AR099138A1 - Piridinas fusionadas como inhibidores del complejo p97 - Google Patents

Piridinas fusionadas como inhibidores del complejo p97

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Publication number
AR099138A1
AR099138A1 ARP150100150A ARP150100150A AR099138A1 AR 099138 A1 AR099138 A1 AR 099138A1 AR P150100150 A ARP150100150 A AR P150100150A AR P150100150 A ARP150100150 A AR P150100150A AR 099138 A1 AR099138 A1 AR 099138A1
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Argentina
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independently
group
hydrogen
optionally substituted
ring
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ARP150100150A
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Cleave Biosciences Inc
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Application filed by Cleave Biosciences Inc filed Critical Cleave Biosciences Inc
Publication of AR099138A1 publication Critical patent/AR099138A1/es

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Abstract

La presente se refiere a ciertas pirimidinas fusionadas que tienen un anillo homo- o hetero-ciclopentilo, ciclohexilo o cicloheptilo como par de fusión de la pirimidina; que tienen un grupo aminobencilo o aminobencilo sustituido en la posición 4 del anillo pirimidina; y un anillo heterobiciclo 5:6 con al menos un N, O ó S en la posición 2 del anillo pirimidina. Estos compuestos son útiles para el tratamiento del cáncer por inhibición del complejo p97. Reivindicación 1: Un compuesto de pirimidina fusionada de fórmula (1), en donde: Y es CR⁴, NH, NR⁵, O ó S y C cuando CR⁴ es un átomo sp³; m y n son cada uno independientemente un número entero de 0 a 4, y la suma de m y n es un número entero de 2, 3 ó 4; Ar es un grupo arilo opcionalmente sustituido; A, D y E son cada uno independientemente C o N, en donde C es un carbono sp² sustituido por hidrógeno o alquilo de 1 a 4 carbonos cuando una de las valencias de C no está designada de otro modo; Z y B son cada uno independientemente CR⁶, N, NR⁷, O ó S, en donde C como CR⁶ es un carbono sp²; R¹, R², R³, R⁴, R⁵, R⁶ y R⁷ se seleccionan cada uno independientemente del grupo que consiste en hidrógeno, un grupo alifático opcionalmente sustituido, un grupo aromático opcionalmente sustituido y un grupo funcional opcionalmente sustituido; con la condición de que; a) al menos uno de D y E sea C; b) al menos uno de A, D, E, Z y B sea distinto de C; c) Z y B no pueden ser ambos simultáneamente cualquiera de NR⁷, O ó S; d) cuando uno de D y E es N y A es C, entonces Z y B son cada uno independientemente CR⁶, N o NR⁷; e) cuando ambos D y E son C y A es N, Z y B son cada uno independientemente CR⁶ o N, pero cuando Y es carbono y R³ es hidrógeno, entonces Z y B no pueden ser ambos CR⁶ y B no puede ser N; f) cuando ambos D y E son C y A es N, Z y B son cada uno independientemente CR⁶ o N, pero cuando ni m ni n es cero y R³ es hidrógeno, entonces Z y B no pueden ser ambos CR⁶ y B no puede ser N; g) cuando D, E y A son todos C, entonces Z y B son cada uno independientemente CR⁶, N, NR⁷, O ó S; h) cuando uno de Z y B es O ó S, entonces el otro es CR⁶ o N, y A, D y E son todos C; i) cuando uno de Z y B es NR⁷, entonces el otro es N o CR⁶, A, D y E son todos C.
ARP150100150A 2014-01-20 2015-01-20 Piridinas fusionadas como inhibidores del complejo p97 AR099138A1 (es)

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US (2) US9828363B2 (es)
EP (1) EP3097092B1 (es)
JP (1) JP6387111B2 (es)
KR (1) KR101922317B1 (es)
CN (1) CN106458996B (es)
AR (1) AR099138A1 (es)
AU (1) AU2015206292B2 (es)
BR (1) BR112016016421B1 (es)
CA (1) CA2936559C (es)
CL (1) CL2016001840A1 (es)
EA (1) EA031317B1 (es)
ES (1) ES2819867T3 (es)
IL (1) IL246692B (es)
MX (1) MX2016009465A (es)
NZ (1) NZ722624A (es)
SG (1) SG11201605699QA (es)
TW (1) TWI640516B (es)
WO (1) WO2015109285A1 (es)
ZA (1) ZA201605107B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015089218A1 (en) 2013-12-10 2015-06-18 David Wustrow Monocyclic pyrimidine/pyridine compounds as inhibitors of p97 complex
WO2015109285A1 (en) 2014-01-20 2015-07-23 Cleave Biosciences, Inc. FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX
CR20190338A (es) * 2016-12-22 2019-09-09 Amgen Inc Inhibidores de kras g12c y métodos para su uso
JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
US20210230170A1 (en) * 2018-08-31 2021-07-29 Mirati Therapeutics, Inc. Kras g12c inhibitors
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
SG11202112855WA (en) 2019-05-21 2021-12-30 Amgen Inc Solid state forms
CN110078749B (zh) * 2019-06-04 2021-01-01 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 3a，3a′-双呋喃[2,3-b]吲哚啉类化合物、制备方法、药物组合物及应用
CN110872291B (zh) * 2019-11-26 2021-06-25 五邑大学 一种四氢吡啶并嘧啶类化合物及其制备方法和应用
EP4149934A4 (en) * 2020-05-11 2024-05-15 Cleave Therapeutics Inc CRYSTALLINE FORMS AND FORMULATIONS OF A VCP/P97 INHIBITOR
CN115916779A (zh) * 2020-05-11 2023-04-04 克立弗治疗学股份有限公司 用于治疗癌症的VCP/p97抑制剂
GB202111193D0 (en) * 2021-08-03 2021-09-15 Phoremost Ltd Pharmaceutical compounds
WO2023086419A1 (en) * 2021-11-10 2023-05-19 Cleave Therapeutics, Inc. Vcp/p97 inhibitor for the treatment of cancer
CN116178374A (zh) * 2023-01-13 2023-05-30 河北医科大学 小电导钙激活钾离子通道激动剂及其合成和应用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69408750T2 (de) 1993-08-26 1998-07-23 Ono Pharmaceutical Co 4-Aminopyrimidin Derivate
AU4499697A (en) 1996-09-13 1998-04-02 New York University Method for treating parasitic diseases with proteasome inhibitors
KR20010091827A (ko) 2000-03-18 2001-10-23 정상훈 통신 단말 번호를 이용한 송금 시스템 및 송금 방법
KR20020020316A (ko) 2000-09-08 2002-03-15 라응찬 인터넷 송금 서비스 방법
KR20030009830A (ko) 2001-07-24 2003-02-05 중소기업은행 이동단말을 이용한 현금출금 서비스 장치 및 방법
EP1352910A1 (en) 2002-04-10 2003-10-15 Grünenthal GmbH New analogs of nitrobenzylthioinosine
JP3862666B2 (ja) 2003-03-31 2006-12-27 株式会社みずほ銀行 バンキング処理方法及びバンキング処理プログラム
CN1894222A (zh) * 2003-08-05 2007-01-10 沃泰克斯药物股份有限公司 作为电压门控离子通道抑制剂的稠合嘧啶化合物
MX2007000791A (es) * 2004-08-03 2007-03-23 Wyeth Corp Indazoles utiles en el tratamiento de enfermedades cardiovasculares.
JP5311209B2 (ja) 2005-05-27 2013-10-09 オニキス セラピューティクス， インク． Ｒｐｎ１１酵素活性のための新規な基質
JP2010505794A (ja) * 2006-10-03 2010-02-25 ノイロサーチ アクティーゼルスカブ カリウムチャネル調節剤として有用なインダゾリル誘導体
US7915268B2 (en) 2006-10-04 2011-03-29 Wyeth Llc 8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression
WO2008060301A1 (en) 2006-11-16 2008-05-22 Pharmacopeia , Llc 7-substituted purine derivatives for immunosuppression
EP2120938A4 (en) 2006-12-20 2010-12-08 Merck Sharp & Dohme IMIDAZOPYRIDINE ANALOGUE AS CB2 RECEPTOR MODULATORS FOR THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES
TWI496779B (zh) 2008-08-19 2015-08-21 Array Biopharma Inc 作為ｐｉｍ激酶抑制劑之***吡啶化合物
KR20110079813A (ko) 2008-09-22 2011-07-08 아이시스 이노베이션 리미티드 이미다조〔1,2－α〕피리디닐 비스포스포네이트
EP2373317B1 (en) 2008-11-25 2016-12-14 Merck Sharp & Dohme Corp. 4-amino-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one or 4-amino-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one derivatives as activators of the soluble guanylat cyclase for the treatment of cardiovascular diseases
MX2011005621A (es) 2008-11-28 2011-06-20 Kowa Co Derivado de piridin-3-carboxiamida.
AR074870A1 (es) * 2008-12-24 2011-02-16 Palau Pharma Sa Derivados de pirazolo (1,5-a ) piridina
CA2761445A1 (en) 2009-05-27 2010-12-02 Genentech, Inc. Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
EP2338888A1 (en) * 2009-12-24 2011-06-29 Almirall, S.A. Imidazopyridine derivatives as JAK inhibitors
UY33213A (es) * 2010-02-18 2011-09-30 Almirall Sa Derivados de pirazol como inhibidores de jak
WO2011115804A1 (en) * 2010-03-17 2011-09-22 Ironwood Pharmaceuticals, Inc. Sgc stimulators
WO2011140527A2 (en) 2010-05-07 2011-11-10 California Institute Of Technology And The University Of Kansas Methods and compositions for inhibition of the transitional endoplasmic reticulum atpase
JP2013166700A (ja) 2010-06-02 2013-08-29 Dainippon Sumitomo Pharma Co Ltd 新規４，５−縮環ピリミジン誘導体
BR112014004569A2 (pt) 2011-09-01 2017-06-13 F. Hoffmann-La Roche Ag composto da fórmula i, métodos para tratar condição inflamatória, artrite reumatoide, asma e distúrbio imune, composição farmacêutica e uso do composto
WO2013170770A1 (zh) 2012-05-16 2013-11-21 上海医药集团股份有限公司 具有抗肿瘤活性的乙炔衍生物
DK2872491T3 (da) 2012-07-11 2021-08-09 Blueprint Medicines Corp Inhibitorer af fibroblastvækstfaktorreceptoren
CN104768946B (zh) 2012-07-20 2017-05-03 克里弗生物科学公司 作为p97复合物的抑制剂的稠合嘧啶
WO2015089218A1 (en) 2013-12-10 2015-06-18 David Wustrow Monocyclic pyrimidine/pyridine compounds as inhibitors of p97 complex
WO2015109285A1 (en) 2014-01-20 2015-07-23 Cleave Biosciences, Inc. FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX
MA46146A1 (fr) 2014-01-20 2020-12-31 Hanmi Pharm Ind Co Ltd Insuline a action prolongée et utilisation associée

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