MA42049A - Sulfones tricycliques utiles commes modulateurs ror-gamma - Google Patents
Sulfones tricycliques utiles commes modulateurs ror-gammaInfo
- Publication number
- MA42049A MA42049A MA042049A MA42049A MA42049A MA 42049 A MA42049 A MA 42049A MA 042049 A MA042049 A MA 042049A MA 42049 A MA42049 A MA 42049A MA 42049 A MA42049 A MA 42049A
- Authority
- MA
- Morocco
- Prior art keywords
- sulphones
- ror
- tricyclic
- useful
- gamma modulators
- Prior art date
Links
Classifications
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- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- Epidemiology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201562158178P | 2015-05-07 | 2015-05-07 |
Publications (1)
Publication Number | Publication Date |
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MA42049A true MA42049A (fr) | 2021-03-17 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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MA042049A MA42049A (fr) | 2015-05-07 | 2016-05-06 | Sulfones tricycliques utiles commes modulateurs ror-gamma |
MA41389A MA41389A1 (fr) | 2015-05-07 | 2016-05-06 | Utilisation de sulfones tricycliques en tant que modulateurs de rory |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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MA41389A MA41389A1 (fr) | 2015-05-07 | 2016-05-06 | Utilisation de sulfones tricycliques en tant que modulateurs de rory |
Country Status (24)
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US (3) | US9815859B2 (fr) |
EP (1) | EP3292101B1 (fr) |
JP (1) | JP6553746B2 (fr) |
KR (1) | KR102114536B1 (fr) |
CN (1) | CN107709295B (fr) |
AR (1) | AR104555A1 (fr) |
AU (1) | AU2016258087B2 (fr) |
BR (1) | BR112017023780A2 (fr) |
CA (1) | CA2987759A1 (fr) |
CL (1) | CL2017002799A1 (fr) |
CO (1) | CO2017012545A2 (fr) |
EA (1) | EA033345B1 (fr) |
ES (1) | ES2887087T3 (fr) |
HK (1) | HK1249500A1 (fr) |
IL (1) | IL255419A0 (fr) |
MA (2) | MA42049A (fr) |
MX (1) | MX2017014189A (fr) |
MY (1) | MY190748A (fr) |
PE (1) | PE20180119A1 (fr) |
PH (1) | PH12017502012A1 (fr) |
TN (1) | TN2017000464A1 (fr) |
TW (1) | TW201706244A (fr) |
UY (1) | UY36673A (fr) |
WO (1) | WO2016179460A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016258087B2 (en) * | 2015-05-07 | 2020-01-02 | Bristol-Myers Squibb Company | Tricyclic sulfones as RORϒ modulators |
SG10201609616TA (en) * | 2016-09-06 | 2018-04-27 | Apple Inc | Electronic device with cooling fan |
EP3523279A1 (fr) * | 2016-10-10 | 2019-08-14 | Bristol-Myers Squibb Company | Sulfones tricycliques en tant que modulateurs de ror gamma |
EP3526218B1 (fr) | 2016-10-13 | 2021-04-21 | Bristol-Myers Squibb Company | Sulfones hétérocycliques comme modulateurs de ror gamma |
DE102017010487A1 (de) * | 2016-12-02 | 2018-06-07 | Merck Patent Gmbh | Monofluorierte cyclohexane |
US10633339B2 (en) | 2018-05-17 | 2020-04-28 | Bristol-Myers Squibb Company | Tricyclic sulfone compound as a ROR gamma modulator |
KR20210032936A (ko) | 2018-06-15 | 2021-03-25 | 리아타 파마슈티컬즈, 아이엔씨. | Il-17 및 ror감마의 저해를 위한 피라졸 및 이미다졸 화합물 |
EP3853234A1 (fr) | 2018-09-18 | 2021-07-28 | Nikang Therapeutics, Inc. | Dérivés d'anneaux tricycliques fusionnés utilisés en tant qu'inhibiteurs de la phosphatase src à homologie-2 |
US20230295087A1 (en) * | 2019-05-13 | 2023-09-21 | Bristol-Myers Squibb Company | AGONISTS OF ROR GAMMAt |
WO2021150803A1 (fr) * | 2020-01-24 | 2021-07-29 | Bristol-Myers Squibb Company | SULFONES TRICYCLIQUES EN TANT QUE MODULATEURS DE RORγ |
US11332442B2 (en) | 2020-08-12 | 2022-05-17 | Bristol-Myers Squibb Company | Synthetic process |
WO2023232870A1 (fr) | 2022-05-31 | 2023-12-07 | Immunic Ag | Modulateurs de rorg/rorgt pour le traitement d'infections virales de type covid-19 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2431524T3 (es) | 2004-04-13 | 2013-11-26 | Incyte Corporation | Derivados de piperazinilpiperidina como antagonistas de los receptores de quimiocinas |
US20070155738A1 (en) | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
WO2007084595A2 (fr) * | 2006-01-20 | 2007-07-26 | Schering Corporation | Benzènesulfonyle-chromane, thiochromane, tétrahydronaphthalène et inhibiteurs de la gamma secrétase associés |
EP2178882B1 (fr) * | 2007-07-17 | 2013-04-17 | Merck Sharp & Dohme Corp. | Benzènesulfonyle-chromane, thiochromane, tétrahydronaphtalène et inhibiteurs de gamma-secrétase associés |
JP6236067B2 (ja) * | 2012-05-08 | 2017-11-22 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | RORγ活性を阻害し疾患を治療するための二環式スルホン化合物 |
EP2669286A1 (fr) | 2012-05-31 | 2013-12-04 | Ares Trading S.A. | Dérivés de spiro tétrahydro-benzothiophène utiles pour le traitement de maladies neuro-dégénératives |
US10035790B2 (en) | 2012-10-19 | 2018-07-31 | Exelixis, Inc. | RORγ modulators |
BR112015021336A2 (pt) | 2013-03-08 | 2017-07-18 | Amgen Inc | compostos 1,3-oxazin-2-amina fundidos ciclopropil perfluorados como inibidores de beta-secretase e métodos de uso |
EP3044219A1 (fr) | 2013-09-09 | 2016-07-20 | Bristol-Myers Squibb Company | Modulateurs de rorgamma |
JP6397488B2 (ja) * | 2013-09-20 | 2018-09-26 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | RORγ調節因子 |
ES2705400T3 (es) | 2014-01-06 | 2019-03-25 | Bristol Myers Squibb Co | Sulfonas heterocíclicas como moduladores de ROR gamma |
ES2713681T3 (es) | 2014-01-06 | 2019-05-23 | Bristol Myers Squibb Co | Moduladores de ROR gamma de sulfona carbocíclica |
CN106061947B (zh) | 2014-01-06 | 2019-12-03 | 百时美施贵宝公司 | 环己基砜RORγ调节剂 |
CA2936116A1 (fr) | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | Derives de pyrrolidinyle sulfone et leur utilisation en tant que modulateurs de ror gamma |
AU2016258087B2 (en) * | 2015-05-07 | 2020-01-02 | Bristol-Myers Squibb Company | Tricyclic sulfones as RORϒ modulators |
-
2016
- 2016-05-06 AU AU2016258087A patent/AU2016258087B2/en not_active Ceased
- 2016-05-06 MA MA042049A patent/MA42049A/fr unknown
- 2016-05-06 EP EP16725289.9A patent/EP3292101B1/fr active Active
- 2016-05-06 CA CA2987759A patent/CA2987759A1/fr not_active Abandoned
- 2016-05-06 MA MA41389A patent/MA41389A1/fr unknown
- 2016-05-06 ES ES16725289T patent/ES2887087T3/es active Active
- 2016-05-06 UY UY0001036673A patent/UY36673A/es unknown
- 2016-05-06 US US15/148,209 patent/US9815859B2/en active Active
- 2016-05-06 CN CN201680034253.8A patent/CN107709295B/zh active Active
- 2016-05-06 PE PE2017002385A patent/PE20180119A1/es unknown
- 2016-05-06 MY MYPI2017704082A patent/MY190748A/en unknown
- 2016-05-06 JP JP2017557912A patent/JP6553746B2/ja active Active
- 2016-05-06 TN TNP/2017/000464A patent/TN2017000464A1/en unknown
- 2016-05-06 AR ARP160101311A patent/AR104555A1/es unknown
- 2016-05-06 MX MX2017014189A patent/MX2017014189A/es unknown
- 2016-05-06 BR BR112017023780-6A patent/BR112017023780A2/pt not_active Application Discontinuation
- 2016-05-06 EA EA201792258A patent/EA033345B1/ru not_active IP Right Cessation
- 2016-05-06 WO PCT/US2016/031118 patent/WO2016179460A1/fr active Application Filing
- 2016-05-06 KR KR1020177035023A patent/KR102114536B1/ko active IP Right Grant
- 2016-05-06 TW TW105114191A patent/TW201706244A/zh unknown
-
2017
- 2017-09-12 US US15/701,818 patent/US10273259B2/en active Active
- 2017-11-03 IL IL255419A patent/IL255419A0/en unknown
- 2017-11-06 PH PH12017502012A patent/PH12017502012A1/en unknown
- 2017-11-06 CL CL2017002799A patent/CL2017002799A1/es unknown
- 2017-12-05 CO CONC2017/0012545A patent/CO2017012545A2/es unknown
-
2018
- 2018-06-04 HK HK18107277.9A patent/HK1249500A1/zh unknown
-
2019
- 2019-03-07 US US16/295,378 patent/US10711020B2/en active Active
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