AR247551A1 - Procedimiento para obtener derivados de 16-deshidro-vitamina d3 - Google Patents
Procedimiento para obtener derivados de 16-deshidro-vitamina d3Info
- Publication number
- AR247551A1 AR247551A1 AR89313011A AR31301189A AR247551A1 AR 247551 A1 AR247551 A1 AR 247551A1 AR 89313011 A AR89313011 A AR 89313011A AR 31301189 A AR31301189 A AR 31301189A AR 247551 A1 AR247551 A1 AR 247551A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- derivatives
- dehydrocholecalciferol
- procedure
- hydroxyllus
- Prior art date
Links
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical class [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- -1 HYDROXYL GROUPS Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 16-DESHIDRO-VITAMINA D3 DE FORMULA I: EN DONDE R ES HIDROGENO, O HIDROXILO Y A ES -C=/-C-, -CH=CH- CON CONFIGURACION E O -CH2-CH2-, DONDE EL PROCEDIMIENTO COMPRENDE, LA REACCION DE UN COMPUESTO CORRESPONDIENTE DE FORMULA I CONTENIENDO EN LUGAR DE LOS DOS O TRES GRUPOS HIDROXILO DOS O TRES GRUPOS HIDROXILO PROTEGIDOS DE FORMULA -OSI(R1, R2, R3), EN DONDE R1 Y R3 SON ALQUILO Y R2 ES ALQUILO, FENILO O FENILALQUILO, CON UNA SAL DE FLUOR CAPAZ DE ELIMINAR LOS GRUPOS DE PROTECCION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14593288A | 1988-01-20 | 1988-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR247551A1 true AR247551A1 (es) | 1995-01-31 |
Family
ID=22515181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR89313011A AR247551A1 (es) | 1988-01-20 | 1989-01-18 | Procedimiento para obtener derivados de 16-deshidro-vitamina d3 |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP0325279B1 (es) |
JP (1) | JPH0764806B2 (es) |
KR (1) | KR960009119B1 (es) |
AR (1) | AR247551A1 (es) |
AT (1) | ATE74350T1 (es) |
AU (1) | AU622139B2 (es) |
BG (1) | BG60530B2 (es) |
CA (1) | CA1337529C (es) |
DE (1) | DE58901056D1 (es) |
DK (1) | DK169945B1 (es) |
ES (1) | ES2033467T3 (es) |
FI (1) | FI90764C (es) |
GR (1) | GR3004786T3 (es) |
HU (1) | HU201007B (es) |
IE (1) | IE60921B1 (es) |
IL (1) | IL88989A (es) |
MC (1) | MC1998A1 (es) |
NO (1) | NO175429C (es) |
NZ (1) | NZ227641A (es) |
PH (1) | PH25605A (es) |
PT (1) | PT89486B (es) |
YU (1) | YU47298B (es) |
ZA (1) | ZA8923B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
EP0398217B1 (de) * | 1989-05-18 | 1994-01-12 | F. Hoffmann-La Roche Ag | Dehydrocholecalciferolderivate |
AU650751B2 (en) * | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
ES2091515T3 (es) * | 1992-05-20 | 1996-11-01 | Hoffmann La Roche | Analogos fluorados de la vitamina d3. |
US5753638A (en) * | 1992-10-07 | 1998-05-19 | Hoffmann-La Roche Inc. | Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs |
CA2096105A1 (en) * | 1992-10-07 | 1994-04-08 | Enrico Giuseppe Baggiolini (Deceased) | Vitamin d3 fluorinated analogs |
TW267161B (es) * | 1992-11-20 | 1996-01-01 | Hoffmann La Roche | |
US5401733A (en) * | 1993-10-01 | 1995-03-28 | Hoffmann-La Roche Inc. | Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol |
US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
TW403735B (en) * | 1995-11-22 | 2000-09-01 | Hoffmann La Roche | 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol |
AU708679B2 (en) * | 1996-03-21 | 1999-08-12 | F. Hoffmann-La Roche Ag | 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives |
SG70009A1 (en) * | 1996-05-23 | 2000-01-25 | Hoffmann La Roche | Vitamin d3 analogs |
US5939408A (en) * | 1996-05-23 | 1999-08-17 | Hoffman-La Roche Inc. | Vitamin D3 analogs |
EP0884308B1 (en) * | 1997-05-02 | 2003-04-16 | Duphar International Research B.V | A method of preparing 16-dehydro vitamin D compounds |
US6331642B1 (en) * | 1999-07-12 | 2001-12-18 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
US9221753B2 (en) * | 2004-02-03 | 2015-12-29 | Chugai Seiyaku Kabushiki Kaisha | Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds |
EP1883626B1 (en) * | 2005-04-25 | 2017-10-11 | OPKO Ireland Global Holdings, Ltd. | Low-calcemic 16,23-diene 25-oxime analogs of 1alpha,25-dihydroxy vitamin d3 |
CA2619311A1 (en) * | 2005-08-18 | 2007-02-22 | Bioxell S.P.A. | Synthesis of 1.alpha.-fluoro-25-hydroxy-16-23e-diene-26,27-bishomo-20-epi-cholecalciferol |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2812741C2 (de) * | 1977-03-24 | 1987-03-12 | Wisconsin Alumni Research Foundation, Madison, Wis. | Vitamin D↓3↓-Derivate, Verfahren und Zwischenprodukte zu deren Herstellung und diese enthaltende Arzneimittel |
FR2426044A2 (fr) * | 1978-05-19 | 1979-12-14 | Wisconsin Research Foundation | Derives de la vitamine d3 ayant une activite anti-vitamine d |
US4360471A (en) * | 1981-12-11 | 1982-11-23 | Wisconsin Alumni Research Foundation | 23-Dehydro-25-hydroxyvitamin D3 |
US4508651A (en) * | 1983-03-21 | 1985-04-02 | Hoffmann-La Roche Inc. | Synthesis of 1α,25-dihydroxyergocalciferol |
US4505906A (en) * | 1984-01-30 | 1985-03-19 | Wisconsin Alumni Research Foundation | Hydroxyvitamin D2 isomers |
US4612308A (en) * | 1984-11-29 | 1986-09-16 | Hoffmann-La Roche Inc. | 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers |
US4898855A (en) * | 1987-09-14 | 1990-02-06 | Hoffman-La Roche Inc. | Deuterated analogs of 1,25-dihydroxycholecalciferol |
US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
EP0398217B1 (de) * | 1989-05-18 | 1994-01-12 | F. Hoffmann-La Roche Ag | Dehydrocholecalciferolderivate |
-
1989
- 1989-01-03 ZA ZA8923A patent/ZA8923B/xx unknown
- 1989-01-17 NZ NZ227641A patent/NZ227641A/en unknown
- 1989-01-17 DK DK019789A patent/DK169945B1/da not_active IP Right Cessation
- 1989-01-17 CA CA000588384A patent/CA1337529C/en not_active Expired - Fee Related
- 1989-01-17 PH PH38057A patent/PH25605A/en unknown
- 1989-01-18 HU HU89175A patent/HU201007B/hu not_active IP Right Cessation
- 1989-01-18 AR AR89313011A patent/AR247551A1/es active
- 1989-01-18 IL IL88989A patent/IL88989A/xx not_active IP Right Cessation
- 1989-01-19 YU YU11789A patent/YU47298B/sh unknown
- 1989-01-19 MC MC902029A patent/MC1998A1/xx unknown
- 1989-01-19 KR KR89000514A patent/KR960009119B1/ko not_active IP Right Cessation
- 1989-01-19 PT PT89486A patent/PT89486B/pt not_active IP Right Cessation
- 1989-01-19 JP JP1008782A patent/JPH0764806B2/ja not_active Expired - Fee Related
- 1989-01-19 AU AU28644/89A patent/AU622139B2/en not_active Ceased
- 1989-01-19 IE IE15789A patent/IE60921B1/en not_active IP Right Cessation
- 1989-01-19 FI FI890283A patent/FI90764C/fi not_active IP Right Cessation
- 1989-01-19 NO NO890239A patent/NO175429C/no unknown
- 1989-01-20 EP EP89100974A patent/EP0325279B1/de not_active Expired - Lifetime
- 1989-01-20 DE DE8989100974T patent/DE58901056D1/de not_active Expired - Fee Related
- 1989-01-20 ES ES198989100974T patent/ES2033467T3/es not_active Expired - Lifetime
- 1989-01-20 AT AT89100974T patent/ATE74350T1/de not_active IP Right Cessation
-
1992
- 1992-06-03 GR GR920401138T patent/GR3004786T3/el unknown
-
1994
- 1994-02-24 BG BG98544A patent/BG60530B2/bg unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR247551A1 (es) | Procedimiento para obtener derivados de 16-deshidro-vitamina d3 | |
BR8600428A (pt) | Compostos heterociclicos,processo para sua preparacao,composicoes inseticidas,processo para combate a insetos daninhos,utilizacao e processo para a preparacao de composicoes | |
ES2080739T3 (es) | Nitro-compuestos insecticidamente activos. | |
ES2196806T3 (es) | Derivados de fenilurea y de feniltiourea. | |
ATE80281T1 (de) | Haarstabilisator. | |
YU160189A (sh) | Anelirani derivati tetrahidropiridinocetne kisline in postopki za njihovo pripravo | |
ES2189941T3 (es) | Derivados de nucleosidos aciclicos. | |
DK534381A (da) | Fremgangsmaade til fremstilling af 2-oxoazetidinderivater | |
ES2321307T8 (es) | Uso de derivados de 4-ciano-naftaleno-1,8-dicarboximida y compuestos relacionados para proteger material orgánico de los efectos dañinos de la luz. | |
DK0553016T3 (da) | Hidtil ukendte naphtalenamider og -sulfonamider, fremgangsmåder til deres fremstilling samt farmaceutiske midler indeholdende dem | |
ES2028042T3 (es) | Procedimiento para la obtencion de derivados de 1,8-naftiridina y fungidas que les contienen. | |
ES2037011T3 (es) | Procedimiento para la preparacion de nuevos derivados de benzofuran-2-il-imidazol. | |
NO992731D0 (no) | Nye substituerte tetrahydropyridinforbindelser, fremgangsmÕte ved fremstilling av dem og farmas°ytiske sammensetninger derav | |
ES2058275T3 (es) | Derivados biciclicos de sulfonamida y su preparacion, su uso y formulaciones que los contienen. | |
DK624989D0 (da) | Hidtil ukendte forbindelser | |
ES2016017A6 (es) | Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico. | |
BG92842A (bg) | Метод за получаване на бета-карбонил-карбоксиамиди на 1,3-тиазолидини | |
NO922151L (no) | Gingerol og gingerdiolderivater som hypokolesterolemiske og antiatherosklerotiske midler | |
DK432086A (da) | Fremgangsmaade til fremstilling af beta-lactamforbindelser eller saltederaf | |
IL84983A0 (en) | Guanidinoacetic and ethanamidinoacetic acid derivatives as sweetening agents and sweetening compositions containing the same | |
AR246511A1 (es) | Acido 2-azabiciclo (2.2.1)hept-5-eno-2-acetico y derivados del mismo, procedimiento para su preparacion y procedimiento para preparar n-fosfonometilglicina con los mismos. | |
ES2074992T3 (es) | Derivados fungicidas de azolilo. | |
ES2094132T3 (es) | Uso de derivados de xantina contra la ulcera peptica. | |
NO933903L (es) | ||
DK0667863T3 (da) | 2-Perhalogenalkyl-substituerede benzimidazoler, deres fremstilling samt deres anvendelse som pesticider |