CL2016001840A1 - Compuestos derivados de pirimidinas fusionadas como inhibidores del complejo p97; composicion farmaceutica y uso en el tratamiento del cancer. - Google Patents
Compuestos derivados de pirimidinas fusionadas como inhibidores del complejo p97; composicion farmaceutica y uso en el tratamiento del cancer.Info
- Publication number
- CL2016001840A1 CL2016001840A1 CL2016001840A CL2016001840A CL2016001840A1 CL 2016001840 A1 CL2016001840 A1 CL 2016001840A1 CL 2016001840 A CL2016001840 A CL 2016001840A CL 2016001840 A CL2016001840 A CL 2016001840A CL 2016001840 A1 CL2016001840 A1 CL 2016001840A1
- Authority
- CL
- Chile
- Prior art keywords
- inhibitors
- complex
- pharmaceutical composition
- cancer treatment
- compounds derived
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D491/04—Ortho-condensed systems
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- C07D491/04—Ortho-condensed systems
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- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
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- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
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Abstract
Compuestos derivados de pirimidinas fusionadas como inhibidores del complejo p97; composicion farmaceutica y uso en el tratamiento del cáncer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461929382P | 2014-01-20 | 2014-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2016001840A1 true CL2016001840A1 (es) | 2017-04-17 |
Family
ID=52478057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2016001840A CL2016001840A1 (es) | 2014-01-20 | 2016-07-20 | Compuestos derivados de pirimidinas fusionadas como inhibidores del complejo p97; composicion farmaceutica y uso en el tratamiento del cancer. |
Country Status (19)
Country | Link |
---|---|
US (2) | US9828363B2 (es) |
EP (1) | EP3097092B1 (es) |
JP (1) | JP6387111B2 (es) |
KR (1) | KR101922317B1 (es) |
CN (1) | CN106458996B (es) |
AR (1) | AR099138A1 (es) |
AU (1) | AU2015206292B2 (es) |
BR (1) | BR112016016421B1 (es) |
CA (1) | CA2936559C (es) |
CL (1) | CL2016001840A1 (es) |
EA (1) | EA031317B1 (es) |
ES (1) | ES2819867T3 (es) |
IL (1) | IL246692B (es) |
MX (1) | MX2016009465A (es) |
NZ (1) | NZ722624A (es) |
SG (1) | SG11201605699QA (es) |
TW (1) | TWI640516B (es) |
WO (1) | WO2015109285A1 (es) |
ZA (1) | ZA201605107B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201605832A (zh) | 2013-12-10 | 2016-02-16 | 克立弗生物科學公司 | 作為p97錯合物之抑制劑之單環嘧啶/吡啶化合物 |
BR112016016421B1 (pt) | 2014-01-20 | 2022-10-18 | Cleave Biosciences, Inc | Composto de pirimidina fundida, composição farmacêutica e respectivos uso |
HUE056777T2 (hu) * | 2016-12-22 | 2022-03-28 | Amgen Inc | Benzizotiazol-, izotiazolo[3,4-b]piridin-, kinazolin-, ftálazin-, pirido[2,3-d]piridazin- és pirido[2,3-d]pirimidin-származékok mint KRAS G12C inhibitorok tüdõ-, hasnyálmirigy- vagy vastagbélrák kezelésére |
JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
JP7150823B2 (ja) | 2017-09-08 | 2022-10-11 | アムジエン・インコーポレーテツド | KRas G12Cの阻害剤及びそれを使用する方法 |
ES2961253T3 (es) * | 2018-08-31 | 2024-03-11 | Mirati Therapeutics Inc | Inhibidores de KRas G12C |
JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法 |
SG11202112855WA (en) | 2019-05-21 | 2021-12-30 | Amgen Inc | Solid state forms |
CN110078749B (zh) * | 2019-06-04 | 2021-01-01 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 3a,3a′-双呋喃[2,3-b]吲哚啉类化合物、制备方法、药物组合物及应用 |
CN110872291B (zh) * | 2019-11-26 | 2021-06-25 | 五邑大学 | 一种四氢吡啶并嘧啶类化合物及其制备方法和应用 |
TW202208357A (zh) * | 2020-05-11 | 2022-03-01 | 美商克立弗治療學股份有限公司 | VCP/p97抑制劑之結晶型及調配物 |
EP4149943A4 (en) * | 2020-05-11 | 2024-06-05 | Cleave Therapeutics Inc | VCP/p97 INHIBITOR FOR CANCER TREATMENT |
GB202111193D0 (en) * | 2021-08-03 | 2021-09-15 | Phoremost Ltd | Pharmaceutical compounds |
TW202333731A (zh) * | 2021-11-10 | 2023-09-01 | 美商克立弗治療學股份有限公司 | 用於治療癌症之VCP/p97抑制劑 |
CN116178374A (zh) * | 2023-01-13 | 2023-05-30 | 河北医科大学 | 小电导钙激活钾离子通道激动剂及其合成和应用 |
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ATE163647T1 (de) | 1993-08-26 | 1998-03-15 | Ono Pharmaceutical Co | 4-aminopyrimidin derivate |
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WO2015109285A1 (en) | 2015-07-23 |
MX2016009465A (es) | 2016-12-02 |
BR112016016421B1 (pt) | 2022-10-18 |
AU2015206292A1 (en) | 2016-08-18 |
KR101922317B1 (ko) | 2018-11-26 |
AU2015206292B2 (en) | 2018-02-15 |
EA031317B1 (ru) | 2018-12-28 |
CN106458996A (zh) | 2017-02-22 |
EP3097092A1 (en) | 2016-11-30 |
US20180044325A1 (en) | 2018-02-15 |
SG11201605699QA (en) | 2016-08-30 |
US9828363B2 (en) | 2017-11-28 |
CA2936559A1 (en) | 2015-07-23 |
TWI640516B (zh) | 2018-11-11 |
ES2819867T3 (es) | 2021-04-19 |
ZA201605107B (en) | 2017-09-27 |
IL246692B (en) | 2019-05-30 |
US20160332990A1 (en) | 2016-11-17 |
JP2017505812A (ja) | 2017-02-23 |
IL246692A0 (en) | 2016-08-31 |
CN106458996B (zh) | 2020-11-03 |
KR20160110506A (ko) | 2016-09-21 |
BR112016016421A2 (es) | 2017-08-08 |
JP6387111B2 (ja) | 2018-09-05 |
EP3097092B1 (en) | 2020-08-26 |
NZ722624A (en) | 2017-09-29 |
EA201691472A1 (ru) | 2017-05-31 |
US10174005B2 (en) | 2019-01-08 |
CA2936559C (en) | 2019-03-12 |
TW201605833A (zh) | 2016-02-16 |
AR099138A1 (es) | 2016-06-29 |
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