CL2017002799A1 - Sulfonas triciclicas como moduladores del receptor huérfano relacionado con retinoide gamma (rory) - Google Patents
Sulfonas triciclicas como moduladores del receptor huérfano relacionado con retinoide gamma (rory)Info
- Publication number
- CL2017002799A1 CL2017002799A1 CL2017002799A CL2017002799A CL2017002799A1 CL 2017002799 A1 CL2017002799 A1 CL 2017002799A1 CL 2017002799 A CL2017002799 A CL 2017002799A CL 2017002799 A CL2017002799 A CL 2017002799A CL 2017002799 A1 CL2017002799 A1 CL 2017002799A1
- Authority
- CL
- Chile
- Prior art keywords
- rory
- modulators
- retinoid
- gamma
- orphan receptor
- Prior art date
Links
- 102000016978 Orphan receptors Human genes 0.000 title 1
- 108070000031 Orphan receptors Proteins 0.000 title 1
- 150000004492 retinoid derivatives Chemical class 0.000 title 1
- 150000003457 sulfones Chemical class 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C07D495/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems
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- Chemical & Material Sciences (AREA)
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Abstract
<p>La presente invención se refiere a moduladores de ROR y de la Fórmula (I), y la Fórmula (II) o estereoisómeros, tautómeros, sales de estos farmacéuticamente aceptable, solvatos o profármacos de aquellos, en donde todos los sustituyentes se definen en la presente. También se proporcionan composiciones farmacéuticas que los comprenden. Tales compuestos y composiciones son útiles en los métodos para modular la actividad de RORy en una célala y en métodos para tratar a un sujeto que tiene una enfermedad o un trastorno en los que el sujeto se beneficiaria terapéuticarrente de la modulación de la actividad de RORy, por ejemplo, trastornos autoinmunitarios y/o inflamatorios.</p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201562158178P | 2015-05-07 | 2015-05-07 |
Publications (1)
Publication Number | Publication Date |
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CL2017002799A1 true CL2017002799A1 (es) | 2018-05-11 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CL2017002799A CL2017002799A1 (es) | 2015-05-07 | 2017-11-06 | Sulfonas triciclicas como moduladores del receptor huérfano relacionado con retinoide gamma (rory) |
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US (3) | US9815859B2 (es) |
EP (1) | EP3292101B1 (es) |
JP (1) | JP6553746B2 (es) |
KR (1) | KR102114536B1 (es) |
CN (1) | CN107709295B (es) |
AR (1) | AR104555A1 (es) |
AU (1) | AU2016258087B2 (es) |
BR (1) | BR112017023780A2 (es) |
CA (1) | CA2987759A1 (es) |
CL (1) | CL2017002799A1 (es) |
CO (1) | CO2017012545A2 (es) |
EA (1) | EA033345B1 (es) |
ES (1) | ES2887087T3 (es) |
HK (1) | HK1249500A1 (es) |
IL (1) | IL255419A0 (es) |
MA (2) | MA42049A (es) |
MX (1) | MX2017014189A (es) |
MY (1) | MY190748A (es) |
PE (1) | PE20180119A1 (es) |
PH (1) | PH12017502012A1 (es) |
TN (1) | TN2017000464A1 (es) |
TW (1) | TW201706244A (es) |
UY (1) | UY36673A (es) |
WO (1) | WO2016179460A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2887087T3 (es) * | 2015-05-07 | 2021-12-21 | Bristol Myers Squibb Co | Sulfonas tricíclicas como moduladores ROR gamma |
SG10201609616TA (en) * | 2016-09-06 | 2018-04-27 | Apple Inc | Electronic device with cooling fan |
CN110072848A (zh) * | 2016-10-10 | 2019-07-30 | 百时美施贵宝公司 | 作为γ调节剂的三环砜 |
WO2018071620A1 (en) * | 2016-10-13 | 2018-04-19 | Bristol-Myers Squibb Company | Heterocyclic sulfones as ror gamma modulators |
DE102017010487A1 (de) * | 2016-12-02 | 2018-06-07 | Merck Patent Gmbh | Monofluorierte cyclohexane |
KR20210009357A (ko) * | 2018-05-17 | 2021-01-26 | 브리스톨-마이어스 스큅 컴퍼니 | Ror 감마 조정제로서의 트리시클릭 술폰 화합물 |
EP3807265A1 (en) * | 2018-06-15 | 2021-04-21 | Reata Pharmaceuticals, Inc. | Pyrazole and imidazole compounds for inhibition of il-17 and rorgamma |
MX2021003158A (es) | 2018-09-18 | 2021-07-16 | Nikang Therapeutics Inc | Derivados de anillo tricíclico condensado como inhibidores de la fosfatasa de homología a src 2. |
US20230295087A1 (en) * | 2019-05-13 | 2023-09-21 | Bristol-Myers Squibb Company | AGONISTS OF ROR GAMMAt |
KR20220131962A (ko) * | 2020-01-24 | 2022-09-29 | 브리스톨-마이어스 스큅 컴퍼니 | Ror 감마 조정제로서의 트리시클릭 술폰 |
US11332442B2 (en) | 2020-08-12 | 2022-05-17 | Bristol-Myers Squibb Company | Synthetic process |
WO2023232870A1 (en) | 2022-05-31 | 2023-12-07 | Immunic Ag | Rorg/rorgt modulators for the treatment of virus infections like covid-19 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
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MXPA06011722A (es) | 2004-04-13 | 2007-01-25 | Incyte Corp | Derivados de piperazinilpiperidina como antagonistas del receptor de quimiocina. |
US20070155738A1 (en) | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
CN102702044A (zh) * | 2006-01-20 | 2012-10-03 | 先灵公司 | 作为γ分泌酶抑制剂的碳环和杂环芳基砜化合物 |
CN101970445A (zh) * | 2007-07-17 | 2011-02-09 | 先灵公司 | 苯磺酰基-色满、硫代色满、四氢萘和相关γ分泌酶抑制剂 |
KR20150013500A (ko) * | 2012-05-08 | 2015-02-05 | 머크 샤프 앤드 돔 코포레이션 | Ror감마 활성의 억제를 위한 비시클릭 술폰 화합물 및 질환의 치료 |
EP2669286A1 (en) | 2012-05-31 | 2013-12-04 | Ares Trading S.A. | Spiro tetrahydro-benzothiophen derivatives useful for the treatment of neurodegenerative diseases |
WO2014062938A1 (en) | 2012-10-19 | 2014-04-24 | Bristol-Myers Squibb Company | Rory modulators |
PE20151794A1 (es) | 2013-03-08 | 2015-12-03 | Amgen Inc | Compuestos de 1,3-oxazin-2-amina fusionados con ciclopropilo perfluorado como inhibidores de beta-secretasa y metodos de uso |
US9663469B2 (en) | 2013-09-09 | 2017-05-30 | Bristol-Myers Squibb Company | RORγ modulators |
CN105555768B (zh) * | 2013-09-20 | 2018-10-16 | 百时美施贵宝公司 | RORγ调节剂 |
ES2704460T3 (es) | 2014-01-06 | 2019-03-18 | Bristol Myers Squibb Co | Moduladores de ROR gamma de ciclohexilsulfona |
US9637455B2 (en) | 2014-01-06 | 2017-05-02 | Bristol-Myers Squibb Company | Heterocyclic sulfone RORγ modulators |
EP3092216B1 (en) | 2014-01-06 | 2018-12-12 | Bristol-Myers Squibb Company | Carbocyclic sulfone ror gamma modulators |
ES2669208T3 (es) | 2014-01-06 | 2018-05-24 | Bristol-Myers Squibb Company | Derivados de pirrolidinilsulfona y su uso como moduladores de ROR gamma |
ES2887087T3 (es) * | 2015-05-07 | 2021-12-21 | Bristol Myers Squibb Co | Sulfonas tricíclicas como moduladores ROR gamma |
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2016
- 2016-05-06 ES ES16725289T patent/ES2887087T3/es active Active
- 2016-05-06 AU AU2016258087A patent/AU2016258087B2/en not_active Ceased
- 2016-05-06 WO PCT/US2016/031118 patent/WO2016179460A1/en active Application Filing
- 2016-05-06 PE PE2017002385A patent/PE20180119A1/es unknown
- 2016-05-06 JP JP2017557912A patent/JP6553746B2/ja active Active
- 2016-05-06 MY MYPI2017704082A patent/MY190748A/en unknown
- 2016-05-06 UY UY0001036673A patent/UY36673A/es unknown
- 2016-05-06 MX MX2017014189A patent/MX2017014189A/es unknown
- 2016-05-06 MA MA042049A patent/MA42049A/fr unknown
- 2016-05-06 CN CN201680034253.8A patent/CN107709295B/zh active Active
- 2016-05-06 US US15/148,209 patent/US9815859B2/en active Active
- 2016-05-06 TN TNP/2017/000464A patent/TN2017000464A1/en unknown
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- 2016-05-06 BR BR112017023780-6A patent/BR112017023780A2/pt not_active Application Discontinuation
- 2016-05-06 EA EA201792258A patent/EA033345B1/ru not_active IP Right Cessation
- 2016-05-06 AR ARP160101311A patent/AR104555A1/es unknown
- 2016-05-06 MA MA41389A patent/MA41389A1/fr unknown
- 2016-05-06 KR KR1020177035023A patent/KR102114536B1/ko active IP Right Grant
- 2016-05-06 EP EP16725289.9A patent/EP3292101B1/en active Active
- 2016-05-06 CA CA2987759A patent/CA2987759A1/en not_active Abandoned
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2017
- 2017-09-12 US US15/701,818 patent/US10273259B2/en active Active
- 2017-11-03 IL IL255419A patent/IL255419A0/en unknown
- 2017-11-06 PH PH12017502012A patent/PH12017502012A1/en unknown
- 2017-11-06 CL CL2017002799A patent/CL2017002799A1/es unknown
- 2017-12-05 CO CONC2017/0012545A patent/CO2017012545A2/es unknown
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2018
- 2018-06-04 HK HK18107277.9A patent/HK1249500A1/zh unknown
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2019
- 2019-03-07 US US16/295,378 patent/US10711020B2/en active Active
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