AR104555A1 - SULFONAS TRICÍCLICAS COMO MODULARES DE RORg - Google Patents

SULFONAS TRICÍCLICAS COMO MODULARES DE RORg

Info

Publication number
AR104555A1
AR104555A1 ARP160101311A ARP160101311A AR104555A1 AR 104555 A1 AR104555 A1 AR 104555A1 AR P160101311 A ARP160101311 A AR P160101311A AR P160101311 A ARP160101311 A AR P160101311A AR 104555 A1 AR104555 A1 AR 104555A1
Authority
AR
Argentina
Prior art keywords
cr2er2f
substituted
alkyl
nr11r11
independently
Prior art date
Application number
ARP160101311A
Other languages
English (en)
Inventor
A Weigelt Carolyn
Beaudoin Bertrand Myra
S Srivastava Anurag
A M Cornelius Lyndon
J Cherney Robert
Liu Qingjie
G Batt Douglas
Shi Qing
Marcoux David
G Murali Dhar T
Duan Jingwu
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR104555A1 publication Critical patent/AR104555A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems

Abstract

Tales compuestos y composiciones son útiles en los métodos para modular la actividad de RORg en una célula y en métodos para tratar a un sujeto que tiene una enfermedad o un trastorno en los que el sujeto se beneficiaría terapéuticamente de la modulación de la actividad de RORg, por ejemplo, trastornos autoinmunitarios y/o inflamatorios. Reivindicación 1: El compuesto caracterizado por la fórmula (1), o un estereoisómero o una sal de aquel aceptable desde el punto de vista farmacéutico, en donde X es -CR⁴R⁵-, -(CR⁴R⁵)₂, -OCR⁶R⁷-, -S(O)ₚCR⁶R⁷- o -NR⁶CR⁶R⁷-; V e Y son independientemente anillos aromáticos o heteroaromáticos de 5 ó 6 miembros; R¹ se selecciona, independientemente de cada caso, de hidrógeno, CD₃, halo, OCF₃, CN, -O-C₁₋₆ alquilo, -O-C₁₋₆ alquil-OH, -alcoxialcoxi, S(O)ₚ-C₁₋₆ alquilo, -S(O)ₚ-C₁₋₆ alquil-OH, -tioalcoxialcoxi (por ejemplo, -SCH₂CH₂OCH₃), NR¹¹R¹¹, C₁₋₆ alquilo sustituido con 0 - 3 R¹ᵃ, -(CR²ᵉR²ᶠ)ʳ-carbociclo de 3 - 14 miembros sustituido con 0 - 3 R¹ᵃ y -(CR²ᵉR²ᶠ)ʳ-heterociclo de 5 - 10 miembros, que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ, sustituido con 0 - 3 R¹ᵃ; R¹ᵃ es, independientemente de cada caso, hidrógeno, =O, halo, CF₃, OCF₃, CN, NO₂, -(CR²ᵉR²ᶠ)ʳ-ORᵇ, -(CR²ᵉR²ᶠ)ʳ-S(O)ₚRᵇ, -(CR²ᵉR²ᶠ)ʳ-C(O)Rᵇ, -(CR²ᵉR²ᶠ)ʳ-C(O)ORᵇ, -(CR²ᵉR²ᶠ)ʳ-OC(O)Rᵇ, -(CR²ᵉR²ᶠ)ʳ-NR¹¹R¹¹, -(CR²ᵉR²ᶠ)ʳ-C(O)NR¹¹R¹¹, -(CR²ᵉR²ᶠ)ʳ-NRᵇC(O)Rᶜ, -(CR²ᵉR²ᶠ)ʳ-NRᵇC(O)ORᶜ, -NRᵇC(O)NR¹¹R¹¹, -S(O)ₚNR¹¹R¹¹, -NRᵇS(O)ₚRᶜ, C₁₋₆ alquilo sustituido con 0 - 3 Rᵃ, C₁₋₆ haloalquilo, C₂₋₆ alquenilo sustituido con 0 - 3 Rᵃ, C₂₋₆ alquinilo sustituido con 0 - 3 Rᵃ, -(CR²ᵉR²ᶠ)ʳ-carbociclo de 3 - 14 miembros sustituido con 0 - 3 Rᵃ o -(CR²ᵉR²ᶠ)ʳ-heterociclo de 5 - 7 miembros, que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ, sustituido con 0 - 3 Rᵃ; R² se selecciona de hidrógeno, CN, -(CR²ᵉR²ᶠ)ʳ-C(O)R²ᵈ, -(CR²ᵉR²ᶠ)ʳ-C(O)OR²ᵇ, -(CR²ᵉR²ᶠ)ʳ-C(O)NR¹¹R¹¹, -(CR²ᵉR²ᶠ)ʳ-S(O)₂R²ᶜ, C₁₋₆ alquilo sustituido con 0 - 3 R²ᵃ, C₂₋₆ alquenilo sustituido con 0 - 3 R²ᵃ, -(CR²ᵉR²ᶠ)ʳ-carbociclo de 3 - 10 miembros sustituido con 0 - 4 Rᵃ, y -(CR²ᵉR²ᶠ)ʳ-heterociclo de 4 - 7 miembros, que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O, P(=O) y S(O)ₚ, sustituido con 0 - 4 Rᵃ; R²ᵃ es, independientemente de cada caso, hidrógeno, =O, halo, OCF₃, CN, NO₂, -(CR²ᵉR²ᶠ)ʳ-ORᵇ, -(CR²ᵉR²ᶠ)ʳ-S(O)ₚRᵇ, -(CR²ᵉR²ᶠ)ʳ-C(O)Rᵇ, -(CR²ᵉR²ᶠ)ʳ-C(O)ORᵇ, -(CR²ᵉR²ᶠ)ʳ-OC(O)Rᵇ, -(CR²ᵉR²ᶠ)ʳ-OC(O)NR¹¹R¹¹, -(CR²ᵉR²ᶠ)ʳ-OC(O)ORᶜ, -(CR²ᵉR²ᶠ)ʳ-NR¹¹R¹¹, -(CR²ᵉR²ᶠ)ʳ-C(O)NR¹¹R¹¹, -(CR²ᵉR²ᶠ)ʳ-NRᵇC(O)Rᶜ, -(CR²ᵉR²ᶠ)ʳ-NRᵇC(O)ORᶜ, -NRᵇC(O)NR¹¹R¹¹, -S(O)ₚNR¹¹R¹¹, -NRᵇS(O)ₚRᶜ, C₁₋₆ alquilo sustituido con 0 - 3 Rᵃ, C₁₋₆ haloalquilo, C₂₋₆ alquenilo sustituido con 0 - 3 Rᵃ, C₂₋₆ alquinilo sustituido con 0 - 3 Rᵃ, -(CR²ᵉR²ᶠ)ʳ-carbociclo de 3 - 14 miembros sustituido con 0 - 3 Rᵃ o -(CR²ᵉR²ᶠ)ʳ-heterociclo de 4 - 7 miembros, que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ, sustituido con 0 - 3 Rᵃ; R²ᵇ es, independientemente de cada caso, hidrógeno, CF₃, -(CR²ᵉR²ᶠ)qORᵇ, -(CR²ᵉR²ᶠ)qS(O)ₚRᵇ, -(CR²ᵉR²ᶠ)ʳ-C(O)R¹ᵈ, -(CR²ᵉR²ᶠ)ʳ-C(O)ORᵇ,-(CR²ᵉR²ᶠ)qOC(O)Rᵇ, -(CR²ᵉR²ᶠ)qNR¹¹R¹¹, -(CR²ᵉR²ᶠ)ʳ-C(O)NR¹¹R¹¹, -(CR²ᵉR²ᶠ)qNRᵇC(O)R¹ᶜ, -(CR²ᵉR²ᶠ)qNRᵇC(O)ORᶜ, -(CR²ᵉR²ᶠ)qNRᵇC(O)NR¹¹R¹¹, -(CR²ᵉR²ᶠ)qS(O)₂NR¹¹R¹¹, -(CR²ᵉR²ᶠ)qNRᵇS(O)₂Rᶜ, C₁₋₆ alquilo sustituido con 0 - 2 Rᵃ, C₁₋₆ haloalquilo, -(CR²ᵉR²ᶠ)ʳ-carbociclo de 3 - 14 miembros sustituido con 0 - 3 Rᵃ o -(CR²ᵉR²ᶠ)ʳ-heterociclo de 5 - 7 miembros, que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O, P(=O) y S(O)ₚ, sustituido con 0 - 4 Rᵃ; R²ᶜ es, independientemente de cada caso, hidrógeno, C₁₋₆ alquilo sustituido con 0 - 3 Rᵃ, C₂₋₆ alquenilo sustituido con 0 - 3 Rᵃ, C₃₋₁₀ cicloalquilo sustituido con 0 - 3 Rᵃ, C₆₋₁₀ arilo sustituido con 0 - 3 Rᵃ o -(CR²ᵉR²ᶠ)ʳ-heterociclo de 5 - 10 miembros, que contiene 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ, sustituido con 0 - 3 Rᵃ; R²ᵈ es, independientemente de cada caso, hidrógeno, C₁₋₆ alquilo sustituido con 0 - 2 Rᵈ, C₁₋₆ haloalquilo, C(O)NR¹¹R¹¹, -(CR²ᵉR²ᶠ)ʳ-C₃₋₁₀ cicloalquilo sustituido con 0 - 3 Rᵈ, en donde el anillo de cicloalquilo puede ser fusionado, en puente o espirocíclico, (CR²ᵉR²ᶠ)ʳ-fenilo sustituido con 0 - 2 Rᵃ o un -(CR²ᵉR²ᶠ)ʳ-heterociclo de 4-10 miembros, en donde el heterociclo puede ser fusionado, en puente o espirocíclico, que contiene 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ, sustituido con 0 - 3 Rᵃ; R²ᵉ y R²ᶠ son, independientemente de cada caso, hidrógeno, halógeno o C₁₋₆ alquilo; R³ se selecciona, independientemente de cada caso, de hidrógeno, halo, N₃, CN, -(CR²ᵉR²ᶠ)ʳ-OR³ᵇ, -(CR²ᵉR²ᶠ)ʳ-NR¹¹R¹¹, C₁₋₆ alquilo sustituido con 0 - 3 R³ᵃ, C₃₋₁₀ cicloalquilo sustituido con 0 - 3 Rᵃ; y fenilo sustituido con 0 - 3 R³ᵃ o heterociclo de 4 - 10 miembros, que contiene 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ, sustituido con 0 - 3 R³ᵃ, o dos R³ ubicados en un enlace de átomos de carbono adyacentes para formar un carbociclo de 5 - 7 miembros o un heterociclo de 5 - 7 miembros, que comprenden átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ, ambos opcionalmente sustituidos con 0 - 3 R³ᵃ; R³ᵃ es, independientemente de cada caso, hidrógeno, =O, halo, OCF₃, OCHF₂, CF₃, CHF₂, CN, NO₂, -(CR²ᵉR²ᶠ)ʳ-ORᵇ, -(CR²ᵉR²ᶠ)ʳ-S(O)ₚRᵇ, -(CR²ᵉR²ᶠ)ʳ-C(O)Rᵇ, -(CR²ᵉR²ᶠ)ʳ-C(O)ORᵇ, -(CR²ᵉR²ᶠ)ʳ-OC(O)Rᵇ, -(CR²ᵉR²ᶠ)ʳ-NR¹¹R¹¹, -(CR²ᵉR²ᶠ)ʳ-C(O)NR¹¹R¹¹, -(CR²ᵉR²ᶠ)ʳ-NRᵇC(O)Rᶜ, -(CR²ᵉR²ᶠ)ʳ-NRᵇC(O)ORᶜ, NRᵇC(O)NR¹¹R¹¹, -S(O)ₚNR¹¹R¹¹, -NRᵇS(O)ₚRᶜ, C₁₋₆ alquilo sustituido con 0 - 3 Rᵃ, C₂₋₆, alquenilo sustituido con 0 - 3 Rᵃ, C₂₋₆ alquinilo sustituido con 0 - 3 Rᵃ, C₁₋₆, haloalquilo, -(CR²ᵉR²ᶠ)ʳ-carbociclo de 3 - 14 miembros sustituido con 0 - 3 Rᵃ o -(CR²ᵉR²ᶠ)ʳ-heterociclo de 5 - 10 miembros, que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ, sustituido con 0 - 3 Rᵃ; R³ᵇ es, independientemente de cada caso, hidrógeno, CF₃, -(CR²ᵉR²ᶠ)qORᵇ, -(CR²ᵉR²ᶠ)qS(O)ₚRᵇ, -(CR²ᵉR²ᶠ)ʳ-C(O)R¹ᵈ, -(CR²ᵉR²ᶠ)ʳ-C(O)ORᵇ, -(CR²ᵉR²ᶠ)qOC(O)Rᵇ, -(CR²ᵉR²ᶠ)qNR¹¹R¹¹, -(CR²ᵉR²ᶠ)ʳ-C(O)NR¹¹R¹¹, -(CR²ᵉR²ᶠ)qNRᵇC(O)R¹ᶜ, -(CR²ᵉR²ᶠ)qNRᵇC(O)ORᶜ, -(CR²ᵉR²ᶠ)qNRᵇC(O)NR¹¹R¹¹, -(CR²ᵉR²ᶠ)qS(O)₂NR¹¹R¹¹, -(CR²ᵉR²ᶠ)qNRᵇS(O)₂Rᶜ, C₁₋₆ alquilo sustituido con 0 - 3 Rᵃ, C₁₋₆ haloalquilo, -(CR²ᵉR²ᶠ)ʳ-carbociclo de 3 - 14 miembros sustituido con 0 - 3 Rᵃ o -(CR²ᵉR²ᶠ)ʳ-heterociclo de 5 - 7 miembros, que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ sustituido con 0 - 3 Rᵃ; R⁴ y R⁵ son independientemente hidrógeno, halo, C₁₋₆ alquilo o C₁₋₆ haloalquilo, o R⁴ y R⁵, junto con el átomo de carbono al que están unidos, forman un anillo espirocarbociclilo de 3 a 6 miembros o un anillo espiroheterociclilo; R⁶ y R⁷ son independientemente hidrógeno, C(=O)C₁₋₄ alquilo, C(=O)OC₁₋₄ alquilo, C₁₋₆ alquilo o C₁₋₆, haloalquilo; o R⁶ y R⁷ en conjunto son =O; R¹¹ es, independientemente de cada caso, hidrógeno, C₁₋₆ alquilo sustituido con 0 - 3 Rᶠ, CF₃, C₃₋₁₀ cicloalquilo sustituido con 0 - 3 Rᶠ, -(CR²ᵉR²ᶠ)ʳ-fenilo sustituido con 0 - 3 Rᵈ o -(CR²ᵉR²ᶠ)ʳ-heterociclo de 5 - 7 miembros, que comprenden átomos de carbono y 1 - 4 heteroátomos-seleccionados N, O, P(=O) y S(O)ₚ, sustituido con 0 - 4 Rᵈ; o un R¹¹ y un segundo R¹¹, ambos unidos al mismo átomo de nitrógeno, se combinan para formar un heterociclo, que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O, P(=O) y S(O)ₚ, sustituido con 0 - 4 Rᵈ; Rᵃ es, independientemente de cada caso, hidrógeno, =O, halo, OCF₃, CF₃, CHF₂, CN, NO₂, -(CR²ᵉR²ᶠ)ʳ-ORᵇ, -(CR²ᵉR²ᶠ)ʳ-S(O)ₚRᵇ, -(CR²ᵉR²ᶠ)ʳ-C(O)Rᵇ, -(CR²ᵉR²ᶠ)ʳ-C(O)ORᵇ, -(CR²ᵉR²ᶠ)ʳ-OC(O)Rᵇ, -(CR²ᵉR²ᶠ)ʳ-NR¹¹R¹¹, -(CR²ᵉR²ᶠ)ʳ-C(O)NR¹¹R¹¹, -(CR²ᵉR²ᶠ)ʳ-NRᵇC(O)Rᶜ, -(CR²ᵉR²ᶠ)ʳ-NRᵇC(O)ORᶜ, -NRᵇC(O)NR¹¹R¹¹, -S(O)ₚNR¹¹R¹¹, -NRᵇS(O)ₚRᶜ, C₁₋₆ alquilo sustituido con 0 - 3 Rᵉ, C₁₋₆ haloalquilo, C₂₋₆ alquenilo sustituido con 0 - 3 Rᵉ, C₂₋₆ alquinilo sustituido con 0 - 3 Rᵉ, -(CR²ᵉR²ᶠ)ʳ-carbociclo de 3 - 14 miembros o -(CR²ᵉR²ᶠ)ʳ-heterociclo de 5 - 7 miembros, que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O, P(=O) y S(O)ₚ, sustituido con 0 - 4 Rᶠ; Rᵇ es, independientemente de cada caso, hidrógeno, C₁₋₆ alquilo sustituido con 0 - 3 Rᵈ, C₁₋₆ haloalquilo, C₃₋₆ cicloalquilo sustituido con 0 - 3 Rᵈ, -(CR²ᵉR²ᶠ)ʳ-heterociclo de 5 - 7 miembros, que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O, P(=O) y S(O)ₚ, sustituido con 0 - 4 Rᶠ o -(CR²ᵉR²ᶠ)ʳ-carbociclo de 6-10 miembros sustituido con 0 - 3 Rᵈ; Rᶜ es, independientemente de cada caso, C₁₋₆ alquilo sustituido con 0 - 3 Rᶠ, -(CR²ᵉR²ᶠ)ʳ-C₃₋₆ cicloalquilo sustituido con 0 - 3 Rᶠ o -(CR²ᵉR²ᶠ)ʳ-fenilo sustituido con 0 - 3 Rᶠ; Rᵈ es, independientemente de cada caso, hidrógeno, =O, halo, OCF₃, CF₃, CN, NO₂, -ORᵉ, -(CR²ᵉR²ᶠ)ʳ-C(O)Rᶜ, -NRᵉRᵉ, -NRᵉC(O)ORᶜ, C(O)NRᵉRᵉ, -NRᵉC(O)Rᶜ, CO₂H, CO₂Rᶜ, -NRᵉSO₂Rᶜ, SO₂Rᶜ, C₁₋₆ alquilo sustituido con 0 - 3 Rᶠ, C₃₋₆ cicloalquilo sustituido con 0 - 3 Rᶠ, -(CR²ᵉR²ᶠ)ʳ-fenilo sustituido con 0 - 3 Rᶠ o -(CR²ᵉR²ᶠ)ʳ-heterociclo de 5 - 7 miembros, que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O, P(=O) y S(O)ₚ, sustituido con 0 - 4 Rᶠ; Rᵉ se selecciona, independientemente de cada caso, de hidrógeno, C(O)NRᶠRᶠ, C₁₋₆ alquilo, C₃₋₆ cicloalquilo, -heterociclo de 5 - 7 miembros o -(CR²ᵉR²ᶠ)ʳ-fenilo sustituido con 0 - 3 Rᶠ; Rᶠ es, independientemente de cada caso, hidrógeno, =O, halo, CN, NH₂, NH(C₁₋₆ alquilo), N(C₁₋₆ alquilo)₂, SO₂(C₁₋₆ alquilo), CO₂H, CO₂(C₁₋₆ alquilo), OH, C₃₋₆ cicloalquilo, CF₃, O(C₁₋₆ alquilo), o un -(CR²ᵉR²ᶠ)ʳ-heterociclo de 5 - 10 miembros opcionalmente sustituido, que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O, P(=O) y S(O)ₚ, fenilo o C₃₋₆ cicloalquilo, cada grupo opcionalmente -sustituido con halo, CN, CF₃, C₁₋₆ alquilo ó O (C₁₋₆ alquilo); m es 0, 1, 2 ó 3, n es 0, 1 ó 2, p y q son, independientemente de cada caso, 0, 1 ó 2; r es 0, 1, 2, 3 ó 4; y t es 0 ó 1.
ARP160101311A 2015-05-07 2016-05-06 SULFONAS TRICÍCLICAS COMO MODULARES DE RORg AR104555A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562158178P 2015-05-07 2015-05-07

Publications (1)

Publication Number Publication Date
AR104555A1 true AR104555A1 (es) 2017-07-26

Family

ID=56081572

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160101311A AR104555A1 (es) 2015-05-07 2016-05-06 SULFONAS TRICÍCLICAS COMO MODULARES DE RORg

Country Status (24)

Country Link
US (3) US9815859B2 (es)
EP (1) EP3292101B1 (es)
JP (1) JP6553746B2 (es)
KR (1) KR102114536B1 (es)
CN (1) CN107709295B (es)
AR (1) AR104555A1 (es)
AU (1) AU2016258087B2 (es)
BR (1) BR112017023780A2 (es)
CA (1) CA2987759A1 (es)
CL (1) CL2017002799A1 (es)
CO (1) CO2017012545A2 (es)
EA (1) EA033345B1 (es)
ES (1) ES2887087T3 (es)
HK (1) HK1249500A1 (es)
IL (1) IL255419A0 (es)
MA (2) MA42049A (es)
MX (1) MX2017014189A (es)
MY (1) MY190748A (es)
PE (1) PE20180119A1 (es)
PH (1) PH12017502012A1 (es)
TN (1) TN2017000464A1 (es)
TW (1) TW201706244A (es)
UY (1) UY36673A (es)
WO (1) WO2016179460A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TN2017000464A1 (en) * 2015-05-07 2019-04-12 Bristol Myers Squibb Co Tricyclic sulfones as rorϒ modulators
SG10201609616TA (en) * 2016-09-06 2018-04-27 Apple Inc Electronic device with cooling fan
CN110072848A (zh) * 2016-10-10 2019-07-30 百时美施贵宝公司 作为γ调节剂的三环砜
KR102506326B1 (ko) * 2016-10-13 2023-03-03 브리스톨-마이어스 스큅 컴퍼니 Ror 감마 조정제로서의 헤테로시클릭 술폰
DE102017010487A1 (de) * 2016-12-02 2018-06-07 Merck Patent Gmbh Monofluorierte cyclohexane
KR20210009357A (ko) * 2018-05-17 2021-01-26 브리스톨-마이어스 스큅 컴퍼니 Ror 감마 조정제로서의 트리시클릭 술폰 화합물
US11459340B2 (en) 2018-09-18 2022-10-04 Nikang Therapeutics, Inc. Tri-substituted heteroaryl derivatives as Src homology-2 phosphatase inhibitors
WO2020231766A1 (en) * 2019-05-13 2020-11-19 Bristol-Myers Squibb Company AGONISTS OF ROR GAMMAt
KR20220131962A (ko) * 2020-01-24 2022-09-29 브리스톨-마이어스 스큅 컴퍼니 Ror 감마 조정제로서의 트리시클릭 술폰
US11332442B2 (en) 2020-08-12 2022-05-17 Bristol-Myers Squibb Company Synthetic process
WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU229709B1 (en) 2004-04-13 2014-05-28 Incyte Corp Wilmington Piperazinyilpiperidine derivatives as chemokine receptor antagonists
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
RU2448964C2 (ru) * 2006-01-20 2012-04-27 Шеринг Корпорейшн КАРБОЦИКЛИЧЕСКИЕ И ГЕТЕРОЦИКЛИЧЕСКИЕ АРИЛСУЛЬФОНЫ, ИХ ПРИМЕНЕНИЕ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, ОБЛАДАЮЩАЯ СВОЙСТВАМИ ИНГИБИТОРА γ-СЕКРЕТАЗЫ
KR20100044840A (ko) * 2007-07-17 2010-04-30 쉐링 코포레이션 벤젠설포닐-크로만, 티오크로만, 테트라하이드로나프탈렌 및 관련 감마 세크레타제 억제제
RU2014149149A (ru) * 2012-05-08 2016-07-10 Мерк Шарп И Доум Корп. БИЦИКЛИЧЕСКИЕ СУЛЬФОНОВЫЕ СОЕДИНЕНИЯ ДЛЯ ИНГИБИРОВАНИЯ RORгамма АКТИВНОСТИ И ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ
EP2669286A1 (en) 2012-05-31 2013-12-04 Ares Trading S.A. Spiro tetrahydro-benzothiophen derivatives useful for the treatment of neurodegenerative diseases
US10035790B2 (en) 2012-10-19 2018-07-31 Exelixis, Inc. RORγ modulators
EP2964644B1 (en) 2013-03-08 2018-12-26 Amgen, Inc. Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
US9663469B2 (en) 2013-09-09 2017-05-30 Bristol-Myers Squibb Company RORγ modulators
US9725443B2 (en) * 2013-09-20 2017-08-08 Bristol-Myers Squibb Company RORγ modulators
ES2704460T3 (es) 2014-01-06 2019-03-18 Bristol Myers Squibb Co Moduladores de ROR gamma de ciclohexilsulfona
ES2705400T3 (es) 2014-01-06 2019-03-25 Bristol Myers Squibb Co Sulfonas heterocíclicas como moduladores de ROR gamma
MX369347B (es) 2014-01-06 2019-11-06 Bristol Myers Squibb Co Derivados de pirrolidinilsulfona y su uso como moduladores del receptor huerfano relacionado con retinoide gamma (ror gamma).
WO2015103508A1 (en) 2014-01-06 2015-07-09 Bristol-Myers Squibb Company CARBOCYCLIC SULFONE RORγ MODULATORS
TN2017000464A1 (en) * 2015-05-07 2019-04-12 Bristol Myers Squibb Co Tricyclic sulfones as rorϒ modulators

Also Published As

Publication number Publication date
ES2887087T3 (es) 2021-12-21
MX2017014189A (es) 2018-04-13
BR112017023780A2 (pt) 2018-07-31
AU2016258087A1 (en) 2018-01-04
KR20180002811A (ko) 2018-01-08
PH12017502012A1 (en) 2018-04-02
TN2017000464A1 (en) 2019-04-12
US20190241588A1 (en) 2019-08-08
JP6553746B2 (ja) 2019-07-31
CL2017002799A1 (es) 2018-05-11
US20160326195A1 (en) 2016-11-10
CN107709295A (zh) 2018-02-16
TW201706244A (zh) 2017-02-16
US20180002358A1 (en) 2018-01-04
CA2987759A1 (en) 2016-11-10
AU2016258087B2 (en) 2020-01-02
EA201792258A1 (ru) 2018-04-30
MA41389A1 (fr) 2018-06-29
US9815859B2 (en) 2017-11-14
EP3292101B1 (en) 2021-07-28
US10711020B2 (en) 2020-07-14
KR102114536B1 (ko) 2020-05-22
EP3292101A1 (en) 2018-03-14
JP2018515494A (ja) 2018-06-14
CO2017012545A2 (es) 2018-05-10
IL255419A0 (en) 2017-12-31
MA42049A (fr) 2021-03-17
MY190748A (en) 2022-05-12
UY36673A (es) 2016-11-30
PE20180119A1 (es) 2018-01-18
HK1249500A1 (zh) 2018-11-02
EA033345B1 (ru) 2019-09-30
WO2016179460A1 (en) 2016-11-10
CN107709295B (zh) 2021-05-04
US10273259B2 (en) 2019-04-30

Similar Documents

Publication Publication Date Title
AR104555A1 (es) SULFONAS TRICÍCLICAS COMO MODULARES DE RORg
AR099029A1 (es) MODULADORES DE PIRROLIDINILSULFONA RORg
AR118275A2 (es) 4-amino-6-(heterocíclico)picolinatos y 6-amino-2-(heterocíclico)pirimidin-4-carboxilatos y su uso como herbicidas
AR094452A1 (es) COMPUESTOS HETEROCÍCLICOS SUSTITUIDOS CON AMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O INFa
AR119698A2 (es) Compuesto amida n-urea sustituida derivado de aminoácido
AR102177A1 (es) Compuestos de heteroarilo como inhibidores de btk y usos de los mismos
AR098136A1 (es) Compuestos de heteroarilo como inhibidores de btk y usos de los mismos
AR093403A1 (es) COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA UTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL23 Y/O INFa
AR108557A1 (es) Uracilpiridinas herbicidas
AR096788A1 (es) Compuestos tricíclicos de carboxamida como inhibidores potentes de rock
AR100809A1 (es) Inhibidores de fosfatidilinositol 3-quinasa
AR104176A1 (es) Inhibidores de ido (indolamina-2,3-dioxigenasa)
AR094537A1 (es) COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa
AR114236A1 (es) Inhibidores de la gcn2 y usos de los mismos
AR104884A1 (es) Compuestos de 4-hidroxi-3-(heteroaril)piridin-2-ona como agonistas de apj
AR095192A1 (es) Quinolina y quinazolinamidas como modulares de canales de sodio
AR089698A1 (es) Compuestos heterociclicos antagonistas del receptor ip
AR054035A1 (es) Derivados benzodioxano y benzodioxolano y uso de los mismos
AR094929A1 (es) Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
AR100808A1 (es) Inhibidores de fosfatidilinositol 3-quinasa
AR096979A1 (es) Derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
AR103990A1 (es) Ureas cíclicas como inhibidoras de rock
AR108906A1 (es) Heterociclos de biarilmetilo
AR095040A1 (es) Antagonistas de h3 que contienen un núcleo estructural de fenoxipiperidina
AR110152A1 (es) SULFONAS TRICÍCLICAS COMO MODULADORES DE RORg

Legal Events

Date Code Title Description
FB Suspension of granting procedure