SG11202106791XA - Heterocyclic compound and use thereof - Google Patents
Heterocyclic compound and use thereofInfo
- Publication number
- SG11202106791XA SG11202106791XA SG11202106791XA SG11202106791XA SG11202106791XA SG 11202106791X A SG11202106791X A SG 11202106791XA SG 11202106791X A SG11202106791X A SG 11202106791XA SG 11202106791X A SG11202106791X A SG 11202106791XA SG 11202106791X A SG11202106791X A SG 11202106791XA
- Authority
- SG
- Singapore
- Prior art keywords
- heterocyclic compound
- heterocyclic
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019015488 | 2019-01-31 | ||
PCT/JP2020/004444 WO2020158958A1 (en) | 2019-01-31 | 2020-01-30 | Heterocyclic compound and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202106791XA true SG11202106791XA (en) | 2021-07-29 |
Family
ID=69770989
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202106791XA SG11202106791XA (en) | 2019-01-31 | 2020-01-30 | Heterocyclic compound and use thereof |
Country Status (20)
Country | Link |
---|---|
US (3) | US11028048B2 (en) |
EP (1) | EP3917616A1 (en) |
JP (2) | JP7253640B2 (en) |
KR (1) | KR20210121080A (en) |
CN (1) | CN113395993B (en) |
AR (1) | AR117916A1 (en) |
AU (1) | AU2020215380A1 (en) |
BR (1) | BR112021014180A2 (en) |
CA (1) | CA3124536A1 (en) |
CL (1) | CL2021001973A1 (en) |
CO (1) | CO2021011188A2 (en) |
EA (1) | EA202192138A1 (en) |
EC (1) | ECSP21056325A (en) |
IL (1) | IL284073A (en) |
MX (1) | MX2021008241A (en) |
PE (1) | PE20211700A1 (en) |
SG (1) | SG11202106791XA (en) |
TW (1) | TWI832962B (en) |
WO (1) | WO2020158958A1 (en) |
ZA (1) | ZA202106304B (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3155885A1 (en) | 2019-11-25 | 2021-06-03 | Lewis D. Pennington | Substituted macrocyclic compounds and related methods of treatment |
EP4066893A4 (en) | 2019-11-27 | 2023-12-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
BR112023002957A2 (en) | 2020-08-18 | 2023-04-04 | Merck Sharp & Dohme Llc | COMPOUND, PHARMACEUTICAL COMPOSITION, AND, METHODS FOR TREATING NARCOLEPSY AND FOR TREATING HYPERSONIA IN A MAMMAL SUBJECT |
TW202227397A (en) * | 2020-09-03 | 2022-07-16 | 英商歐瑞夏治療公司 | Bicyclic-heterocycle derivatives and related uses |
JP2023540350A (en) * | 2020-09-03 | 2023-09-22 | センテッサ ファーマシューティカルズ (オレキシア) リミテッド | Medium or macrocyclic benzyl-substituted heterocyclic derivatives and their use as orexin-2 receptor agonists |
US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
WO2022207935A1 (en) * | 2021-04-02 | 2022-10-06 | Orexia Therapeutics Limited | 2-(3-ethynylbenzyl)-substituted heterocycle derivatives as orexin-2 agonists |
BR112023020104A2 (en) | 2021-04-02 | 2023-11-14 | Takeda Pharmaceuticals Co | METHODS FOR POSTOPERATIVE RECOVERY, TO FACILITATE RECOVERY OR REDUCE RECOVERY TIME FROM ANESTHESIA, TO PREVENT OR TREAT POSTOPERATIVE RESPIRATORY DISORDERS/DEPRESSION OR OPIOID-INDUCED RESPIRATORY DISORDERS/DEPRESSION, POSTOPERATIVE SEDATION OR THEREOF EDUCATION INDUCED BY OPIOIDS AND TO REDUCE AN OPIOID SIDE EFFECT |
WO2023167925A1 (en) | 2022-03-01 | 2023-09-07 | Orexia Therapeutics Limited | Medium- or macro-cyclic benzyl-substituted heterocycle derivatives and related uses |
WO2023199091A1 (en) | 2022-04-12 | 2023-10-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
WO2024095133A1 (en) | 2022-10-31 | 2024-05-10 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
WO2024095158A1 (en) | 2022-10-31 | 2024-05-10 | Takeda Pharmaceutical Company Limited | Dosing of orexin type 2 receptor agonists |
Family Cites Families (40)
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US6166193A (en) | 1997-07-25 | 2000-12-26 | Board Of Regents, University Of Texas System | Polynucleotides encoding MY1 receptor |
US6545127B1 (en) | 1999-06-28 | 2003-04-08 | Oklahoma Medical Research Foundation | Catalytically active recombinant memapsin and methods of use thereof |
EP1252329A4 (en) | 1999-07-30 | 2004-12-22 | Univ Leland Stanford Junior | Hypocretin and hypocretin receptors in regulation of sleep and related disorders |
US6204245B1 (en) | 1999-09-17 | 2001-03-20 | The Regents Of The University Of California | Treatment of narcolepsy with immunosuppressants |
US7112566B1 (en) | 1999-09-17 | 2006-09-26 | The Regents Of The University Of California | Systemic administration of Hypocretin-1 |
WO2001074162A1 (en) | 2000-04-04 | 2001-10-11 | The Regents Of The University Of California | Treatment of sleep disorders with hypocretin-1 |
US20080260744A1 (en) | 2002-09-09 | 2008-10-23 | Omeros Corporation | G protein coupled receptors and uses thereof |
JP2006513702A (en) | 2002-09-09 | 2006-04-27 | ヌラ インコーポレーティッド | G protein-coupled receptor and use thereof |
DK1572133T3 (en) | 2002-12-13 | 2008-07-14 | Janssen Pharmaceutica Nv | Method for identifying modulators of the human orexin-2 receptor |
HUP0304101A3 (en) * | 2003-12-22 | 2008-10-28 | Sanofi Aventis | Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates |
JP5232987B2 (en) | 2006-04-14 | 2013-07-10 | アボット ゲーエムベーハー ウント カンパニー カーゲー | Aryloxyethylamine compounds suitable for the treatment of disorders responsive to modulation of dopamine D3 receptors |
AU2012200270A1 (en) * | 2007-05-23 | 2012-02-09 | Merck Sharp & Dohme Corp. | Pyridyl piperidine orexin receptor antagonists |
WO2009049215A1 (en) | 2007-10-10 | 2009-04-16 | Wake Forest University Health Sciences | Methods to reduce the effects of sleep deprivation |
US8258163B2 (en) | 2008-06-04 | 2012-09-04 | Board Of Regents, The University Of Texas System | Small-molecule agonists for type-2 orexin receptor |
WO2012137982A2 (en) | 2011-04-05 | 2012-10-11 | Takeda Pharmaceutical Company Limited | Sulfonamide derivative and use thereof |
TW201341380A (en) * | 2012-04-05 | 2013-10-16 | Takeda Pharmaceutical | Sulfonamide derivative and use thereof |
SG11201502493XA (en) | 2012-10-10 | 2015-04-29 | Actelion Pharmaceuticals Ltd | Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives |
WO2014170343A1 (en) | 2013-04-15 | 2014-10-23 | Icm (Institut Du Cerveau Et De La Moelle Épinière) | Depolarizing agents and nicotinic acetylcholine receptor modulators for treating dopaminergic-related disorders |
WO2014198880A1 (en) | 2013-06-14 | 2014-12-18 | Ferrer Internacional, S.A. | 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity |
US20160250224A1 (en) | 2013-09-24 | 2016-09-01 | The Board Of Regents Of The University Of Texas System | Orexin-control of bone formation and loss |
US10172916B2 (en) | 2013-11-15 | 2019-01-08 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating heart failure with agonists of hypocretin receptor 2 |
US9815787B2 (en) | 2013-12-12 | 2017-11-14 | University Of Tsukuba | Sulfonamide derivative or pharmaceutically acceptable acid addition salt thereof |
JP6552117B2 (en) | 2014-03-28 | 2019-07-31 | 国立大学法人 筑波大学 | Sepsis preventive and therapeutic agent |
JP6663909B2 (en) | 2014-08-13 | 2020-03-13 | エオラス セラピューティクス, インコーポレイテッド | Difluoropyrrolidine as an orexin receptor modulator |
EP3029024A1 (en) | 2014-12-02 | 2016-06-08 | Ferrer Internacional, S.A. | 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity |
WO2016133160A1 (en) | 2015-02-19 | 2016-08-25 | 国立大学法人筑波大学 | Sulfonamide derivative or pharmaceutically acceptable acid addition salt thereof |
JP6775803B2 (en) | 2015-06-12 | 2020-10-28 | 国立大学法人 筑波大学 | Sulfonamide derivative or pharmaceutically acceptable acid addition salt thereof |
WO2017044889A1 (en) | 2015-09-10 | 2017-03-16 | The Regents Of The University Of California | Lrh-1 modulators |
ES2907373T3 (en) | 2016-02-04 | 2022-04-25 | Takeda Pharmaceuticals Co | Substituted piperidine compound and use thereof |
WO2018164191A1 (en) * | 2017-03-08 | 2018-09-13 | 武田薬品工業株式会社 | Substituted pyrrolidine compound and use thereof |
JP7012703B2 (en) | 2017-03-08 | 2022-02-14 | 武田薬品工業株式会社 | Substituted pyrrolidine compounds and their uses |
JP6574918B1 (en) | 2017-08-03 | 2019-09-11 | 武田薬品工業株式会社 | Heterocyclic compounds and uses thereof |
WO2019027003A1 (en) | 2017-08-03 | 2019-02-07 | 武田薬品工業株式会社 | Heterocyclic compound and application thereof |
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WO2020004536A1 (en) | 2018-06-29 | 2020-01-02 | 武田薬品工業株式会社 | Heterocyclic compound and application thereof |
EP3816153B1 (en) | 2018-06-29 | 2023-10-18 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
US20220017514A1 (en) | 2018-12-12 | 2022-01-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
EP3895707B1 (en) | 2018-12-12 | 2023-10-04 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
WO2020167701A1 (en) | 2019-02-13 | 2020-08-20 | Merck Sharp & Dohme Corp. | Pyrrolidine orexin receptor agonists |
WO2020167706A1 (en) | 2019-02-13 | 2020-08-20 | Merck Sharp & Dohme Corp. | 5-alkyl pyrrolidine orexin receptor agonists |
-
2020
- 2020-01-30 MX MX2021008241A patent/MX2021008241A/en unknown
- 2020-01-30 AU AU2020215380A patent/AU2020215380A1/en active Pending
- 2020-01-30 BR BR112021014180-4A patent/BR112021014180A2/en unknown
- 2020-01-30 CN CN202080011417.1A patent/CN113395993B/en active Active
- 2020-01-30 JP JP2021568451A patent/JP7253640B2/en active Active
- 2020-01-30 AR ARP200100236A patent/AR117916A1/en unknown
- 2020-01-30 US US16/777,273 patent/US11028048B2/en active Active
- 2020-01-30 US US17/427,490 patent/US20230040770A1/en not_active Abandoned
- 2020-01-30 EP EP20709748.6A patent/EP3917616A1/en active Pending
- 2020-01-30 KR KR1020217024931A patent/KR20210121080A/en unknown
- 2020-01-30 EA EA202192138A patent/EA202192138A1/en unknown
- 2020-01-30 SG SG11202106791XA patent/SG11202106791XA/en unknown
- 2020-01-30 TW TW109102825A patent/TWI832962B/en active
- 2020-01-30 PE PE2021001139A patent/PE20211700A1/en unknown
- 2020-01-30 CA CA3124536A patent/CA3124536A1/en active Pending
- 2020-01-30 WO PCT/JP2020/004444 patent/WO2020158958A1/en unknown
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2021
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- 2021-06-16 IL IL284073A patent/IL284073A/en unknown
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2023
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AR117916A1 (en) | 2021-09-01 |
JP2023078426A (en) | 2023-06-06 |
AU2020215380A1 (en) | 2021-08-19 |
EA202192138A1 (en) | 2022-03-10 |
AU2020215380A2 (en) | 2021-08-19 |
CL2021001973A1 (en) | 2022-04-08 |
US20200247747A1 (en) | 2020-08-06 |
CN113395993A (en) | 2021-09-14 |
MX2021008241A (en) | 2021-08-16 |
JP2022519331A (en) | 2022-03-22 |
US11028048B2 (en) | 2021-06-08 |
CA3124536A1 (en) | 2020-08-06 |
US20230040770A1 (en) | 2023-02-09 |
ECSP21056325A (en) | 2021-09-30 |
BR112021014180A2 (en) | 2021-09-21 |
KR20210121080A (en) | 2021-10-07 |
WO2020158958A1 (en) | 2020-08-06 |
JP7253640B2 (en) | 2023-04-06 |
ZA202106304B (en) | 2023-06-28 |
US20210276949A1 (en) | 2021-09-09 |
EP3917616A1 (en) | 2021-12-08 |
TW202043196A (en) | 2020-12-01 |
CO2021011188A2 (en) | 2021-10-29 |
CN113395993B (en) | 2024-02-20 |
IL284073A (en) | 2021-08-31 |
PE20211700A1 (en) | 2021-09-01 |
TWI832962B (en) | 2024-02-21 |
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