otsuka Chem Co Ltd	アセチジノン誘導体
DE3342929A1 (de) *	1983-11-26	1985-06-05	Bayer Ag, 5090 Leverkusen	Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel
US4883869A (en) *	1984-12-20	1989-11-28	The Upjohn Company	Novel beta-lactams containing amino acid substituents
US5006650A (en) *	1987-02-11	1991-04-09	The Upjohn Company	Novel N-1 substituted beta-lactams as antibiotics
EP0357604A1 (de) *	1987-02-27	1990-03-14	The Upjohn Company	Pyridon-carbonsäure oder säurederivat enthaltendes beta-lactame-antibiotikum
CA1317298C (en) *	1987-03-03	1993-05-04	Upjohn Company (The)	Antibiotic sulfonylaminocarbonyl activated .beta.-lactams
US5015737A (en) *	1987-07-22	1991-05-14	The Upjohn Company	Therapeutically useful beta-lactams
CA2266639A1 (en) *	1996-09-23	1998-03-26	Rajeshwar Singh	3,4-disubstituted azetidin-2-one derivatives useful as cysteine proteinase regulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6046955B2 (ja) *	1977-12-30	1985-10-18	武田薬品工業株式会社	抗生物質ｇ−６３０２
JPS5549394A (en) *	1978-10-03	1980-04-09	Takeda Chem Ind Ltd	Antibiotic substance sb-72310
US4260627A (en) *	1978-10-24	1981-04-07	Merck & Co., Inc.	1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
DE3069587D1 (en) *	1979-06-08	1984-12-13	Takeda Chemical Industries Ltd	1-sulpho-2-oxoazetidine derivatives, their production and pharmaceutical compositions thereof
EP0021676B1 (de) *	1979-06-08	1983-09-14	Takeda Chemical Industries, Ltd.	3-Methoxy-2-azetidinon-Derivate und ihre Herstellung
NZ205240A (en) *	1980-02-07	1984-07-31	Squibb & Sons Inc	Sulphonamide derivatives,being starting materials for producing beta-lactams
NZ199828A (en) *	1981-03-30	1985-11-08	Squibb & Sons Inc	4-substituted mercapto-2-oxo-1-azetidine-sulphonic acid derivatives and pharmaceutical compositions
JPS588060A (ja) *	1981-06-29	1983-01-18	イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド	アリ−ルチオアゼチジノンスルホン酸塩類
IT1157292B (it) *	1981-07-16	1987-02-11	Squibb & Sons Inc	Derivati 4-sostituiti dei sali dell'acido 2-osso-1-azetidinsolfonico e procedimento per la loro preparazione
FR2515182B1 (fr) *	1981-10-23	1986-05-09	Roussel Uclaf	Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine 1-sulfamique, leur procede de preparation, leur application comme medicaments et les produits intermediaires necessaires a leur preparation

1980
- 1980-12-05 MX MX819801U patent/MX7096E/es unknown
1981
- 1981-11-19 IL IL64314A patent/IL64314A/xx unknown
- 1981-11-26 HU HU813576A patent/HU189545B/hu not_active IP Right Cessation
- 1981-12-02 DK DK534381A patent/DK534381A/da not_active Application Discontinuation
- 1981-12-02 NO NO814113A patent/NO160297C/no unknown
- 1981-12-02 FI FI813851A patent/FI79528C/fi not_active IP Right Cessation
- 1981-12-03 SU SU813364650A patent/SU1662348A3/ru active
- 1981-12-03 US US06/326,939 patent/US4822790A/en not_active Expired - Fee Related
- 1981-12-04 IT IT68585/81A patent/IT1146726B/it active
- 1981-12-04 IE IE2859/81A patent/IE53451B1/en unknown
- 1981-12-04 GB GB8136617A patent/GB2091723B/en not_active Expired
- 1981-12-04 LU LU83820A patent/LU83820A1/xx unknown
- 1981-12-04 FR FR8122774A patent/FR2495612A1/fr active Granted
- 1981-12-04 EP EP81110154A patent/EP0053815B1/de not_active Expired
- 1981-12-04 NL NL8105468A patent/NL8105468A/nl not_active Application Discontinuation
- 1981-12-04 AT AT81110154T patent/ATE13178T1/de not_active IP Right Cessation
- 1981-12-04 DE DE19813148020 patent/DE3148020A1/de not_active Withdrawn
- 1981-12-04 ES ES507716A patent/ES507716A0/es active Granted
- 1981-12-04 CH CH7786/81A patent/CH656122A5/de not_active IP Right Cessation
- 1981-12-04 JP JP56196078A patent/JPS57131759A/ja active Pending
- 1981-12-04 PT PT74087A patent/PT74087B/pt unknown
- 1981-12-04 SE SE8107273A patent/SE8107273L/xx unknown
- 1981-12-04 AT AT0520781A patent/AT379800B/de not_active IP Right Cessation
- 1981-12-04 NZ NZ199168A patent/NZ199168A/en unknown
- 1981-12-04 DE DE8181110154T patent/DE3170437D1/de not_active Expired
- 1981-12-05 WO PCT/JP1981/000368 patent/WO1982002042A1/ja unknown
- 1981-12-05 KR KR1019810004759A patent/KR880001564B1/ko active
- 1981-12-07 AU AU78313/81A patent/AU551463B2/en not_active Ceased
1982
- 1982-06-25 ES ES513420A patent/ES513420A0/es active Granted
1983
- 1983-02-02 SU SU833547568A patent/SU1531852A3/ru active
1984
- 1984-05-23 AT AT0170384A patent/AT380471B/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL64314A0 (en)	1982-02-28
DK534381A (da)	1982-06-06
FI79528B (fi)	1989-09-29
EP0053815A1 (de)	1982-06-16
GB2091723A (en)	1982-08-04
IT8168585A0 (it)	1981-12-04
ES8301915A1 (es)	1982-12-16
SE8107273L (sv)	1982-06-06
DE3148020A1 (de)	1982-10-21
KR830007549A (ko)	1983-10-21
ES507716A0 (es)	1982-12-16
LU83820A1 (fr)	1982-05-07
AT380471B (de)	1986-05-26
ATA520781A (de)	1985-07-15
HU189545B (en)	1986-07-28
US4822790A (en)	1989-04-18
WO1982002042A1 (en)	1982-06-24
ATE13178T1 (de)	1985-05-15
AU7831381A (en)	1982-06-10
SU1662348A3 (ru)	1991-07-07
JPS57131759A (en)	1982-08-14
KR880001564B1 (ko)	1988-08-22
GB2091723B (en)	1985-06-12
FR2495612A1 (fr)	1982-06-11
PT74087A (en)	1982-01-01
IE812859L (en)	1982-06-05
NO160297B (no)	1988-12-27
ES8305325A1 (es)	1983-04-01
ATA170384A (de)	1985-10-15
NO814113L (no)	1982-06-07
FI813851L (fi)	1982-06-06
IT1146726B (it)	1986-11-19
FI79528C (fi)	1990-01-10
EP0053815B1 (de)	1985-05-08
CH656122A5 (de)	1986-06-13
IE53451B1 (en)	1988-11-23
SU1531852A3 (ru)	1989-12-23
NO160297C (no)	1989-04-05
ES513420A0 (es)	1983-04-01
IL64314A (en)	1988-06-30
DE3170437D1 (en)	1985-06-13
MX7096E (es)	1987-06-19
AU551463B2 (en)	1986-05-01
PT74087B (en)	1983-05-23
NL8105468A (nl)	1982-07-01
NZ199168A (en)	1985-08-30
FR2495612B1 (de)	1984-06-01

Legal Events

Date

Code

Title

Description

1991-04-15

ELJ

Ceased due to non-payment of the annual fee

2008-06-15

UEP

Publication of translation of european patent specification

Ref document number: 0980028

Country of ref document: EP

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