AR247551A1 - Procedimiento para obtener derivados de 16-deshidro-vitamina d3 - Google Patents

Procedimiento para obtener derivados de 16-deshidro-vitamina d3

Info

Publication number
AR247551A1
AR247551A1 AR89313011A AR31301189A AR247551A1 AR 247551 A1 AR247551 A1 AR 247551A1 AR 89313011 A AR89313011 A AR 89313011A AR 31301189 A AR31301189 A AR 31301189A AR 247551 A1 AR247551 A1 AR 247551A1
Authority
AR
Argentina
Prior art keywords
formula
derivatives
dehydrocholecalciferol
procedure
hydroxyllus
Prior art date
Application number
AR89313011A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of AR247551A1 publication Critical patent/AR247551A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 16-DESHIDRO-VITAMINA D3 DE FORMULA I: EN DONDE R ES HIDROGENO, O HIDROXILO Y A ES -C=/-C-, -CH=CH- CON CONFIGURACION E O -CH2-CH2-, DONDE EL PROCEDIMIENTO COMPRENDE, LA REACCION DE UN COMPUESTO CORRESPONDIENTE DE FORMULA I CONTENIENDO EN LUGAR DE LOS DOS O TRES GRUPOS HIDROXILO DOS O TRES GRUPOS HIDROXILO PROTEGIDOS DE FORMULA -OSI(R1, R2, R3), EN DONDE R1 Y R3 SON ALQUILO Y R2 ES ALQUILO, FENILO O FENILALQUILO, CON UNA SAL DE FLUOR CAPAZ DE ELIMINAR LOS GRUPOS DE PROTECCION.
AR89313011A 1988-01-20 1989-01-18 Procedimiento para obtener derivados de 16-deshidro-vitamina d3 AR247551A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14593288A 1988-01-20 1988-01-20

Publications (1)

Publication Number Publication Date
AR247551A1 true AR247551A1 (es) 1995-01-31

Family

ID=22515181

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89313011A AR247551A1 (es) 1988-01-20 1989-01-18 Procedimiento para obtener derivados de 16-deshidro-vitamina d3

Country Status (23)

Country Link
EP (1) EP0325279B1 (es)
JP (1) JPH0764806B2 (es)
KR (1) KR960009119B1 (es)
AR (1) AR247551A1 (es)
AT (1) ATE74350T1 (es)
AU (1) AU622139B2 (es)
BG (1) BG60530B2 (es)
CA (1) CA1337529C (es)
DE (1) DE58901056D1 (es)
DK (1) DK169945B1 (es)
ES (1) ES2033467T3 (es)
FI (1) FI90764C (es)
GR (1) GR3004786T3 (es)
HU (1) HU201007B (es)
IE (1) IE60921B1 (es)
IL (1) IL88989A (es)
MC (1) MC1998A1 (es)
NO (1) NO175429C (es)
NZ (1) NZ227641A (es)
PH (1) PH25605A (es)
PT (1) PT89486B (es)
YU (1) YU47298B (es)
ZA (1) ZA8923B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
EP0398217B1 (de) * 1989-05-18 1994-01-12 F. Hoffmann-La Roche Ag Dehydrocholecalciferolderivate
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
ES2091515T3 (es) * 1992-05-20 1996-11-01 Hoffmann La Roche Analogos fluorados de la vitamina d3.
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
TW267161B (es) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
AU708679B2 (en) * 1996-03-21 1999-08-12 F. Hoffmann-La Roche Ag 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
US5939408A (en) * 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
EP0884308B1 (en) * 1997-05-02 2003-04-16 Duphar International Research B.V A method of preparing 16-dehydro vitamin D compounds
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
US9221753B2 (en) * 2004-02-03 2015-12-29 Chugai Seiyaku Kabushiki Kaisha Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds
EP1883626B1 (en) * 2005-04-25 2017-10-11 OPKO Ireland Global Holdings, Ltd. Low-calcemic 16,23-diene 25-oxime analogs of 1alpha,25-dihydroxy vitamin d3
CA2619311A1 (en) * 2005-08-18 2007-02-22 Bioxell S.P.A. Synthesis of 1.alpha.-fluoro-25-hydroxy-16-23e-diene-26,27-bishomo-20-epi-cholecalciferol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2812741C2 (de) * 1977-03-24 1987-03-12 Wisconsin Alumni Research Foundation, Madison, Wis. Vitamin D↓3↓-Derivate, Verfahren und Zwischenprodukte zu deren Herstellung und diese enthaltende Arzneimittel
FR2426044A2 (fr) * 1978-05-19 1979-12-14 Wisconsin Research Foundation Derives de la vitamine d3 ayant une activite anti-vitamine d
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
EP0398217B1 (de) * 1989-05-18 1994-01-12 F. Hoffmann-La Roche Ag Dehydrocholecalciferolderivate

Also Published As

Publication number Publication date
FI890283A0 (fi) 1989-01-19
PT89486A (pt) 1989-10-04
ZA8923B (en) 1989-09-27
ATE74350T1 (de) 1992-04-15
DK19789A (da) 1989-07-21
KR890011838A (ko) 1989-08-22
NZ227641A (en) 1991-06-25
GR3004786T3 (es) 1993-04-28
IE890157L (en) 1989-07-20
YU11789A (en) 1991-04-30
AU622139B2 (en) 1992-04-02
PH25605A (en) 1991-08-08
DK19789D0 (da) 1989-01-17
CA1337529C (en) 1995-11-07
ES2033467T3 (es) 1993-03-16
NO175429B (no) 1994-07-04
NO175429C (no) 1994-10-12
MC1998A1 (fr) 1990-01-26
AU2864489A (en) 1989-07-20
DK169945B1 (da) 1995-04-10
IE60921B1 (en) 1994-09-07
HUT49317A (en) 1989-09-28
EP0325279B1 (de) 1992-04-01
EP0325279A1 (de) 1989-07-26
FI890283A (fi) 1989-07-21
YU47298B (sh) 1995-01-31
JPH029861A (ja) 1990-01-12
BG60530B2 (bg) 1995-07-28
NO890239D0 (no) 1989-01-19
IL88989A (en) 1993-08-18
PT89486B (pt) 1993-12-31
DE58901056D1 (de) 1992-05-07
FI90764B (fi) 1993-12-15
KR960009119B1 (en) 1996-07-13
JPH0764806B2 (ja) 1995-07-12
IL88989A0 (en) 1989-08-15
NO890239L (no) 1989-07-21
HU201007B (en) 1990-09-28
FI90764C (fi) 1994-03-25

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