AR224111A1 - DERIVATIVES OF 1-OXIDE OF PENICILANIC ACID, LOST FROM THERAPEUTIC ACTIVITY, USEFUL AS INTERMEDIARIES IN THE PREPARATION OF PHARMACEUTICALLY ACTIVE PENICILANIC ACID 1,1-DIOXIDE, PROCEDURE FOR PREPARING SUCH INTERMEDIARIES AND PROCEDURE PHARMACEUTICALLY ACTIVE FROM THOSE INTERMEDIARIES - Google Patents

DERIVATIVES OF 1-OXIDE OF PENICILANIC ACID, LOST FROM THERAPEUTIC ACTIVITY, USEFUL AS INTERMEDIARIES IN THE PREPARATION OF PHARMACEUTICALLY ACTIVE PENICILANIC ACID 1,1-DIOXIDE, PROCEDURE FOR PREPARING SUCH INTERMEDIARIES AND PROCEDURE PHARMACEUTICALLY ACTIVE FROM THOSE INTERMEDIARIES

Info

Publication number: AR224111A1
Authority: AR; Argentina
Prior art keywords: intermediaries; procedure; pharmaceutically active; penicilanic acid; lost
Prior art date: 1977-06-07

Application number

AR272228A

Other languages

Spanish (es)

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-06-07

Filing date

1978-08-18

Publication date

1981-10-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27122691&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR224111(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1978-08-18 Application filed by Pfizer filed Critical Pfizer

1981-10-30 Application granted granted Critical

1981-10-30 Publication of AR224111A1 publication Critical patent/AR224111A1/en

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AR272228A 1977-06-07 1978-08-18 DERIVATIVES OF 1-OXIDE OF PENICILANIC ACID, LOST FROM THERAPEUTIC ACTIVITY, USEFUL AS INTERMEDIARIES IN THE PREPARATION OF PHARMACEUTICALLY ACTIVE PENICILANIC ACID 1,1-DIOXIDE, PROCEDURE FOR PREPARING SUCH INTERMEDIARIES AND PROCEDURE PHARMACEUTICALLY ACTIVE FROM THOSE INTERMEDIARIES AR224111A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US80432077A	1977-06-07	1977-06-07
US87938178A	1978-02-21	1978-02-21

Publications (1)

Publication Number	Publication Date
AR224111A1 true AR224111A1 (en)	1981-10-30

Family

ID=27122691

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AR272228A AR224111A1 (en)	1977-06-07	1978-08-18	DERIVATIVES OF 1-OXIDE OF PENICILANIC ACID, LOST FROM THERAPEUTIC ACTIVITY, USEFUL AS INTERMEDIARIES IN THE PREPARATION OF PHARMACEUTICALLY ACTIVE PENICILANIC ACID 1,1-DIOXIDE, PROCEDURE FOR PREPARING SUCH INTERMEDIARIES AND PROCEDURE PHARMACEUTICALLY ACTIVE FROM THOSE INTERMEDIARIES

Country Status (35)

Country	Link
AR (1)	AR224111A1 (en)
AT (2)	AT360649B (en)
AU (1)	AU513636B2 (en)
BE (1)	BE867859A (en)
BG (2)	BG34614A3 (en)
CH (1)	CH634073A5 (en)
CS (1)	CS208472B2 (en)
DD (2)	DD140888A5 (en)
DE (2)	DE2824535C3 (en)
DK (1)	DK155740C (en)
EG (1)	EG13869A (en)
FI (1)	FI66003C (en)
FR (2)	FR2393804A1 (en)
GB (1)	GB2000138B (en)
GR (1)	GR72255B (en)
HK (1)	HK13184A (en)
HU (1)	HU180042B (en)
IE (1)	IE47079B1 (en)
IL (2)	IL54867A (en)
IN (1)	IN149747B (en)
IT (1)	IT1096381B (en)
KE (1)	KE3355A (en)
LU (1)	LU79774A1 (en)
MY (1)	MY8500092A (en)
NL (2)	NL180009C (en)
NO (2)	NO151746C (en)
NZ (1)	NZ187476A (en)
OA (1)	OA05964A (en)
PH (3)	PH26810A (en)
PL (1)	PL114501B1 (en)
PT (1)	PT68146A (en)
SE (2)	SE436206B (en)
SG (1)	SG65383G (en)
SU (1)	SU860706A1 (en)
YU (1)	YU41829B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU77306A1 (en) *	1977-05-09	1979-01-18
DE2912511C2 (en) *	1977-06-07	1982-06-24	Pfizer Inc., 10017 New York, N.Y.	Pharmaceutical composition containing penicillanic acid
DK155942C (en) *	1977-12-23	1989-10-23	Pfizer	METHOD OF ANALOGUE FOR THE PREPARATION OF 6-AMINOPENICILLANIC ACID-1,1-DIOXIDE AND PHYSIOLOGICALLY ACCEPTABLE ACID ADDITION AND BASIS SALTS.
JPS54126735A (en) *	1978-03-24	1979-10-02	Toyama Chem Co Ltd	Bactericidal composition for medical use
US4241050A (en) *	1978-09-01	1980-12-23	Pfizer Inc.	Penam 1,1-dioxides as beta-lactamase inhibitors
CA1158639A (en) *	1978-12-11	1983-12-13	Eric M. Gordon	6-bromopenicillanic acid sulfone
IE49880B1 (en) *	1979-02-13	1986-01-08	Leo Pharm Prod Ltd	Penicillin derivatives
US4420426A (en)	1979-03-05	1983-12-13	Pfizer Inc.	6-Alpha-halopenicillanic acid 1,1-dioxides
SE449103B (en) *	1979-03-05	1987-04-06	Pfizer	SET TO PENICILLANIC ACID-1,1-DIOXIDE AND ESSERS THEREOF
US4714761A (en) *	1979-03-05	1987-12-22	Pfizer Inc.	6,6-dihalopenicillanic acid 1,1-dioxides and process
GB2045236A (en) *	1979-03-26	1980-10-29	Hoechst Uk Ltd	Oxapenem derivatives
US4309347A (en) *	1979-05-16	1982-01-05	Pfizer Inc.	Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
US4244951A (en) *	1979-05-16	1981-01-13	Pfizer Inc.	Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
IE49768B1 (en) *	1979-05-21	1985-12-11	Leo Pharm Prod Ltd	6beta-halopenicillanic acid derivatives
DE3051044C2 (en) *	1979-06-19	1989-03-30	Leo Pharmaceutical Products Ltd. A/S (Loevens Kemiske Fabrik Produktionsaktieselskab), Ballerup, Dk
US4256733A (en) *	1979-09-26	1981-03-17	Pfizer Inc.	Acetoxymethyl penam compounds as β-lactamase inhibitors
US4432970A (en) *	1979-11-23	1984-02-21	Pfizer Inc.	6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
IL61880A (en) *	1980-01-21	1984-11-30	Bristol Myers Co	2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them
US4488994A (en) *	1980-09-08	1984-12-18	Pfizer Inc.	Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4432903A (en) *	1980-09-08	1984-02-21	Pfizer Inc.	Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4474698A (en) *	1980-12-11	1984-10-02	Pfizer Inc.	Process for preparing esters of penicillanic acid sulfone
US4419284A (en) *	1981-03-23	1983-12-06	Pfizer Inc.	Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
EP0069962B1 (en) *	1981-07-15	1985-01-02	Kanebo, Ltd.	Novel ester of 1,1-dioxopenicillanic acid, process for production thereof, and use thereof as beta-lactamase inhibitor
PT76527B (en) *	1982-04-19	1985-12-09	Gist Brocades Nv	A process for the preparation of penicillanic acid 1,1-dioxide and derivatives thereof
US4502988A (en) *	1983-08-08	1985-03-05	Eli Lilly And Company	Oxidation process
EP0139047A1 (en) *	1983-10-18	1985-05-02	Gist-Brocades N.V.	Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4647457A (en) *	1983-12-16	1987-03-03	Hoffmann-La Roche Inc.	Penicillanic acid derivatives
WO1987006230A1 (en) *	1986-04-10	1987-10-22	Leo Pharmaceutical Products Ltd. A/S	Method for preparing penicillanic acid derivatives
GB8808701D0 (en) *	1988-04-13	1988-05-18	Erba Carlo Spa	Beta-lactam derivatives
CN102977120B (en) *	2012-12-14	2015-05-27	江西富祥药业股份有限公司	Method for preparing and crystallizing sulbactam pivoxyl

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3197466A (en) *	1961-10-30	1965-07-27	Smith Kline French Lab	Penicillin sulfoxides and process
LU77306A1 (en) *	1977-05-09	1979-01-18
EP0000636A1 (en) *	1977-07-13	1979-02-07	Glaxo Group Limited	Penem compounds, processes for their preparation, their use in pharmaceutical compositions and azetidinones used in their preparation

1978
- 1978-05-04 IN IN327/DEL/78A patent/IN149747B/en unknown
- 1978-05-09 PH PH21116A patent/PH26810A/en unknown
- 1978-05-16 YU YU1170/78A patent/YU41829B/en unknown
- 1978-05-18 OA OA56500A patent/OA05964A/en unknown
- 1978-05-20 EG EG322/78A patent/EG13869A/en active
- 1978-05-30 BG BG7839910A patent/BG34614A3/en unknown
- 1978-05-30 BG BG7942176A patent/BG34615A3/en unknown
- 1978-06-01 CS CS783579A patent/CS208472B2/en unknown
- 1978-06-02 AU AU36838/78A patent/AU513636B2/en not_active Ceased
- 1978-06-02 GB GB7826308A patent/GB2000138B/en not_active Expired
- 1978-06-05 DE DE2824535A patent/DE2824535C3/en not_active Expired
- 1978-06-05 GR GR56439A patent/GR72255B/el unknown
- 1978-06-05 DE DE2857263A patent/DE2857263C3/en not_active Expired
- 1978-06-06 IE IE1140/78A patent/IE47079B1/en not_active IP Right Cessation
- 1978-06-06 IL IL54867A patent/IL54867A/en unknown
- 1978-06-06 NO NO781970A patent/NO151746C/en unknown
- 1978-06-06 FR FR787816893A patent/FR2393804A1/en active Granted
- 1978-06-06 SU SU782624408A patent/SU860706A1/en active
- 1978-06-06 SE SE7806628A patent/SE436206B/en not_active IP Right Cessation
- 1978-06-06 BE BE188352A patent/BE867859A/en not_active IP Right Cessation
- 1978-06-06 NZ NZ187476A patent/NZ187476A/en unknown
- 1978-06-06 PT PT68146A patent/PT68146A/en unknown
- 1978-06-06 AT AT411278A patent/AT360649B/en active Protection Beyond IP Right Term
- 1978-06-06 NL NLAANVRAGE7806126,A patent/NL180009C/en not_active IP Right Cessation
- 1978-06-06 FI FI781800A patent/FI66003C/en not_active IP Right Cessation
- 1978-06-06 LU LU79774A patent/LU79774A1/en unknown
- 1978-06-06 IT IT24270/78A patent/IT1096381B/en active Protection Beyond IP Right Term
- 1978-06-06 DK DK251478A patent/DK155740C/en not_active IP Right Cessation
- 1978-06-06 HU HU78PI630A patent/HU180042B/en unknown
- 1978-06-06 PL PL1978207396A patent/PL114501B1/en unknown
- 1978-06-06 CH CH618078A patent/CH634073A5/en not_active IP Right Cessation
- 1978-06-07 DD DD78205839A patent/DD140888A5/en unknown
- 1978-06-07 DD DD78218400A patent/DD148585A5/en unknown
- 1978-08-18 AR AR272228A patent/AR224111A1/en active
- 1978-09-08 PH PH21587A patent/PH16465A/en unknown
- 1978-09-08 PH PH21586A patent/PH21116A/en unknown
- 1978-09-19 FR FR787826789A patent/FR2393805A1/en active Granted
1980
- 1980-03-07 AT AT0128580A patent/AT364084B/en not_active IP Right Cessation
1981
- 1981-02-19 IL IL62168A patent/IL62168A0/en unknown
1982
- 1982-09-15 NO NO823126A patent/NO152448C/en unknown
1983
- 1983-10-27 SE SE8305916A patent/SE447995B/en not_active IP Right Cessation
- 1983-11-02 SG SG653/83A patent/SG65383G/en unknown
- 1983-11-22 KE KE3355A patent/KE3355A/en unknown
1984
- 1984-02-16 HK HK131/84A patent/HK13184A/en not_active IP Right Cessation
1985
- 1985-12-30 MY MY92/85A patent/MY8500092A/en unknown
1993
- 1993-06-11 NL NL930064C patent/NL930064I2/en unknown

Also Published As

Publication number	Publication date
DD140888A5 (en)	1980-04-02
IL54867A (en)	1981-11-30
IL54867A0 (en)	1978-08-31
GB2000138B (en)	1982-03-03
AT360649B (en)	1981-01-26
SE7806628L (en)	1978-12-08
LU79774A1 (en)	1980-01-22
PH26810A (en)	1992-11-05
NL930064I1 (en)	1993-09-01
GB2000138A (en)	1979-01-04
PL207396A1 (en)	1979-06-04
DK155740C (en)	1989-10-23
SU860706A1 (en)	1981-08-30
NO823126L (en)	1978-12-08
IL62168A0 (en)	1981-03-31
IT1096381B (en)	1985-08-26
SE8305916L (en)	1983-10-27
PT68146A (en)	1978-07-01
BE867859A (en)	1978-12-06
PH21116A (en)	1987-07-16
ATA411278A (en)	1980-06-15
FI781800A (en)	1978-12-08
NO151746C (en)	1985-06-05
SG65383G (en)	1985-03-29
DE2824535A1 (en)	1978-12-14
IN149747B (en)	1982-04-03
CS208472B2 (en)	1981-09-15
ATA128580A (en)	1981-02-15
NL180009C (en)	1986-12-16
NO151746B (en)	1985-02-18
DE2824535C3 (en)	1981-01-22
PL114501B1 (en)	1981-02-28
YU41829B (en)	1988-02-29
DE2857263B2 (en)	1981-04-23
DK251478A (en)	1978-12-08
FR2393805A1 (en)	1979-01-05
FR2393804A1 (en)	1979-01-05
BG34614A3 (en)	1983-10-15
NL930064I2 (en)	1994-04-18
DE2857263C3 (en)	1981-12-17
AU513636B2 (en)	1980-12-11
BG34615A3 (en)	1983-10-15
DK155740B (en)	1989-05-08
CH634073A5 (en)	1983-01-14
NZ187476A (en)	1982-08-17
PH16465A (en)	1983-10-20
NO781970L (en)	1978-12-08
FR2393804B1 (en)	1980-11-07
SE436206B (en)	1984-11-19
SE447995B (en)	1987-01-12
YU117078A (en)	1983-01-21
FR2393805B1 (en)	1984-02-24
NO152448B (en)	1985-06-24
EG13869A (en)	1983-03-31
IE781140L (en)	1978-12-07
NL7806126A (en)	1978-12-11
KE3355A (en)	1983-12-16
NO152448C (en)	1985-10-02
DD148585A5 (en)	1981-06-03
SE8305916D0 (en)	1983-10-27
FI66003C (en)	1984-08-10
AT364084B (en)	1981-09-25
HK13184A (en)	1984-02-24
FI66003B (en)	1984-04-30
IE47079B1 (en)	1983-12-14
MY8500092A (en)	1985-12-31
OA05964A (en)	1981-06-30
HU180042B (en)	1983-01-28
GR72255B (en)	1983-10-06
IT7824270A0 (en)	1978-06-06
AU3683878A (en)	1979-12-06
DE2824535B2 (en)	1980-05-14

Publication	Publication Date	Title
AR224111A1 (en)	1981-10-30	DERIVATIVES OF 1-OXIDE OF PENICILANIC ACID, LOST FROM THERAPEUTIC ACTIVITY, USEFUL AS INTERMEDIARIES IN THE PREPARATION OF PHARMACEUTICALLY ACTIVE PENICILANIC ACID 1,1-DIOXIDE, PROCEDURE FOR PREPARING SUCH INTERMEDIARIES AND PROCEDURE PHARMACEUTICALLY ACTIVE FROM THOSE INTERMEDIARIES
NO782127L (en)	1978-12-21	PROCEDURE FOR THE PREPARATION OF PHYSIOLOGICAL ACTIVE ISOKSAZOLO-PYRIDINE DERIVATIVES
NO149035C (en)	1984-02-01	ANALOGUE PROCEDURE FOR THE PREPARATION OF PHYSIOLOGICALLY ACTIVE ACYLANILIDE DERIVATIVES
NO148148C (en)	1983-08-17	PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 4-HYDROXY-2-PYRROLIDINON DERIVATIVES
NO803136L (en)	1981-04-23	PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICAL ACTIVE 6BETA-HYDROXYLKYLPENICILLANIC ACID DERIVATIVES
NO784231L (en)	1979-06-19	ANALOGICAL PROCEDURE FOR THE PREPARATION OF PHYSIOLOGICALLY ACTIVE BENZOTIAZINE DERIVATIVES
NO155055C (en)	1987-02-04	ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE BETA-CARBOLIN-3-CARBOXYLIC ACID DERIVATIVES.
NO782756L (en)	1979-02-16	PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE ANTHRAKINON DERIVATIVES
NO802015L (en)	1981-01-07	PROCEDURE FOR THE PREPARATION OF PHYSIOLOGICALLY ACTIVE INDOLIZIN DERIVATIVES.
NO151287C (en)	1985-03-13	ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 9-HYDRAZONO-6,7,8,9-TETRAHYDRO-4H-PYRIDO (1,2-A) -PYRIMIDINE DERIVATIVES
AR219561A1 (en)	1980-08-29	PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 1-PIPERIDINE-6,7-DIALCOXI-FTALAZINE USEFUL AS THERAPEUTIC AGENTS
IT1105054B (en)	1985-10-28	ALPHA-ACETYLENE DERIVATIVES OF AMINES WITH PHARMACEUTICAL ACTIVITY AND PROCEDURE FOR THEIR PREPARATION
AR221051A1 (en)	1980-12-30	PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF AMINODESOXICLAVULANIC ACID
IT7820957A0 (en)	1978-03-07	DERIVATIVES OF 1-AZAXANTONE-3-CARBOXYLIC ACID AND PROCEDURE FOR THEIR PREPARATION.
MX6206E (en)	1984-12-14	PROCEDURE FOR THE PREPARATION OF ACID 4-ARIL-5-TIAZOL-CARBOXILICO 2-SUBSTITUTED AND DERIVATIVES OF THE SAME
AR215666A1 (en)	1979-10-31	OLEANDOMYCIN DERIVATIVES, THERAPEUTICALLY RELEVANT DERIVATIVES, APPLICABLE AS INTERMEDIARIES FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE OLEANDOMYCINS; PROCEDURE FOR PREPARING SAID INTERMEDIARY DERIVATIVES; AND PROCEDURE FOR PREPARING THERAPEUTICALLY ACTIVE OLEANDOMYCIN DERIVATIVES;
NO780743L (en)	1978-09-06	PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICALLY ACTIVE BENZYLPYRIMIDINES
MX6032E (en)	1984-10-04	PROCEDURE FOR THE PREPARATION OF 1,1-DIOXIDE OF PENICILANIC ACID AND ESTERS THEREOF
NO780644L (en)	1978-08-25	PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 9-HYDROXYETHOXYMETHYLGUANINE DERIVATIVES
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