AR106588A1 - Derivados de indolin-2-ona para el tratamiento de enfermedades del snc - Google Patents
Derivados de indolin-2-ona para el tratamiento de enfermedades del sncInfo
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- AR106588A1 AR106588A1 ARP160103363A ARP160103363A AR106588A1 AR 106588 A1 AR106588 A1 AR 106588A1 AR P160103363 A ARP160103363 A AR P160103363A AR P160103363 A ARP160103363 A AR P160103363A AR 106588 A1 AR106588 A1 AR 106588A1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- Urology & Nephrology (AREA)
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- Cardiology (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Derivados de indolin-2-ona. Los compuestos pueden usarse en el tratamiento de enfermedades del SNC relacionadas con síntomas positivos (psicosis) y negativos de la esquizofrenia, abuso de sustancias, alcohol y drogadicción, trastornos obsesivo-compulsivos, deterioro cognitivo, trastornos bipolares, trastornos del estado de ánimo, depresión mayor, depresión resistente al tratamiento, trastornos de ansiedad, enfermedad de Alzheimer, autismo, enfermedad de Parkinson, dolor crónico, trastorno límite de la personalidad, enfermedad neurodegenerativa, alteraciones del sueño, síndrome de la fatiga crónica, rigidez, enfermedad inflamatoria, asma, enfermedad de Huntington, ADHD, esclerosis lateral amiotrófica, efectos en la artritis, enfermedad autoinmunitaria, enfermedades víricas y fúngicas, enfermedades cardiovasculares, enfermedades oftalmológicas e inflamatorias de la retina y problemas de equilibrio, epilepsia y trastornos del neurodesarrollo con epilepsia comórbida. Reivindicación 1: Un compuesto de fórmula (1) en donde A es fenilo o un grupo heteroarilo de cinco o seis miembros, que contiene uno o dos átomos de N, seleccionados entre los restos del grupo de fórmulas (2); o el grupo amida -C(O)-NR¹R² puede formar junto con dos átomos de carbono colindantes a partir del grupo A un anillo condensado adicional, seleccionados entre los restos del grupo de fórmulas (3); R¹ / R² son independientemente el uno del otro, hidrógeno, alquilo inferior, alquilo inferior sustituido con halógeno, alquilo inferior sustituido con hidroxi, -(CH₂)₂-alcoxi inferior, oxetanilo, cicloalquilo, CH₂-cicloalquilo, anillos cicloalquilo que están opcionalmente sustituidos con halógeno; o R¹ y R² pueden formar junto con el átomo de N al que están unidos el grupo de fórmula (4); R³ es hidrógeno o alquilo inferior; así como sales farmacéuticamente aceptables de los mismos, con una mezcla racémica, o con su enantiómero correspondiente y/o isómero óptico y/o estereoisómero del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15193342 | 2015-11-06 |
Publications (1)
Publication Number | Publication Date |
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AR106588A1 true AR106588A1 (es) | 2018-01-31 |
Family
ID=54476820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP160103363A AR106588A1 (es) | 2015-11-06 | 2016-11-04 | Derivados de indolin-2-ona para el tratamiento de enfermedades del snc |
Country Status (34)
Country | Link |
---|---|
US (2) | US10710985B2 (es) |
EP (1) | EP3371168B1 (es) |
JP (1) | JP6857662B2 (es) |
KR (1) | KR20180080305A (es) |
CN (1) | CN108349944B (es) |
AR (1) | AR106588A1 (es) |
AU (1) | AU2016348493B2 (es) |
BR (1) | BR112018008056A2 (es) |
CA (1) | CA3002489C (es) |
CL (1) | CL2018001085A1 (es) |
CO (1) | CO2018005718A2 (es) |
CR (1) | CR20180255A (es) |
DK (1) | DK3371168T3 (es) |
ES (1) | ES2808920T3 (es) |
HK (1) | HK1257170A1 (es) |
HR (1) | HRP20201158T1 (es) |
HU (1) | HUE050083T2 (es) |
IL (1) | IL258656A (es) |
LT (1) | LT3371168T (es) |
MA (1) | MA43159B1 (es) |
MX (1) | MX2018005121A (es) |
MY (1) | MY197370A (es) |
PE (1) | PE20181885A1 (es) |
PH (1) | PH12018500978A1 (es) |
PL (1) | PL3371168T3 (es) |
PT (1) | PT3371168T (es) |
RS (1) | RS60504B1 (es) |
RU (1) | RU2727179C2 (es) |
SG (1) | SG11201803796SA (es) |
SI (1) | SI3371168T1 (es) |
TW (1) | TWI631117B (es) |
UA (1) | UA122589C2 (es) |
WO (1) | WO2017076852A1 (es) |
ZA (1) | ZA201802411B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017076842A1 (en) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Indolin-2-one derivatives |
PE20181885A1 (es) | 2015-11-06 | 2018-12-07 | Hoffmann La Roche | Derivados de indolin-2-ona |
WO2017076931A1 (en) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Indolin-2-one derivatives for use in the treatment of cns and related disorders |
EP3371170B1 (en) | 2015-11-06 | 2019-07-31 | H. Hoffnabb-La Roche Ag | Indolin-2-one derivatives useful in the treatment of cns diseases |
EP4038192A4 (en) | 2019-10-01 | 2023-11-01 | Empyrean Neuroscience, Inc. | GENETIC MANIPULATION OF MUSHROOMS TO MODULATE TRYPTAMINE EXPRESSION |
CN115298163A (zh) * | 2020-04-29 | 2022-11-04 | 巴斯夫欧洲公司 | 通过钯催化的羰基化反应制备芳族羧酰胺 |
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TW251284B (es) | 1992-11-02 | 1995-07-11 | Pfizer | |
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AR053713A1 (es) | 2005-04-20 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos heterociclicos y sus usos como agentes terapeuticos |
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