AR127743A1 - Anticuerpos capaces de unirse a cd27, variantes y usos de los mismos - Google Patents
Anticuerpos capaces de unirse a cd27, variantes y usos de los mismosInfo
- Publication number
- AR127743A1 AR127743A1 ARP220102407A ARP220102407A AR127743A1 AR 127743 A1 AR127743 A1 AR 127743A1 AR P220102407 A ARP220102407 A AR P220102407A AR P220102407 A ARP220102407 A AR P220102407A AR 127743 A1 AR127743 A1 AR 127743A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibody
- binding
- kit
- nucleic acid
- host cell
- Prior art date
Links
- 102100027207 CD27 antigen Human genes 0.000 title abstract 3
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical group 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 239000001963 growth medium Substances 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
La presente invención se refiere a anticuerpos capaces de unirse a CD27 humano y a variantes del mismo, que comprenden una región Fc modificada que comprende una o más mutaciones que potencian la interacción Fc-Fc del anticuerpo. La invención proporciona además composiciones farmacéuticas que comprenden los anticuerpos y el uso de los anticuerpos para procedimientos terapéuticos y de diagnóstico, en particular en la terapia del cáncer. Reivindicación 1: Un anticuerpo que comprende al menos una región de unión a antígeno capaz de unirse a CD27 humano, en donde dicho anticuerpo comprende una región variable de cadena pesada (VH) CDR1, CDR2 y CDR3 que comprende las secuencias que se presentan en SEQ ID Nº 5, 6 y 7, respectivamente, y una región variable de cadena liviana (VL) CDR1, CDR2 y CDR3 que comprende las secuencias que se presentan en SEQ ID Nº 9, 10 y 11, respectivamente. Reivindicación 45: Una secuencia de ácido nucleico aislada o una combinación de secuencias de ácido nucleico que codifican el anticuerpo de acuerdo con cualquiera de las reivindicaciones 1 a 36. Reivindicación 58: Un vector de expresión que comprende la secuencia de ácido nucleico o una combinación de ella de acuerdo con cualquiera de las reivindicaciones 45 a 57. Reivindicación 60: Una célula huésped recombinante, que produce un anticuerpo como se define en cualquiera de las reivindicaciones 1 a 36, en donde opcionalmente la célula huésped comprende el vector de expresión de la reivindicación 58. Reivindicación 63: Un método para producir un anticuerpo de acuerdo con cualquiera de las reivindicaciones 1 a 36, que comprende cultivar la célula huésped recombinante de la reivindicación 60 o 61 en un medio de cultivo y en condiciones adecuadas para producir el anticuerpo y, opcionalmente, purificar o aislar el anticuerpo del medio de cultivo. Reivindicación 64: Un kit de piezas, tal como un kit para usar como diagnóstico complementario / para identificar dentro de una población de pacientes a aquellos pacientes que tienen propensión a responder al tratamiento con un anticuerpo como se define en cualquiera de las reivindicaciones 1 a 36, que comprende un anticuerpo como se define en cualquiera de las reivindicaciones 1 a 36; e instrucciones de uso de dicho kit.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP21195118 | 2021-09-06 | ||
EP22173126 | 2022-05-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR127743A1 true AR127743A1 (es) | 2024-02-28 |
Family
ID=83400576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP220102407A AR127743A1 (es) | 2021-09-06 | 2022-09-06 | Anticuerpos capaces de unirse a cd27, variantes y usos de los mismos |
Country Status (8)
Country | Link |
---|---|
US (2) | US20230109496A1 (es) |
KR (1) | KR20240051280A (es) |
AR (1) | AR127743A1 (es) |
AU (1) | AU2022338208A1 (es) |
CA (1) | CA3231003A1 (es) |
IL (1) | IL311141A (es) |
TW (1) | TW202328192A (es) |
WO (1) | WO2023031473A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023218046A1 (en) * | 2022-05-12 | 2023-11-16 | Genmab A/S | Binding agents capable of binding to cd27 in combination therapy |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6077A (en) | 1849-01-30 | Improved hinged claw-wrench | ||
US835A (en) | 1838-07-12 | X i i i x | ||
US4699880A (en) | 1984-09-25 | 1987-10-13 | Immunomedics, Inc. | Method of producing monoclonal anti-idiotype antibody |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
KR970029803A (ko) | 1995-11-03 | 1997-06-26 | 김광호 | 반도체 메모리장치의 프리차지 회로 |
AU751659B2 (en) | 1997-05-02 | 2002-08-22 | Genentech Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
PT1071700E (pt) | 1998-04-20 | 2010-04-23 | Glycart Biotechnology Ag | Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
US6355271B1 (en) | 1999-02-03 | 2002-03-12 | Biosante Pharmaceuticals, Inc. | Therapeutic calcium phosphate particles and methods of manufacture and use |
PT1914244E (pt) | 1999-04-09 | 2013-07-26 | Kyowa Hakko Kirin Co Ltd | Processo para regular a actividade de moléculas funcionais sob o ponto de vista imunológico |
US6281005B1 (en) | 1999-05-14 | 2001-08-28 | Copernicus Therapeutics, Inc. | Automated nucleic acid compaction device |
JP4668498B2 (ja) | 1999-10-19 | 2011-04-13 | 協和発酵キリン株式会社 | ポリペプチドの製造方法 |
DE10043437A1 (de) | 2000-09-04 | 2002-03-28 | Horst Lindhofer | Verwendung von trifunktionellen bispezifischen und trispezifischen Antikörpern zur Behandlung von malignem Aszites |
AU2001294175A1 (en) | 2000-10-06 | 2002-04-22 | Kyowa Hakko Kogyo Co. Ltd. | Method of purifying antibody |
CA2785941C (en) | 2000-10-06 | 2017-01-10 | Kyowa Hakko Kirin Co., Ltd. | Antibody composition-producing cell |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
EP1443961B1 (en) | 2001-10-25 | 2009-05-06 | Genentech, Inc. | Glycoprotein compositions |
ES2442615T5 (es) | 2002-07-18 | 2023-03-16 | Merus Nv | Producción recombinante de mezclas de anticuerpos |
US7741568B2 (en) | 2005-01-13 | 2010-06-22 | The Wiremold Company | Downward facing receptacle assembly for cable raceway |
WO2006106905A1 (ja) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | 会合制御によるポリペプチド製造方法 |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
WO2007059782A1 (en) | 2005-11-28 | 2007-05-31 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
WO2007109254A2 (en) | 2006-03-17 | 2007-09-27 | Biogen Idec Ma Inc. | Stabilized polypeptide compositions |
EP1999154B1 (en) | 2006-03-24 | 2012-10-24 | Merck Patent GmbH | Engineered heterodimeric protein domains |
AT503902B1 (de) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von immunglobulinen |
GB0620894D0 (en) | 2006-10-20 | 2006-11-29 | Univ Southampton | Human immune therapies using a CD27 agonist alone or in combination with other immune modulators |
DE102007001370A1 (de) | 2007-01-09 | 2008-07-10 | Curevac Gmbh | RNA-kodierte Antikörper |
JP5718637B2 (ja) | 2007-06-21 | 2015-05-13 | マクロジェニクス,インコーポレーテッド | 共有結合型ダイアボディおよびその使用 |
WO2009089004A1 (en) | 2008-01-07 | 2009-07-16 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
JP5397668B2 (ja) | 2008-09-02 | 2014-01-22 | ソニー株式会社 | 記憶素子および記憶装置 |
CN106432503B (zh) | 2008-12-19 | 2020-03-06 | 宏观基因有限公司 | 共价双抗体及其用途 |
CA2751342C (en) | 2009-01-29 | 2019-05-07 | Alnylam Pharmaceuticals, Inc. | Lipid formulations comprising cationic lipid and a targeting lipid comprising n-acetyl galactosamine for delivery of nucleic acid |
JP2012525149A (ja) | 2009-04-27 | 2012-10-22 | オンコメッド ファーマシューティカルズ インコーポレイテッド | ヘテロ多量体分子を作製するための方法 |
PL2975051T3 (pl) | 2009-06-26 | 2021-09-20 | Regeneron Pharmaceuticals, Inc. | Wyizolowane z łatwością dwuswoiste przeciwciała o formacie natywnej immunoglobuliny |
US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
CA2781682A1 (en) | 2009-12-04 | 2011-06-09 | Genentech, Inc. | Multispecific antibodies, antibody analogs, compositions, and methods |
AR080794A1 (es) | 2010-03-26 | 2012-05-09 | Hoffmann La Roche | Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2 |
NZ623807A (en) | 2010-04-13 | 2016-03-31 | Celldex Therapeutics Inc | Antibodies that bind human cd27 and uses thereof |
SG184427A1 (en) | 2010-04-20 | 2012-11-29 | Genmab As | Heterodimeric antibody fc-containing proteins and methods for production thereof |
WO2011143545A1 (en) | 2010-05-14 | 2011-11-17 | Rinat Neuroscience Corporation | Heterodimeric proteins and methods for producing and purifying them |
AU2011275749C1 (en) | 2010-07-09 | 2015-09-17 | Aduro Biotech Holdings, Europe B.V. | Agonistic antibody to CD27 |
RU2608640C2 (ru) | 2010-08-16 | 2017-01-23 | Новиммун С.А. | Способы получения мультиспецифичных и мультивалентных антител |
CN103068846B9 (zh) | 2010-08-24 | 2016-09-28 | 弗·哈夫曼-拉罗切有限公司 | 包含二硫键稳定性Fv片段的双特异性抗体 |
WO2012025525A1 (en) | 2010-08-24 | 2012-03-01 | Roche Glycart Ag | Activatable bispecific antibodies |
JP6167040B2 (ja) | 2010-11-05 | 2017-07-19 | ザイムワークス,インコーポレイテッド | Fcドメイン中に突然変異を有する、安定したヘテロ二量体抗体の設計 |
CN102250246A (zh) | 2011-06-10 | 2011-11-23 | 常州亚当生物技术有限公司 | 抗VEGF/PDGFRβ双特异性抗体及其应用 |
UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
PT2794905T (pt) | 2011-12-20 | 2020-06-30 | Medimmune Llc | Polipéptidos modificados para estrutura de anticorpos bispecíficos |
US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
NZ630551A (en) | 2012-04-20 | 2017-11-24 | Merus Nv | Methods and means for the production of ig-like molecules |
AU2013285355A1 (en) | 2012-07-06 | 2015-01-29 | Genmab B.V. | Dimeric protein with triple mutations |
MX2015002269A (es) | 2012-08-20 | 2015-07-06 | Gliknik Inc | Moleculas con actividad de union al antigeno y al receptor fc gamma polivalente. |
EA201500741A1 (ru) | 2013-01-10 | 2016-01-29 | Генмаб Б.В. | ВАРИАНТЫ Fc-ОБЛАСТИ IGG1 ЧЕЛОВЕКА И ИХ ПРИМЕНЕНИЕ |
LT2970456T (lt) | 2013-03-14 | 2021-08-10 | Translate Bio, Inc. | Būdai ir kompozicijos, skirti mrnr koduojamų antikūnų pristatymui |
ES2967701T3 (es) | 2013-03-15 | 2024-05-03 | Translate Bio Inc | Mejora sinergística de la entrega de ácidos nucleicos mediante formulaciones mezcladas |
BR112016023948A2 (pt) | 2014-04-16 | 2018-01-30 | Ucb Biopharma Sprl | proteínas fc multiméricas |
US20180044429A1 (en) | 2015-03-09 | 2018-02-15 | Celldex Therapeutics, Inc. | Cd27 agonists |
AU2016377681B2 (en) | 2015-12-22 | 2021-05-13 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
EP3397613A1 (en) | 2015-12-30 | 2018-11-07 | Acuitas Therapeutics Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
WO2018006052A1 (en) | 2016-06-30 | 2018-01-04 | Protiva Biotherapeutics, Inc. | Compositions and methods for delivering messenger rna |
SG11201900746RA (en) | 2016-08-12 | 2019-02-27 | Janssen Biotech Inc | Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions |
JOP20190055A1 (ar) | 2016-09-26 | 2019-03-24 | Merck Sharp & Dohme | أجسام مضادة ضد cd27 |
WO2018083126A1 (en) | 2016-11-01 | 2018-05-11 | Genmab B.V. | Polypeptide variants and uses thereof |
AU2017381656B2 (en) | 2016-12-21 | 2020-07-02 | F. Hoffmann-La Roche Ag | Re-use of enzymes in in vitro glycoengineering of antibodies |
JP6850351B2 (ja) | 2016-12-21 | 2021-03-31 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 抗体のインビトロ糖鎖工学 |
US10526284B2 (en) | 2016-12-21 | 2020-01-07 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
CA3045970A1 (en) | 2016-12-21 | 2018-06-28 | F. Hoffmann-La Roche Ag | Method for in vitro glycoengineering of antibodies |
US20200181277A1 (en) | 2017-02-10 | 2020-06-11 | Genmab B.V. | Polypeptide variants and uses thereof |
MA51666A (fr) | 2018-01-24 | 2020-12-02 | Genmab Bv | Variants polypeptidiques et leurs utilisations |
JP2021520201A (ja) | 2018-04-04 | 2021-08-19 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 抗cd27抗体およびその使用 |
MA52951A (fr) | 2018-06-22 | 2021-04-28 | Genmab Holding B V | Anticorps anti-cd37 et anticorps anti-cd20, compositions et méthodes d'utilisation de ceux-ci |
EP4025227A4 (en) * | 2019-09-05 | 2023-11-01 | Sorrento Therapeutics, Inc. | DIMER ANTIGEN RECEPTORS (DAR) THAT BIND TO BCMA |
-
2022
- 2022-09-06 IL IL311141A patent/IL311141A/en unknown
- 2022-09-06 CA CA3231003A patent/CA3231003A1/en active Pending
- 2022-09-06 WO PCT/EP2022/074696 patent/WO2023031473A1/en active Application Filing
- 2022-09-06 US US17/929,799 patent/US20230109496A1/en active Pending
- 2022-09-06 TW TW111133765A patent/TW202328192A/zh unknown
- 2022-09-06 KR KR1020247011157A patent/KR20240051280A/ko unknown
- 2022-09-06 AU AU2022338208A patent/AU2022338208A1/en active Pending
- 2022-09-06 AR ARP220102407A patent/AR127743A1/es unknown
- 2022-11-14 US US18/055,362 patent/US20230212301A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20240051280A (ko) | 2024-04-19 |
TW202328192A (zh) | 2023-07-16 |
US20230212301A1 (en) | 2023-07-06 |
US20230109496A1 (en) | 2023-04-06 |
AU2022338208A1 (en) | 2024-03-21 |
IL311141A (en) | 2024-04-01 |
CA3231003A1 (en) | 2023-03-09 |
WO2023031473A1 (en) | 2023-03-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2669395T3 (es) | Anticuerpos humanizados que reconocen la alfa-sinucleína | |
ES2764833T3 (es) | Anticuerpos contra TEM8 y su uso | |
JP2019511222A5 (es) | ||
JP2020531515A (ja) | 癌治療向け免疫療法とサイトカイン制御療法の組合せ | |
CN110505877A (zh) | Rna癌症疫苗 | |
CA3014885A1 (en) | Combination immune therapy and cytokine control therapy for cancer treatment | |
PE20221580A1 (es) | Anticuerpos terapeuticos y sus usos | |
CN105026428A (zh) | PD-l抗体、其抗原结合片段及其医药用途 | |
AR109715A1 (es) | Anticuerpos anti-cd27 | |
CN104994873A (zh) | 人单克隆抗-pd-l1抗体和使用方法 | |
ITMI20071522A1 (it) | Vaccino idiotipico | |
BR112013012555B8 (pt) | Peptídeo imunogênico isolado derivado de uma proteína antigênica, seus usos, método para a preparação de um peptídeo com capacidade de provocar a ativação de células nkt e método in vitro para obtenção de uma população de células nkt cd4+ antígeno específicas | |
JP6154895B2 (ja) | ヒト二重特異性EGFRvIII抗体結合分子 | |
AR127743A1 (es) | Anticuerpos capaces de unirse a cd27, variantes y usos de los mismos | |
MX2020003945A (es) | Tratamiento de enfermedades oculares y cancer de colon metastasico con vegf-trap humano modificado post-traduccionalmente . | |
CN106999556A (zh) | 细胞因子诱导的杀伤细胞的双特异性抗体介导的癌症治疗 | |
AR111265A1 (es) | Combinaciones farmacéuticas, kit, célula huésped, uso | |
ECSP15028696A (es) | Anticuerpos anti-lamp1 y conjugados anticuerpo fármaco, y usos de éstos | |
AR118997A1 (es) | Partículas virales modificadas y usos de estas | |
BR112021008263A2 (pt) | materiais e métodos para tratamento de câncer | |
JPWO2018026018A1 (ja) | T細胞受容体の認識機構を用いたがん又は感染症の治療及び診断 | |
JP2019511246A (ja) | 改変hsp70ドメインを有する抗原結合融合タンパク質 | |
Chrun et al. | A DNA vaccine encoding the gn ectodomain of Rift Valley fever virus protects mice via a humoral response decreased by dec205 targeting | |
PE20231082A1 (es) | Muteinas de il-10 y proteinas de fusion de las mismas referencia cruzada a solicitudes relacionadas | |
Mintern et al. | Antigen-presenting cells look within during influenza infection |