AR117728A1 - Moléculas superagonistas de unión al antígeno cd28 con diana tumoral - Google Patents

Moléculas superagonistas de unión al antígeno cd28 con diana tumoral

Info

Publication number
AR117728A1
AR117728A1 ARP190103768A ARP190103768A AR117728A1 AR 117728 A1 AR117728 A1 AR 117728A1 AR P190103768 A ARP190103768 A AR P190103768A AR P190103768 A ARP190103768 A AR P190103768A AR 117728 A1 AR117728 A1 AR 117728A1
Authority
AR
Argentina
Prior art keywords
binding
antigen
molecules
tumor
superagonist
Prior art date
Application number
ARP190103768A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR117728A1 publication Critical patent/AR117728A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

Abstract

La presente se refiere a moléculas superagonistas de unión a antígeno con diana tumoral capaces de unión multivalente a CD28, a métodos para su producción, a composiciones que contienen dichos anticuerpos y a métodos de utilización de los mismos. Reivindicación 1: Una molécula superagonista de unión al antígeno CD28, caracterizada porque es capaz de unión bivalente a CD28 y que comprende: (a) dos o más dominios de unión a antígeno capaces de unión específica a CD28, (b) por lo menos un dominio de unión a antígeno capaz de unión específica a un antígeno asociado a tumor, y (c) un dominio Fc compuesto de una primera y una segunda subunidades capaces de asociación estable, que comprende una o más sustituciones de aminoácidos que reducen la afinidad de unión de la molécula de unión a antígeno a un receptor de Fc y/o la función efectora. Reivindicación 23: La molécula superagonista de unión al antígeno CD28 según cualquiera de las reivindicaciones 1 a 17, o la composición farmacéutica según la reivindicación 21 caracterizada porque se usa en el tratamiento del cáncer.
ARP190103768A 2018-12-21 2019-12-19 Moléculas superagonistas de unión al antígeno cd28 con diana tumoral AR117728A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18215116 2018-12-21

Publications (1)

Publication Number Publication Date
AR117728A1 true AR117728A1 (es) 2021-08-25

Family

ID=64755399

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190103768A AR117728A1 (es) 2018-12-21 2019-12-19 Moléculas superagonistas de unión al antígeno cd28 con diana tumoral

Country Status (7)

Country Link
US (1) US20200223925A1 (es)
EP (1) EP3898683A1 (es)
JP (1) JP2022513495A (es)
CN (1) CN113286822A (es)
AR (1) AR117728A1 (es)
TW (1) TW202030204A (es)
WO (1) WO2020127628A1 (es)

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MY198034A (en) 2018-12-21 2023-07-27 Hoffmann La Roche Tumor-targeted agonistic cd28 antigen binding molecules
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WO2023278693A1 (en) * 2021-06-30 2023-01-05 The Regents Of The University Of California Altering cytokine specificity through binding valency
TW202321457A (zh) 2021-08-04 2023-06-01 美商薩那生物科技公司 靶向ｃｄ４之病毒載體之用途
WO2023150518A1 (en) 2022-02-01 2023-08-10 Sana Biotechnology, Inc. Cd3-targeted lentiviral vectors and uses thereof
WO2023155845A1 (zh) * 2022-02-16 2023-08-24 上海优替济生生物医药有限公司 人源化抗cd28抗体及其与抗cd40的双特异性抗体
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Also Published As

Publication number Publication date
TW202030204A (zh) 2020-08-16
CN113286822A (zh) 2021-08-20
JP2022513495A (ja) 2022-02-08
US20200223925A1 (en) 2020-07-16
EP3898683A1 (en) 2021-10-27
WO2020127628A1 (en) 2020-06-25

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