AR123001A1 - Anticuerpos anti-notch2 y métodos de uso - Google Patents

Anticuerpos anti-notch2 y métodos de uso

Info

Publication number
AR123001A1
AR123001A1 ARP210102016A ARP210102016A AR123001A1 AR 123001 A1 AR123001 A1 AR 123001A1 AR P210102016 A ARP210102016 A AR P210102016A AR P210102016 A ARP210102016 A AR P210102016A AR 123001 A1 AR123001 A1 AR 123001A1
Authority
AR
Argentina
Prior art keywords
methods
notch2
antibody
antibodies
mediated signaling
Prior art date
Application number
ARP210102016A
Other languages
English (en)
Inventor
Cecilia Pui Chi Chiu
Yan Wu
Adel Mahmoud Elsohly
Daniel George Lafkas
Jian Mehr-Dean Payandeh
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR123001A1 publication Critical patent/AR123001A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

La invención proporciona anticuerpos anti-Notch2 y sus métodos de uso. Reivindicación 1: Un anticuerpo aislado que se une a Notch2 humana, en donde el anticuerpo inhibe la señalización mediada por Jagged1, pero no inhibe la señalización mediada por DLL1. Reivindicación 52: El anticuerpo de acuerdo con cualquiera de las reivindicaciones 1 - 41 o la composición farmacéutica de acuerdo con cualquiera de las reivindicaciones 48 - 50 para su uso en el tratamiento de una enfermedad pulmonar mucoobstructiva.
ARP210102016A 2020-07-17 2021-07-16 Anticuerpos anti-notch2 y métodos de uso AR123001A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063053034P 2020-07-17 2020-07-17

Publications (1)

Publication Number Publication Date
AR123001A1 true AR123001A1 (es) 2022-10-19

Family

ID=77338798

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210102016A AR123001A1 (es) 2020-07-17 2021-07-16 Anticuerpos anti-notch2 y métodos de uso

Country Status (17)

Country Link
US (1) US20230303682A1 (es)
EP (1) EP4182348A1 (es)
JP (1) JP2023534458A (es)
KR (1) KR20230038735A (es)
CN (1) CN116406377A (es)
AR (1) AR123001A1 (es)
AU (1) AU2021308653A1 (es)
BR (1) BR112023000839A2 (es)
CA (1) CA3185122A1 (es)
CL (1) CL2023000129A1 (es)
CO (1) CO2023000505A2 (es)
CR (1) CR20230087A (es)
IL (1) IL299799A (es)
MX (1) MX2023000617A (es)
PE (1) PE20231300A1 (es)
TW (1) TW202216780A (es)
WO (1) WO2022016037A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230322958A1 (en) * 2022-01-19 2023-10-12 Genentech, Inc. Anti-Notch2 Antibodies and Conjugates and Methods of Use

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Also Published As

Publication number Publication date
TW202216780A (zh) 2022-05-01
CL2023000129A1 (es) 2023-07-07
WO2022016037A1 (en) 2022-01-20
AU2021308653A1 (en) 2023-02-16
IL299799A (en) 2023-03-01
MX2023000617A (es) 2023-02-13
CO2023000505A2 (es) 2023-04-05
KR20230038735A (ko) 2023-03-21
CR20230087A (es) 2023-03-20
EP4182348A1 (en) 2023-05-24
JP2023534458A (ja) 2023-08-09
CN116406377A (zh) 2023-07-07
US20230303682A1 (en) 2023-09-28
BR112023000839A2 (pt) 2023-02-07
CA3185122A1 (en) 2022-01-20
PE20231300A1 (es) 2023-08-24

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