AR117916A1 - Compuesto heterocíclico y su uso - Google Patents

Compuesto heterocíclico y su uso

Info

Publication number
AR117916A1
AR117916A1 ARP200100236A ARP200100236A AR117916A1 AR 117916 A1 AR117916 A1 AR 117916A1 AR P200100236 A ARP200100236 A AR P200100236A AR P200100236 A ARP200100236 A AR P200100236A AR 117916 A1 AR117916 A1 AR 117916A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
optionally substituted
substituents selected
alkoxy
Prior art date
Application number
ARP200100236A
Other languages
English (en)
Inventor
Yoshiteru Ito
Tohru Miyazaki
Tsuneo Oda
Alexander Martin Pawliczek
Norihito Tokunaga
Yasutaka Hoashi
Tatsuki Koike
Yuichi Kajita
Yuhei Miyanohana
Yasushi Hattori
Kohei Takeuchi
Keisuke Imamura
Takahiro Sugimoto
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of AR117916A1 publication Critical patent/AR117916A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

La presente proporciona un compuesto heterocíclico que tiene actividad de un agonista del receptor de orexina tipo 2. Un compuesto representado por la fórmula [1] en donde cada símbolo es como se describe en la memoria descriptiva, o una de sus sales tiene una actividad del agonista del receptor de orexina tipo 2, y es útil como un agente para la profilaxis o tratamiento de la narcolepsia. Reivindicación 1: Un compuesto representado por la fórmula [1] caracterizado porque R¹ es (1) un grupo alquilo C₁₋₆, (2) un grupo mono o dialquilamino C₁₋₆, o (3) un grupo cicloalquilo C₃₋₆; R² es (1) un átomo de hidrógeno, (2) un átomo de flúor, o (3) un grupo alquilo C₁₋₆; R³ es (1) un grupo alquilo C₁₋₆ carbonilo opcionalmente sustituido con 1 a 3 sustituyentes seleccionados de (a) un átomo de halógeno, (b) un grupo hidroxi, y (c) un grupo ciano, (2) un grupo alcoxi C₁₋₆ carbonilo, (3) un grupo cicloalquil C₃₋₁₀ carbonilo (el resto cicloalquilo C₃₋₁₀ del grupo cicloalquil C₃₋₁₀ carbonilo está opcionalmente unido con puente) opcionalmente sustituido con 1 a 3 sustituyentes seleccionados de (a) un átomo de halógeno, (b) un grupo hidroxi, (c) un grupo ciano, y (d) un grupo alquilo C₁₋₆, (4) un grupo heterociclilcarbonilo no aromático de 3 a 14 miembros opcionalmente sustituido con 1 a 3 sustituyentes seleccionados de (a) un átomo de halógeno, (b) un grupo hidroxi, y (c) un grupo alquilo C₁₋₆, (5) un grupo mono o dialquil C₁₋₆ carbamoílo, (6) un grupo N-alquil C₁₋₆-N-alcoxi C₁₋₆-carbamoílo, o (7) un grupo N-alquil C₁₋₆-N’,N’-di-alquil C₁₋₆hidrazina-carbonilo; y el Anillo A es (1) un anillo benceno también sustituido con un sustituyente seleccionado de (a) un grupo arilo C₆₋₁₄ opcionalmente sustituido con 1 a 3 sustituyentes seleccionados de (i) un átomo de halógeno, (ii) un grupo alquilo C₁₋₆ opcionalmente halogenado, y (iii) un grupo alcoxi C₁₋₆ opcionalmente halogenado, y (b) un grupo heterocíclico aromático de 5 a 14 miembros opcionalmente sustituido con 1 a 3 sustituyentes seleccionados de (i) un grupo alquilo C₁₋₆ opcionalmente sustituido con 1 a 3 sustituyentes seleccionados de un átomo de halógeno y un grupo hidroxi, (ii) un grupo alcoxi C₁₋₆, (iii) un átomo de halógeno, y (iv) un grupo alcoxi C₁₋₆ carbonilo, y opcionalmente también sustituidos con 1 a 3 átomos de halógeno, o (2) un heterociclo aromático de 5 ó 6 miembros también sustituido con un grupo arilo C₆₋₁₄ opcionalmente sustituido con 1 a 3 átomos de halógeno, o una de sus sales.
ARP200100236A 2019-01-31 2020-01-30 Compuesto heterocíclico y su uso AR117916A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2019015488 2019-01-31

Publications (1)

Publication Number Publication Date
AR117916A1 true AR117916A1 (es) 2021-09-01

Family

ID=69770989

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200100236A AR117916A1 (es) 2019-01-31 2020-01-30 Compuesto heterocíclico y su uso

Country Status (20)

Country Link
US (3) US11028048B2 (es)
EP (1) EP3917616A1 (es)
JP (2) JP7253640B2 (es)
KR (1) KR20210121080A (es)
CN (1) CN113395993B (es)
AR (1) AR117916A1 (es)
AU (1) AU2020215380A1 (es)
BR (1) BR112021014180A2 (es)
CA (1) CA3124536A1 (es)
CL (1) CL2021001973A1 (es)
CO (1) CO2021011188A2 (es)
EA (1) EA202192138A1 (es)
EC (1) ECSP21056325A (es)
IL (1) IL284073A (es)
MX (1) MX2021008241A (es)
PE (1) PE20211700A1 (es)
SG (1) SG11202106791XA (es)
TW (1) TWI832962B (es)
WO (1) WO2020158958A1 (es)
ZA (1) ZA202106304B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023502441A (ja) 2019-11-25 2023-01-24 アルカームス インコーポレーテッド 置換大環状化合物および関連する治療方法
EP4066893A4 (en) 2019-11-27 2023-12-20 Takeda Pharmaceutical Company Limited HETEROCYCLIC COMPOUND
CR20230089A (es) 2020-08-18 2023-04-11 Merck Sharp & Dohme Llc Agonistas de bicicloheptano pirrolidina de los receptores de orexina
US20230271973A1 (en) * 2020-09-03 2023-08-31 Orexia Therapeutics Limited Bicyclic-heterocycle derivatives and their uses as orexin-2 receptor agonists
US20230331720A1 (en) * 2020-09-03 2023-10-19 Orexia Therapeutics Limited Medium- or macro-cyclic benzyl-substituted heterocycle derivatives and their uses as orexin-2 receptor agonists
US11760747B2 (en) 2020-12-21 2023-09-19 Alkermes, Inc. Substituted piperidino compounds and related methods of treatment
CA3215906A1 (en) 2021-04-02 2022-10-06 Takeda Pharmaceutical Company Limited Use of an orexin 2 receptor agonist for post operation recovery
WO2022207935A1 (en) * 2021-04-02 2022-10-06 Orexia Therapeutics Limited 2-(3-ethynylbenzyl)-substituted heterocycle derivatives as orexin-2 agonists
WO2023167925A1 (en) 2022-03-01 2023-09-07 Orexia Therapeutics Limited Medium- or macro-cyclic benzyl-substituted heterocycle derivatives and related uses
WO2023199091A1 (en) 2022-04-12 2023-10-19 Takeda Pharmaceutical Company Limited Heterocyclic compound

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6166193A (en) 1997-07-25 2000-12-26 Board Of Regents, University Of Texas System Polynucleotides encoding MY1 receptor
EP1196609A2 (en) 1999-06-28 2002-04-17 Oklahoma Medical Research Foundation Catalytically active recombinant memapsin and methods of use thereof
EP1252329A4 (en) 1999-07-30 2004-12-22 Univ Leland Stanford Junior HYPOCRETINE AND HYPOCRETINE RECEPTORS FOR THE REGULATION OF SLEEP AND SLEEP DISORDERS
US7112566B1 (en) 1999-09-17 2006-09-26 The Regents Of The University Of California Systemic administration of Hypocretin-1
US6204245B1 (en) 1999-09-17 2001-03-20 The Regents Of The University Of California Treatment of narcolepsy with immunosuppressants
WO2001074162A1 (en) 2000-04-04 2001-10-11 The Regents Of The University Of California Treatment of sleep disorders with hypocretin-1
US20060134109A1 (en) 2002-09-09 2006-06-22 Nura Inc. G protein coupled receptors and uses thereof
US20080260744A1 (en) 2002-09-09 2008-10-23 Omeros Corporation G protein coupled receptors and uses thereof
JP2006518709A (ja) 2002-12-13 2006-08-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒトオレキシン−２受容体のモジュレーターを同定する方法
HUP0304101A3 (en) * 2003-12-22 2008-10-28 Sanofi Aventis Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
MX2008013114A (es) 2006-04-14 2008-10-21 Abbott Gmbh & Co Kg Compuestos de ariloxietilamina apropiados para tratar trastornos que responden a la modulacion del receptor de dopamina d3.
AU2012200270A1 (en) * 2007-05-23 2012-02-09 Merck Sharp & Dohme Corp. Pyridyl piperidine orexin receptor antagonists
WO2009049215A1 (en) 2007-10-10 2009-04-16 Wake Forest University Health Sciences Methods to reduce the effects of sleep deprivation
US8258163B2 (en) 2008-06-04 2012-09-04 Board Of Regents, The University Of Texas System Small-molecule agonists for type-2 orexin receptor
EP2694472B1 (en) * 2011-04-05 2020-03-11 Takeda Pharmaceutical Company Limited Sulfonamide derivative and use thereof
TW201341380A (zh) * 2012-04-05 2013-10-16 Takeda Pharmaceutical 磺醯胺衍生物及其用途
AU2013328301A1 (en) 2012-10-10 2015-05-28 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero-)aryl]-[2-(meta bi (hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives
WO2014170343A1 (en) 2013-04-15 2014-10-23 Icm (Institut Du Cerveau Et De La Moelle Épinière) Depolarizing agents and nicotinic acetylcholine receptor modulators for treating dopaminergic-related disorders
WO2014198880A1 (en) 2013-06-14 2014-12-18 Ferrer Internacional, S.A. 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity
WO2015048091A1 (en) 2013-09-24 2015-04-02 The Board Of Regents Of The University Of Texas System Orexin-control of bone formation and loss
EP3068783B1 (en) 2013-11-15 2020-09-23 The Board of Trustees of the Leland Stanford Junior University Agonists of hypocretin receptor 2 for use for treating heart failure
MX2016007661A (es) 2013-12-12 2017-01-06 Univ Tsukuba Derivado de sulfonamida o sales de adicion de acido farmaceuticamente aceptables del mismo.
JP6552117B2 (ja) 2014-03-28 2019-07-31 国立大学法人 筑波大学 敗血症の予防治療剤
WO2016025669A1 (en) * 2014-08-13 2016-02-18 Eolas Therapeutics, Inc. Difluoropyrrolidines as orexin receptor modulators
EP3029024A1 (en) 2014-12-02 2016-06-08 Ferrer Internacional, S.A. 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity
WO2016133160A1 (ja) 2015-02-19 2016-08-25 国立大学法人筑波大学 スルホンアミド誘導体またはその薬学的に許容される酸付加塩
WO2016199906A1 (ja) 2015-06-12 2016-12-15 国立大学法人筑波大学 スルホンアミド誘導体またはその薬学的に許容される酸付加塩
US10980755B2 (en) 2015-09-10 2021-04-20 The Regents Of The University Of California LRH-1 modulators
US10508083B2 (en) * 2016-02-04 2019-12-17 Takeda Pharmaceutical Company Limited Substituted piperidine compound and use thereof
JP6957598B2 (ja) 2017-03-08 2021-11-02 武田薬品工業株式会社 置換ピロリジン化合物およびその用途
EP3594202B1 (en) 2017-03-08 2021-08-11 Takeda Pharmaceutical Company Limited Substituted pyrrolidine compound and use thereof
US10428023B2 (en) 2017-08-03 2019-10-01 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
EP3663281B1 (en) 2017-08-03 2022-12-28 Takeda Pharmaceutical Company Limited Heterocyclic compound and application thereof
JPWO2019112007A1 (ja) 2017-12-07 2020-12-24 国立大学法人 筑波大学 鎮痛薬による眠気の予防または治療薬
WO2020004537A1 (ja) 2018-06-29 2020-01-02 武田薬品工業株式会社 複素環化合物およびその用途
EP3816154A4 (en) 2018-06-29 2022-03-30 Takeda Pharmaceutical Company Limited HETEROCYCLIC COMPOUND AND APPLICATION THEREOF
US20220017514A1 (en) 2018-12-12 2022-01-20 Takeda Pharmaceutical Company Limited Heterocyclic compound
US20230042358A1 (en) 2018-12-12 2023-02-09 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2020167701A1 (en) 2019-02-13 2020-08-20 Merck Sharp & Dohme Corp. Pyrrolidine orexin receptor agonists
WO2020167706A1 (en) 2019-02-13 2020-08-20 Merck Sharp & Dohme Corp. 5-alkyl pyrrolidine orexin receptor agonists

Also Published As

Publication number Publication date
US20200247747A1 (en) 2020-08-06
US20230040770A1 (en) 2023-02-09
US11028048B2 (en) 2021-06-08
BR112021014180A2 (pt) 2021-09-21
CN113395993A (zh) 2021-09-14
ECSP21056325A (es) 2021-09-30
TW202043196A (zh) 2020-12-01
US20210276949A1 (en) 2021-09-09
CL2021001973A1 (es) 2022-04-08
EP3917616A1 (en) 2021-12-08
JP2022519331A (ja) 2022-03-22
TWI832962B (zh) 2024-02-21
PE20211700A1 (es) 2021-09-01
AU2020215380A1 (en) 2021-08-19
ZA202106304B (en) 2023-06-28
CN113395993B (zh) 2024-02-20
CO2021011188A2 (es) 2021-10-29
IL284073A (en) 2021-08-31
KR20210121080A (ko) 2021-10-07
JP7253640B2 (ja) 2023-04-06
WO2020158958A1 (en) 2020-08-06
MX2021008241A (es) 2021-08-16
SG11202106791XA (en) 2021-07-29
AU2020215380A2 (en) 2021-08-19
JP2023078426A (ja) 2023-06-06
EA202192138A1 (ru) 2022-03-10
CA3124536A1 (en) 2020-08-06

Similar Documents

Publication Publication Date Title
AR117916A1 (es) Compuesto heterocíclico y su uso
AR108388A2 (es) Compuestos de oxazol sustituidos con indazol como inhibidores de pi3-quinasas
AR088226A1 (es) Derivados piperidinicos heterociclicos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades neurodegenerativas
NZ732657A (en) Picolinamides with fungicidal activity and other related compounds
UY30830A1 (es) Piperidinas sustituidas que presentan actividad inhibitoria de proteinquinasa
BRPI0607062A2 (pt) composto de aminopiridina com atividade inibidora de syk, composição farmacêutica e agente terapêutico compreendendo os mesmos
ES2188016T3 (es) Derivaqdo de benzamidoxima, productos intermedios y procedimiento para su obtencion y su empleo como fungicidas.
ES2191484T3 (es) Compuestos heterociclicos como inhibidores de enzimas de rotamasa.
CO6331462A2 (es) Compuesto de fenil pirrol o una sal farmaceuticamente aceptable del mismo con actividad activadora de la glucoquinasa
AR068538A1 (es) Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido
AR103742A1 (es) Derivados de trifluorometilpropanamida
CO5660292A2 (es) Pirimidinas 2-sustituidas
DOP2012000318A (es) Compuestos heterociclicos fusionados
ECSP088805A (es) 2-(piridin-2-il)-pirimidinas como fungicidas
AR094812A1 (es) Derivado de piridina monocíclico como inhibidor del fgfr
MY169179A (en) Novel piperidine compound or salt thereof
AR113842A1 (es) Derivados de tiazol microbiocidas
AR109991A1 (es) Tratamientos de combinación que comprenden la administración de imidazopirazinonas
RS53378B (en) CONDENSED RING UNITS AND THEIR USE
AR111248A1 (es) Derivados de ciclopropilmetilamida activos como pesticida
AR095059A1 (es) Compuestos herbicidas
AR115020A1 (es) Compuesto heterocíclico nitrogenado y su uso como antagonista del receptor nmda
ECSP078009A (es) Derivados del 4,5-diarilpirrol, su preparación y su aplicación en terapéutica
CY1124702T1 (el) Μεθοδοι χρησης για παραγωγα τριυποκατεστημενου βενζοτριαζολιου ως αναστολεις διυδροοροτικης οξυγονασης
AR095895A1 (es) Compuestos de acil-imino-piridina n-sustituidos y derivados para combatir plagas de animales